6022
PubChem-compound
923
PubChem-compound
ReactionCoupledTransportCatalysis4
ACTIVATION
Voltage-gated slow delayed rectifying potassium channel (IK5)
Voltage-gated ultra rapid delayed rectifying potassium channel
Disks large homolog 1
Voltage-gated rapidly activating transient outward delayed rectifying potassium channel (IKto)
ATP-binding cassette sub-family C member 9
937
ChemSpider
Sodium/potassium-transporting ATPase subunit beta-3
Acetylcholine-activated potassium channel (IKACh)
SubPathwayActivation
Inward rectifier potassium channel (IK1)
Potassium voltage-gated channel subfamily A member 5
direct_interaction
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
SubPathwayInhibition
Sodium/calcium exchanger 1
Transport119
false
Calcium (→), Sodium (←) Transport: Homo sapiens, Cardiomyocyte , Cytosol to Homo sapiens, Extracellular Space
LEFT_TO_RIGHT
O00180
UniProt
Transport116
false
Potassium (→) Transport: Homo sapiens, Cardiomyocyte , Cytosol to Homo sapiens, Extracellular Space
LEFT_TO_RIGHT
Reaction179579
false
Calcium + Troponin → Calcium + Troponin
LEFT_TO_RIGHT
Transport120
false
Sodium (→), Potassium (←) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cardiomyocyte , Cytosol
LEFT_TO_RIGHT
Voltage-gated T-type calcium channel (ICaT)
Calcium
SubPathwayActivator
Voltage-gated sodium channel (INa)
ATP
BioCyc
Voltage-depenent L-type calcium channel
P63252
UniProt
Voltage-depenent L-type calcium channel
SubPathwayActivation
C25H29I2NO3
Amiodarone
645.0237
ATP-sensitive inward rectifier potassium channel (IKATP)
Voltage-gated rapid delayed rectifying potassium channel (IKr)
Ryanodine receptor 2
Voltage-dependent calcium channel subunit alpha-2/delta-2
SubPathwayInteraction109962
SubPathwayReaction
SubPathway109962Reaction
Voltage-dependent T-type calcium channel subunit alpha-1G
1.0
cAMP-dependent protein kinase catalytic subunit beta
P05023
UniProt
SMP0000665
SMPDB
P05026
UniProt
1.0
5742
ChemSpider
C00575
KEGG Compound
2.0
Sodium channel protein type 5 subunit alpha
ALPHA-GLUCOSE-16-BISPHOSPHATE
BioCyc
cAMP-dependent protein kinase type I-alpha regulatory subunit
BTO:0000887
BRENDA TISSUE ONTOLOGY
Q13936
UniProt
813
PubChem-compound
HMDB0015250
HMDB
Sodium/potassium ATPase
5851
ChemSpider
cAMP-dependent protein kinase type II-alpha regulatory subunit
1010
ChemSpider
CL:0000746
CELL TYPE ONTOLOGY
Sodium/potassium-transporting ATPase subunit beta-2
Sodium/potassium-transporting ATPase subunit beta-1
P48050
UniProt
C00238
KEGG Compound
Q92736
UniProt
Cytosol
Troponin
Transport10361
false
Calcium (→), Sodium (←) Transport: Homo sapiens, Cell, Mitochondrion to Homo sapiens, Cell, Cytoplasm
LEFT_TO_RIGHT
1.0
Beta-2-syntrophin
Alpha-1-syntrophin
1.0
C00009
KEGG Compound
C00008
KEGG Compound
Q13884
UniProt
cAMP-dependent protein kinase type I-alpha regulatory subunit
SubPathwayActivation
1.0
1.0
24203-36-9
CAS
C00001
KEGG Compound
Transport10359
false
Sodium (→), Hydrogen Ion (←) Transport: Homo sapiens, Cell, Mitochondrion to Homo sapiens, Cell, Cytoplasm
LEFT_TO_RIGHT
Sodium/potassium-transporting ATPase subunit alpha-4
C01330
KEGG Compound
Transport53
false
