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6022 PubChem-compound Mitochondrial pyruvate carrier 1 937 ChemSpider 96860 ChemSpider 1.0 Glucose-6-phosphatase 439278 PubChem-compound 439153 PubChem-compound Phosphoglycerate mutase 2 Phosphoglycerate mutase 1 Bisphosphoglycerate mutase ReactionCatalysis942 ACTIVATION 50 ChemSpider ReactionCatalysis940 ACTIVATION 58238 ChemSpider PW000055 PathWhiz C6H14O12P2 Fructose 1,6-bisphosphate 339.99606 PW000054 PathWhiz OXALACETIC_ACID BioCyc ATP BioCyc Reaction1242 false 2,3-Diphosphoglyceric acid + Water ↔ 3-Phosphoglyceric acid + Phosphate REVERSIBLE Reaction1243 false 2,3-Diphosphoglyceric acid + Water ↔ 3-Phosphoglyceric acid + Phosphate REVERSIBLE Reaction1240 false Glyceric acid 1,3-biphosphate ↔ 2,3-Diphosphoglyceric acid REVERSIBLE ReactionCatalysis939 ACTIVATION ReactionCatalysis937 ACTIVATION Oxoglutaric acid Reaction1246 false 3-Phosphoglyceric acid ↔ 2-Phospho-D-glyceric acid REVERSIBLE HMDB0003498 HMDB Malic acid 5743 ChemSpider 1.0 HCO3 BioCyc 5742 ChemSpider NADH PW000042 PathWhiz 2280-44-6 CAS ALPHA-GLUCOSE-16-BISPHOSPHATE BioCyc 1.0 ReactionCatalysis965 ACTIVATION SMILES OC1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@H]1O Malate dehydrogenase, mitochondrial ReactionCatalysis960 ACTIVATION C6H13O9P Beta-D-Glucose 6-phosphate 260.02972 PW000032 PathWhiz HMDB0003391 HMDB PW000159 PathWhiz 709 ChemSpider PW000036 PathWhiz C00221 KEGG Compound 2,3-Diphosphoglyceric acid 704 ChemSpider 1.0 945 ChemSpider PW000031 PathWhiz C00103 KEGG Compound 1010 ChemSpider PW000150 PathWhiz C10H15N5O11P2 Guanosine diphosphate 443.02432 O43826 UniProt 439165 PubChem-compound 488-69-7 CAS ReactionCatalysis958 ACTIVATION ReactionCatalysis713 ACTIVATION ReactionCatalysis955 ACTIVATION ReactionCatalysis954 ACTIVATION 2.0 ReactionCatalysis952 ACTIVATION 1.0 C3H7O6P D-Glyceraldehyde 3-phosphate 169.99803 138-08-9 CAS 1.0 C10H16N5O14P3 Guanosine triphosphate 522.99066 59-56-3 CAS C3H8O10P2 Glyceric acid 1,3-biphosphate 265.95926 Transport68 false Glucose 6-phosphate (←) Transport: Homo sapiens, Cell, Endoplasmic Reticulum to Homo sapiens, Cell, Cytosol LEFT_TO_RIGHT C00111 KEGG Compound Transport67 false Phosphate (→) Transport: Homo sapiens, Cell, Endoplasmic Reticulum to Homo sapiens, Cell, Cytosol LEFT_TO_RIGHT Cytosol Alpha-enolase Q02978 UniProt C00236 KEGG Compound 388311 ChemSpider 1.0 C00597 KEGG Compound C00354 KEGG Compound P60174 UniProt Transport70 false Phosphoenolpyruvic acid (?) Transport: Homo sapiens, Cell, Mitochondrial Matrix to Homo sapiens, Cell, Cytosol LEFT_TO_RIGHT Aldose 1-epimerase Glyceraldehyde-3-phosphate dehydrogenase 7664-38-2 CAS 1.0 Fructose 1,6-bisphosphate 1.0 false Fructose 6-phosphate ↔ Glucose 6-phosphate REVERSIBLE false Alpha-D-Glucose ↔ Beta-D-Glucose REVERSIBLE C00009 KEGG Compound C00008 KEGG Compound SMILES O[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@H]1O 1.0 C3H8O10P2 2,3-Diphosphoglyceric acid 265.95926 Hydrogen Ion C00001 KEGG Compound P15259 UniProt Fructose 6-phosphate SubPathwayInput SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1 CHEBI:18367 