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CHEBI:16015 ChEBI 30572 ChemSpider 6022 PubChem-compound C4H4O5 Oxalacetic acid 132.00587 L-Alanyl-tRNA(Ala) Adenosine triphosphate 1.0 Adenosine monophosphate C10H14N5O7P Adenosine monophosphate 347.06308 50 ChemSpider CHEBI:16027 ChEBI P11498 UniProt HMDB0000538 HMDB OXALACETIC_ACID BioCyc ATP BioCyc Q5JTZ9 UniProt 1.0 328-42-7 CAS 51 PubChem-compound 559142 ChemSpider SMILES OC([O-])=O ADP BioCyc C3H4O3 Pyruvic acid 88.016045 HCO3 BioCyc 1.0 5742 ChemSpider GO:0005829 GENE ONTOLOGY 1.0 C5H6O5 Oxoglutaric acid 146.02153 Citric Acid Cycle SubPathway 5858 ChemSpider SubPathwayInteraction1 SubPathway1Reaction SubPathwayReaction SMP0000313 SMPDB 5735 ChemSpider Pyrophosphate O4P Phosphate 94.95342 945 ChemSpider Serine--pyruvate aminotransferase PPI BioCyc SubPathwayInteraction2 SubPathwayReaction SubPathway2Reaction Mitochondrion GLY BioCyc 1.0 CHEBI:16977 ChEBI HMDB0000208 HMDB Cytosol 1.0 SMILES [O-]P([O-])([O-])=O Adenosine monophosphate L-Alanyl-tRNA(Ala) SMILES OC(=O)CCC(=O)C(O)=O CHEBI:30915 ChEBI C2H5NO2 Glycine 75.03203 ReactionCatalysis5 ACTIVATION L-Alanine C2H2O3 Glyoxylic acid 74.0004 C00009 KEGG Compound C00008 KEGG Compound ReactionCatalysis3 ACTIVATION ReactionCatalysis4 ACTIVATION ReactionCatalysis1 ACTIVATION Alanine--tRNA ligase, mitochondrial ReactionCatalysis2 ACTIVATION L-ALPHA-ALANINE BioCyc HMDB0001429 HMDB 4.0 56-41-7 CAS CHEBI:18361 ChEBI CHEBI:18367 ChEBI 1032 ChemSpider C00002 KEGG Compound 1031 ChemSpider HMDB0000223 HMDB 5257127 PubChem-compound Alanine--tRNA ligase, cytoplasmic GO:0005759 GENE ONTOLOGY Pyrophosphate GLT BioCyc 1.0 SMP0000057 SMPDB Oxoglutaric acid Pyruvic acid SMILES C[C@H](N)C(O)=O 5950 PubChem-compound tRNA(Ala) C00013 KEGG Compound O7P2 Pyrophosphate 173.91193 HMDB0000595 HMDB Alanine aminotransferase 1 2.0 5957 PubChem-compound 1.0 Phosphate C00022 KEGG Compound HMDB0000119 HMDB 56-65-5 CAS Pyruvate carboxylase, mitochondrial C00020 KEGG Compound L-Glutamic acid C00026 KEGG Compound C00025 KEGG Compound HMDB0000123 HMDB HMDB0000243 HMDB Adenosine triphosphate GO:0005739 GENE ONTOLOGY C10H15N5O10P2 Adenosine diphosphate 427.02942 298-12-4 CAS Selenoamino Acid Metabolism SubPathway Alanine--tRNA ligase, mitochondrial CHEBI:29170 ChEBI 769 PubChem-compound Serine--pyruvate aminotransferase 1.0 CPD-8587 BioCyc P49588 UniProt Pyruvate carboxylase, mitochondrial 1.0 760 PubChem-compound CHEBI:16891 ChEBI C00037 KEGG Compound Transport1 false Pyruvic acid (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Mitochondrial Matrix LEFT_TO_RIGHT C00036 KEGG Compound 328-50-7 CAS AMP