Sodium (→), Potassium (←) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space
LEFT_TO_RIGHT
CHEBI:18367
ChEBI
1032
ChemSpider
C00002
KEGG Compound
Transport10350
false
Calcium (→) Transport: Homo sapiens, Cell, Cytoplasm to Homo sapiens, Cell, Mitochondrion
LEFT_TO_RIGHT
Transport10351
false
Hydrogen (→) Transport: Homo sapiens, Cell, Mitochondrion to Homo sapiens, Cell, Cytoplasm
LEFT_TO_RIGHT
Sodium/potassium-transporting ATPase subunit alpha-1
Transport62
false
Sodium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol
LEFT_TO_RIGHT
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Inward rectifier potassium channel 2
CHEBI:17489
ChEBI
BiologicalState47
Homo sapiens, Cardiomyocyte
P54710
UniProt
1.0
Transport10347
false
Calcium (→) Transport: Homo sapiens, sarcoplasmic reticulum to Homo sapiens, Cell, Cytoplasm
LEFT_TO_RIGHT
1.0
Transport10348
false
Calcium (→) Transport: Homo sapiens, Cell, Cytoplasm to Homo sapiens, sarcoplasmic reticulum
LEFT_TO_RIGHT
Transport10349
false
Potassium (→), Sodium (←) Transport: Homo sapiens, Cell, Extracellular Space to Homo sapiens, Cell, Cytoplasm
LEFT_TO_RIGHT
Extracellular Space
Transport10340
false
Potassium (→) Transport: Homo sapiens, Cell, Cytoplasm to Homo sapiens, Extracellular Space
LEFT_TO_RIGHT
Transport10341
false
Calcium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytoplasm
LEFT_TO_RIGHT
14127-61-8
CAS
Interaction2911
Amiodarone inhibits ATPase Na+/K+ transporting family member beta 4
ATP-sensitive inward rectifier potassium channel 11
BiologicalState50
Homo sapiens, Muscle, Myocyte
Q9NS61
UniProt
P15382
UniProt
Q13733
UniProt
Q9UK17
UniProt
H
Hydrogen Ion
1.007825
1.0
Calcium
1.0
56-65-5
CAS
Interaction2902
Amiodarone inhibits Voltage-gated rapid delayed rectifying potassium channel (IKr)
Interaction2903
Amiodarone inhibits Beta-1 adrenergic receptor
Sodium
Interaction2904
Amiodarone inhibits Voltage-depenent L-type calcium channel
CHEBI:29108
ChEBI
Troponin
Q8NE86
UniProt
P19634
UniProt
60-92-4
CAS
Beta-1 adrenergic receptor
Interaction2905
Calcium activates Ryanodine receptor 2
CHEBI:29101
ChEBI
CHEBI:29103
ChEBI
cAMP
CHEBI:18276
ChEBI
899
ChemSpider
Sodium
C00282
KEGG Compound
P51787
UniProt
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Potassium
Ryanodine receptor 2
HMDB0001341
HMDB
P07951
UniProt
Voltage-dependent L-type calcium channel subunit alpha-1C
Potassium voltage-gated channel subfamily H member 2
Calcium uniporter protein, mitochondrial
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
1.0
K%2b
BioCyc
C06823
KEGG Compound
P54709
UniProt
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
4.0
762
ChemSpider
Potassium voltage-gated channel subfamily E member 2
Transport1172
false
Calcium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytoplasm
LEFT_TO_RIGHT
17341-25-2
CAS
Potassium voltage-gated channel subfamily KQT member 1
1951-25-3
CAS
SubPathwayControl320
ActivatingSubPathwayControl
SubPathway320Control
Phosphate
SubPathwayControl321
SubPathway321Control
ActivatingSubPathwayControl
Voltage-gated rapid delayed rectifying potassium channel (IKr)
SubPathwayControl322
ActivatingSubPathwayControl
SubPathway322Control
Potassium
SubPathwayControl325
