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454-29-5 CAS C00315 KEGG Compound 7722-84-1 CAS 937 ChemSpider CYS BioCyc CHEBI:16134 ChEBI S-methyl-5'-thioadenosine phosphorylase HMDB0003125 HMDB 439153 PubChem-compound 57 ChemSpider HMDB0000092 HMDB HMDB0000097 HMDB 10-FORMYL-THF BioCyc HMDB0001185 HMDB HMDB0000099 HMDB CHEBI:20506 ChEBI CHEBI:17115 ChEBI CHEBI:16027 ChEBI CHEBI:17119 ChEBI C00440 KEGG Compound CHEBI:17230 ChEBI ATP BioCyc 6137 PubChem-compound 5-METHYL-THF BioCyc S-adenosylmethionine synthase isoform type-2 18714427 ChemSpider 124-20-9 CAS 559142 ChemSpider 4.0 Betaine Tetrahydrofolic acid C15H23N6O5S S-Adenosylmethionine 399.14505 1.0 NADH 5742 ChemSpider C00213 KEGG Compound CHEBI:17561 ChEBI C00212 KEGG Compound PW000040 PathWhiz CHEBI:15022 ChEBI 952 ChemSpider 439176 PubChem-compound Methionine adenosyltransferase 2 subunit beta 439175 PubChem-compound P42898 UniProt L-CYSTATHIONINE BioCyc ReactionCatalysis724 ACTIVATION 107-43-7 CAS 10-Formyltetrahydrofolate 5858 ChemSpider 5736 ChemSpider 1.0 C00109 KEGG Compound PW000157 PathWhiz METHYLENE-THF BioCyc CHEBI:16240 ChEBI 824 ChemSpider 1.0 C00101 KEGG Compound CHEBI:15033 ChEBI 1.0 ReactionCatalysis717 ACTIVATION PPI BioCyc SMILES NCCCCN 72843-83-5 CAS Serine hydroxymethyltransferase, cytosolic ReactionCatalysis750 ACTIVATION CHEBI:17148 ChEBI 1.0 1.0 SMILES C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N 979-92-0 CAS Cytosol Spermidine synthase 1.0 C00114 KEGG Compound 1.0 C00234 KEGG Compound C14H20N6O5S S-Adenosylhomocysteine 384.12158 SARCOSINE BioCyc Dimethylglycine Q8IXL7 UniProt 122347 PubChem-compound 1.0 2.1.2.1 false 2.1.2.1 L-Serine + Tetrahydrofolic acid → 5,10-Methylene-THF + Glycine + Water LEFT_TO_RIGHT Glycine C00009 KEGG Compound 110-60-1 CAS C00007 KEGG Compound C00001 KEGG Compound Adenosine CHEBI:18361 ChEBI 388321 ChemSpider C00004 KEGG Compound CHEBI:18367 ChEBI 135-16-0 CAS C00003 KEGG Compound 2-OXOBUTANOATE BioCyc 1032 ChemSpider 1.0 388320 ChemSpider C00002 KEGG Compound CHEBI:49033 ChEBI Cystathionine gamma-lyase Q8NE62 UniProt Cystathionine gamma-lyase Methionine--tRNA ligase, cytoplasmic Betaine--homocysteine S-methyltransferase 1 SubPathwayInteraction135 SubPathway135Reaction SubPathwayReaction C00019 KEGG Compound 1.0 ReactionCatalysis774 ACTIVATION ReactionCatalysis771 ACTIVATION SubPathwayInteraction136 SubPathwayReaction SubPathway136Reaction C21H28N7O14P2 NAD 664.11694 Methionine--tRNA ligase, cytoplasmic CHEBI:17482 ChEBI 2.4.2.28 false 2.4.2.28 5'-Methylthioadenosine + Phosphate → 5-Methylthioribose 1-phosphate + L-Methionine LEFT_TO_RIGHT C00011 KEGG Compound HMDB0000902 HMDB S-adenosylmethionine synthase isoform type-2 C00014 KEGG Compound C00134 KEGG Compound C00013 KEGG Compound 2.1.1.5 false 2.1.1.5 L-Cystathionine → Homocysteine LEFT_TO_RIGHT 2.1.1.37 false 2.1.1.37 Glycine + S-Adenosylmethionine → S-Adenosylhomocysteine + Sarcosine LEFT_TO_RIGHT 4.4.1.1 false 4.4.1.1 L-Cystathionine + Water → 2-Ketobutyric acid + L-Cysteine LEFT_TO_RIGHT 1.8.4.