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ReactionCatalysis155 ACTIVATION 1.0 Urokinase C05849 KEGG Compound Fibrinogen beta chain Coagulation factor V BiologicalState29 Homo sapiens, Liver 5284607 PubChem-compound 1.0 Fibrin (loose) Coagulation factor XIII B chain Tissue-type plasminogen activator P00750 UniProt 4.1.1.90 false 4.1.1.90 Precursors of Prothrombin and coagulation factors VII, IX, ad X → Prothrombin and coagulation factors VII, IX and X LEFT_TO_RIGHT Plasminogen 1.0 Activate Coagulatin factor VII to VIIa by binding to Tissue Factor ActivatingSubPathway 82688 ChemSpider ReactionCatalysis142 ACTIVATION 4447652 ChemSpider 4.1.1.90 false 4.1.1.90 Reduced Vitamin K (phylloquinone) → Vitamin K1 2,3-epoxide LEFT_TO_RIGHT 3.4.21.68 false 3.4.21.68 Plasminogen → Plasmin LEFT_TO_RIGHT Fibrinogen alpha chain Fibrin (mesh) ReactionCatalysis381 ACTIVATION Plasma kallikrein SubPathwayActivation C05850 KEGG Compound Fibrinogen gamma chain 1.0 Coagulation factor XIII B chain SubPathwayActivator 1.0 Prothrombin and coagulation factors VII, IX and X BTO:0001102 BRENDA TISSUE ONTOLOGY Urokinase Action Pathway SMILES CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC\C(C)=C\CC1=C(C)C(=O)C2=C(C=CC=C2)C1=O 1.0 3.4.21.7 false 3.4.21.7 Fibrin (mesh) → Fibrin degradation products LEFT_TO_RIGHT P38435 UniProt P00488 UniProt Vitamin K-dependent gamma-carboxylase Coagulation factor XI Coagulation factor XIII A chain SubPathwayActivator Coagulation factor X P02671 UniProt Vitamin K epoxide reductase complex subunit 1 BTO:0000759 BRENDA TISSUE ONTOLOGY Fibrinogen gamma chain Coagulation factor VII Homo sapiens Tenase complex SubPathwayControl567 SubPathway567Control ActivatingSubPathwayControl 1.0 Urokinase SubPathwayActivator Vitamin K-dependent gamma-carboxylase Coagulation factor VIII Coagulation factor IX P13726 UniProt ReactionCatalysis1103 ACTIVATION 2.3.2.13 false 2.3.2.13 Fibrin (loose) → Fibrin (mesh) LEFT_TO_RIGHT Coagulation factor VIII ReactionCatalysis1105 ACTIVATION HMDB0002972 HMDB 3.4.21.5 false 3.4.21.5 Fibrinogen → Fibrin (loose) LEFT_TO_RIGHT HMDB0004198 HMDB P02675 UniProt 1.1.4.1 false 1.1.4.1 Vitamin K1 2,3-epoxide → Reduced Vitamin K (phylloquinone) LEFT_TO_RIGHT ReactionCatalysis1100 ACTIVATION Q9BQB6 UniProt P02679 UniProt 1.0 Tissue factor Collagen alpha-1(I) chain Fibrinogen 23-EPOXY-23-DIHYDRO-2-METHYL-14-NAPHTHOQ BioCyc C31H46O3 Vitamin K1 2,3-epoxide 466.3447 ReactionCatalysis1115 ACTIVATION 3.4.21.5 false 3.4.21.5 Coagulation factor V → Coagulation factor Va LEFT_TO_RIGHT 3.4.21.5 false 3.4.21.5 Coagulation factor VIII → Coagulation factor VIIIa LEFT_TO_RIGHT 1.0 3.4.21.22 false 3.4.21.22 Coagulation factor X → Coagulation factor Xa LEFT_TO_RIGHT 1.0 PW000306 PathWhiz P08709 UniProt Precursors of Prothrombin and coagulation factors VII, IX, ad X Reaction1389 false Prothrombin → Thrombin LEFT_TO_RIGHT 3.4.21.38 false 3.4.21.38 Coagulation factor XI → Coagulation factor XIa LEFT_TO_RIGHT ReactionCatalysis1110 ACTIVATION 9606 TAXONOMY SubPathwayControl184 ActivatingSubPathwayControl SubPathway184Control Collagen alpha-1(I) chain SubPathwayActivator Coagulation factor XII SubPathwayControl186 ActivatingSubPathwayControl SubPathway186Control P12259 UniProt P02452 UniProt SubPathwayControl188 ActivatingSubPathwayControl