3-HYDROXY-N6N6N6-TRIMETHYL-L-LYSINE
BioCyc
1.0
C00318
KEGG Compound
937
ChemSpider
P49189
UniProt
S-Adenosylhomocysteine
439153
PubChem-compound
SMILES
O
131
ChemSpider
Succinic acid
130
ChemSpider
HMDB0001185
HMDB
50
ChemSpider
1.0
N6,N6,N6-Trimethyl-L-lysine
5962
PubChem-compound
64595-66-0
CAS
51
PubChem-compound
Water
Histone-lysine N-methyltransferase SETD7
CHEBI:15846
ChEBI
C7H15NO3
L-Carnitine
161.1052
N6,N6,N6-Trimethyl-L-lysine
5747
ChemSpider
Glycine
C15H23N6O5S
S-Adenosylmethionine
399.14505
BTO:0000759
BRENDA TISSUE ONTOLOGY
1038
PubChem-compound
LYS
BioCyc
952
ChemSpider
4-trimethylaminobutyraldehyde dehydrogenase
Carbon dioxide
274
ChemSpider
4-trimethylaminobutyraldehyde dehydrogenase
C5H6O5
Oxoglutaric acid
146.02153
CHEBI:16908
ChEBI
1.0
Serine hydroxymethyltransferase, cytosolic
ADENOSYL-HOMO-CYS
BioCyc
Serine hydroxymethyltransferase, cytosolic
3-Hydroxy-N6,N6,N6-trimethyl-L-lysine
485-80-3
CAS
133
PubChem-compound
134
PubChem-compound
1010
ChemSpider
SMILES
C[N+](C)(C)CCCC(O)[C@H](N)C(O)=O
L-Lysine
4.0
Mitochondrion
GLY
BioCyc
ReactionCatalysis199
ACTIVATION
1.0
ReactionCatalysis197
ACTIVATION
ReactionCatalysis195
ACTIVATION
ReactionCatalysis196
ACTIVATION
541-15-1
CAS
N6,N6,N6-Trimethyl-L-lysine
SubPathwayInput
SMILES
C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N
979-92-0
CAS
HMDB0000208
HMDB
CPD-6641
BioCyc
C14H20N6O5S
S-Adenosylhomocysteine
384.12158
SUC
BioCyc
58-68-4
CAS
HMDB0001422
HMDB
56-87-1
CAS
SMILES
OC(=O)CCC(=O)C(O)=O
Serine hydroxymethyltransferase, cytosolic
4.0
CHEBI:30915
ChEBI
124-38-9
CAS
C2H5NO2
Glycine
75.03203
C00007
KEGG Compound
388565
ChemSpider
CHEBI:15414
ChEBI
C00001
KEGG Compound
C00004
KEGG Compound
C00003
KEGG Compound
Liver
1.0
5257127
PubChem-compound
GO:0005634
GENE ONTOLOGY
Oxygen
C00019
KEGG Compound
CHEBI:15741
ChEBI
C21H27N7O14P2
NAD
663.10913
S-ADENOSYLMETHIONINE
BioCyc
C00011
KEGG Compound
SMILES
O=C=O
1.0
HMDB0000902
HMDB
N6N6N6-TRIMETHYL-L-LYSINE
BioCyc
Oxygen
1110
PubChem-compound
C9H20N2O2
N6,N6,N6-Trimethyl-L-lysine
188.15248
C21H29N7O14P2
NADH
665.12476
HMDB0001325
HMDB
1.0
Histone-lysine N-methyltransferase SETD7
CHEBI:1941
ChEBI
C4H6O4
Succinic acid
118.02661
H
Hydrogen Ion
1.007825
388301
ChemSpider
CARNITINE
BioCyc
SMILES
NCCCC[C@H](N)C(O)=O
C00021
KEGG Compound
53-84-9
CAS
C00026
KEGG Compound
HMDB0000123
HMDB
GO:0005739
GENE ONTOLOGY
Nucleoplasm
GO:0005737
GENE ONTOLOGY
Gamma-butyrobetaine dioxygenase
C7H16NO
4-Trimethylammoniobutanal
130.12318
1.0
1.0
NADH
SMILES
NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP([O-])(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O
Trimethyllysine dioxygenase, mitochondrial
C00037
KEGG Compound
5682
ChemSpider
328-50-7
CAS
SMILES
NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O
SMILES
C[N+](C)(C)CCCC[C@H](N)C([O-])=O
HMDB0000254
HMDB
Trimethyllysine dioxygenase, mitochondrial
SMILES
OC(=O)CCC(O)=O
1.0
HMDB0001345
HMDB
1.0
4-Trimethylammoniobutanoic acid
BiologicalState31