- false 1.8.4.- L-Methionine + oxidized thioredoxin → Methionine sulfoxide + reduced thioredoxin LEFT_TO_RIGHT P19623 UniProt C7H19N3 Spermidine 145.1579 ReactionCatalysis408 ACTIVATION ReactionCatalysis769 ACTIVATION 4.1.1.50 false 4.1.1.50 S-Adenosylmethionine → Carbon dioxide + S-Adenosylmethioninamine LEFT_TO_RIGHT ReactionCatalysis764 ACTIVATION SubPathwayInteraction133 SubPathwayReaction SubPathway133Reaction 12126 ChemSpider ReactionCatalysis762 ACTIVATION ReactionCatalysis760 ACTIVATION 388301 ChemSpider 1057 ChemSpider SMILES CSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N C00143 KEGG Compound C00263 KEGG Compound C00021 KEGG Compound MET BioCyc 56-65-5 CAS 53-84-9 CAS 56-88-2 CAS 5653 ChemSpider C00020 KEGG Compound C00027 KEGG Compound 3432-99-3 CAS 4.2.1.22 false 4.2.1.22 L-Homoserine + L-Serine → L-Cystathionine + Water LEFT_TO_RIGHT Methylenetetrahydrofolate reductase 1118-68-9 CAS ReactionCatalysis759 ACTIVATION C5H11NO2S L-Methionine 149.05106 PUTRESCINE BioCyc 52-90-4 CAS C00037 KEGG Compound SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O 653 ChemSpider AMP BioCyc HYDROGEN-PEROXIDE BioCyc CHEBI:29173 ChEBI L-methionyl-tRNA(Met) HMDB0000250 HMDB SMILES [O-]P([O-])(=O)OP([O-])([O-])=O N-formylmethionyl-tRNA(fMet) C01137 KEGG Compound 107-97-1 CAS 5-Methylthioribose 1-phosphate SMILES C[N+](C)(C)CCO SMILES CNCC(O)=O 763 ChemSpider 6.1.1.10 false 6.1.1.10 Adenosine triphosphate + L-Methionine + tRNA(Met) → Adenosine monophosphate + L-methionyl-tRNA(Met) + Pyrophosphate LEFT_TO_RIGHT 1.1.99.1 false 1.1.99.1 Acceptor + Choline → Betaine + Reduced acceptor LEFT_TO_RIGHT 1.8.4.- false 1.8.4.- L-Methionine + oxidized thioredoxin → Methionine sulfoxide + reduced thioredoxin LEFT_TO_RIGHT SMILES N[C@@H](CCSC[C@H](N)C(O)=O)C(O)=O C00170 KEGG Compound 3.0 Cystathionine beta-synthase 388529 ChemSpider SMILES CN(C)CC(O)=O 1.0 1.0 CPD-479 BioCyc 784 PubChem-compound 4.2.1.22 false 4.2.1.22 Homocysteine + L-Serine → L-Cystathionine + Water LEFT_TO_RIGHT 53477720 PubChem-compound 1.0 4.0 305 PubChem-compound 4.0 12647 PubChem-compound P32929 UniProt 7732-18-5 CAS C01026 KEGG Compound HMDB0001487 HMDB Reduced acceptor 61-19-8 CAS SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 SMILES C[N+](C)(C)CC([O-])=O AMMONIA BioCyc SMILES N SMILES NC1=C2N=CN([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C2=NC=N1 63-68-3 CAS HMDB0000271 HMDB 5,10-Methylene-THF C6H13O7PS 5-Methylthioribose 1-phosphate 260.01196 