6022
PubChem-compound
923
PubChem-compound
ReactionCoupledTransportCatalysis4
ACTIVATION
Voltage-gated slow delayed rectifying potassium channel (IK5)
Voltage-gated ultra rapid delayed rectifying potassium channel
Disks large homolog 1
Voltage-gated rapidly activating transient outward delayed rectifying potassium channel (IKto)
ATP-binding cassette sub-family C member 9
937
ChemSpider
Sodium/potassium-transporting ATPase subunit beta-3
Acetylcholine-activated potassium channel (IKACh)
SubPathwayActivation
Inward rectifier potassium channel (IK1)
Potassium voltage-gated channel subfamily A member 5
direct_interaction
Sodium/calcium exchanger 1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
SubPathwayInhibition
Transport119
false
Calcium (→), Sodium (←) Transport: Homo sapiens, Cardiomyocyte , Cytosol to Homo sapiens, Extracellular Space
LEFT_TO_RIGHT
O00180
UniProt
C15H12N2O2
Phenytoin
252.08987
Transport116
false
Potassium (→) Transport: Homo sapiens, Cardiomyocyte , Cytosol to Homo sapiens, Extracellular Space
LEFT_TO_RIGHT
Reaction179579
false
Calcium + Troponin → Calcium + Troponin
LEFT_TO_RIGHT
Transport120
false
Sodium (→), Potassium (←) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cardiomyocyte , Cytosol
LEFT_TO_RIGHT
Voltage-gated T-type calcium channel (ICaT)
Calcium
SubPathwayActivator
Voltage-gated sodium channel (INa)
ATP
BioCyc
Voltage-depenent L-type calcium channel
P63252
UniProt
Voltage-depenent L-type calcium channel
SubPathwayActivation
ATP-sensitive inward rectifier potassium channel (IKATP)
Voltage-gated rapid delayed rectifying potassium channel (IKr)
Ryanodine receptor 2
Voltage-dependent calcium channel subunit alpha-2/delta-2
SubPathwayInteraction109962
SubPathwayReaction
SubPathway109962Reaction
1.0
P05023
UniProt
P05026
UniProt
1.0
5742
ChemSpider
HMDB0014397
HMDB
Sodium channel protein type 5 subunit alpha
Phenytoin
SubPathwayInhibitor
BTO:0000887
BRENDA TISSUE ONTOLOGY
Q13936
UniProt
813
PubChem-compound
Sodium/potassium ATPase
Beta-1-syntrophin
CL:0000746
CELL TYPE ONTOLOGY
Sodium/potassium-transporting ATPase subunit beta-2
Sodium/potassium-transporting ATPase subunit beta-1
Voltage-gated sodium channel (INa)
SubPathwayInhibition
P48050
UniProt
C00238
KEGG Compound
Q92736
UniProt
57-41-0
CAS
Cytosol
Troponin
Beta-2-syntrophin
Alpha-1-syntrophin
C00009
KEGG Compound
C00008
KEGG Compound
Q13884
UniProt
cAMP-dependent protein kinase type I-alpha regulatory subunit
SubPathwayActivation
24203-36-9
CAS
C00001
KEGG Compound
Sodium/potassium-transporting ATPase subunit alpha-4
C01330
KEGG Compound
Transport53
false
Sodium (→), Potassium (←) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space
LEFT_TO_RIGHT
CHEBI:18367
ChEBI
1032
ChemSpider
C00002
KEGG Compound
Sodium/potassium-transporting ATPase subunit alpha-1
Transport62
false
Sodium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol
LEFT_TO_RIGHT
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
50839
ChemSpider
Fosphenytoin
C16H15N2O6P
Fosphenytoin
362.06677
Inward rectifier potassium channel 2
P54710
UniProt
BiologicalState45
Homo sapiens, Cardiomyocyte
1.0
Extracellular Space
ATP-sensitive inward rectifier potassium channel 11
14127-61-8
CAS
BiologicalState50
Homo sapiens, Muscle, Myocyte
Q9NS61
UniProt
P15382
UniProt
Q13733
UniProt
Q9UK17
UniProt
Calcium
1.0
56-65-5
CAS
Sodium
CHEBI:8107
ChEBI
CHEBI:29108
ChEBI
Troponin
CHEBI:29101
ChEBI
CHEBI:29103
ChEBI
1775
PubChem-compound
899
ChemSpider
P51787
UniProt
93390-81-9
CAS
CHEBI:775287
ChEBI
Potassium
Ryanodine receptor 2
HMDB0001341
HMDB
P07951
UniProt
Voltage-dependent L-type calcium channel subunit alpha-1C
Potassium voltage-gated channel subfamily H member 2
K%2b
BioCyc
P54709
UniProt
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
4.0
17341-25-2
CAS
Potassium voltage-gated channel subfamily KQT member 1
SubPathwayControl320