ChEBI C00004 KEGG Compound Pyruvic acid SubPathwayOutput 1032 ChemSpider C00003 KEGG Compound 1.0 C00002 KEGG Compound 1031 ChemSpider Mitochondrial 2-oxoglutarate/malate carrier protein GLC-1-P BioCyc C6H12O6 Alpha-D-Glucose 180.06339 Phosphate 388411 ChemSpider 388538 ChemSpider Pyruvic acid SubPathwayOutput C21H28N7O14P2 NAD 664.11694 107689 PubChem-compound 2.0 C00011 KEGG Compound HMDB0000902 HMDB 161681 ChemSpider FRUCTOSE-6P BioCyc Glucose-6-phosphatase CHEBI:17138 ChEBI H Hydrogen Ion 1.007825 1.0 P52789 UniProt C00022 KEGG Compound 56-65-5 CAS P18669 UniProt Pyruvate carboxylase, mitochondrial 53-84-9 CAS C00026 KEGG Compound C00267 KEGG Compound 62713 ChemSpider CHEBI:26078 ChEBI 1.0 ReactionCatalysis513 ACTIVATION P06733 UniProt 769 PubChem-compound 525 PubChem-compound C00031 KEGG Compound 186004 PubChem-compound C00036 KEGG Compound Transport1 false Pyruvic acid (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Mitochondrial Matrix LEFT_TO_RIGHT C00035 KEGG Compound HMDB0001586 HMDB SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O 328-50-7 CAS L-Lactic acid SubPathwayOutput Oxalacetic acid D-Glucose SubPathwayOutput SubPathwayInput Adenosine diphosphate 492-61-5 CAS HMDB0001341 HMDB 4.0 false Glucose 1-phosphate + Water → D-Glucose + Phosphate LEFT_TO_RIGHT false Fructose 1,6-bisphosphate + Water → Fructose 6-phosphate + Phosphate LEFT_TO_RIGHT P06744 UniProt C00044 KEGG Compound 648 ChemSpider false Fructose 1,6-bisphosphate ↔ D-Glyceraldehyde 3-phosphate + Dihydroxyacetone phosphate REVERSIBLE false Glucose 6-phosphate + Water ↔ D-Glucose + Phosphate REVERSIBLE C00288 KEGG Compound SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O HMDB0001112 HMDB PHOSPHO-ENOL-PYRUVATE BioCyc 4.0 HMDB0001473 HMDB HMDB0000263 HMDB SMILES OC(=O)C(=C)OP(O)(O)=O 64689 PubChem-compound Reaction812 false D-Glyceraldehyde 3-phosphate + NAD + Phosphoric acid ↔ Glyceric acid 1,3-biphosphate + NADH REVERSIBLE 1.0 C3H7O7P 3-Phosphoglyceric acid 185.99294 false Dihydroxyacetone phosphate ↔ D-Glyceraldehyde 3-phosphate REVERSIBLE 668 PubChem-compound Hexokinase-2 SMILES OC(=O)CC(=O)C(O)=O 7732-18-5 CAS CHEBI:16077 ChEBI CHEBI:4170 ChEBI 591-59-3 CAS HMDB0001487 HMDB NAD SMILES OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O Pyruvic acid 1.0 492-62-6 CAS 1.0 NAD SubPathwayInteraction203 SubPathway203Reaction SubPathwayReaction SubPathwayInteraction200 SubPathway200Reaction SubPathwayReaction false Glucose 1-phosphate ↔ Glucose 6-phosphate REVERSIBLE Malic acid C10H16N5O13P3 Adenosine triphosphate 506.99576 SubPathwayInteraction206 SubPathway206Reaction SubPathwayReaction Phosphoric acid DPG BioCyc SubPathwayInteraction207 SubPathwayReaction SubPathway207Reaction DIHYDROXY-ACETONE-PHOSPHATE BioCyc MAL BioCyc C00186 KEGG Compound SubPathwayInteraction208 SubPathway208Reaction SubPathwayReaction SubPathwayInteraction209 SubPathway209Reaction SubPathwayReaction C01159 KEGG Compound 445557 PubChem-compound SMILES CC(=O)C(O)=O 663 ChemSpider Alpha-D-Glucose C3H7O7P 2-Phospho-D-glyceric acid 185.99294 C00074 KEGG Compound CHEBI:17050 ChEBI Mitochondrial