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DG(14:0/14:1(9Z)/0:0) 6022 PubChem-compound 1.0 CHEBI:200929 ChEBI 923 PubChem-compound ReactionCoupledTransportCatalysis4 ACTIVATION Voltage-gated slow delayed rectifying potassium channel (IK5) Voltage-gated ultra rapid delayed rectifying potassium channel Disks large homolog 1 P62158 UniProt Voltage-gated rapidly activating transient outward delayed rectifying potassium channel (IKto) ATP-binding cassette sub-family C member 9 937 ChemSpider Sodium/potassium-transporting ATPase subunit beta-3 Acetylcholine-activated potassium channel (IKACh) SubPathwayActivation Inward rectifier potassium channel (IK1) Potassium voltage-gated channel subfamily A member 5 direct_interaction SMILES CC1=CC(OCC(O)CNC(C)(C)C)=C(Cl)C=C1 Sodium/calcium exchanger 1 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 SubPathwayInhibition Transport119 false Calcium (→), Sodium (←) Transport: Homo sapiens, Cardiomyocyte , Cytosol to Homo sapiens, Extracellular Space LEFT_TO_RIGHT O00180 UniProt Transport116 false Potassium (→) Transport: Homo sapiens, Cardiomyocyte , Cytosol to Homo sapiens, Extracellular Space LEFT_TO_RIGHT Transport120 false Sodium (→), Potassium (←) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cardiomyocyte , Cytosol LEFT_TO_RIGHT Transport123 false Calcium (→) Transport: Homo sapiens, Cell, Endoplasmic Reticulum to Homo sapiens, Cardiomyocyte , Cytosol LEFT_TO_RIGHT P30556 UniProt Voltage-gated T-type calcium channel (ICaT) Calcium SubPathwayActivator Voltage-gated sodium channel (INa) ATP BioCyc Voltage-depenent L-type calcium channel P63252 UniProt Voltage-depenent L-type calcium channel SubPathwayActivation ATP-sensitive inward rectifier potassium channel (IKATP) Voltage-gated rapid delayed rectifying potassium channel (IKr) Ryanodine receptor 2 Voltage-dependent calcium channel subunit alpha-2/delta-2 1.0 P05023 UniProt P05026 UniProt 24765843 ChemSpider 1.0 5742 ChemSpider P19429 UniProt CHEBI:16595 ChEBI Sodium channel protein type 5 subunit alpha Q9NQ66 UniProt Q13936 UniProt 813 PubChem-compound Sodium/potassium ATPase Inositol 1,4,5-trisphosphate receptor type 1 CL:0000746 CELL TYPE ONTOLOGY Troponin, slow skeletal muscle SubPathwayActivation Sodium/potassium-transporting ATPase subunit beta-2 Sodium/potassium-transporting ATPase subunit beta-1 SMP0000670 SMPDB 24767919 ChemSpider P48050 UniProt C00238 KEGG Compound Q92736 UniProt BiologicalState65 Homo sapiens, Heart 1.0 Cytosol 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 SubPathwayActivation Tropomyosin beta chain Beta-2-syntrophin 1.0 Alpha-1-syntrophin inositol_1,4,5-trisphosphate BioCyc C00009 KEGG Compound C00008 KEGG Compound Q13884 UniProt cAMP-dependent protein kinase type I-alpha regulatory subunit SubPathwayActivation Phosphatidylinositols BioCyc Tropomyosin SubPathwayActivation 24203-36-9 CAS C00001 KEGG Compound Sodium/potassium-transporting ATPase subunit alpha-4 C01330 KEGG Compound Troponin I, cardiac muscle Transport53 false Sodium (→), Potassium (←) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space LEFT_TO_RIGHT CHEBI:18367 ChEBI 1032 ChemSpider 388562 ChemSpider C00002 KEGG Compound Sodium/potassium-transporting ATPase subunit alpha-1 Transport62 false Sodium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol