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CHEBI:16015 ChEBI SubPathwayInteraction277 SubPathwayReaction SubPathway277Reaction 6022 PubChem-compound 937 ChemSpider CHEBI:16134 ChEBI 1.0 1.0 439153 PubChem-compound SubPathwayInteraction271 SubPathway271Reaction SubPathwayReaction 1.0 SubPathwayInteraction272 SubPathwayReaction SubPathway272Reaction Tetrahydrofolic acid SubPathwayOutput SubPathwayInput 58-05-9 CAS SubPathwayInteraction270 SubPathway270Reaction SubPathwayReaction 10-FORMYL-THF BioCyc SubPathwayInteraction275 SubPathway275Reaction SubPathwayReaction Methylenetetrahydrofolate reductase SubPathwayInteraction276 SubPathway276Reaction SubPathwayReaction SubPathwayInteraction273 SubPathwayReaction SubPathway273Reaction 10-Formyltetrahydrofolate SubPathwayInteraction274 SubPathway274Reaction SubPathwayReaction SubPathwayInteraction268 SubPathway268Reaction SubPathwayReaction L-Glutamic acid PW000056 PathWhiz SubPathwayInteraction269 SubPathway269Reaction SubPathwayReaction CHEBI:20506 ChEBI SubPathwayInteraction266 SubPathwayReaction SubPathway266Reaction 7444-29-3 CAS SubPathwayInteraction267 SubPathwayReaction SubPathway267Reaction C19H21N7O6 Dihydrofolic acid 443.15533 CHEBI:17119 ChEBI C00440 KEGG Compound ATP BioCyc C00445 KEGG Compound 1.0 PW000052 PathWhiz 5-METHYL-THF BioCyc 18714427 ChemSpider 2.0 Proton-coupled folate transporter SubPathwayInteraction265 SubPathway265Reaction SubPathwayReaction 390680 ChemSpider PW000043 PathWhiz 5742 ChemSpider CHEBI:16474 ChEBI PW000160 PathWhiz Carbon dioxide Formimidoyltransferase-cyclodeaminase 439175 PubChem-compound P42898 UniProt 5-formyltetrahydrofolate cyclo-ligase SMP0000543 SMPDB 1.0 PW000157 PathWhiz METHYLENE-THF BioCyc 1010 ChemSpider 6037 PubChem-compound C00101 KEGG Compound C6H9NO5 N-Formyl-L-glutamic acid 175.04807 1.0 45479706 PubChem-compound L-Glutamic acid SubPathwayOutput Tetrahydrofolyl-[Glu](n) C00234 KEGG Compound 5-FORMYL-THF BioCyc 1.0 122347 PubChem-compound C00009 KEGG Compound C00008 KEGG Compound Q6UB35 UniProt C00006 KEGG Compound 5-Methyltetrahydrofolic acid SubPathwayOutput N-Formyl-L-glutamic acid CHEBI:18009 ChEBI O75891 UniProt C00001 KEGG Compound C00005 KEGG Compound CHEBI:18367 ChEBI SMILES OC(=O)CC[C@H](NC=O)C(O)=O C00004 KEGG Compound 135-16-0 CAS 1032 ChemSpider C00003 KEGG Compound NADP C00002 KEGG Compound 388320 ChemSpider Q96NT5 UniProt 1.0 Phosphate 1.0 1.0 Tetrahydrofolyl-[Glu](n) C21H28N7O14P2 NAD 664.11694 Adenosine triphosphate C00011 KEGG Compound HMDB0000902 HMDB Formimidoyltransferase-cyclodeaminase C00014 KEGG Compound 1.0 Extracellular Space NAD(P) BioCyc 11267158 ChemSpider H Hydrogen Ion 1.007825 C00143 KEGG Compound 56-65-5 CAS 53-84-9 CAS C00025 KEGG Compound C-1-tetrahydrofolate synthase, cytoplasmic 3432-99-3 CAS 8.0 C-1-tetrahydrofolate synthase, cytoplasmic C03541 KEGG Compound SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O 1.0 Adenosine diphosphate 98792 PubChem-compound L-methionyl-tRNA(Met) HMDB0001341 HMDB N-formylmethionyl-tRNA(fMet) 644350 PubChem-compound 1.0 SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Folylpolyglutamate synthase, mitochondrial DIHYDROFOLATE BioCyc HMDB0001354 HMDB L-methionyl-tRNA(Met) HMDB0000148 HMDB 1.0 Methylenetetrahydrofolate reductase HMDB0000142 HMDB 2.0 Cytosolic 10-formyltetrahydrofolate dehydrogenase 7732-18-5 CAS C00058 KEGG Compound HMDB0001487 HMDB NAD AMMONIA BioCyc SMILES N 56-86-0 CAS FORMATE BioCyc Adenosine diphosphate C10H16N5O13P3 Adenosine triphosphate 506.99576 C20H23N7O7 10-Formyltetrahydrofolate 473.1659 442163 PubChem-compound Q92820 UniProt C24H30N8O9 Tetrahydrofolyl-[Glu](2) 574.21356 C29H37N9O12 Tetrahydrofolyl-[Glu](n) 703.25616 2800-34-2 CAS 530 PubChem-compound 4033-27-6 CAS HMDB0006825 HMDB HMDB0006826 HMDB Ammonia 1.0 962 PubChem-compound 5,10-Methylene-THF SubPathwayInput 5800 ChemSpider C01045 KEGG Compound CO2 Carbon dioxide 43.98983 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial C-1-tetrahydrofolate synthase, cytoplasmic C00080 KEGG Compound Glutamate Metabolism SubPathway HMDB0000051 HMDB HMDB0002111 HMDB SMILES N[C@@H](CCC(O)=O)C(O)=O SMILES OC=O 14265-44-2 CAS 5,10-methenyl-thf BioCyc Methionyl-tRNA formyltransferase, mitochondrial Monofunctional C1-tetrahydrofolate synthase, mitochondrial 58-64-0 CAS C03479 KEGG Compound CHEBI:209153 ChEBI SMILES NC1=NC2=C(N(C=O)C(CNC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)CN2)C(=O)N1 FOLATE BioCyc SMILES CN1C(CNC2=CC=C(C=C2)C(=O)N[C@H](CCC(O)=O)C(O)=O)CNC2=C1C(=O)NC(N)=N2 10-Formyltetrahydrofolate SubPathwayInput HMDB0001396 HMDB 1.0 64-18-6 CAS 1.0 SMILES [H][C@@]12CN(C=[N+]1C1=C(NC2)NC(N)=NC1=O)C1=CC=C(C=C1)C(=O)N[C@@H](CCC(O)=O)C([O-])=O 1.0 SMILES NC1=NC(=O)C2=NC(CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)=CN=C2N1 22833512 PubChem-compound N-formylmethionyl-tRNA(fMet) H2O Water 18.010565 Cytosolic 10-formyltetrahydrofolate dehydrogenase 1.0 NADH BioCyc 5-Formiminotetrahydrofolic acid SubPathwayOutput NAD BioCyc 5815 ChemSpider HMDB0059597 HMDB 559356 ChemSpider 5,10-Methenyltetrahydrofolic acid 1.0 Formimidoyltransferase-cyclodeaminase Formic acid SMILES NC1=NC2=C(N(C=N)C(CNC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)CN2)C(=O)N1 SMILES [H][C@@]12CN(CN1C1=C(NC2)N=C(N)NC1=O)C1=CC=C(C=C1)C(=O)NC(CCC(O)=O)C(O)=O 134-35-0 CAS NAD HMDB0003470 HMDB HMDB0001056 HMDB 1.0 30572 ChemSpider 17215925 ChemSpider 2.0 Folic acid 5-formyltetrahydrofolate cyclo-ligase Dihydrofolic acid SubPathwayInput Methionine Metabolism SubPathway SMILES O Methionyl-tRNA formyltransferase, mitochondrial H3N Ammonia 17.026548 1.0 2.0 HMDB0000538 HMDB Gamma-glutamyl hydrolase Dihydrofolate reductase Histidine Metabolism SubPathway Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial Water CHEBI:15846 ChEBI Folic acid ADP BioCyc Pyrimidine Metabolism SubPathway 53-59-8 CAS Lysosome P00374 UniProt 1.0 CHEBI:48309 ChEBI 1038 PubChem-compound 143 PubChem-compound 278 ChemSpider C19H23N7O6 Tetrahydrofolic acid 445.171 2.0 Purine Metabolism SubPathway 274 ChemSpider Hydrogen Ion CHEBI:16908 ChEBI 1.5.1.20 false 1.5.1.20 5,10-Methylene-THF + NADH → 5-Methyltetrahydrofolic