BioCyc Oxalacetic acid C00041 KEGG Compound 2.0 1.0 Glyoxylic acid Mitochondrial Matrix Lactic Acidemia HMDB0000250 HMDB SMILES [O-]P([O-])(=O)OP([O-])([O-])=O 14000-31-8 CAS HMDB0001341 HMDB 1.0 1.0 C00048 KEGG Compound C00288 KEGG Compound SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Alanine aminotransferase 1 1.0 HMDB0000148 HMDB 1.0 1.0 1.0 CHEBI:15422 ChEBI Glycine SMP0000029 SMPDB Homo sapiens SMILES OC(=O)CC(=O)C(O)=O 61-19-8 CAS GLYOX BioCyc SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 127-17-3 CAS 1.0 Pyruvic acid 56-86-0 CAS C5H9NO4 L-Glutamic acid 147.05316 CHEBI:17732 ChEBI 33032 PubChem-compound C10H16N5O13P3 Adenosine triphosphate 506.99576 1.0 56-40-6 CAS P24298 UniProt CHEBI:16761 ChEBI 2.6.1.2 false 2.6.1.2 L-Alanine + Oxoglutaric acid ↔ L-Glutamic acid + Pyruvic acid REVERSIBLE 6.1.1.7 false 6.1.1.7 Adenosine triphosphate + L-Alanine + tRNA(Ala) → Adenosine monophosphate + L-Alanyl-tRNA(Ala) + Pyrophosphate LEFT_TO_RIGHT HMDB0000045 HMDB SMILES CC(=O)C(O)=O 6.4.1.1 false 6.4.1.1 Adenosine triphosphate + Hydrogen carbonate + Pyruvic acid → Adenosine diphosphate + Oxalacetic acid + Phosphate LEFT_TO_RIGHT Reaction3 false Glyoxylic acid + L-Alanine ↔ Glycine + Pyruvic acid REVERSIBLE CHEBI:15428 ChEBI HMDB0000161 HMDB 9606 TAXONOMY CHEBI:17544 ChEBI C3H7NO2 L-Alanine 89.047676 2-KETOGLUTARATE BioCyc L-Alanine SubPathwayOutput 5800 ChemSpider Serine--pyruvate aminotransferase 730 ChemSpider SMILES N[C@@H](CCC(O)=O)C(O)=O CHEBI:32816 ChEBI Adenosine diphosphate 14265-44-2 CAS PYRUVATE BioCyc 58-64-0 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Alanine aminotransferase 1 Pyruvate carboxylase, mitochondrial CHEBI:30744 ChEBI Oxalacetic acid SubPathwayInput tRNA(Ala) PW000007 PathWhiz Alanine--tRNA ligase, cytoplasmic L-Alanyl-tRNA(Ala) tRNA(Ala) 644102 PubChem-compound PW000005 PathWhiz 6083 PubChem-compound SMILES OC(=O)C=O SMILES NCC(O)=O Hydrogen carbonate 1060 PubChem-compound 1061 PubChem-compound PW000114 PathWhiz 1.0 749 ChemSpider 71-52-3 CAS 1.0 970 PubChem-compound 1.0 740 ChemSpider CHO3 Hydrogen carbonate 60.99257 P21549 UniProt Alanine--tRNA ligase, cytoplasmic Alanine aminotransferase 1 Pyruvate carboxylase, mitochondrial Serine-- pyruvate aminotransferase Alanine--tRNA ligase, mitochondrial Accumulation L-Alanine Oxalacetic acid Pyruvic acid Pyruvic acid ATP AMP PP i Oxoglutaric acid L-Glutamic acid ATP HCO 3 - ADP P i Accumulation L-Alanine Glyoxylic acid Glycine ATP AMP PP i Zinc (II) ion Pyridoxal 5'-phosphate Biotin Manganese Pyridoxal 5'-phosphate Zinc (II) ion tRNA(Ala) L-Alanyl- tRNA(Ala) tRNA(Ala) L-Alanyl- tRNA(Ala) Selenoamino Acid Metabolism Citric Acid Cycle Mitochondria Intracellular Space