LEFT_TO_RIGHT Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Inward rectifier potassium channel 2 P54710 UniProt BiologicalState46 Homo sapiens, Cardiomyocyte 1.0 1.0 Extracellular Space ATP-sensitive inward rectifier potassium channel 11 14127-61-8 CAS Q9NS61 UniProt P15382 UniProt SMILES [H][C@](CO)(COC(=O)CCCCCCCCCCCCC)OC(=O)CCCCCCC\C=C/CCCC 1.0 Q13733 UniProt Q9UK17 UniProt Calcium Type-1 angiotensin II receptor P63316 UniProt 1.0 56-65-5 CAS 1.0 Calmodulin SubPathwayActivator 2381 ChemSpider Sodium Troponin T, fast skeletal muscle CHEBI:29108 ChEBI CHEBI:29101 ChEBI CHEBI:29103 ChEBI DIACYLGLYCEROL BioCyc 899 ChemSpider C01245 KEGG Compound P51787 UniProt 53477948 PubChem-compound Potassium Ryanodine receptor 2 PIP2(16:0/20:3(8Z,11Z,14Z)) HMDB0001341 HMDB P07951 UniProt Voltage-dependent L-type calcium channel subunit alpha-1C Potassium voltage-gated channel subfamily H member 2 Heart C00165 KEGG Compound K%2b BioCyc P54709 UniProt SMILES O[C@@H]1[C@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1OP(O)(O)=O SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 4.0 17341-25-2 CAS Potassium voltage-gated channel subfamily KQT member 1 SubPathwayControl320 ActivatingSubPathwayControl SubPathway320Control Phosphate SubPathwayControl321 SubPathway321Control ActivatingSubPathwayControl SubPathwayControl684 SubPathway684Control ActivatingSubPathwayControl SubPathwayControl322 ActivatingSubPathwayControl SubPathway322Control SubPathwayControl323 SubPathway323Control ActivatingSubPathwayControl SubPathwayControl324 ActivatingSubPathwayControl SubPathway324Control Potassium SubPathwayControl325 SubPathway325Control ActivatingSubPathwayControl SubPathwayControl326 ActivatingSubPathwayControl SubPathway326Control 7732-18-5 CAS 791 ChemSpider Voltage-dependent calcium channel subunit alpha-2/delta-2 Voltage-dependent T-type calcium channel subunit alpha-1G C10H16N5O13P3 Adenosine triphosphate 506.99576 Inositol 1,4,5-trisphosphate SubPathwayControl318 SubPathway318Control ActivatingSubPathwayControl SubPathwayControl319 SubPathway319Control InhibitorySubPathwayControl 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 1.0 HMDB0001498 HMDB O95180 UniProt Inositol 1,4,5-trisphosphate receptor type 1 C45H83O19P3 PIP2(16:0/20:3(8Z,11Z,14Z)) 1020.4741 Voltage-dependent T-type calcium channel subunit alpha-1H Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase 962 PubChem-compound G-protein signalling cascade ActivatingSubPathway Cardiac phospholamban inhibits Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 InhibitorySubPathway Voltage-dependent L-type calcium channel subunit beta-1 Beta-1 adrenergic receptor 5800 ChemSpider cAMP-dependent protein kinase type I-alpha regulatory subunit C00076 KEGG Compound P16615 UniProt Sodium 1.0 Ca Calcium 39.96259 1.0 Q9Y3Q4 UniProt HMDB0002111 HMDB Potassium voltage-gated channel subfamily E member 1 14265-44-2 CAS P02585 UniProt 58-64-0 CAS Kv channel-interacting protein 2 Q09428 UniProt Ryanodine receptor 2 Q12959 UniProt G-protein signalling cascade ActivatingSubPathway cAMP-dependent protein kinase catalytic subunit alpha activates Voltage-depenent L-type calcium channel ActivatingSubPathway Calcium activates Troponin ActivatingSubPathway cAMP-dependent protein kinase catalytic subunit alpha activates Ryanodine