5462309
PubChem-compound
6022
PubChem-compound
ReactionCoupledTransportCatalysis5
ACTIVATION
SubPathwayControl422
SubPathway422Control
InhibitorySubPathwayControl
937
ChemSpider
CPD-8587
BioCyc
Multidrug resistance-associated protein 1
ReactionCoupledTransportCatalysis52
ACTIVATION
C06262
KEGG Compound
SMILES
O
C47H51NO14
Paclitaxel
853.33093
Adenosine triphosphate
Paclitaxel Action Pathway
ReactionCoupledTransportCatalysis54
ACTIVATION
ReactionCoupledTransportCatalysis53
ACTIVATION
HMDB0001341
HMDB
Transport240
false
Paclitaxel (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytoplasm
LEFT_TO_RIGHT
Q92887
UniProt
HMDB0000538
HMDB
Phosphorus
Water
ATP
BioCyc
1.0
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
Q9H4B7
UniProt
Solute carrier organic anion transporter family member 1B3
Multidrug resistance protein 1
P
Phosphorus
30.97376
Cytoplasm
ADP
BioCyc
1.0
Q9NPD5
UniProt
CHEBI:15422
ChEBI
1.0
Homo sapiens
HMDB0015360
HMDB
5742
ChemSpider
7732-18-5
CAS
P68363
UniProt
GO:0005829
GENE ONTOLOGY
Tubulin beta-1 chain
SMILES
[H][C@]12[C@H](OC(=O)C3=CC=CC=C3)[C@]3(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)C4=CC=CC=C4)C4=CC=CC=C4)C(C)=C([C@@H](OC(C)=O)C(=O)[C@]1(C)[C@@H](O)C[C@H]1OC[C@@]21OC(C)=O)C3(C)C
1.0
TransportCatalysis198
ACTIVATION
TransportCatalysis110
ACTIVATION
Phosphate
Transport144
false
Paclitaxel (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space
LEFT_TO_RIGHT
C10H16N5O13P3
Adenosine triphosphate
506.99576
ATP-binding cassette sub-family G member 2
SMP0000434
SMPDB
O4P
Phosphate
94.95342
1.0
Paclitaxel
CHEBI:16761
ChEBI
SMILES
[P]
ATP-binding cassette sub-family G member 2
TransportCatalysis109
ACTIVATION
Transport147
false
Paclitaxel (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space
LEFT_TO_RIGHT
Paclitaxel Inhibition of Tubulin
InhibitorySubPathway
Transport148
false
Paclitaxel (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space
LEFT_TO_RIGHT
Tubulin alpha-1B chain
9606
TAXONOMY
962
PubChem-compound
Multidrug resistance-associated protein 1
10368587
ChemSpider
Canalicular multispecific organic anion transporter 1
Tubulin alpha-1B chain
5800
ChemSpider
Cytosol
36314
PubChem-compound
Paclitaxel
ReactionCoupledTransport45
false
Adenosine triphosphate + Paclitaxel + Water → Adenosine diphosphate + Paclitaxel + Phosphorus
LEFT_TO_RIGHT
SMILES
[O-]P([O-])([O-])=O
Paclitaxel
ReactionCoupledTransport47
false
Adenosine triphosphate + Paclitaxel + Water → Adenosine diphosphate + Paclitaxel + Phosphorus
LEFT_TO_RIGHT
C07394
KEGG Compound
ReactionCoupledTransport46
false
Adenosine triphosphate + Paclitaxel + Water → Adenosine diphosphate + Paclitaxel + Phosphorus
LEFT_TO_RIGHT
GO:0005886
GENE ONTOLOGY
HMDB0002111
HMDB
CHEBI:45863
ChEBI
Tubulin beta-1 chain
Cell Membrane
CHEBI:15377
ChEBI
C00009
KEGG Compound
C00008
KEGG Compound
Multidrug resistance-associated protein 1
14265-44-2
CAS
C00001
KEGG Compound
58-64-0
CAS
HMDB0001429
HMDB
Tubulin
SubPathwayInhibition
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
1.0
CHEBI:18367
ChEBI
1032
ChemSpider
C00002
KEGG Compound
7723-14-0
CAS
Solute carrier organic anion transporter family member 1B3
HMDB0001315
HMDB
ATP-binding cassette sub-family G member 2
Canalicular multispecific organic anion transporter 1
Extracellular Space
H2O
Water
18.010565
5957
PubChem-compound
PW000239
PathWhiz
33069-62-4
CAS
4575369
ChemSpider
1.0
1.0
1.0
1061
PubChem-compound
1.0
Q9UNQ0
UniProt
Multidrug resistance protein 1
1.0
56-65-5
CAS
P33527
UniProt
P08183
UniProt
3.6.3.44
false
3.6.3.44
Adenosine triphosphate + Paclitaxel + Water → Adenosine diphosphate + Paclitaxel + Phosphate
LEFT_TO_RIGHT
Adenosine diphosphate
GO:0005615
GENE ONTOLOGY
C10H15N5O10P2
Adenosine diphosphate
427.02942
GO:0005737
GENE ONTOLOGY
CHEBI:28659
ChEBI
Paclitaxel
SubPathwayInhibitor