CHEBI:16015 ChEBI 30572 ChemSpider 6022 PubChem-compound C4H4O5 Oxalacetic acid 132.00587 L-Alanyl-tRNA(Ala) Adenosine triphosphate 1.0 Adenosine monophosphate C10H14N5O7P Adenosine monophosphate 347.06308 50 ChemSpider CHEBI:16027 ChEBI P11498 UniProt HMDB0000538 HMDB OXALACETIC_ACID BioCyc ATP BioCyc Q5JTZ9 UniProt 1.0 328-42-7 CAS 51 PubChem-compound 559142 ChemSpider SMILES OC([O-])=O ADP BioCyc C3H4O3 Pyruvic acid 88.016045 HCO3 BioCyc 1.0 5742 ChemSpider GO:0005829 GENE ONTOLOGY 1.0 C5H6O5 Oxoglutaric acid 146.02153 Citric Acid Cycle SubPathway 5858 ChemSpider SubPathwayInteraction1 SubPathway1Reaction SubPathwayReaction SMP0000313 SMPDB 5735 ChemSpider Pyrophosphate O4P Phosphate 94.95342 945 ChemSpider Serine--pyruvate aminotransferase PPI BioCyc SubPathwayInteraction2 SubPathwayReaction SubPathway2Reaction Mitochondrion GLY BioCyc 1.0 CHEBI:16977 ChEBI HMDB0000208 HMDB Cytosol 1.0 SMILES [O-]P([O-])([O-])=O Adenosine monophosphate L-Alanyl-tRNA(Ala) SMILES OC(=O)CCC(=O)C(O)=O CHEBI:30915 ChEBI C2H5NO2 Glycine 75.03203 ReactionCatalysis5 ACTIVATION L-Alanine C2H2O3 Glyoxylic acid 74.0004 C00009 KEGG Compound C00008 KEGG Compound ReactionCatalysis3 ACTIVATION ReactionCatalysis4 ACTIVATION ReactionCatalysis1 ACTIVATION Alanine--tRNA ligase, mitochondrial ReactionCatalysis2 ACTIVATION L-ALPHA-ALANINE BioCyc HMDB0001429 HMDB 4.0 56-41-7 CAS CHEBI:18361 ChEBI CHEBI:18367 ChEBI 1032 ChemSpider C00002 KEGG Compound 1031 ChemSpider HMDB0000223 HMDB 5257127 PubChem-compound Alanine--tRNA ligase, cytoplasmic GO:0005759 GENE ONTOLOGY Pyrophosphate GLT BioCyc 1.0 SMP0000057 SMPDB Oxoglutaric acid Pyruvic acid SMILES C[C@H](N)C(O)=O 5950 PubChem-compound tRNA(Ala) C00013 KEGG Compound O7P2 Pyrophosphate 173.91193 HMDB0000595 HMDB Alanine aminotransferase 1 2.0 5957 PubChem-compound 1.0 Phosphate C00022 KEGG Compound HMDB0000119 HMDB 56-65-5 CAS Pyruvate carboxylase, mitochondrial C00020 KEGG Compound L-Glutamic acid C00026 KEGG Compound C00025 KEGG Compound HMDB0000123 HMDB HMDB0000243 HMDB Adenosine triphosphate GO:0005739 GENE ONTOLOGY C10H15N5O10P2 Adenosine diphosphate 427.02942 298-12-4 CAS Selenoamino Acid Metabolism SubPathway Alanine--tRNA ligase, mitochondrial CHEBI:29170 ChEBI 769 PubChem-compound Serine--pyruvate aminotransferase 1.0 CPD-8587 BioCyc P49588 UniProt Pyruvate carboxylase, mitochondrial 1.0 760 PubChem-compound CHEBI:16891 ChEBI C00037 KEGG Compound Transport1 false Pyruvic acid (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Mitochondrial Matrix LEFT_TO_RIGHT C00036 KEGG