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9606 TAXONOMY 962 PubChem-compound Epidermal growth factor receptor SubPathwayInhibition 6022 PubChem-compound Erlotinib 5800 ChemSpider 937 ChemSpider CPD-8587 BioCyc Cytosol Epidermal growth factor receptor Erlotinib Action Pathway 154044 ChemSpider SMILES [O-]P([O-])([O-])=O SMILES O GO:0005886 GENE ONTOLOGY SMILES COCCOC1=C(OCCOC)C=C2C(NC3=CC=CC(=C3)C#C)=NC=NC2=C1 Adenosine triphosphate Erlotinib Inhibition of Epidermal growth factor receptor InhibitorySubPathway HMDB0002111 HMDB HMDB0001341 HMDB Cell Membrane CHEBI:15377 ChEBI C00009 KEGG Compound C00008 KEGG Compound 14265-44-2 CAS Erlotinib SubPathwayInhibitor C00001 KEGG Compound HMDB0000538 HMDB HMDB0001429 HMDB 58-64-0 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 1.0 Water ATP BioCyc PW000251 PathWhiz CHEBI:18367 ChEBI 1032 ChemSpider 1.0 C00002 KEGG Compound SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Multidrug resistance protein 1 1.0 ReactionCoupledTransportCatalysis68 ACTIVATION ADP BioCyc ReactionCoupledTransportCatalysis67 ACTIVATION CHEBI:15422 ChEBI 1.0 Homo sapiens 183321-74-6 CAS CHEBI:114785 ChEBI 5742 ChemSpider 7732-18-5 CAS HMDB0014671 HMDB GO:0005829 GENE ONTOLOGY C22H23N3O4 Erlotinib 393.16885 H2O Water 18.010565 5957 PubChem-compound 2.0 P00533 UniProt 1061 PubChem-compound 176870 PubChem-compound Phosphate Q9UNQ0 UniProt C10H16N5O13P3 Adenosine triphosphate 506.99576 ATP-binding cassette sub-family G member 2 Multidrug resistance protein 1 SubPathwayControl553 InhibitorySubPathwayControl SubPathway553Control O4P Phosphate 94.95342 56-65-5 CAS 1.0 P08183 UniProt CHEBI:16761 ChEBI Adenosine diphosphate C10H15N5O10P2 Adenosine diphosphate 427.02942 3.6.3.44 false 3.6.3.44 Adenosine triphosphate + Erlotinib + Water ↔ Adenosine diphosphate + Erlotinib + Phosphate REVERSIBLE ATP-binding cassette sub-family G member 2 SMP0000472 SMPDB Epidermal growth factor receptor Epidermal growth factor receptor Multidrug resistance protein 1 ATP-binding cassette sub-family G member 2 Erlotinib H 2 O ATP Erlotinib P i ADP H 2 O ATP Erlotinib P i ADP
9606 TAXONOMY 962 PubChem-compound Epidermal growth factor receptor SubPathwayInhibition 6022 PubChem-compound Erlotinib 5800 ChemSpider 937 ChemSpider CPD-8587 BioCyc Cytosol Epidermal growth factor receptor Erlotinib Action Pathway 154044 ChemSpider SMILES [O-]P([O-])([O-])=O SMILES O GO:0005886 GENE ONTOLOGY SMILES COCCOC1=C(OCCOC)C=C2C(NC3=CC=CC(=C3)C#C)=NC=NC2=C1 Adenosine triphosphate Erlotinib Inhibition of Epidermal growth factor receptor InhibitorySubPathway HMDB0002111 HMDB HMDB0001341 HMDB Cell Membrane CHEBI:15377 ChEBI C00009 KEGG Compound C00008 KEGG Compound 14265-44-2 CAS Erlotinib SubPathwayInhibitor C00001 KEGG Compound HMDB0000538 HMDB HMDB0001429 HMDB 58-64-0 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 1.0 Water ATP BioCyc PW000251 PathWhiz CHEBI:18367 ChEBI 1032 ChemSpider 1.0 C00002 KEGG Compound SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Multidrug resistance protein 1 1.0 ReactionCoupledTransportCatalysis68 ACTIVATION ADP BioCyc ReactionCoupledTransportCatalysis67 ACTIVATION CHEBI:15422 ChEBI 1.0 Homo sapiens 183321-74-6 CAS CHEBI:114785 ChEBI 5742 ChemSpider 7732-18-5 CAS HMDB0014671 HMDB GO:0005829 GENE ONTOLOGY C22H23N3O4 Erlotinib 393.16885 H2O Water 18.010565 5957 PubChem-compound 2.0 P00533 UniProt 1061 PubChem-compound 176870 PubChem-compound Phosphate Q9UNQ0 UniProt C10H16N5O13P3 Adenosine triphosphate 506.99576 ATP-binding cassette sub-family G member 2 Multidrug resistance protein 1 SubPathwayControl553 InhibitorySubPathwayControl SubPathway553Control O4P Phosphate 94.95342 56-65-5 CAS 1.0 P08183 UniProt CHEBI:16761 ChEBI Adenosine diphosphate C10H15N5O10P2 Adenosine diphosphate 427.02942 3.6.3.44 false 3.6.3.44 Adenosine triphosphate + Erlotinib + Water ↔ Adenosine diphosphate + Erlotinib + Phosphate REVERSIBLE ATP-binding cassette sub-family G member 2 SMP0000472 SMPDB Epidermal growth factor receptor EGFR ABCB1 ABCG2 Erlotinib Water Adenosine triphosphate Erlotinib Phosphate Adenosine diphosphate Water Adenosine triphosphate Erlotinib Phosphate Adenosine diphosphate