receptor 2 ActivatingSubPathway Potassium voltage-gated channel subfamily E member 2 Calcium and Calmodulin activates Myosin light chain kinase, smooth muscle ActivatingSubPathway Muscle Contraction ActivatingSubPathway 14556-46-8 CAS Calcium activates Ryanodine receptor 2 ActivatingSubPathway G-protein signalling cascade ActivatingSubPathway G protein-activated inward rectifier potassium channel 1 G protein-activated inward rectifier potassium channel 4 Inward rectifier potassium channel 4 Potassium voltage-gated channel subfamily D member 3 Q12809 UniProt Sodium channel protein type 5 subunit alpha H2O Water 18.010565 P50993 UniProt Potassium channel subfamily K member 1 Na Sodium 22.989769 Sodium/potassium-transporting ATPase subunit alpha-2 K Potassium 38.963707 Voltage-dependent L-type calcium channel subunit alpha-1C Cardiomyocyte Troponin I, slow skeletal muscle ATP-sensitive inward rectifier potassium channel 8 Troponin I, fast skeletal muscle HMDB0015697 HMDB 3.6.3.8 false 3.6.3.8 Adenosine triphosphate + Calcium + Water → Adenosine diphosphate + Calcium + Phosphate LEFT_TO_RIGHT P17612 UniProt P26678 UniProt Inositol 1,4,5-trisphosphate 2.0 Sodium/potassium-transporting ATPase subunit alpha-3 Myosin light chain kinase, smooth muscle Interaction331 Inositol 1,4,5-trisphosphate activates Inositol 1,4,5-trisphosphate receptor type 1 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 1.0 TransportCatalysis93 ACTIVATION TransportCatalysis92 ACTIVATION TransportCatalysis91 ACTIVATION TransportCatalysis90 ACTIVATION TransportCatalysis96 ACTIVATION SMILES O TransportCatalysis9 ACTIVATION HMDB0000538 HMDB SMILES [Na+] SMILES [K+] P48544 UniProt Troponin C, skeletal muscle Inward rectifier potassium channel 2 Ryanodine receptor 2 SubPathwayActivation P48549 UniProt Q5I7T1 UniProt P48788 UniProt ADP BioCyc GO:0016529 GENE ONTOLOGY O60706 UniProt P14415 UniProt ATP-binding cassette sub-family C member 8 GO:0005829 GENE ONTOLOGY Type-1 angiotensin II receptor SubPathwayActivator Tropomyosin alpha-1 chain 1.0 85166-31-0 CAS O43497 UniProt ATPase, (Na+)/K+ transporting, beta 4 polypeptide O4P Phosphate 94.95342 2475 PubChem-compound P45379 UniProt P45378 UniProt 266 ChemSpider Troponin T, slow skeletal muscle 4.0 Voltage-dependent L-type calcium channel subunit beta-1 Sodium/potassium-transporting ATPase subunit gamma P22460 UniProt Potassium voltage-gated channel subfamily H member 2 1.0 Calmodulin Beta-1-syntrophin Voltage-dependent L-type calcium channel subunit alpha-1C SMILES [O-]P([O-])([O-])=O sarcoplasmic reticulum Adenosine diphosphate GO:0005886 GENE ONTOLOGY 1.0 53480233 PubChem-compound Voltage-dependent calcium channel subunit alpha-2/delta-2 ATP-binding cassette sub-family C member 9 Sodium/potassium-transporting ATPase subunit beta-3 Potassium voltage-gated channel subfamily A member 5 Disks large homolog 1 1.0 1.0 HMDB0001429 HMDB Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 Sodium/calcium exchanger 1 Potassium voltage-gated channel subfamily KQT member 1 P13637 UniProt Q9NY47 UniProt P09493 UniProt HMDB0000464 HMDB HMDB0000586 HMDB HMDB0000588 HMDB PW000647 PathWhiz Calcium Voltage-dependent T-type calcium channel subunit alpha-1G Voltage-dependent T-type calcium channel subunit alpha-1H Cardiac phospholamban Muscarinic acetylcholine receptor M2 