SubPathway188Control Coagulation factor XIIIa SubPathwayActivation 3.4.21.27 false 3.4.21.27 Coagulation factor IX → Coagulation factor IXa LEFT_TO_RIGHT Prothrombin and coagulation factors VII, IX and X Vitamin K1 2,3-epoxide 1.0 P05160 UniProt 84-80-0 CAS ReactionCatalysis1126 ACTIVATION ReactionCatalysis1125 ACTIVATION ReactionCatalysis1129 ACTIVATION 1.0 Coagulation factor V ReactionCatalysis1124 ACTIVATION Fibrin degradation products SMP0000284 SMPDB 91577 PubChem-compound SMILES CC(C)CCCC(C)CCCC(C)CCC\C(C)=C\CC12OC1(C)C(=O)C1=C(C=CC=C1)C2=O Coagulation factor XIII A chain Coagulation factor X Coagulation factor XIII A chain Tissue factor:Coagulation factor VIIa SubPathwayActivation Vitamin K epoxide reductase complex subunit 1 Precursors of Prothrombin and coagulation factors VII, IX, ad X SubPathwayControl216 SubPathway216Control ActivatingSubPathwayControl Coagulation factor VII SubPathwayActivator Prothrombin and coagulation factors VII, IX and X 1.0 Plasminogen SubPathwayActivation Liver Coagulation factor XI Prothrombin 25486-55-9 CAS Coagulation factor IX P03951 UniProt P03952 UniProt Urokinase inhibition of Plasminogen ActivatingSubPathway ReactionCatalysis1134 ACTIVATION Plasma kallikrein P00451 UniProt Tissue-type plasminogen activator Coagulation factor XIIIa 1.0 Tissue factor SubPathwayActivator Coagulation factor XIII B chain Fibrinogen alpha chain Extracellular Space Fibrinogen beta chain Blood Vessel 1.0 Prothrombin BiologicalState51 Homo sapiens, Blood Vessel P00734 UniProt Coagulation factor XIII A and B activate to Coagulation factor XIIIa ActivatingSubPathway Coagulation factor XII SubPathwayActivation SubPathwayActivator Vitamin K-dependent gamma-carboxylase SubPathwayControl235 SubPathway235Control ActivatingSubPathwayControl 1.0 Plasma kallikrein SubPathwayActivator CHEBI:18067 ChEBI Coagulation factor XII P00747 UniProt Reduced Vitamin K (phylloquinone) P00748 UniProt Coagulation factor XI C31H46O2 Reduced Vitamin K (phylloquinone) 450.3498 GO:0005615 GENE ONTOLOGY XII activated to XIIa by Collagen ActivatingSubPathway Transport80 false Prothrombin and coagulation factors VII, IX and X (→) Transport: Homo sapiens, Liver, Cell to Homo sapiens, Blood Vessel LEFT_TO_RIGHT XII activated to XIIa by Plasma kallikrein ActivatingSubPathway 1.0 P00740 UniProt Coagulation factor X CHEBI:28371 ChEBI Plasma prekallikrein activated to Plasma kallikrein by XIIa ActivatingSubPathway P00742 UniProt DB00013 DrugBank Urokinase Plasminogen Coagulation factor XII Collagen alpha-1(I) chain Coagulation factor XIIa Plasma kallikrein Coagulation factor XIII A chain Coagulation factor XIII B chain Coagulation factor VII Tissue factor Tissue factor:Coagulation factor VIIa Plasma prekallikrein Coagulation factor XIIa Coagulation factor XI Coagulation factor XIa Coagulation factor IX Coagulation factor IXa Coagulation factor VIII Coagulation factor VIIIa Prothrombin Coagulation factor V Coagulation factor Va Prothrombin Coagulation factor X Coagulation factor Xa Prothrombin Thrombin Fibrinogen alpha chain Fibrinogen beta chain Fibrinogen gamma chain Fibrin (loose) Fibrin (mesh) Coagulation factor XIIIa Fibrin degradation products Plasmin Plasminogen Tissue-type plasminogen activator Coagulation factor X Vitamin K epoxide reductase complex subunit 1 Vitamin K-dependent gamma- carboxylase Vitamin K1 2,3-epoxide Reduced Vitamin K (phylloquinone) Cortexolone Calcium Calcium Cortexolone Calcium Cortexolone Calcium Calcium Calcium Calcium Calcium Calcium Precursors of Prothrombin and coagulation factors VII, IX, ad X Prothrombin and coagulation factors VII, IX and X Platelet Factor 3 Tenase complex Platelet factor 3 Prothrombinase complex ENDOTHELIAL CELL SUBENDOTHELIUM VASCULAR INJURY ENDOTHELIAL CELL SUBENDOTHELIUM COAGULATION