ActivatingSubPathwayControl
SubPathway320Control
Phosphate
SubPathwayControl321
SubPathway321Control
ActivatingSubPathwayControl
SubPathwayControl322
ActivatingSubPathwayControl
SubPathway322Control
Potassium
SubPathwayControl325
SubPathway325Control
ActivatingSubPathwayControl
7732-18-5
CAS
791
ChemSpider
Tropomyosin
SubPathwayInput
Voltage-dependent calcium channel subunit alpha-2/delta-2
Voltage-dependent T-type calcium channel subunit alpha-1G
HMDB0015417
HMDB
C10H16N5O13P3
Adenosine triphosphate
506.99576
SubPathwayControl318
SubPathway318Control
ActivatingSubPathwayControl
SubPathwayControl319
SubPathway319Control
InhibitorySubPathwayControl
O95180
UniProt
Tropomyosin alpha-1 chain
Voltage-dependent T-type calcium channel subunit alpha-1H
Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase
962
PubChem-compound
SubPathwayControl581
InhibitorySubPathwayControl
SubPathway581Control
G-protein signalling cascade
ActivatingSubPathway
Cardiac phospholamban inhibits Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
InhibitorySubPathway
Voltage-dependent L-type calcium channel subunit beta-1
5800
ChemSpider
Beta-1 adrenergic receptor
cAMP-dependent protein kinase type I-alpha regulatory subunit
C00076
KEGG Compound
P16615
UniProt
Sodium
1.0
Ca
Calcium
39.96259
1.0
Q9Y3Q4
UniProt
HMDB0002111
HMDB
Potassium voltage-gated channel subfamily E member 1
14265-44-2
CAS
58-64-0
CAS
Kv channel-interacting protein 2
Q09428
UniProt
C07840
KEGG Compound
Ryanodine receptor 2
Q12959
UniProt
G-protein signalling cascade
ActivatingSubPathway
cAMP-dependent protein kinase catalytic subunit alpha activates Voltage-depenent L-type calcium channel
ActivatingSubPathway
cAMP-dependent protein kinase catalytic subunit alpha activates Ryanodine receptor 2
ActivatingSubPathway
Potassium voltage-gated channel subfamily E member 2
Calcium activates Ryanodine receptor 2
ActivatingSubPathway
G protein-activated inward rectifier potassium channel 1
1.0
G protein-activated inward rectifier potassium channel 4
Inward rectifier potassium channel 4
Potassium voltage-gated channel subfamily D member 3
Q12809
UniProt
Sodium channel protein type 5 subunit alpha
H2O
Water
18.010565
1.0
P50993
UniProt
Tropomyosin beta chain
Potassium channel subfamily K member 1
Na
Sodium
22.989769
Sodium/potassium-transporting ATPase subunit alpha-2
K
Potassium
38.963707
Voltage-dependent L-type calcium channel subunit alpha-1C
Cardiomyocyte
ATP-sensitive inward rectifier potassium channel 8
3.6.3.8
false
3.6.3.8
Adenosine triphosphate + Calcium + Water → Adenosine diphosphate + Calcium + Phosphate
LEFT_TO_RIGHT
P17612
UniProt
Phenytoin inhibition of Voltage-gated sodium channel
InhibitorySubPathway
P26678
UniProt
1.0
2.0
Sodium/potassium-transporting ATPase subunit alpha-3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
TransportCatalysis93
ACTIVATION
TransportCatalysis92
ACTIVATION
TransportCatalysis91
ACTIVATION
TransportCatalysis90
ACTIVATION
SMILES
O
TransportCatalysis9
ACTIVATION
HMDB0000538
HMDB
SMILES
[Na+]
SMILES
[K+]
P48544
UniProt
Inward rectifier potassium channel 2
Ryanodine receptor 2
SubPathwayActivation
P48549
UniProt
Q5I7T1
UniProt
ADP
BioCyc
GO:0016529
GENE ONTOLOGY
1.0
CL:0000187
CELL TYPE ONTOLOGY
O60706
UniProt
P14415
UniProt
ATP-binding cassette sub-family C member 8
Calcium_Troponin
GO:0005829
GENE ONTOLOGY
1.0
1.0
O43497
UniProt
ATPase, (Na+)/K+ transporting, beta 4 polypeptide
O4P
Phosphate
94.95342
266
ChemSpider
4.0
Voltage-dependent L-type calcium channel subunit beta-1
Sodium/potassium-transporting ATPase subunit gamma
P22460
UniProt
Potassium voltage-gated channel subfamily H member 2
1.0
Beta-1-syntrophin
Muscle Contraction
SubPathway
Voltage-dependent L-type calcium channel subunit alpha-1C
Sodium channel protein type 5 subunit alpha
SMILES
[O-]P([O-])([O-])=O
sarcoplasmic reticulum
GO:0005886
GENE ONTOLOGY