P08172 UniProt SMILES [Ca++] 5957 PubChem-compound 1.0 1.0 HMDB0010042 HMDB Voltage-dependent L-type calcium channel subunit beta-1 Beta-1 adrenergic receptor SubPathwayInhibition cAMP-dependent protein kinase catalytic subunit alpha GO:0005615 GENE ONTOLOGY C6H15O15P3 Inositol 1,4,5-trisphosphate 419.96237 C10H15N5O10P2 Adenosine diphosphate 427.02942 1.0 3.0 Potassium voltage-gated channel subfamily E member 2 Q14643 UniProt Inositol 1,4,5-trisphosphate receptor type 1 3.1.4.11 false 3.1.4.11 PIP2(16:0/20:3(8Z,11Z,14Z)) → DG(14:0/14:1(9Z)/0:0) + Inositol 1,4,5-trisphosphate LEFT_TO_RIGHT Endoplasmic Reticulum Sodium/potassium-transporting ATPase subunit beta-1 Kv channel-interacting protein 2 1.0 CPD-8587 BioCyc TransportCatalysis10 ACTIVATION Sodium/potassium-transporting ATPase subunit beta-2 B7ZKV8 UniProt Potassium voltage-gated channel subfamily E member 1 Bupranolol Action Pathway Bupranolol SubPathwayInhibitor Q14524 UniProt Potassium channel subfamily K member 1 G protein-activated inward rectifier potassium channel 4 Q14654 UniProt 1.0 3.0 1.0 2.0 1.0 TransportCatalysis23 ACTIVATION Beta-2-syntrophin Potassium voltage-gated channel subfamily D member 3 Inward rectifier potassium channel 4 Alpha-1-syntrophin G protein-activated inward rectifier potassium channel 1 Q02641 UniProt Q15746 UniProt Troponin, cardiac muscle SubPathwayActivation Troponin T, cardiac muscle CHEBI:15422 ChEBI Sodium/potassium-transporting ATPase subunit alpha-4 Homo sapiens Sodium/potassium-transporting ATPase subunit alpha-2 Cardiac phospholamban Ryanodine receptor 2 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Sodium/potassium-transporting ATPase subunit alpha-1 Troponin C, slow skeletal and cardiac muscles 439456 PubChem-compound ATP-sensitive inward rectifier potassium channel 8 GO:0005783 GENE ONTOLOGY Beta-1 adrenergic receptor SubPathwayActivator Q15842 UniProt C00626 KEGG Compound Transport35 false Calcium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cardiomyocyte , Cytosol LEFT_TO_RIGHT ATP-sensitive inward rectifier potassium channel 11 Transport36 false Calcium (?) Transport: Homo sapiens, Cardiomyocyte , sarcoplasmic reticulum to Homo sapiens, Cardiomyocyte , Cytosol LEFT_TO_RIGHT Sodium/potassium-transporting ATPase subunit alpha-3 CHEBI:16761 ChEBI Q9Y6J6 UniProt cAMP-dependent protein kinase catalytic subunit alpha SubPathwayActivation SubPathwayActivator Myosin light chain kinase, smooth muscle SubPathwayActivation SubPathwayActivator Q13424 UniProt Q13425 UniProt 9606 TAXONOMY 1.0 CA%2b2 BioCyc SubPathwayControl906 SubPathway906Control InhibitorySubPathwayControl HMDB0007009 HMDB C31H58O5 DG(14:0/14:1(9Z)/0:0) 510.42844 CHEBI:15377 ChEBI Cell Membrane P10644 UniProt SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 271 PubChem-compound Adenosine triphosphate P32418 UniProt ATP-binding cassette sub-family C member 8 SMILES CCCCCCCCCCCCCCCC(=O)OC[C@]([H])(COP(O)(=O)O[C@H]1C(O)C(O)C(OP(=O)(O)O)[C@@H](OP(=O)(O)O)C1O)OC(=O)CCCCCC\C=C/C\C=C/C\C=C/CCCCC P13805 UniProt ATPase, (Na+)/K+ transporting, beta 4 polypeptide Water Troponin C, skeletal muscle Troponin C, slow skeletal and cardiac muscles Troponin I, slow skeletal muscle C14H22ClNO2 Bupranolol 271.1339 ReactionCatalysis1269 ACTIVATION Troponin I, cardiac muscle Troponin I, fast skeletal muscle