5907 ChemSpider NAD C10H16N5O13P3 Adenosine triphosphate 506.99576 C20H23N7O7 10-Formyltetrahydrofolate 473.1659 56-40-6 CAS C00065 KEGG Compound 1.0 58-61-7 CAS 2800-34-2 CAS HMDB0001377 HMDB HMDB0000045 HMDB S-Adenosylhomocysteine Spermidine synthase HMDB0001257 HMDB 1.0 C00073 KEGG Compound P26358 UniProt C14H23N6O3S S-Adenosylmethioninamine 355.15524 HMDB0000043 HMDB 962 PubChem-compound DIMETHYL-GLYCINE BioCyc 31983 ChemSpider Methionine sulfoxide CO2 Carbon dioxide 43.98983 Hydrogen peroxide P17707 UniProt 2.0 730 ChemSpider BETAINE BioCyc SMILES O=O 583-92-6 CAS P56192 UniProt 847 PubChem-compound HMDB0000051 HMDB HMDB0000050 HMDB 1.0 HMDB0002111 HMDB Betaine C4H9NO2S Homocysteine 135.0354 14265-44-2 CAS S-adenosylmethionine synthase Putrescine 1.0 Cystathionine gamma-lyase HOMO-CYS BioCyc HMDB0002005 HMDB C01180 KEGG Compound SMILES CN1C(CNC2=CC=C(C=C2)C(=O)N[C@H](CCC(O)=O)C(O)=O)CNC2=C1C(=O)NC(N)=N2 C4H6O3 2-Ketobutyric acid 102.03169 1.0 C3H7NO3 L-Serine 105.042595 SMILES CSCCC(=O)C(O)=O HMDB0000187 HMDB 1.0 HMDB0001396 HMDB 1.0 C3H7NO2S L-Cysteine 121.01975 644102 PubChem-compound 6083 PubChem-compound CHEBI:33574 ChEBI 1.0 C00097 KEGG Compound 757 ChemSpider N-formylmethionyl-tRNA(fMet) Glycine 25246222 PubChem-compound 1.0 1.0 H2O Water 18.010565 H2O2 Hydrogen peroxide 34.005478 SMILES NCC(O)=O 1.0 54923 ChemSpider NADH BioCyc C4H9NO3 L-Homoserine 119.05824 Nucleus NAD BioCyc Choline 1.0 977 PubChem-compound SPERMIDINE BioCyc 1.0 2.0 62-49-7 CAS 1.0 Betaine--homocysteine S-methyltransferase 1 S-adenosylmethionine decarboxylase proenzyme C02291 KEGG Compound SMILES [H][C@@]12CN(CN1C1=C(NC2)N=C(N)NC1=O)C1=CC=C(C=C1)C(=O)NC(CCC(O)=O)C(O)=O 134-35-0 CAS L-Homoserine SubPathwayOutput HMDB0001173 HMDB 247 PubChem-compound 2457-80-9 CAS 2.5.1.16 false 2.5.1.16 Putrescine + S-Adenosylmethioninamine → 5'-Methylthioadenosine + Spermidine LEFT_TO_RIGHT L-Methionine Q96RQ9 UniProt SMILES N[C@@H](CS)C(O)=O 1.0 C05330 KEGG Compound 1.0 SMILES N[C@@H](CCO)C(O)=O Adenosine monophosphate SMILES O 13837702 ChemSpider SMILES OO H3N Ammonia 17.026548 C10H13N5O4 Adenosine 267.09674 1.0 C10H14N5O7P Adenosine monophosphate 347.06308 C5H11NO2 Betaine 117.07898 CHEBI:15611 ChEBI L-amino-acid oxidase 1.0 HMDB0000538 HMDB 1.0 S-ADENOSYLMETHIONINAMINE BioCyc 473 PubChem-compound S-Adenosylmethionine Sulfate/Sulfite Metabolism SubPathway 242 ChemSpider 2-Ketobutyric acid CHEBI:15846 ChEBI 5-Methyltetrahydrofolic acid 58 PubChem-compound 49791978 PubChem-compound Methionine-R-sulfoxide reductase B3 L-Cystathionine S-adenosylmethionine decarboxylase proenzyme Cystathionine beta-synthase Q93088 UniProt SMILES CSCC[C@H](N)C(O)=O Acceptor GO:0005829 GENE ONTOLOGY C19H23N7O6 Tetrahydrofolic acid 445.171 C5H11NO3S