acid + NAD LEFT_TO_RIGHT Reaction789 false 5-Formiminotetrahydrofolic acid ↔ 5,10-Methenyltetrahydrofolic acid + Ammonia REVERSIBLE O4P Phosphate 94.95342 Gamma-glutamyl hydrolase Dihydrofolate reductase HMDB0001533 HMDB Adenosine triphosphate HMDB0001534 HMDB TransportCatalysis229 ACTIVATION C21H30N7O17P3 NADPH 745.0911 6.3.3.2 false 6.3.3.2 Adenosine triphosphate + N5-Formyl-THF → 5,10-Methenyltetrahydrofolic acid + Adenosine diphosphate + Phosphate LEFT_TO_RIGHT 140 ChemSpider Reaction787 false 5,10-Methenyltetrahydrofolic acid + NADPH ↔ 5,10-Methylene-THF + NADP REVERSIBLE Reaction784 false L-Glutamic acid + N5-Formyl-THF → N-Formyl-L-glutamic acid + Tetrahydrofolic acid LEFT_TO_RIGHT C21H29N7O17P3 NADP 744.08325 Reaction785 false 10-Formyltetrahydrofolate + Hydrogen Ion ↔ 5,10-Methenyltetrahydrofolic acid + Water REVERSIBLE Mitochondrion THF BioCyc Reaction782 false Adenosine triphosphate + Formic acid + Tetrahydrofolic acid → 10-Formyltetrahydrofolate + Adenosine diphosphate + Phosphate LEFT_TO_RIGHT 1.5.1.6 false 1.5.1.6 10-Formyltetrahydrofolate + NADP + Water → Carbon dioxide + NADPH + Tetrahydrofolic acid LEFT_TO_RIGHT 1.5.1.3 false 1.5.1.3 NADP + Tetrahydrofolic acid ↔ Dihydrofolic acid + NADPH REVERSIBLE CHEBI:15641 ChEBI NADPH BioCyc 1.0 O95954 UniProt 217 ChemSpider SMILES NC1=NC(=O)C2=C(NC[C@H](CNC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)N2)N1 58-68-4 CAS Water SMILES [O-]P([O-])([O-])=O C20H21N7O6 5,10-Methenyltetrahydrofolic acid 455.15533 HMDB0000217 HMDB 1.0 Dihydrofolate reductase CHEBI:15637 ChEBI 124-38-9 CAS CHEBI:15639 ChEBI GO:0005764 GENE ONTOLOGY SMP0000046 SMPDB C19H19N7O6 Folic acid 441.13968 SMP0000044 SMPDB Tetrahydrofolyl-[Glu](2) HMDB0001429 HMDB P13995 UniProt SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O SMP0000050 SMPDB HMDB0000221 HMDB 1.0 1.0 SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O C20H23N7O6 5,10-Methylene-THF 457.171 C20H24N8O6 5-Formiminotetrahydrofolic acid 472.1819 Q96DP5 UniProt GLT BioCyc 7664-41-7 CAS Glycine and Serine Metabolism SubPathway 53-57-6 CAS P11586 UniProt SMILES O=C=O 1.0 222 PubChem-compound Proton-coupled folate transporter Monofunctional C1-tetrahydrofolate synthase, mitochondrial C21H29N7O14P2 NADH 665.12476 1.0 5-FORMIMINO-THF BioCyc 5957 PubChem-compound 1681-96-5 CAS PW000519 PathWhiz HMDB0001562 HMDB CHEBI:15633 ChEBI CHEBI:15636 ChEBI Folylpolyglutamate synthase, mitochondrial Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial 5,10-Methenyltetrahydrofolic acid SMP0000072 SMPDB 1.0 GO:0005739 GENE ONTOLOGY Monofunctional C1-tetrahydrofolate synthase, mitochondrial C10H15N5O10P2 Adenosine diphosphate 427.02942 GO:0005615 GENE ONTOLOGY GO:0005737 GENE ONTOLOGY 1.0 HMDB0000121 HMDB 1.5.1.3 false 1.5.1.3 Dihydrofolic acid + NADP ↔ Folic acid + NADPH REVERSIBLE Transport24 false Folic acid (↔) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytoplasm LEFT_TO_RIGHT 1.0 NADH CPD-8587 BioCyc SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O Transport22 false Tetrahydrofolic acid (→) Transport: Homo sapiens, Cell, Cytoplasm to Homo sapiens, Cell, Mitochondrion LEFT_TO_RIGHT 5682 ChemSpider Q05932 UniProt 1.0 1.0 SMP0000004 SMPDB 21231977 ChemSpider 5675 ChemSpider P49914 UniProt 18971002 PubChem-compound Cytoplasm 5,10-Methylene-THF SubPathwayInput NADPH Gamma-glutamyl hydrolase CHEBI:15422 ChEBI CHEBI:16635 ChEBI ReactionCatalysis330 ACTIVATION Homo sapiens 388299 ChemSpider Hydrogen Ion CH2O2 Formic acid 46.005478 Tetrahydrofolyl-[Glu](2) CHEBI:28624 ChEBI 1.0 ReactionCatalysis328 ACTIVATION ReactionCatalysis329 ACTIVATION ReactionCatalysis326 ACTIVATION ReactionCatalysis324 ACTIVATION CHEBI:27650 ChEBI C5H9NO4 L-Glutamic acid 147.05316 ReactionCatalysis325 ACTIVATION C00504 KEGG Compound 33032 PubChem-compound ReactionCatalysis322 ACTIVATION ReactionCatalysis323 ACTIVATION 1.0 ReactionCatalysis320 ACTIVATION Water ReactionCatalysis321 ACTIVATION CHEBI:16526 ChEBI SMILES NC1=NC2=C(N=C(CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)CN2)C(=O)N1 CHEBI:16761 ChEBI C20H23N7O7 N5-Formyl-THF 473.1659 C20H25N7O6 5-Methyltetrahydrofolic acid 459.18665 ReactionCatalysis319 ACTIVATION ReactionCatalysis317 ACTIVATION ReactionCatalysis318 ACTIVATION ReactionCatalysis315 ACTIVATION ReactionCatalysis316 ACTIVATION NADH SMP0000033 SMPDB ReactionCatalysis313 ACTIVATION ReactionCatalysis314 ACTIVATION 9606 TAXONOMY 1.0 1.0 1.0 5893 PubChem-compound Formic acid 439234 PubChem-compound 6.3.2.17 false 6.3.2.17 Adenosine triphosphate + L-Glutamic acid + Tetrahydrofolic acid → Adenosine diphosphate + Phosphate + Tetrahydrofolyl-[Glu](2) LEFT_TO_RIGHT HMDB0000972 HMDB CHEBI:30751 ChEBI SMILES NC1=NC(=O)C2=C(NCC(CN(C=O)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)N2)N1 2.0 CHEBI:27470 ChEBI Methylenetetrahydrofolate reductase 2.1.2.9 false 2.1.2.9 10-Formyltetrahydrofolate + L-methionyl-tRNA(Met) → N-formylmethionyl-tRNA(fMet) + Tetrahydrofolic acid LEFT_TO_RIGHT Reaction794 false 5,10-Methenyltetrahydrofolic acid + NADH ↔ 5,10-Methylene-THF + NAD REVERSIBLE 6.3.2.17 false 6.3.2.17 Adenosine triphosphate + L-Glutamic acid + Tetrahydrofolyl-[Glu](2) → Adenosine diphosphate + Phosphate + Tetrahydrofolyl-[Glu](n) LEFT_TO_RIGHT 3.4.19.9 false 3.4.19.9 Tetrahydrofolyl-[Glu](n) + Water → L-Glutamic acid + Tetrahydrofolyl-[Glu](2) LEFT_TO_RIGHT 1.0 CHEBI:15377 ChEBI CHEBI:15378 ChEBI SMILES [H+] SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound SMILES NC1=NC2=C(NC(CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)NC(CCC(O)=O)C(O)=O)C(O)=O)CN2)C(=O)N1 1.0 Phosphate SMILES NC1=NC(=O)C2=C(NCC(CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)NC(CCC(=O)NC(CCC(O)=O)C(O)=O)C(O)=O)C(O)=O)N2)N1 1.0 280 PubChem-compound C00415 KEGG Compound PW000003 PathWhiz 89228 ChemSpider 388371 ChemSpider 1.0 388496 ChemSpider 2311-81-1 CAS 439376 PubChem-compound 1061 PubChem-compound CPD-600 BioCyc 109092 ChemSpider HMDB0001846 HMDB HMDB0001967 HMDB C00664 KEGG Compound Tetrahydrofolic acid SubPathwayInput 13781857 PubChem-compound N5-Formyl-THF 1.0 59-30-3 CAS Methylenetetrahydrofolate Reductase Deficiency (MTHFRD)