Compound 328-50-7 CAS AMP BioCyc Oxalacetic acid C00041 KEGG Compound 2.0 1.0 Glyoxylic acid Mitochondrial Matrix Lactic Acidemia HMDB0000250 HMDB SMILES [O-]P([O-])(=O)OP([O-])([O-])=O 14000-31-8 CAS HMDB0001341 HMDB 1.0 1.0 C00048 KEGG Compound C00288 KEGG Compound SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Alanine aminotransferase 1 1.0 HMDB0000148 HMDB 1.0 1.0 1.0 CHEBI:15422 ChEBI Glycine SMP0000029 SMPDB Homo sapiens SMILES OC(=O)CC(=O)C(O)=O 61-19-8 CAS GLYOX BioCyc SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 127-17-3 CAS 1.0 Pyruvic acid 56-86-0 CAS C5H9NO4 L-Glutamic acid 147.05316 CHEBI:17732 ChEBI 33032 PubChem-compound C10H16N5O13P3 Adenosine triphosphate 506.99576 1.0 56-40-6 CAS P24298 UniProt CHEBI:16761 ChEBI 2.6.1.2 false 2.6.1.2 L-Alanine + Oxoglutaric acid ↔ L-Glutamic acid + Pyruvic acid REVERSIBLE 6.1.1.7 false 6.1.1.7 Adenosine triphosphate + L-Alanine + tRNA(Ala) → Adenosine monophosphate + L-Alanyl-tRNA(Ala) + Pyrophosphate LEFT_TO_RIGHT HMDB0000045 HMDB SMILES CC(=O)C(O)=O 6.4.1.1 false 6.4.1.1 Adenosine triphosphate + Hydrogen carbonate + Pyruvic acid → Adenosine diphosphate + Oxalacetic acid + Phosphate LEFT_TO_RIGHT Reaction3 false Glyoxylic acid + L-Alanine ↔ Glycine + Pyruvic acid REVERSIBLE CHEBI:15428 ChEBI HMDB0000161 HMDB 9606 TAXONOMY CHEBI:17544 ChEBI C3H7NO2 L-Alanine 89.047676 2-KETOGLUTARATE BioCyc L-Alanine SubPathwayOutput 5800 ChemSpider Serine--pyruvate aminotransferase 730 ChemSpider SMILES N[C@@H](CCC(O)=O)C(O)=O CHEBI:32816 ChEBI Adenosine diphosphate 14265-44-2 CAS PYRUVATE BioCyc 58-64-0 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Alanine aminotransferase 1 Pyruvate carboxylase, mitochondrial CHEBI:30744 ChEBI Oxalacetic acid SubPathwayInput tRNA(Ala) PW000007 PathWhiz Alanine--tRNA ligase, cytoplasmic L-Alanyl-tRNA(Ala) tRNA(Ala) 644102 PubChem-compound PW000005 PathWhiz 6083 PubChem-compound SMILES OC(=O)C=O SMILES NCC(O)=O Hydrogen carbonate 1060 PubChem-compound 1061 PubChem-compound PW000114 PathWhiz 1.0 749 ChemSpider 71-52-3 CAS 1.0 970 PubChem-compound 1.0 740 ChemSpider CHO3 Hydrogen carbonate 60.99257 P21549 UniProt Mitochondria AARS GPT PC AGXT AARS2 Accumulation L-Alanine Oxalacetic acid Pyruvic acid Pyruvic acid Adenosine triphosphate Adenosine monophosphate Pyrophosphate Oxoglutaric acid L-Glutamic acid Adenosine triphosphate Hydrogen carbonate Adenosine diphosphate Phosphate Accumulation L-Alanine Glyoxylic acid Glycine Adenosine triphosphate Adenosine monophosphate Pyrophosphate tRNA(Ala) L-Alanyl- tRNA(Ala) tRNA(Ala) L-Alanyl- tRNA(Ala) Selenoamino Acid Metabolism Citric Acid Cycle