Methionine sulfoxide 165.04596 274 ChemSpider Methionine-R-sulfoxide reductase B2, mitochondrial 2.0 CHEBI:16908 ChEBI ReactionCatalysis168 ACTIVATION ReactionCatalysis166 ACTIVATION 1.4.3.2 false 1.4.3.2 L-Methionine + Oxygen + Water → 2-Oxo-4-methylthiobutanoic acid + Ammonia + Hydrogen peroxide LEFT_TO_RIGHT Ammonia ADENOSYL-HOMO-CYS BioCyc 2.1.1.5 false 2.1.1.5 Betaine + Homocysteine → Dimethylglycine + L-Methionine LEFT_TO_RIGHT Serine hydroxymethyltransferase, cytosolic S-Adenosylhomocysteine 1.5.1.20 false 1.5.1.20 5,10-Methylene-THF + NADH → 5-Methyltetrahydrofolic acid + NAD LEFT_TO_RIGHT Pyrophosphate 485-80-3 CAS O4P Phosphate 94.95342 4.0 5862 PubChem-compound SER BioCyc HMDB0001533 HMDB Cystathionine beta-synthase HMDB0001414 HMDB 600-18-0 CAS Mitochondrion THF BioCyc S-Adenosylmethioninamine CHEBI:15641 ChEBI GLY BioCyc CHEBI:16610 ChEBI 672-15-1 CAS Carbon dioxide 1.0 CPD-6641 BioCyc L-methionyl-tRNA(Met) 217 ChemSpider SMILES NC1=NC(=O)C2=C(NC[C@H](CNC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)N2)N1 58-68-4 CAS HMDB0000574 HMDB SMILES CS(=O)CCC(N)C(O)=O HMDB0000696 HMDB SMILES [O-]P([O-])([O-])=O 124-38-9 CAS CHEBI:15637 ChEBI C2H5NO2 Glycine 75.03203 L-amino-acid oxidase SMP0000041 SMPDB CHEBI:15414 ChEBI HMDB0001429 HMDB 1.0 CHEBI:27859 ChEBI 1.0 673 PubChem-compound HMDB0001553 HMDB 5257127 PubChem-compound C20H23N7O6 5,10-Methylene-THF 457.171 GO:0005634 GENE ONTOLOGY 7664-41-7 CAS P35520 UniProt Glycine and Serine Metabolism SubPathway 60961 PubChem-compound CHEBI:15625 ChEBI S-ADENOSYLMETHIONINE BioCyc SMILES O=C=O 5951 PubChem-compound 222 PubChem-compound Homocysteine SubPathwayOutput DNA (cytosine-5)-methyltransferase 1 O7P2 Pyrophosphate 173.91193 C04188 KEGG Compound C21H29N7O14P2 NADH 665.12476 5957 PubChem-compound SMILES NC(CCS)C(O)=O 439415 PubChem-compound Cysteine Metabolism SubPathway tRNA(Met) 22365-13-5 CAS CPD-444 BioCyc CHEBI:15636 ChEBI CPD-563 BioCyc 1.0 1102 PubChem-compound 1.0 reduced thioredoxin HMDB0000123 HMDB SMILES N[C@@H](CO)C(O)=O Choline dehydrogenase, mitochondrial GO:0005739 GENE ONTOLOGY Adenosine triphosphate HMDB0000005 HMDB SMILES CCC(=O)C(O)=O 460 ChemSpider C7H14N2O4S L-Cystathionine 222.06743 C5H14NO Choline 104.10754 C3H7NO2 Sarcosine 89.047676 C4H9NO2 Dimethylglycine 103.06333 PW000104 PathWhiz 4.0 SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O CPD-8587 BioCyc 5682 ChemSpider CHEBI:30831 ChEBI oxidized thioredoxin SMILES NCCCCNCCCN 1.0 1.0 SMP0000004 SMPDB C00719 KEGG Compound 5-METHYLTHIOADENOSINE BioCyc 1.0 oxidized thioredoxin 14000-31-8 CAS CHEBI:15699 ChEBI CHEBI:15339 ChEBI 1071 ChemSpider CHEBI:17750 ChEBI 1088 PubChem-compound S-Adenosylmethionine HMDB0000939 HMDB CHEBI:17509 ChEBI SMP0000013 SMPDB C4H12N2 Putrescine 