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Sodium channel protein type 5 subunit alpha Beta-2- syntrophin Beta-1- syntrophin Alpha-1- syntrophin Cytochrome P450 1A2 Cytochrome P450 3A4 Cytochrome P450 1A2 Cytochrome P450 3A4 Inositol 1,4,5- trisphosphate receptor type 1 Beta-1 adrenergic receptor cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase type I-alpha regulatory subunit Type-1 angiotensin II receptor 1- phosphatidylinositol 4,5- bisphosphate phosphodiesterase beta-1 Troponin C, skeletal muscle Troponin I, slow skeletal muscle Troponin T, slow skeletal muscle Troponin C, slow skeletal and cardiac muscles Troponin I, cardiac muscle Troponin T, cardiac muscle Troponin C, skeletal muscle Troponin I, fast skeletal muscle Troponin T, fast skeletal muscle Tropomyosin alpha-1 chain Tropomyosin beta chain Calmodulin Myosin light chain kinase, smooth muscle Voltage- dependent L-type calcium channel subunit alpha-1C Voltage- dependent calcium channel subunit alpha-2/delta-2 Voltage- dependent L-type calcium channel subunit beta-1 Ryanodine receptor 2 Muscarinic acetylcholine receptor M2 G protein- activated inward rectifier potassium channel 1 G protein- activated inward rectifier potassium channel 4 Cardiac phospholamban Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 Sodium/potassium- transporting ATPase subunit alpha-1 Sodium/potassium- transporting ATPase subunit alpha-2 Sodium/potassium- transporting ATPase subunit alpha-3 Sodium/potassium- transporting ATPase subunit alpha-4 Sodium/potassium- transporting ATPase subunit beta-1 Sodium/potassium- transporting ATPase subunit beta-2 Sodium/potassium- transporting ATPase subunit beta-3 ATPase, (Na+)/K+ transporting, beta 4 polypeptide Sodium/potassium- transporting ATPase subunit gamma Inward rectifier potassium channel 2 Inward rectifier potassium channel 4 Potassium voltage-gated channel subfamily D member 3 Kv channel- interacting protein 2 Potassium voltage-gated channel subfamily A member 5 Disks large homolog 1 Potassium voltage-gated channel subfamily KQT member 1 Potassium voltage-gated channel subfamily E member 1 Potassium voltage-gated channel subfamily E member 2 Potassium voltage-gated channel subfamily H member 2 Putative Dol-P- Glc:Glc(2)Man(9)GlcNAc(2)- PP-Dol alpha-1,2- glucosyltransferase ATP-binding cassette sub-family C member 8 ATP-sensitive inward rectifier potassium channel 8 ATP-sensitive inward rectifier potassium channel 11 ATP-binding cassette sub-family C member 9 Potassium channel subfamily K member 1 Sodium/calcium exchanger 1 Potassium/sodium hyperpolarization- activated cyclic nucleotide- gated channel 4 Sodium channel protein type 5 subunit alpha Beta-2- syntrophin Beta-1- syntrophin Alpha-1- syntrophin Voltage- dependent T-type calcium channel subunit alpha-1H Voltage- dependent T-type calcium channel subunit alpha-1G Lidocaine 3-Hydroxylidocaine 3- Hydroxymonoethylglycinexylidide Monoethylglycinexylidide 2,6-Dimethylaniline Glycinexylidide 2-Amino-3-methylbenzoate 4-Hydroxy-2,6-dimethylaniline O 2 NADPH H + H 2 O NADP O 2 NADH H 2 O Formaldehyde NAD Lidocaine Heme Heme Heme Heme Inositol 1,4,5- trisphosphate Ca + Ca + Na + Na + K + K + K + K + K + K + K + K + K + K + K + K + K + K + K + K + K + K + Ca + Ca + Na + Na + Na + Na + K + K + Na + Na + Ca + Ca + Ca + Ca + PIP2(16:0/20:3(8Z,11Z,14Z)) DG(14:0/14:1(9Z)/0:0) ATP H 2 O Ca + ADP P i Ca + Calcium Magnesium Calcium G-protein signalling cascade G-protein signalling cascade G-protein signalling cascade Muscle Contraction Cardiac Myocyte Voltage-gated sodium channel (INa) MYOCYTE SARCOPLASMIC RETICULUM In smooth muscle In striated muscle