Homo sapiens, Liver
Gamma-butyrobetaine dioxygenase
3-Hydroxy-N6,N6,N6-trimethyl-L-lysine
Transport15
false
4-Trimethylammoniobutanoic acid (→) Transport: Homo sapiens, Cell, Cytoplasm to Homo sapiens, Liver, Cell, Cytoplasm
LEFT_TO_RIGHT
C00042
KEGG Compound
C03793
KEGG Compound
C01259
KEGG Compound
1078
ChemSpider
C00047
KEGG Compound
1.0
HMDB0000939
HMDB
Carbon dioxide
4-Trimethylammoniobutanal
C9H21N2O3
3-Hydroxy-N6,N6,N6-trimethyl-L-lysine
205.15521
10917
PubChem-compound
SMILES
C[N+](C)(C)CCCC=O
1.0
Cytoplasm
1.0
10455
ChemSpider
ReactionCatalysis212
ACTIVATION
CHEBI:18019
ChEBI
CHEBI:15786
ChEBI
Oxoglutaric acid
Q9NVH6
UniProt
Homo sapiens
C01149
KEGG Compound
7732-18-5
CAS
388299
ChemSpider
25203146
PubChem-compound
HMDB0001487
HMDB
Reaction130
false
4-Trimethylammoniobutanal + NAD + Water → 4-Trimethylammoniobutanoic acid + Hydrogen Ion + NADH
LEFT_TO_RIGHT
Hydrogen Ion
O2
Oxygen
31.98983
SubPathwayInteraction69
SubPathway69Reaction
SubPathwayReaction
1.14.11.1
false
1.14.11.1
4-Trimethylammoniobutanoic acid + Oxoglutaric acid + Oxygen → Carbon dioxide + L-Carnitine + Succinic acid
LEFT_TO_RIGHT
C7H15NO2
4-Trimethylammoniobutanoic acid
145.11028
CHEBI:16526
ChEBI
P34896
UniProt
56-40-6
CAS
CHEBI:18020
ChEBI
7782-44-7
CAS
4-trimethylaminobutyraldehyde dehydrogenase
HMDB0001377
HMDB
SMILES
C[N+](C)(C)C[C@H](O)CC([O-])=O
1.0
CHEBI:15428
ChEBI
GO:0005654
GENE ONTOLOGY
Carnitine Synthesis
9606
TAXONOMY
962
PubChem-compound
31983
ChemSpider
2.0
2-KETOGLUTARATE
BioCyc
389120
ChemSpider
1.0
Trimethyllysine dioxygenase, mitochondrial
CO2
Carbon dioxide
43.98983
5893
PubChem-compound
C00080
KEGG Compound
SMILES
O=O
110-15-6
CAS
730
ChemSpider
Oxoglutaric acid
HMDB0002111
HMDB
CHEBI:15377
ChEBI
CHEBI:15379
ChEBI
CHEBI:16347
ChEBI
C6H14N2O2
L-Lysine
146.10553
19253-88-4
CAS
CHEBI:15378
ChEBI
SMILES
[H+]
O75936
UniProt
PW000016
PathWhiz
SMILES
C[N+](C)(C)CCCC([O-])=O
Protein degradation
SubPathway
1.0
S-Adenosylmethionine
1.0
CHEBI:17311
ChEBI
C01181
KEGG Compound
280
PubChem-compound
1.0
HMDB0000062
HMDB
HMDB0000182
HMDB
4-TRIMETHYLAMMONIOBUTANAL
BioCyc
1.0
1.0
L-Carnitine
SMILES
N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N)C(O)=O
25246222
PubChem-compound
407-64-7
CAS
440120
PubChem-compound
H2O
Water
18.010565
4-TRIMETHYLAMMONIOBUTANOATE
BioCyc
Succinic acid
SMILES
NCC(O)=O
SMP0000465
SMPDB
1.14.11.8
false
1.14.11.8
N6,N6,N6-Trimethyl-L-lysine + Oxoglutaric acid + Oxygen → 3-Hydroxy-N6,N6,N6-trimethyl-L-lysine + Carbon dioxide + Succinic acid
LEFT_TO_RIGHT
2.1.2.1
false
2.1.2.1
3-Hydroxy-N6,N6,N6-trimethyl-L-lysine → 4-Trimethylammoniobutanal + Glycine
LEFT_TO_RIGHT
2.1.1.43
false
2.1.1.43
L-Lysine + S-Adenosylmethionine → N6,N6,N6-Trimethyl-L-lysine + S-Adenosylhomocysteine
LEFT_TO_RIGHT
HMDB0001161
HMDB
NADH
BioCyc
Nucleus
NAD
BioCyc
977
PubChem-compound
HMDB0059597
HMDB
HMDB0001967
HMDB
CHEBI:16680
ChEBI
1.0
24762165
PubChem-compound
1.0
Q8WTS6
UniProt
NAD
N6,N6,N6-Trimethyl-L-lysine
SubPathwayOutput