88.10005 1.0 ReactionCatalysis776 ACTIVATION CHEBI:15422 ChEBI CHEBI:16635 ChEBI CHEBI:17724 ChEBI Homo sapiens Methionine adenosyltransferase 2 subunit beta 388299 ChemSpider S-methyl-5'-thioadenosine phosphorylase Acceptor 1.0 Reduced acceptor 1.0 O2 Oxygen 31.98983 2-Oxo-4-methylthiobutanoic acid P31153 UniProt Water 1.0 ReactionCatalysis321 ACTIVATION CHEBI:16643 ChEBI P34896 UniProt CHEBI:16526 ChEBI DNA (cytosine-5)-methyltransferase 1 HMDB0000719 HMDB 7782-44-7 CAS C5H8O3S 2-Oxo-4-methylthiobutanoic acid 148.01941 Q9Y3D2 UniProt Methylenetetrahydrofolate Reductase Deficiency (MTHFRD) HMDB0000963 HMDB C20H25N7O6 5-Methyltetrahydrofolic acid 459.18665 CHEBI:15428 ChEBI 1.0 ReactionCatalysis2164 ACTIVATION 9606 TAXONOMY ReactionCatalysis356 ACTIVATION Spermidine synthase CHEBI:16335 ChEBI 1.0 Betaine--homocysteine S-methyltransferase 1 388392 ChemSpider S-adenosylmethionine decarboxylase proenzyme L-Methionine 5893 PubChem-compound L-METHIONINE_SULFOXIDE BioCyc SMILES CSCC1OC(OP(O)(O)=O)[C@H](O)[C@@H]1O 439234 PubChem-compound HMDB0000972 HMDB 299 ChemSpider SMILES NC1=NC(=O)C2=C(NCC(CN(C=O)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)N2)N1 5'-Methylthioadenosine Methylenetetrahydrofolate reductase Reaction795 false 10-Formyltetrahydrofolate + L-methionyl-tRNA(Met) → N-formylmethionyl-tRNA(fMet) + Tetrahydrofolic acid LEFT_TO_RIGHT PW000018 PathWhiz L-Serine Reaction673 false S-Adenosylhomocysteine + Water → Adenosine + Homocysteine LEFT_TO_RIGHT Reaction670 false 5-Methyltetrahydrofolic acid + Homocysteine → L-Methionine + Tetrahydrofolic acid LEFT_TO_RIGHT 2.5.1.6 false 2.5.1.6 Adenosine triphosphate + L-Methionine + Water → Phosphate + Pyrophosphate + S-Adenosylmethionine LEFT_TO_RIGHT ADENOSINE BioCyc CHEBI:15377 ChEBI L-Cysteine SubPathwayOutput CHEBI:15379 ChEBI C11H15N5O3S 5'-Methylthioadenosine 297.08957 56-45-1 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 1045 PubChem-compound Phosphate Oxygen 62697-73-8 CAS Choline dehydrogenase, mitochondrial Serine hydroxymethyltransferase, cytosolic HMDB0000742 HMDB 280 PubChem-compound SMILES C[S+](CCCN)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N Q13126 UniProt Q9NZL9 UniProt 25243997 PubChem-compound HMDB0000988 HMDB 1.0 1.0 388371 ChemSpider SMILES N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N)C(O)=O HOMO-SER BioCyc Spermidine tRNA(Met) SMP0000340 SMPDB Sarcosine 1061 PubChem-compound CHEBI:15354 ChEBI 109092 ChemSpider Methylenetetrahydrofolate reductase Methionine-R-sulfoxide reductase B3 HMDB0001846 HMDB HMDB0001967 HMDB CHEBI:16680 ChEBI S-methyl-5'-thioadenosine phosphorylase Methionine-R-sulfoxide reductase B2, mitochondrial 24762165 PubChem-compound reduced thioredoxin 13781857 PubChem-compound 1.0