6022
PubChem-compound
937
ChemSpider
CPD-8587
BioCyc
SubPathwayControl547
SubPathway547Control
InhibitorySubPathwayControl
SubPathwayControl548
SubPathway548Control
ActivatingSubPathwayControl
Multidrug resistance-associated protein 1
SMILES
O
Vindesine Action Pathway
Adenosine triphosphate
HMDB0001341
HMDB
CHEBI:36373
ChEBI
Cyclin-dependent kinase inhibitor 1
SubPathwayActivation
Q92887
UniProt
HMDB0000538
HMDB
Canalicular multispecific organic anion transporter 1
ATP
BioCyc
Water
1.0
C43H55N5O7
Vindesine
753.41016
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
O15438
UniProt
Q9H4B7
UniProt
Multidrug resistance protein 1
1.0
Cytoplasm
ADP
BioCyc
Transport245
false
Vindesine (→) Transport: Homo sapiens, Liver, Cell, Cytoplasm to Homo sapiens, Extracellular Space
LEFT_TO_RIGHT
Q15311
UniProt
CHEBI:15422
ChEBI
1.0
Homo sapiens
5742
ChemSpider
Multidrug resistance protein 1
7732-18-5
CAS
P68363
UniProt
GO:0005829
GENE ONTOLOGY
RalA-binding protein 1
1.0
TransportCatalysis211
ACTIVATION
TransportCatalysis210
ACTIVATION
Vindesine Inhibition of Tubulin
InhibitorySubPathway
Vindesine Activation of Cellular Tumor Antigen p53
ActivatingSubPathway
SMP0000438
SMPDB
Phosphate
Tubulin alpha-1B chain
SubPathwayControl550
ActivatingSubPathwayControl
SubPathway550Control
C10H16N5O13P3
Adenosine triphosphate
506.99576
Q5T3U5
UniProt
O4P
Phosphate
94.95342
1.0
CHEBI:16761
ChEBI
Vindesine
SMILES
[H][C@@]12N3CC[C@@]11C4=CC(=C(OC)C=C4N(C)[C@@]1([H])[C@](O)([C@H](O)[C@]2(CC)C=CC3)C(N)=O)[C@]1(C[C@]2([H])CN(C[C@](O)(CC)C2)CCC2=C1NC1=CC=CC=C21)C(=O)OC
9606
TAXONOMY
962
PubChem-compound
Multidrug resistance-associated protein 1
Canalicular multispecific organic anion transporter 1
Tubulin beta-1 chain
Tubulin alpha-1B chain
5800
ChemSpider
Canalicular multispecific organic anion transporter 2
Cytosol
HMDB0014454
HMDB
SMILES
[O-]P([O-])([O-])=O
GO:0005886
GENE ONTOLOGY
Vindesine Activation of Cyclin-dependent kinase inhibitor 1
ActivatingSubPathway
ReactionCoupledTransportCatalysis16
ACTIVATION
Vindesine
ReactionCoupledTransportCatalysis15
ACTIVATION
HMDB0002111
HMDB
P04637
UniProt
Tubulin beta-1 chain
Cell Membrane
CHEBI:15377
ChEBI
C00009
KEGG Compound
Cyclin-dependent kinase inhibitor 1
C00008
KEGG Compound
Multidrug resistance-associated protein 1
Canalicular multispecific organic anion transporter 2
14265-44-2
CAS
Cellular tumor antigen p53
ReactionCoupledTransportCatalysis19
ACTIVATION
C00001
KEGG Compound
58-64-0
CAS
HMDB0001429
HMDB
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
1.0
CHEBI:18367
ChEBI
Vindesine
1032
ChemSpider
C00002
KEGG Compound
TransportCatalysis209
ACTIVATION
53643-48-4
CAS
1.0
ReactionCoupledTransportCatalysis24
ACTIVATION
GO:0005634
GENE ONTOLOGY
Tubulin
SubPathwayInhibition
ReactionCoupledTransportCatalysis20
ACTIVATION
ReactionCoupledTransportCatalysis22
ACTIVATION
PW000243
PathWhiz
RalA-binding protein 1
40839
PubChem-compound
Multidrug resistance-associated protein 7
Canalicular multispecific organic anion transporter 1
1.0
Extracellular Space
ReactionCoupledTransport20
false
Adenosine triphosphate + Vindesine + Water → Adenosine diphosphate + Phosphate + Vindesine
LEFT_TO_RIGHT
ReactionCoupledTransport22
false
Adenosine triphosphate + Vindesine + Water → Adenosine diphosphate + Phosphate + Vindesine
LEFT_TO_RIGHT
H2O
Water
18.010565
5957
PubChem-compound
ReactionCoupledTransport24
false
Adenosine triphosphate + Vindesine + Water → Adenosine diphosphate + Phosphate + Vindesine
LEFT_TO_RIGHT
37302
ChemSpider
Nucleus
1061
PubChem-compound
P38936
UniProt
Multidrug resistance protein 1
ReactionCoupledTransport16
false
Adenosine triphosphate + Vindesine + Water → Adenosine diphosphate + Phosphate + Vindesine
LEFT_TO_RIGHT
3.6.3.44
false
3.6.3.44
Adenosine triphosphate + Vindesine + Water → Adenosine diphosphate + Phosphate + Vindesine
LEFT_TO_RIGHT
56-65-5
CAS
P33527
UniProt
ReactionCoupledTransport19
false
Adenosine triphosphate + Vindesine + Water → Adenosine diphosphate + Phosphate + Vindesine
LEFT_TO_RIGHT
P08183
UniProt
Adenosine diphosphate
Vindesine
SubPathwayInhibitor
SubPathwayActivator
C10H15N5O10P2
Adenosine diphosphate
427.02942
GO:0005615
GENE ONTOLOGY
GO:0005737
GENE ONTOLOGY
1.0
Multidrug resistance-associated protein 7
Cellular tumor antigen p53
SubPathwayActivation