Troponin T, cardiac muscle BTO:0000562 BRENDA TISSUE ONTOLOGY Troponin T, slow skeletal muscle 1061 PubChem-compound 1.0 Calcium Bupranolol Inhibition of Beta-1 adrenergic receptor InhibitorySubPathway P08588 UniProt TransportCatalysis89 ACTIVATION TransportCatalysis88 ACTIVATION 1.0 TransportCatalysis87 ACTIVATION 1.0 Troponin T, fast skeletal muscle TransportCatalysis82 ACTIVATION Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase Beta-1-syntrophin Tropomyosin beta chain TransportCatalysis86 ACTIVATION Muscarinic acetylcholine receptor M2 SubPathwayActivator TransportCatalysis85 ACTIVATION 1.0 Sodium/potassium-transporting ATPase subunit gamma TransportCatalysis84 ACTIVATION Tropomyosin alpha-1 chain TransportCatalysis83 ACTIVATION P19237 UniProt 5.0 Troponin, fast skeletal muscle SubPathwayActivation Cardiac phospholamban SubPathwayInhibitor Beta-1 adrenergic receptor Inositol 1,4,5- trisphosphate receptor type 1 Beta-1 adrenergic receptor cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase type I-alpha regulatory subunit Type-1 angiotensin II receptor 1- phosphatidylinositol 4,5- bisphosphate phosphodiesterase beta-1 Troponin C, skeletal muscle Troponin I, slow skeletal muscle Troponin T, slow skeletal muscle Troponin C, slow skeletal and cardiac muscles Troponin I, cardiac muscle Troponin T, cardiac muscle Troponin C, skeletal muscle Troponin I, fast skeletal muscle Troponin T, fast skeletal muscle Tropomyosin alpha-1 chain Tropomyosin beta chain Calmodulin Myosin light chain kinase, smooth muscle Voltage- dependent L-type calcium channel subunit alpha-1C Voltage- dependent calcium channel subunit alpha-2/delta-2 Voltage- dependent L-type calcium channel subunit beta-1 Ryanodine receptor 2 Muscarinic acetylcholine receptor M2 G protein- activated inward rectifier potassium channel 1 G protein- activated inward rectifier potassium channel 4 Cardiac phospholamban Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 Sodium/potassium- transporting ATPase subunit alpha-1 Sodium/potassium- transporting ATPase subunit alpha-2 Sodium/potassium- transporting ATPase subunit alpha-3 Sodium/potassium- transporting ATPase subunit alpha-4 Sodium/potassium- transporting ATPase subunit beta-1 Sodium/potassium- transporting ATPase subunit beta-2 Sodium/potassium- transporting ATPase subunit beta-3 ATPase, (Na+)/K+ transporting, beta 4 polypeptide Sodium/potassium- transporting ATPase subunit gamma Inward rectifier potassium channel 2 Inward rectifier potassium channel 4 Potassium voltage-gated channel subfamily D member 3 Kv channel- interacting protein 2 Potassium voltage-gated channel subfamily A member 5 Disks large homolog 1 Potassium voltage-gated channel subfamily KQT member 1 Potassium voltage-gated channel subfamily E member 1 Potassium voltage-gated channel subfamily E member 2 Potassium voltage-gated channel subfamily H member 2 Putative Dol-P- Glc:Glc(2)Man(9)GlcNAc(2)- PP-Dol alpha-1,2- glucosyltransferase ATP-binding cassette sub-family C member 8 ATP-sensitive inward rectifier potassium channel 8 ATP-sensitive inward rectifier potassium channel 11 ATP-binding cassette sub-family C member 9 Potassium channel subfamily K member 1 Sodium/calcium exchanger 1 Potassium/sodium hyperpolarization- activated cyclic nucleotide- gated channel 4 Sodium channel protein