SubPathway325Control
ActivatingSubPathwayControl
cAMP-dependent protein kinase catalytic subunit gamma
7732-18-5
CAS
Cytochrome b-c1 complex subunit 10
1.0
791
ChemSpider
Tropomyosin
SubPathwayInput
HMDB0001362
HMDB
Voltage-dependent calcium channel subunit alpha-2/delta-2
Q9UN42
UniProt
Hydrogen
Sodium/hydrogen exchanger 1
Voltage-dependent T-type calcium channel subunit alpha-1G
C10H16N5O13P3
Adenosine triphosphate
506.99576
SubPathwayControl318
SubPathway318Control
ActivatingSubPathwayControl
SubPathwayControl319
SubPathway319Control
InhibitorySubPathwayControl
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@@H]2COP(O)(=O)O[C@H]2[C@H]1O
O95180
UniProt
Tropomyosin alpha-1 chain
Voltage-dependent T-type calcium channel subunit alpha-1H
Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase
962
PubChem-compound
G-protein signalling cascade
ActivatingSubPathway
Cardiac phospholamban inhibits Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
InhibitorySubPathway
Voltage-dependent L-type calcium channel subunit beta-1
Beta-1 adrenergic receptor
5800
ChemSpider
cAMP-dependent protein kinase type I-alpha regulatory subunit
C00076
KEGG Compound
P16615
UniProt
Sodium
2.0
C00080
KEGG Compound
HMDB0000058
HMDB
O14957
UniProt
1.0
Ca
Calcium
39.96259
1.0
Q9Y3Q4
UniProt
HMDB0002111
HMDB
Potassium voltage-gated channel subfamily E member 1
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
14265-44-2
CAS
58-64-0
CAS
Kv channel-interacting protein 2
Q09428
UniProt
Ryanodine receptor 2
Q12959
UniProt
G-protein signalling cascade
ActivatingSubPathway
cAMP-dependent protein kinase catalytic subunit alpha activates Voltage-depenent L-type calcium channel
ActivatingSubPathway
cAMP-dependent protein kinase catalytic subunit alpha activates Ryanodine receptor 2
ActivatingSubPathway
Potassium voltage-gated channel subfamily E member 2
Calcium activates Ryanodine receptor 2
ActivatingSubPathway
G protein-activated inward rectifier potassium channel 1
G protein-activated inward rectifier potassium channel 4
Inward rectifier potassium channel 4
Potassium voltage-gated channel subfamily D member 3
Q12809
UniProt
Sodium channel protein type 5 subunit alpha
1.0
H2O
Water
18.010565
1.0
P50993
UniProt
Tropomyosin beta chain
Potassium channel subfamily K member 1
6076
PubChem-compound
Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase
Na
Sodium
22.989769
K
Potassium
38.963707
Voltage-dependent L-type calcium channel subunit alpha-1C
HMDB0059597
HMDB
Sodium/potassium-transporting ATPase subunit alpha-2
Cardiomyocyte
ATP-sensitive inward rectifier potassium channel 8
3.6.3.8
false
3.6.3.8
Adenosine triphosphate + Calcium + Water → Adenosine diphosphate + Calcium + Phosphate
LEFT_TO_RIGHT
P17612
UniProt
P26678
UniProt
1.0
SMILES
[H][H]
2.0
Sodium/potassium-transporting ATPase subunit alpha-3
Amiodarone
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
cAMP-dependent protein kinase catalytic subunit beta
Interaction2895
Beta-1 adrenergic receptor activates Guanine nucleotide-binding protein alpha
TransportCatalysis93
ACTIVATION
TransportCatalysis92
ACTIVATION
TransportCatalysis91
ACTIVATION
TransportCatalysis90