pyruvate carrier 1 false Adenosine triphosphate + Hydrogen carbonate + Pyruvic acid → Adenosine diphosphate + Oxalacetic acid + Phosphate LEFT_TO_RIGHT SMILES OCC(=O)COP(O)(O)=O 3-Phosphoglyceric acid SubPathwayInput P07738 UniProt 962 PubChem-compound 724 PubChem-compound P11168 UniProt 5800 ChemSpider Phosphoenolpyruvate carboxykinase, cytosolic [GTP] Malate dehydrogenase, mitochondrial Fructose-bisphosphate aldolase A Fructose-1,6-bisphosphatase 1 979 ChemSpider CO2 Carbon dioxide 43.98983 C00080 KEGG Compound Thiamine Metabolism SubPathway C00085 KEGG Compound H3O4P Phosphoric acid 97.9769 C01172 KEGG Compound 2.0 729 PubChem-compound Phosphoglycerate mutase 1 Q9Y5U8 UniProt HMDB0002111 HMDB C4H6O5 Malic acid 134.02153 14265-44-2 CAS CHEBI:44897 ChEBI Glucose-6-phosphate isomerase PYRUVATE BioCyc 58-64-0 CAS C6H13O9P Glucose 1-phosphate 260.02972 GTP BioCyc C00092 KEGG Compound 71358 ChemSpider G3P BioCyc Glucose-6-phosphate isomerase CHEBI:4167 ChEBI HMDB0001270 HMDB Oxalacetic acid C3H6O3 L-Lactic acid 90.03169 HMDB0001273 HMDB P04406 UniProt 1.0 HMDB0000190 HMDB 56-73-5 CAS 2-PG BioCyc 1.0 23-DIPHOSPHOGLYCERATE BioCyc SMILES OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O Phosphoglucomutase-1 1.0 Pantothenate kinase 1 Malate dehydrogenase, mitochondrial HMDB0003345 HMDB 510 ChemSpider H2O Water 18.010565 138-81-8 CAS SMILES OCC(=O)[C@@H](O)[C@H](O)[C@H](O)COP(O)(O)=O 1.0 393165 ChemSpider Triosephosphate isomerase NADH BioCyc 1.0 Glucose 6-phosphate Beta-D-Glucose NAD BioCyc 1.0 Glucose-6-phosphate translocase Malic acid HMDB0059597 HMDB 1.0 Glyceraldehyde-3-phosphate dehydrogenase 749 ChemSpider 71-52-3 CAS 1.0 970 PubChem-compound 4.0 HMDB0001058 HMDB 980 ChemSpider 1.0 146-91-8 CAS HMDB0001294 HMDB CHO3 Hydrogen carbonate 60.99257 CHEBI:15903 ChEBI Aldose 1-epimerase 820-11-1 CAS HMDB0002142 HMDB 2-Phospho-D-glyceric acid 1.0 C4H4O5 Oxalacetic acid 132.00587 4.0 CHEBI:6650 ChEBI Glyceraldehyde-3-phosphate dehydrogenase Pentose Phosphate Pathway SubPathway 1.0 1.0 SMILES O P35575 UniProt Q96C23 UniProt Glycerolipid Metabolism SubPathway C6H12O6 Beta-D-Glucose 180.06339 1.0 Triosephosphate isomerase P11498 UniProt HMDB0000538 HMDB Phosphoenolpyruvate carboxykinase, cytosolic [GTP] 1004 PubChem-compound 1005 PubChem-compound TransportCatalysis6 ACTIVATION TransportCatalysis8 ACTIVATION 643-13-0 CAS 1981-49-3 CAS Galactose Metabolism SubPathway 328-42-7 CAS C3H7O6P Dihydroxyacetone phosphate 169.99803 51 PubChem-compound SMILES OC([O-])=O CHEBI:15846 ChEBI ADP BioCyc C3H4O3 Pyruvic acid 88.016045 1038 PubChem-compound Pantothenate kinase 1 GO:0005829 GENE ONTOLOGY Alanine Metabolism SubPathway HMDB0001401 HMDB 274 ChemSpider C5H6O5 Oxoglutaric acid 146.02153 Hydrogen Ion CHEBI:16905 ChEBI Fructose-1,6-bisphosphatase 1 Guanosine triphosphate Starch and Sucrose Metabolism SubPathway CHEBI:16908 ChEBI Guanosine diphosphate O4P Phosphate 94.95342 6830 PubChem-compound 1.0 Aspartate Metabolism SubPathway Adenosine triphosphate Fructose and Mannose Degradation SubPathway Pyruvate Metabolism SubPathway CHEBI:15946 ChEBI L-LACTATE BioCyc Mitochondrion