type 5 subunit alpha Beta-2- syntrophin Beta-1- syntrophin Alpha-1- syntrophin Voltage- dependent T-type calcium channel subunit alpha-1H Voltage- dependent T-type calcium channel subunit alpha-1G Bupranolol Inositol 1,4,5- trisphosphate Ca + Ca + Na + Na + K + K + K + K + K + K + K + K + K + K + K + K + K + K + K + K + K + K + Ca + Ca + Na + Na + Na + Na + K + K + Na + Na + Ca + Ca + Ca + Ca + PIP2(16:0/20:3(8Z,11Z,14Z)) DG(14:0/14:1(9Z)/0:0) ATP H 2 O Ca + ADP P i Ca + Calcium Magnesium Calcium G-protein signalling cascade G-protein signalling cascade G-protein signalling cascade Muscle Contraction MYOCYTE SARCOPLASMIC RETICULUM In smooth muscle In striated muscle
DG(14:0/14:1(9Z)/0:0) 6022 PubChem-compound 1.0 CHEBI:200929 ChEBI 923 PubChem-compound ReactionCoupledTransportCatalysis4 ACTIVATION Voltage-gated slow delayed rectifying potassium channel (IK5) Voltage-gated ultra rapid delayed rectifying potassium channel Disks large homolog 1 P62158 UniProt Voltage-gated rapidly activating transient outward delayed rectifying potassium channel (IKto) ATP-binding cassette sub-family C member 9 937 ChemSpider Sodium/potassium-transporting ATPase subunit beta-3 Acetylcholine-activated potassium channel (IKACh) SubPathwayActivation Inward rectifier potassium channel (IK1) Potassium voltage-gated channel subfamily A member 5 direct_interaction SMILES CC1=CC(OCC(O)CNC(C)(C)C)=C(Cl)C=C1 Sodium/calcium exchanger 1 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 SubPathwayInhibition Transport119 false Calcium (→), Sodium (←) Transport: Homo sapiens, Cardiomyocyte , Cytosol to Homo sapiens, Extracellular Space LEFT_TO_RIGHT O00180 UniProt Transport116 false Potassium (→) Transport: Homo sapiens, Cardiomyocyte , Cytosol to Homo sapiens, Extracellular Space LEFT_TO_RIGHT Transport120 false Sodium (→), Potassium (←) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cardiomyocyte , Cytosol LEFT_TO_RIGHT Transport123 false Calcium (→) Transport: Homo sapiens, Cell, Endoplasmic Reticulum to Homo sapiens, Cardiomyocyte , Cytosol LEFT_TO_RIGHT P30556 UniProt Voltage-gated T-type calcium channel (ICaT) Calcium SubPathwayActivator Voltage-gated sodium channel (INa) ATP BioCyc Voltage-depenent L-type calcium channel P63252 UniProt Voltage-depenent L-type calcium channel SubPathwayActivation ATP-sensitive inward rectifier potassium channel (IKATP) Voltage-gated rapid delayed rectifying potassium channel (IKr) Ryanodine receptor 2 Voltage-dependent calcium channel subunit alpha-2/delta-2 1.0 P05023 UniProt P05026 UniProt 24765843 ChemSpider 1.0 5742 ChemSpider P19429 UniProt CHEBI:16595 ChEBI Sodium channel protein type 5 subunit alpha Q9NQ66 UniProt Q13936 UniProt 813 PubChem-compound Sodium/potassium ATPase Inositol 1,4,5-trisphosphate receptor type 1 CL:0000746 CELL TYPE ONTOLOGY Troponin, slow skeletal muscle SubPathwayActivation Sodium/potassium-transporting ATPase subunit beta-2 Sodium/potassium-transporting ATPase subunit beta-1 SMP0000670 SMPDB 24767919 ChemSpider P48050 UniProt C00238 KEGG Compound Q92736 UniProt BiologicalState65 Homo sapiens, Heart 1.0 Cytosol 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 SubPathwayActivation Tropomyosin beta chain Beta-2-syntrophin 1.0 Alpha-1-syntrophin inositol_1,4,5-trisphosphate BioCyc C00009 KEGG Compound C00008 KEGG