Sodium/potassium-transporting ATPase subunit alpha-3
6022
PubChem-compound
923
PubChem-compound
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
ReactionCoupledTransportCatalysis4
ACTIVATION
Voltage-gated slow delayed rectifying potassium channel (IK5)
Voltage-gated ultra rapid delayed rectifying potassium channel
Disks large homolog 1
Voltage-gated rapidly activating transient outward delayed rectifying potassium channel (IKto)
ATP-binding cassette sub-family C member 9
937
ChemSpider
Sodium/potassium-transporting ATPase subunit beta-3
Acetylcholine-activated potassium channel (IKACh)
SubPathwayActivation
Inward rectifier potassium channel (IK1)
Potassium voltage-gated channel subfamily A member 5
TransportCatalysis93
ACTIVATION
TransportCatalysis92
ACTIVATION
direct_interaction
TransportCatalysis91
ACTIVATION
TransportCatalysis90
ACTIVATION
Sodium/calcium exchanger 1
SMILES
O
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
SubPathwayInhibition
Transport119
false
Calcium (→), Sodium (←) Transport: Homo sapiens, Cardiomyocyte , Cytosol to Homo sapiens, Extracellular Space
LEFT_TO_RIGHT
O00180
UniProt
Transport116
false
Potassium (→) Transport: Homo sapiens, Cardiomyocyte , Cytosol to Homo sapiens, Extracellular Space
LEFT_TO_RIGHT
Reaction179579
false
Calcium + Troponin → Calcium + Troponin
LEFT_TO_RIGHT
Transport120
false
Sodium (→), Potassium (←) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cardiomyocyte , Cytosol
LEFT_TO_RIGHT
TransportCatalysis9
ACTIVATION
HMDB0000538
HMDB
SMILES
[Na+]
Voltage-gated T-type calcium channel (ICaT)
SMILES
[K+]
Calcium
SubPathwayActivator
Voltage-gated sodium channel (INa)
P48544
UniProt
ATP
BioCyc
Voltage-depenent L-type calcium channel
P63252
UniProt
Inward rectifier potassium channel 2
Voltage-depenent L-type calcium channel
SubPathwayActivation
Ryanodine receptor 2
SubPathwayActivation
P48549
UniProt
ATP-sensitive inward rectifier potassium channel (IKATP)
Voltage-gated rapid delayed rectifying potassium channel (IKr)
Q5I7T1
UniProt
Ryanodine receptor 2
Voltage-dependent calcium channel subunit alpha-2/delta-2
SubPathwayInteraction109962
SubPathwayReaction
SubPathway109962Reaction
ADP
BioCyc
1.0
GO:0016529
GENE ONTOLOGY
P05023
UniProt
SMP0000668
SMPDB
P05026
UniProt
1.0
CL:0000187
CELL TYPE ONTOLOGY
O60706
UniProt
5742
ChemSpider
P14415
UniProt
ATP-binding cassette sub-family C member 8
Calcium_Troponin
GO:0005829
GENE ONTOLOGY
Sodium channel protein type 5 subunit alpha
1.0
BTO:0000887
BRENDA TISSUE ONTOLOGY
1.0
Q13936
UniProt
O43497
UniProt
ATPase, (Na+)/K+ transporting, beta 4 polypeptide
813
PubChem-compound
O4P
Phosphate
94.95342
Sodium/potassium ATPase
CL:0000746
CELL TYPE ONTOLOGY
Sodium/potassium-transporting ATPase subunit beta-2
266
ChemSpider
Sodium/potassium-transporting ATPase subunit beta-1
4.0
Voltage-dependent L-type calcium channel subunit beta-1
P48050
UniProt
C00238
KEGG Compound
Q92736
UniProt
BiologicalState65
Homo sapiens, Heart
Sodium/potassium-transporting ATPase subunit gamma
P22460
UniProt
Potassium voltage-gated channel subfamily H member 2
Cytosol
1.0
Beta-1-syntrophin
Muscle Contraction
SubPathway
Voltage-dependent L-type calcium channel subunit alpha-1C
Troponin
Beta-2-syntrophin
SMILES
[O-]P([O-])([O-])=O
Alpha-1-syntrophin
sarcoplasmic reticulum
Adenosine diphosphate
GO:0005886
GENE ONTOLOGY
C20H27NO4
Bevantolol
345.194
C00009
KEGG Compound
Voltage-dependent calcium channel subunit alpha-2/delta-2
C00008
KEGG Compound
Q13884
UniProt
cAMP-dependent protein kinase type I-alpha regulatory subunit
SubPathwayActivation
ATP-binding cassette sub-family C member 9
Sodium/potassium-transporting ATPase subunit beta-3
Potassium voltage-gated channel subfamily A member 5
Disks large homolog 1
1.0
1.0
24203-36-9