ReactionCatalysis155 ACTIVATION 1.0 Urokinase C05849 KEGG Compound Fibrinogen beta chain Coagulation factor V BiologicalState29 Homo sapiens, Liver 5284607 PubChem-compound 1.0 Fibrin (loose) Coagulation factor XIII B chain Tissue-type plasminogen activator P00750 UniProt 4.1.1.90 false 4.1.1.90 Precursors of Prothrombin and coagulation factors VII, IX, ad X → Prothrombin and coagulation factors VII, IX and X LEFT_TO_RIGHT Plasminogen 1.0 Activate Coagulatin factor VII to VIIa by binding to Tissue Factor ActivatingSubPathway 82688 ChemSpider ReactionCatalysis142 ACTIVATION 4447652 ChemSpider 4.1.1.90 false 4.1.1.90 Reduced Vitamin K (phylloquinone) → Vitamin K1 2,3-epoxide LEFT_TO_RIGHT 3.4.21.68 false 3.4.21.68 Plasminogen → Plasmin LEFT_TO_RIGHT Fibrinogen alpha chain Fibrin (mesh) ReactionCatalysis381 ACTIVATION Plasma kallikrein SubPathwayActivation C05850 KEGG Compound Fibrinogen gamma chain 1.0 Coagulation factor XIII B chain SubPathwayActivator 1.0 Prothrombin and coagulation factors VII, IX and X BTO:0001102 BRENDA TISSUE ONTOLOGY Urokinase Action Pathway SMILES CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC\C(C)=C\CC1=C(C)C(=O)C2=C(C=CC=C2)C1=O 1.0 3.4.21.7 false 3.4.21.7 Fibrin (mesh) → Fibrin degradation products LEFT_TO_RIGHT P38435 UniProt P00488 UniProt Vitamin K-dependent gamma-carboxylase Coagulation factor XI Coagulation factor XIII A chain SubPathwayActivator Coagulation factor X P02671 UniProt Vitamin K epoxide reductase complex subunit 1 BTO:0000759 BRENDA TISSUE ONTOLOGY Fibrinogen gamma chain Coagulation factor VII Homo sapiens Tenase complex SubPathwayControl567 SubPathway567Control ActivatingSubPathwayControl 1.0 Urokinase SubPathwayActivator Vitamin K-dependent gamma-carboxylase Coagulation factor VIII Coagulation factor IX P13726 UniProt ReactionCatalysis1103 ACTIVATION 2.3.2.13 false 2.3.2.13 Fibrin (loose) → Fibrin (mesh) LEFT_TO_RIGHT Coagulation factor VIII ReactionCatalysis1105 ACTIVATION HMDB0002972 HMDB 3.4.21.5 false 3.4.21.5 Fibrinogen → Fibrin (loose) LEFT_TO_RIGHT HMDB0004198 HMDB P02675 UniProt 1.1.4.1 false 1.1.4.1 Vitamin K1 2,3-epoxide → Reduced Vitamin K (phylloquinone) LEFT_TO_RIGHT ReactionCatalysis1100 ACTIVATION Q9BQB6 UniProt P02679 UniProt 1.0 Tissue factor Collagen alpha-1(I) chain Fibrinogen 23-EPOXY-23-DIHYDRO-2-METHYL-14-NAPHTHOQ BioCyc C31H46O3 Vitamin K1 2,3-epoxide 466.3447 ReactionCatalysis1115 ACTIVATION 3.4.21.5 false 3.4.21.5 Coagulation factor V → Coagulation factor Va LEFT_TO_RIGHT 3.4.21.5 false 3.4.21.5 Coagulation factor VIII → Coagulation factor VIIIa LEFT_TO_RIGHT 1.0 3.4.21.22 false 3.4.21.22 Coagulation factor X → Coagulation factor Xa LEFT_TO_RIGHT 1.0 PW000306 PathWhiz P08709 UniProt Precursors of Prothrombin and coagulation factors VII, IX, ad X Reaction1389 false Prothrombin → Thrombin LEFT_TO_RIGHT 