Compound Q13884 UniProt cAMP-dependent protein kinase type I-alpha regulatory subunit SubPathwayActivation Phosphatidylinositols BioCyc Tropomyosin SubPathwayActivation 24203-36-9 CAS C00001 KEGG Compound Sodium/potassium-transporting ATPase subunit alpha-4 C01330 KEGG Compound Troponin I, cardiac muscle Transport53 false Sodium (→), Potassium (←) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space LEFT_TO_RIGHT CHEBI:18367 ChEBI 1032 ChemSpider 388562 ChemSpider C00002 KEGG Compound Sodium/potassium-transporting ATPase subunit alpha-1 Transport62 false Sodium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol LEFT_TO_RIGHT Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Inward rectifier potassium channel 2 P54710 UniProt BiologicalState46 Homo sapiens, Cardiomyocyte 1.0 1.0 Extracellular Space ATP-sensitive inward rectifier potassium channel 11 14127-61-8 CAS Q9NS61 UniProt P15382 UniProt SMILES [H][C@](CO)(COC(=O)CCCCCCCCCCCCC)OC(=O)CCCCCCC\C=C/CCCC 1.0 Q13733 UniProt Q9UK17 UniProt Calcium Type-1 angiotensin II receptor P63316 UniProt 1.0 56-65-5 CAS 1.0 Calmodulin SubPathwayActivator 2381 ChemSpider Sodium Troponin T, fast skeletal muscle CHEBI:29108 ChEBI CHEBI:29101 ChEBI CHEBI:29103 ChEBI DIACYLGLYCEROL BioCyc 899 ChemSpider C01245 KEGG Compound P51787 UniProt 53477948 PubChem-compound Potassium Ryanodine receptor 2 PIP2(16:0/20:3(8Z,11Z,14Z)) HMDB0001341 HMDB P07951 UniProt Voltage-dependent L-type calcium channel subunit alpha-1C Potassium voltage-gated channel subfamily H member 2 Heart C00165 KEGG Compound K%2b BioCyc P54709 UniProt SMILES O[C@@H]1[C@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1OP(O)(O)=O SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 4.0 17341-25-2 CAS Potassium voltage-gated channel subfamily KQT member 1 SubPathwayControl320 ActivatingSubPathwayControl SubPathway320Control Phosphate SubPathwayControl321 SubPathway321Control ActivatingSubPathwayControl SubPathwayControl684 SubPathway684Control ActivatingSubPathwayControl SubPathwayControl322 ActivatingSubPathwayControl SubPathway322Control SubPathwayControl323 SubPathway323Control ActivatingSubPathwayControl SubPathwayControl324 ActivatingSubPathwayControl SubPathway324Control Potassium SubPathwayControl325 SubPathway325Control ActivatingSubPathwayControl SubPathwayControl326 ActivatingSubPathwayControl SubPathway326Control 7732-18-5 CAS 791 ChemSpider Voltage-dependent calcium channel subunit alpha-2/delta-2 Voltage-dependent T-type calcium channel subunit alpha-1G C10H16N5O13P3 Adenosine triphosphate 506.99576 Inositol 1,4,5-trisphosphate SubPathwayControl318 SubPathway318Control ActivatingSubPathwayControl SubPathwayControl319 SubPathway319Control InhibitorySubPathwayControl 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 1.0 HMDB0001498 HMDB O95180 UniProt Inositol 1,4,5-trisphosphate receptor type 1 C45H83O19P3 PIP2(16:0/20:3(8Z,11Z,14Z)) 1020.4741 Voltage-dependent T-type calcium channel subunit alpha-1H Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase 962 PubChem-compound G-protein signalling cascade ActivatingSubPathway Cardiac phospholamban inhibits Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 InhibitorySubPathway Voltage-dependent L-type calcium channel subunit beta-1 Beta-1 adrenergic receptor 5800 ChemSpider cAMP-dependent