CAS
C00001
KEGG Compound
HMDB0001429
HMDB
Sodium/potassium-transporting ATPase subunit alpha-4
C01330
KEGG Compound
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
Sodium/calcium exchanger 1
Transport53
false
Sodium (→), Potassium (←) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space
LEFT_TO_RIGHT
Potassium voltage-gated channel subfamily KQT member 1
CHEBI:18367
ChEBI
P13637
UniProt
Q9NY47
UniProt
1032
ChemSpider
C00002
KEGG Compound
P09493
UniProt
HMDB0000464
HMDB
Sodium/potassium-transporting ATPase subunit alpha-1
Transport62
false
Sodium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol
LEFT_TO_RIGHT
Myocyte
HMDB0000586
HMDB
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
HMDB0000588
HMDB
PW000645
PathWhiz
Calcium
Muscle
Voltage-dependent T-type calcium channel subunit alpha-1G
Inward rectifier potassium channel 2
Voltage-dependent T-type calcium channel subunit alpha-1H
BiologicalState47
Homo sapiens, Cardiomyocyte
P54710
UniProt
Cardiac phospholamban
Muscarinic acetylcholine receptor M2
1.0
P08172
UniProt
Extracellular Space
ATP-sensitive inward rectifier potassium channel 11
14127-61-8
CAS
SMILES
[Ca++]
5957
PubChem-compound
Bevantolol
SubPathwayInhibitor
BiologicalState50
Homo sapiens, Muscle, Myocyte
Q9NS61
UniProt
P15382
UniProt
1.0
Q13733
UniProt
Q9UK17
UniProt
Calcium
1.0
Voltage-dependent L-type calcium channel subunit beta-1
56-65-5
CAS
Beta-1 adrenergic receptor
SubPathwayInhibition
cAMP-dependent protein kinase catalytic subunit alpha
Sodium
GO:0005615
GENE ONTOLOGY
C10H15N5O10P2
Adenosine diphosphate
427.02942
CHEBI:29108
ChEBI
GO:0005737
GENE ONTOLOGY
Troponin
CHEBI:29101
ChEBI
CHEBI:29103
ChEBI
3.0
Potassium voltage-gated channel subfamily E member 2
Sodium/potassium-transporting ATPase subunit beta-1
Kv channel-interacting protein 2
CPD-8587
BioCyc
TransportCatalysis10
ACTIVATION
Sodium/potassium-transporting ATPase subunit beta-2
B7ZKV8
UniProt
899
ChemSpider
Potassium voltage-gated channel subfamily E member 1
P51787
UniProt
Calcium
Q14524
UniProt
Potassium
Ryanodine receptor 2
HMDB0001341
HMDB
Potassium channel subfamily K member 1
P07951
UniProt
G protein-activated inward rectifier potassium channel 4
Voltage-dependent L-type calcium channel subunit alpha-1C
Q14654
UniProt
1.0
Potassium voltage-gated channel subfamily H member 2
Heart
3.0
1.0
2.0
1.0
TransportCatalysis23
ACTIVATION
Beta-2-syntrophin
K%2b
BioCyc
Potassium voltage-gated channel subfamily D member 3
2282
ChemSpider
P54709
UniProt
Inward rectifier potassium channel 4
Alpha-1-syntrophin
G protein-activated inward rectifier potassium channel 1
Q02641
UniProt
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
4.0
Cytoplasm
CHEBI:238698
ChEBI
17341-25-2
CAS
Potassium voltage-gated channel subfamily KQT member 1
CHEBI:15422
ChEBI
SubPathwayControl320
ActivatingSubPathwayControl
SubPathway320Control
Sodium/potassium-transporting ATPase subunit alpha-4
Phosphate
SubPathwayControl321
SubPathway321Control
ActivatingSubPathwayControl
1.0
SubPathwayControl322
ActivatingSubPathwayControl
SubPathway322Control
Homo sapiens
Potassium
SubPathwayControl325
SubPathway325Control
ActivatingSubPathwayControl
Sodium/potassium-transporting ATPase subunit alpha-2
Cardiac phospholamban
Ryanodine receptor 2
59170-23-9
CAS
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
7732-18-5
CAS
Sodium/potassium-transporting ATPase subunit alpha-1
ATP-sensitive inward rectifier potassium channel 8
791
ChemSpider
Tropomyosin
SubPathwayInput
Voltage-dependent calcium channel subunit alpha-2/delta-2
Beta-1 adrenergic receptor
SubPathwayActivator
Q15842
UniProt
Voltage-dependent T-type calcium channel subunit alpha-1G
C10H16N5O13P3
Adenosine triphosphate
506.99576
Transport35
false