ACTIVATION
Interaction2897
Guanine nucleotide-binding protein alpha activates Adenylyl cyclase
Interaction2898
Adenylyl cyclase activates cAMP
Interaction2899
Amiodarone inhibits Voltage-gated T-type calcium channel (ICaT)
SMILES
O
58838673
PubChem-compound
TransportCatalysis9
ACTIVATION
HMDB0000538
HMDB
SMILES
[Na+]
SMILES
[K+]
P48544
UniProt
Inward rectifier potassium channel 2
Ryanodine receptor 2
SubPathwayActivation
P48549
UniProt
Q5I7T1
UniProt
ADP
BioCyc
C10H12N5O6P
cAMP
329.05252
GO:0016529
GENE ONTOLOGY
CL:0000187
CELL TYPE ONTOLOGY
1.0
O60706
UniProt
1038
PubChem-compound
P14415
UniProt
ATP-binding cassette sub-family C member 8
Calcium_Troponin
GO:0005829
GENE ONTOLOGY
1.0
Hydrogen Ion
1.0
O43497
UniProt
Protein ATP1B4
ATPase, (Na+)/K+ transporting, beta 4 polypeptide
Calcium
O4P
Phosphate
94.95342
Cytochrome b-c1 complex subunit 10
266
ChemSpider
4.0
Mitochondrion
Voltage-dependent L-type calcium channel subunit beta-1
1.0
1.0
TransportCatalysis1520
ACTIVATION
Sodium/potassium-transporting ATPase subunit gamma
Potassium voltage-gated channel subfamily H member 2
P22460
UniProt
1.0
Calcium uniporter protein, mitochondrial
Beta-1-syntrophin
Muscle Contraction
SubPathway
Voltage-dependent L-type calcium channel subunit alpha-1C
TransportCatalysis1528
ACTIVATION
SMILES
[O-]P([O-])([O-])=O
P13861
UniProt
sarcoplasmic reticulum
GO:0005886
GENE ONTOLOGY
Adenosine diphosphate
Potassium voltage-gated channel subfamily H member 2
Voltage-dependent calcium channel subunit alpha-2/delta-2
ATP-binding cassette sub-family C member 9
Sodium/potassium-transporting ATPase subunit beta-3
Potassium voltage-gated channel subfamily A member 5
1.0
TransportCatalysis1530
ACTIVATION
Disks large homolog 1
1.0
HMDB0001429
HMDB
P22694
UniProt
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
Sodium/calcium exchanger 1
Potassium voltage-gated channel subfamily KQT member 1
Q9NY47
UniProt
P13637
UniProt
P09493
UniProt
HMDB0000464
HMDB
1.0
Myocyte
HMDB0000586
HMDB
HMDB0000588
HMDB
cAMP-dependent protein kinase type I-beta regulatory subunit
Calcium
H2
Hydrogen
2.01565
Muscle
Voltage-dependent T-type calcium channel subunit alpha-1G
Protein kinase A
Voltage-dependent T-type calcium channel subunit alpha-1H
Cardiac phospholamban
PW000642
PathWhiz
Muscarinic acetylcholine receptor M2
CAMP
BioCyc
1.0
cAMP-dependent protein kinase catalytic subunit gamma
Sodium/hydrogen exchanger 1
P08172
UniProt
SMILES
[Ca++]
5957
PubChem-compound
1.0
Voltage-dependent L-type calcium channel subunit beta-1
Hydrogen
cAMP-dependent protein kinase catalytic subunit alpha
GO:0005739
GENE ONTOLOGY
GO:0005615
GENE ONTOLOGY
C10H15N5O10P2
Adenosine diphosphate
427.02942
GO:0005737
GENE ONTOLOGY
Potassium voltage-gated channel subfamily E member 2
3.0
Sodium/potassium-transporting ATPase subunit beta-1
Kv channel-interacting protein 2
CPD-8587
BioCyc
TransportCatalysis10
ACTIVATION
Sodium/potassium-transporting ATPase subunit beta-2
B7ZKV8
UniProt
Potassium voltage-gated channel subfamily E member 1
Protein ATP1B4
Calcium
Q14524
UniProt
Potassium channel subfamily K member 1
G protein-activated inward rectifier potassium channel 4
Q14654
UniProt
1.0
1.0