P40926 UniProt Hexokinase-2 Solute carrier family 2, facilitated glucose transporter member 2 Glucose 1-phosphate SubPathwayOutput HMDB0000208 HMDB Carbon dioxide 683 PubChem-compound Phosphoenolpyruvic acid SubPathwayInput Triosephosphate isomerase 58-68-4 CAS SMILES [O-]P([O-])([O-])=O Pantothenate kinase 1 SMILES OC(=O)CCC(=O)C(O)=O PW000538 PathWhiz 1.0 C6H13O9P Fructose 6-phosphate 260.02972 124-38-9 CAS CHEBI:30915 ChEBI C6H12O6 D-Glucose 180.06339 SMP0000043 SMPDB 2.0 Fructose-bisphosphate aldolase A CHEBI:17835 ChEBI Phosphoenolpyruvic acid ReactionCatalysis4 ACTIVATION GLC BioCyc HMDB0001429 HMDB 1.0 1.0 HMDB0000223 HMDB Malate dehydrogenase, mitochondrial GO:0005758 GENE ONTOLOGY GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE BioCyc GO:0005759 GENE ONTOLOGY SMP0000058 SMPDB 1.0 Phenylalanine and Tyrosine Metabolism SubPathway Tyrosine Metabolism SubPathway 57-04-5 CAS SMP0000055 SMPDB 69507 PubChem-compound Pyruvate carboxylase, mitochondrial P35558 UniProt 1.0 SMILES O=C=O 1.0 Malate dehydrogenase, mitochondrial SubPathwayInteraction814 SubPathway814Reaction SubPathwayReaction SMILES OP(O)(O)=O HMDB0001201 HMDB HMDB0000595 HMDB SMILES OC(CC(O)=O)C(O)=O Nucleotide Sugars Metabolism SubPathway SMP0000060 SMPDB 5958 PubChem-compound C21H29N7O14P2 NADH 665.12476 D-Glucose 5957 PubChem-compound Malic acid SMP0000067 SMPDB Propanoate Metabolism SubPathway P00338 UniProt SMP0000064 SMPDB CHEBI:15996 ChEBI SMILES OC[C@H]1OC(OP(O)(O)=O)[C@H](O)[C@@H](O)[C@@H]1O L-lactate dehydrogenase A chain Alpha-enolase HMDB0000122 HMDB 1.0 HMDB0000243 HMDB C3H5O6P Phosphoenolpyruvic acid 167.98238 1.0 HMDB0000124 HMDB Adenosine triphosphate GO:0005739 GENE ONTOLOGY C10H15N5O10P2 Adenosine diphosphate 427.02942 SMILES C[C@H](O)C(O)=O P36871 UniProt D-Glyceraldehyde 3-phosphate SubPathwayOutput SubPathwayInput CHEBI:17925 ChEBI SMP0000076 SMPDB Pantothenate and CoA Biosynthesis SubPathway C00711 KEGG Compound SMP0000008 SMPDB Endoplasmic Reticulum 1.0 SMP0000006 SMPDB L-lactate dehydrogenase A chain CPD-8587 BioCyc SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O TransportCatalysis15 ACTIVATION 5682 ChemSpider HMDB0000807 HMDB Dihydroxyacetone phosphate Mitochondrial Matrix C6H13O9P Glucose 6-phosphate 260.02972 2.0 ReactionCatalysis661 ACTIVATION SMP0000016 SMPDB Phosphoglucomutase-1 Phosphoglycerate mutase 2 Pyruvate carboxylase, mitochondrial Fructose-1,6-diphosphatase Deficiency Mitochondrial 2-oxoglutarate/malate carrier protein Adenosine diphosphate SMILES OC(COP(O)(O)=O)C(=O)OP(O)(O)=O Q8TE04 UniProt 6915-15-7 CAS ReactionCatalysis658 ACTIVATION ReactionCatalysis1053 ACTIVATION false 2-Phospho-D-glyceric acid ↔ Phosphoenolpyruvic acid + Water REVERSIBLE SMP0000010 SMPDB 439427 PubChem-compound 1.0 CHEBI:15422 ChEBI CHEBI:17720 ChEBI 5589 ChemSpider P09467 UniProt SMP0000027 SMPDB Homo sapiens Glucose-6-phosphate translocase TransportCatalysis34 ACTIVATION Hydrogen carbonate Beta-D-Glucose 6-phosphate Transport42 false D-Glucose (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel LEFT_TO_RIGHT 388299 ChemSpider 1.0 1.0 79-33-4 CAS 127-17-3 CAS