3.4.21.38 false 3.4.21.38 Coagulation factor XI → Coagulation factor XIa LEFT_TO_RIGHT ReactionCatalysis1110 ACTIVATION 9606 TAXONOMY SubPathwayControl184 ActivatingSubPathwayControl SubPathway184Control Collagen alpha-1(I) chain SubPathwayActivator Coagulation factor XII SubPathwayControl186 ActivatingSubPathwayControl SubPathway186Control P12259 UniProt P02452 UniProt SubPathwayControl188 ActivatingSubPathwayControl SubPathway188Control Coagulation factor XIIIa SubPathwayActivation 3.4.21.27 false 3.4.21.27 Coagulation factor IX → Coagulation factor IXa LEFT_TO_RIGHT Prothrombin and coagulation factors VII, IX and X Vitamin K1 2,3-epoxide 1.0 P05160 UniProt 84-80-0 CAS ReactionCatalysis1126 ACTIVATION ReactionCatalysis1125 ACTIVATION ReactionCatalysis1129 ACTIVATION 1.0 Coagulation factor V ReactionCatalysis1124 ACTIVATION Fibrin degradation products SMP0000284 SMPDB 91577 PubChem-compound SMILES CC(C)CCCC(C)CCCC(C)CCC\C(C)=C\CC12OC1(C)C(=O)C1=C(C=CC=C1)C2=O Coagulation factor XIII A chain Coagulation factor X Coagulation factor XIII A chain Tissue factor:Coagulation factor VIIa SubPathwayActivation Vitamin K epoxide reductase complex subunit 1 Precursors of Prothrombin and coagulation factors VII, IX, ad X SubPathwayControl216 SubPathway216Control ActivatingSubPathwayControl Coagulation factor VII SubPathwayActivator Prothrombin and coagulation factors VII, IX and X 1.0 Plasminogen SubPathwayActivation Liver Coagulation factor XI Prothrombin 25486-55-9 CAS Coagulation factor IX P03951 UniProt P03952 UniProt Urokinase inhibition of Plasminogen ActivatingSubPathway ReactionCatalysis1134 ACTIVATION Plasma kallikrein P00451 UniProt Tissue-type plasminogen activator Coagulation factor XIIIa 1.0 Tissue factor SubPathwayActivator Coagulation factor XIII B chain Fibrinogen alpha chain Extracellular Space Fibrinogen beta chain Blood Vessel 1.0 Prothrombin BiologicalState51 Homo sapiens, Blood Vessel P00734 UniProt Coagulation factor XIII A and B activate to Coagulation factor XIIIa ActivatingSubPathway Coagulation factor XII SubPathwayActivation SubPathwayActivator Vitamin K-dependent gamma-carboxylase SubPathwayControl235 SubPathway235Control ActivatingSubPathwayControl 1.0 Plasma kallikrein SubPathwayActivator CHEBI:18067 ChEBI Coagulation factor XII P00747 UniProt Reduced Vitamin K (phylloquinone) P00748 UniProt Coagulation factor XI C31H46O2 Reduced Vitamin K (phylloquinone) 450.3498 GO:0005615 GENE ONTOLOGY XII activated to XIIa by Collagen ActivatingSubPathway Transport80 false Prothrombin and coagulation factors VII, IX and X (→) Transport: Homo sapiens, Liver, Cell to Homo sapiens, Blood Vessel LEFT_TO_RIGHT XII activated to XIIa by Plasma kallikrein ActivatingSubPathway 1.0 P00740 UniProt Coagulation factor X CHEBI:28371 ChEBI Plasma prekallikrein activated to Plasma kallikrein by XIIa ActivatingSubPathway P00742 UniProt DB00013 DrugBank Unknown PLG F12 COL1A1 F12 KLKB1 F13A1 Unknown F7 Unknown F7 KLKB1 F12 Unknown Unknown F9 F9 F8 F8 Unknown F5 F5 Unknown F10 F10 Unknown Unknown Unknown Unknown FGG Unknown Unknown F13A1 Unknown PLG PLG PLAT F10 VKORC1 GGCX Vitamin K1 2,3-epoxide Reduced Vitamin K (phylloquinone) Precursors of Prothrombin and coagulation factors VII, IX, ad X Prothrombin and coagulation factors VII, IX and X Created with Snap