3.0
2.0
1.0
TransportCatalysis23
ACTIVATION
Beta-2-syntrophin
Potassium voltage-gated channel subfamily D member 3
Inward rectifier potassium channel 4
Alpha-1-syntrophin
G protein-activated inward rectifier potassium channel 1
Q02641
UniProt
P63092
UniProt
Cytoplasm
1.0
CHEBI:15422
ChEBI
cAMP-dependent protein kinase type II-beta regulatory subunit
cAMP-dependent protein kinase type II-alpha regulatory subunit
Sodium/potassium-transporting ATPase subunit alpha-4
1.0
Homo sapiens
TransportCatalysis1508
ACTIVATION
cAMP-dependent protein kinase type I-beta regulatory subunit
Ryanodine receptor 2
Sodium/potassium-transporting ATPase subunit alpha-2
Cardiac phospholamban
TransportCatalysis1509
ACTIVATION
2072
ChemSpider
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Sodium/potassium-transporting ATPase subunit alpha-1
Interaction2835
cAMP activates Protein kinase A
Hydrogen Ion
ATP-sensitive inward rectifier potassium channel 8
Beta-1 adrenergic receptor
SubPathwayActivator
Q15842
UniProt
TransportCatalysis1512
ACTIVATION
TransportCatalysis1519
ACTIVATION
Transport35
false
Calcium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cardiomyocyte , Cytosol
LEFT_TO_RIGHT
TransportCatalysis1518
ACTIVATION
ATP-sensitive inward rectifier potassium channel 11
Transport36
false
Calcium (?) Transport: Homo sapiens, Cardiomyocyte , sarcoplasmic reticulum to Homo sapiens, Cardiomyocyte , Cytosol
LEFT_TO_RIGHT
Sodium/potassium-transporting ATPase subunit alpha-3
TransportCatalysis1517
ACTIVATION
CHEBI:16761
ChEBI
TransportCatalysis1516
ACTIVATION
Q9Y6J6
UniProt
cAMP-dependent protein kinase catalytic subunit alpha
SubPathwayActivation
SubPathwayActivator
SMILES
CCCCC1=C(C(=O)C2=CC(I)=C(OCCN(CC)CC)C(I)=C2)C2=CC=CC=C2O1
Q13424
UniProt
Q13425
UniProt
9606
TAXONOMY
Voltage-dependent T-type calcium channel subunit alpha-1H
1333-74-0
CAS
Potassium
Interaction2851
Calcium + Troponin activates Tropomyosin
1.0
cAMP-dependent protein kinase type II-beta regulatory subunit
Adenylyl cyclase
CA%2b2
BioCyc
Voltage-gated T-type calcium channel (ICaT)
cAMP-dependent protein kinase catalytic subunit alpha
Cell Membrane
CHEBI:15377
ChEBI
P31321
UniProt
P10644
UniProt
CHEBI:15378
ChEBI
SMILES
[H+]
Sodium
P31323
UniProt
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
271
PubChem-compound
Adenosine triphosphate
P32418
UniProt
P22612
UniProt
CHEBI:2663
ChEBI
ATP-binding cassette sub-family C member 8
3.0
ATPase, (Na+)/K+ transporting, beta 4 polypeptide
Water
Adenylyl cyclase
Protein ATP1B4
1061
PubChem-compound
1.0
P08588
UniProt
2157
PubChem-compound
TransportCatalysis89
ACTIVATION
TransportCatalysis88
ACTIVATION
1.0
TransportCatalysis87
ACTIVATION
Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase
TransportCatalysis82
ACTIVATION
Beta-1-syntrophin
Tropomyosin beta chain
TransportCatalysis86
ACTIVATION
Muscarinic acetylcholine receptor M2
SubPathwayActivator
TransportCatalysis85
ACTIVATION
1.0
Sodium/potassium-transporting ATPase subunit gamma
TransportCatalysis84
ACTIVATION
Tropomyosin alpha-1 chain
Adenylyl cyclase
TransportCatalysis83
ACTIVATION
2.0
5.0
Cardiac phospholamban
SubPathwayInhibitor
Amiodarone Action Pathway