Quantitative metabolomics services for biomarker discovery and validation.
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Mitochondrial ornithine transporter 1 Argininosuccinate synthase Argininosuccinate lyase Carbamoyl- phosphate synthase [ammonia], mitochondrial Glutamate dehydrogenase 1, mitochondrial Ornithine aminotransferase, mitochondrial Delta-1- pyrroline-5- carboxylate dehydrogenase, mitochondrial Delta-1- pyrroline-5- carboxylate dehydrogenase, mitochondrial Proline dehydrogenase 1, mitochondrial Pyrroline-5- carboxylate reductase 2 Prolyl 4-hydroxylase subunit alpha-3 Proline dehydrogenase 1, mitochondrial Pyrroline-5- carboxylate reductase 2 Probable arginine--tRNA ligase, mitochondrial Glycine amidinotransferase, mitochondrial Guanidinoacetate N- methyltransferase Creatine kinase B-type Arginase-1 Ornithine carbamoyltransferase, mitochondrial D-amino-acid oxidase D-amino-acid oxidase Delta-1- pyrroline-5- carboxylate dehydrogenase, mitochondrial Proline dehydrogenase 1, mitochondrial Delta-1- pyrroline-5- carboxylate dehydrogenase, mitochondrial Aspartate aminotransferase, cytoplasmic Nitric oxide synthase, brain Bifunctional glutamate/proline- -tRNA ligase Fumaric acid L-Aspartic acid Accumulation Ornithine L-Arginine Accumulation Ornithine Citrulline Citrulline ATP AMP PPi Argininosuccinic acid ATP Accumulation NH3 CO2 H2O ADP Phosphoric acid Carbamoyl phosphate L-Glutamic acid H2O NAD Oxoglutaric acid NADH Oxoglutaric acid L-Glutamic γ-semialdehyde NAD H2O NADH H+ 1-Pyrroline-5-carboxylic acid NAD H2O NADH L-Proline NAD NADH Oxoglutaric acid O2 4- Hydroxyproline Succinic acid CO2 Pyrroline hydroxycarboxylic acid NAD NADH ATP AMP PPi Glycine Accumulation Ornithine Guanidoacetic acid S-Adenosylmethionine S-Adenosylhomocysteine Creatine ATP ADP Phosphocreatine H2O Urea Pi D-Proline H2O O2 1-Pyrroline- 2-carboxylic acid Accumulation NH3 H2O"="">2 H2O O2 1-Pyrroline- 4-hydroxy-2- carboxylate Accumulation NH3 H2O"="">2