Adenosine diphosphate
1710
ChemSpider
Voltage-dependent calcium channel subunit alpha-2/delta-2
ATP-binding cassette sub-family C member 9
Sodium/potassium-transporting ATPase subunit beta-3
Potassium voltage-gated channel subfamily A member 5
Disks large homolog 1
1.0
1.0
HMDB0001429
HMDB
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
Sodium/calcium exchanger 1
Potassium voltage-gated channel subfamily KQT member 1
P13637
UniProt
Q9NY47
UniProt
P09493
UniProt
C07443
KEGG Compound
HMDB0000464
HMDB
Myocyte
HMDB0000586
HMDB
HMDB0000588
HMDB
Calcium
Muscle
Voltage-dependent T-type calcium channel subunit alpha-1G
Voltage-dependent T-type calcium channel subunit alpha-1H
Cardiac phospholamban
Muscarinic acetylcholine receptor M2
P08172
UniProt
SMILES
[Ca++]
5957
PubChem-compound
1.0
Voltage-dependent L-type calcium channel subunit beta-1
56339
PubChem-compound
cAMP-dependent protein kinase catalytic subunit alpha
GO:0005615
GENE ONTOLOGY
C10H15N5O10P2
Adenosine diphosphate
427.02942
GO:0005737
GENE ONTOLOGY
3.0
Potassium voltage-gated channel subfamily E member 2
Sodium/potassium-transporting ATPase subunit beta-1
Kv channel-interacting protein 2
CPD-8587
BioCyc
TransportCatalysis10
ACTIVATION
Sodium/potassium-transporting ATPase subunit beta-2
B7ZKV8
UniProt
Potassium voltage-gated channel subfamily E member 1
Calcium
Q14524
UniProt
Potassium channel subfamily K member 1
G protein-activated inward rectifier potassium channel 4
Q14654
UniProt
1.0
3.0
1.0
2.0
1.0
Beta-2-syntrophin
TransportCatalysis23
ACTIVATION
Potassium voltage-gated channel subfamily D member 3
Alpha-1-syntrophin
Inward rectifier potassium channel 4
G protein-activated inward rectifier potassium channel 1
Q02641
UniProt
Cytoplasm
Fosphenytoin (Antiarrhythmic) Action Pathway
CHEBI:15422
ChEBI
Sodium/potassium-transporting ATPase subunit alpha-4
1.0
Homo sapiens
Sodium/potassium-transporting ATPase subunit alpha-2
Cardiac phospholamban
Ryanodine receptor 2
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Sodium/potassium-transporting ATPase subunit alpha-1
ATP-sensitive inward rectifier potassium channel 8
SMILES
O=C1NC(=O)C(N1)(C1=CC=CC=C1)C1=CC=CC=C1
Beta-1 adrenergic receptor
SubPathwayActivator
Q15842
UniProt
Transport35
false
Calcium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cardiomyocyte , Cytosol
LEFT_TO_RIGHT
ATP-sensitive inward rectifier potassium channel 11
Transport36
false
Calcium (?) Transport: Homo sapiens, Cardiomyocyte , sarcoplasmic reticulum to Homo sapiens, Cardiomyocyte , Cytosol
LEFT_TO_RIGHT
Sodium/potassium-transporting ATPase subunit alpha-3
CHEBI:16761
ChEBI
Q9Y6J6
UniProt
cAMP-dependent protein kinase catalytic subunit alpha
SubPathwayActivation
SubPathwayActivator
Q13424
UniProt
Reaction1784
false
Fosphenytoin → Phenytoin
LEFT_TO_RIGHT
Q13425
UniProt
9606
TAXONOMY
SMP0000326
SMPDB
Interaction2851
Calcium + Troponin activates Tropomyosin
1.0
CA%2b2
BioCyc
Cell Membrane
CHEBI:15377
ChEBI
P10644
UniProt
PW000379
PathWhiz
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
271
PubChem-compound
Adenosine triphosphate
P32418
UniProt
ATP-binding cassette sub-family C member 8
ATPase, (Na+)/K+ transporting, beta 4 polypeptide
Alpha-1-syntrophin
Water
1061
PubChem-compound
1.0
P08588
UniProt
TransportCatalysis89
ACTIVATION
TransportCatalysis88
ACTIVATION
1.0
Beta-2-syntrophin
TransportCatalysis87
ACTIVATION
TransportCatalysis82
ACTIVATION
Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase
Beta-1-syntrophin
Tropomyosin beta chain
TransportCatalysis86
ACTIVATION
Muscarinic acetylcholine receptor M2
SubPathwayActivator
TransportCatalysis85
ACTIVATION
1.0
Sodium/potassium-transporting ATPase subunit gamma
TransportCatalysis84
ACTIVATION
Tropomyosin alpha-1 chain
TransportCatalysis83
ACTIVATION
5.0
Cardiac phospholamban
SubPathwayInhibitor
SMILES
OP(O)(=O)OCN1C(=O)NC(C1=O)(C1=CC=CC=C1)C1=CC=CC=C1