Calcium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cardiomyocyte , Cytosol
LEFT_TO_RIGHT
ATP-sensitive inward rectifier potassium channel 11
Transport36
false
Calcium (?) Transport: Homo sapiens, Cardiomyocyte , sarcoplasmic reticulum to Homo sapiens, Cardiomyocyte , Cytosol
LEFT_TO_RIGHT
Sodium/potassium-transporting ATPase subunit alpha-3
SubPathwayControl318
SubPathway318Control
ActivatingSubPathwayControl
CHEBI:16761
ChEBI
SubPathwayControl319
SubPathway319Control
InhibitorySubPathwayControl
Q9Y6J6
UniProt
cAMP-dependent protein kinase catalytic subunit alpha
SubPathwayActivation
SubPathwayActivator
HMDB0015409
HMDB
O95180
UniProt
Tropomyosin alpha-1 chain
Q13424
UniProt
Voltage-dependent T-type calcium channel subunit alpha-1H
Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase
Q13425
UniProt
9606
TAXONOMY
962
PubChem-compound
G-protein signalling cascade
ActivatingSubPathway
Cardiac phospholamban inhibits Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
InhibitorySubPathway
Voltage-dependent L-type calcium channel subunit beta-1
Beta-1 adrenergic receptor
5800
ChemSpider
cAMP-dependent protein kinase type I-alpha regulatory subunit
C00076
KEGG Compound
P16615
UniProt
Interaction2851
Calcium + Troponin activates Tropomyosin
Sodium
1.0
SubPathwayControl904
SubPathway904Control
InhibitorySubPathwayControl
CA%2b2
BioCyc
1.0
Ca
Calcium
39.96259
1.0
Q9Y3Q4
UniProt
HMDB0002111
HMDB
Potassium voltage-gated channel subfamily E member 1
CHEBI:15377
ChEBI
Cell Membrane
P10644
UniProt
2372
PubChem-compound
14265-44-2
CAS
58-64-0
CAS
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
Kv channel-interacting protein 2
271
PubChem-compound
Adenosine triphosphate
P32418
UniProt
Q09428
UniProt
Ryanodine receptor 2
Q12959
UniProt
ATP-binding cassette sub-family C member 8
G-protein signalling cascade
ActivatingSubPathway
cAMP-dependent protein kinase catalytic subunit alpha activates Voltage-depenent L-type calcium channel
ActivatingSubPathway
cAMP-dependent protein kinase catalytic subunit alpha activates Ryanodine receptor 2
ActivatingSubPathway
Potassium voltage-gated channel subfamily E member 2
Calcium activates Ryanodine receptor 2
ActivatingSubPathway
G protein-activated inward rectifier potassium channel 1
ATPase, (Na+)/K+ transporting, beta 4 polypeptide
G protein-activated inward rectifier potassium channel 4
Inward rectifier potassium channel 4
Potassium voltage-gated channel subfamily D member 3
Water
Q12809
UniProt
Sodium channel protein type 5 subunit alpha
BTO:0000562
BRENDA TISSUE ONTOLOGY
H2O
Water
18.010565
1.0
P50993
UniProt
SMILES
COC1=C(OC)C=C(CCNCC(O)COC2=CC=CC(C)=C2)C=C1
Tropomyosin beta chain
Potassium channel subfamily K member 1
1061
PubChem-compound
Na
Sodium
22.989769
Bevantolol Inhibition of Beta-1 adrenergic receptor
InhibitorySubPathway
Sodium/potassium-transporting ATPase subunit alpha-2
K
Potassium
38.963707
Voltage-dependent L-type calcium channel subunit alpha-1C
1.0
P08588
UniProt
TransportCatalysis89
ACTIVATION
Cardiomyocyte
TransportCatalysis88
ACTIVATION
1.0
TransportCatalysis87
ACTIVATION
ATP-sensitive inward rectifier potassium channel 8
TransportCatalysis82
ACTIVATION
Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase
Beta-1-syntrophin
3.6.3.8
false
3.6.3.8
Adenosine triphosphate + Calcium + Water → Adenosine diphosphate + Calcium + Phosphate
LEFT_TO_RIGHT
Tropomyosin beta chain
TransportCatalysis86
ACTIVATION
Muscarinic acetylcholine receptor M2
SubPathwayActivator
TransportCatalysis85
ACTIVATION
1.0
P17612
UniProt
Sodium/potassium-transporting ATPase subunit gamma
TransportCatalysis84
ACTIVATION
Tropomyosin alpha-1 chain
P26678
UniProt
TransportCatalysis83
ACTIVATION
5.0
Bevantolol Action Pathway
1.0
Cardiac phospholamban
SubPathwayInhibitor
2.0