Fructose-1,6-bisphosphatase 1 CHEBI:17719 ChEBI GO:0005783 GENE ONTOLOGY Water false L-Lactic acid + NAD ↔ Hydrogen Ion + NADH + Pyruvic acid REVERSIBLE FRUCTOSE-16-DIPHOSPHATE BioCyc 1.0 CHEBI:16526 ChEBI SMP0000039 SMPDB SMILES O[C@H]1[C@H](O)[C@](O)(COP(O)(O)=O)O[C@@H]1COP(O)(O)=O 8977 PubChem-compound CHEBI:16761 ChEBI Transport32 false Oxoglutaric acid (←), Malic acid (→) Transport: Homo sapiens, Cell, Mitochondrial Matrix to Homo sapiens, Cell, Mitochondrial Intermembrane Space LEFT_TO_RIGHT GLC-6-P BioCyc false Malic acid + NAD ↔ Hydrogen Ion + NADH + Oxalacetic acid REVERSIBLE 1.0 NADH 1.0 SMP0000031 SMPDB 9606 TAXONOMY PW000144 PathWhiz P04075 UniProt Glucose 6-phosphate CHEBI:17544 ChEBI PW000142 PathWhiz PW000149 PathWhiz 2-KETOGLUTARATE BioCyc PW000025 PathWhiz SMILES OC(COP(O)(O)=O)C(O)=O Oxoglutaric acid C00631 KEGG Compound 8630 ChemSpider 5893 PubChem-compound SubPathwayInteraction190 SubPathway190Reaction SubPathwayReaction false 3-Phosphoglyceric acid + Adenosine triphosphate → Adenosine diphosphate + Glyceric acid 1,3-biphosphate LEFT_TO_RIGHT SubPathwayInteraction194 SubPathway194Reaction SubPathwayReaction SubPathwayInteraction195 SubPathway195Reaction SubPathwayReaction SMP0000562 SMPDB Fructose-bisphosphate aldolase A false Adenosine triphosphate + Beta-D-Glucose → Adenosine diphosphate + Beta-D-Glucose 6-phosphate LEFT_TO_RIGHT Mitochondrial Intermembrane Space SubPathwayInteraction193 SubPathwayReaction SubPathway193Reaction CHEBI:32816 ChEBI SubPathwayInteraction198 SubPathway198Reaction SubPathwayReaction ReactionCatalysis349 ACTIVATION SubPathwayInteraction199 SubPathwayReaction SubPathway199Reaction SubPathwayInteraction196 SubPathwayReaction SubPathway196Reaction ReactionCatalysis347 ACTIVATION SubPathwayInteraction197 SubPathway197Reaction SubPathwayReaction CHEBI:15377 ChEBI ReactionCatalysis344 ACTIVATION ReactionCatalysis343 ACTIVATION CHEBI:15378 ChEBI SMILES [H+] Glucose-6-phosphate isomerase CHEBI:16108 ChEBI 6569 ChemSpider SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Glyceric acid 1,3-biphosphate CHEBI:17552 ChEBI Phosphate SMILES OC[C@@H](OP(O)(O)=O)C(O)=O CHEBI:422 ChEBI 280 PubChem-compound CHEBI:30744 ChEBI HMDB0000744 HMDB 79025 PubChem-compound Phosphate false Guanosine triphosphate + Oxalacetic acid ↔ Carbon dioxide + Guanosine diphosphate + Phosphoenolpyruvic acid REVERSIBLE PW000002 PathWhiz 5793 PubChem-compound PW000001 PathWhiz ReactionCatalysis375 ACTIVATION ReactionCatalysis373 ACTIVATION SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1 1.0 1.0 SMILES OC(COP(O)(O)=O)C=O false Adenosine triphosphate + Alpha-D-Glucose → Adenosine diphosphate + Glucose 6-phosphate LEFT_TO_RIGHT 86-01-1 CAS false Beta-D-Glucose 6-phosphate ↔ Fructose 6-phosphate REVERSIBLE GAP BioCyc 1060 PubChem-compound 1061 PubChem-compound 2.0 Bisphosphoglycerate mutase HMDB0000516 HMDB C00661 KEGG Compound SMILES OC(=O)[C@@H](COP(O)(O)=O)OP(O)(O)=O HMDB0001967 HMDB 1.0 Solute carrier family 2, facilitated glucose transporter member 2 Bisphosphoglycerate mutase SMILES OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O 1.0