protein kinase type I-alpha regulatory subunit C00076 KEGG Compound P16615 UniProt Sodium 1.0 Ca Calcium 39.96259 1.0 Q9Y3Q4 UniProt HMDB0002111 HMDB Potassium voltage-gated channel subfamily E member 1 14265-44-2 CAS P02585 UniProt 58-64-0 CAS Kv channel-interacting protein 2 Q09428 UniProt Ryanodine receptor 2 Q12959 UniProt G-protein signalling cascade ActivatingSubPathway cAMP-dependent protein kinase catalytic subunit alpha activates Voltage-depenent L-type calcium channel ActivatingSubPathway Calcium activates Troponin ActivatingSubPathway cAMP-dependent protein kinase catalytic subunit alpha activates Ryanodine receptor 2 ActivatingSubPathway Potassium voltage-gated channel subfamily E member 2 Calcium and Calmodulin activates Myosin light chain kinase, smooth muscle ActivatingSubPathway Muscle Contraction ActivatingSubPathway 14556-46-8 CAS Calcium activates Ryanodine receptor 2 ActivatingSubPathway G-protein signalling cascade ActivatingSubPathway G protein-activated inward rectifier potassium channel 1 G protein-activated inward rectifier potassium channel 4 Inward rectifier potassium channel 4 Potassium voltage-gated channel subfamily D member 3 Q12809 UniProt Sodium channel protein type 5 subunit alpha H2O Water 18.010565 P50993 UniProt Potassium channel subfamily K member 1 Na Sodium 22.989769 Sodium/potassium-transporting ATPase subunit alpha-2 K Potassium 38.963707 Voltage-dependent L-type calcium channel subunit alpha-1C Cardiomyocyte Troponin I, slow skeletal muscle ATP-sensitive inward rectifier potassium channel 8 Troponin I, fast skeletal muscle HMDB0015697 HMDB 3.6.3.8 false 3.6.3.8 Adenosine triphosphate + Calcium + Water → Adenosine diphosphate + Calcium + Phosphate LEFT_TO_RIGHT P17612 UniProt P26678 UniProt Inositol 1,4,5-trisphosphate 2.0 Sodium/potassium-transporting ATPase subunit alpha-3 Myosin light chain kinase, smooth muscle Interaction331 Inositol 1,4,5-trisphosphate activates Inositol 1,4,5-trisphosphate receptor type 1 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 1.0 TransportCatalysis93 ACTIVATION TransportCatalysis92 ACTIVATION TransportCatalysis91 ACTIVATION TransportCatalysis90 ACTIVATION TransportCatalysis96 ACTIVATION SMILES O TransportCatalysis9 ACTIVATION HMDB0000538 HMDB SMILES [Na+] SMILES [K+] P48544 UniProt Troponin C, skeletal muscle Inward rectifier potassium channel 2 Ryanodine receptor 2 SubPathwayActivation P48549 UniProt Q5I7T1 UniProt P48788 UniProt ADP BioCyc GO:0016529 GENE ONTOLOGY O60706 UniProt P14415 UniProt ATP-binding cassette sub-family C member 8 GO:0005829 GENE ONTOLOGY Type-1 angiotensin II receptor SubPathwayActivator Tropomyosin alpha-1 chain 1.0 85166-31-0 CAS O43497 UniProt ATPase, (Na+)/K+ transporting, beta 4 polypeptide O4P Phosphate 94.95342 2475 PubChem-compound P45379 UniProt P45378 UniProt 266 ChemSpider Troponin T, slow skeletal muscle 4.0 Voltage-dependent L-type calcium channel subunit beta-1 Sodium/potassium-transporting ATPase subunit gamma P22460 UniProt Potassium voltage-gated channel subfamily H member 2 1.0 Calmodulin Beta-1-syntrophin Voltage-dependent L-type calcium channel subunit alpha-1C SMILES [O-]P([O-])([O-])=O sarcoplasmic reticulum Adenosine diphosphate GO:0005886 GENE ONTOLOGY 1.0 53480233 PubChem-compound Voltage-dependent calcium channel subunit alpha-2/delta-2 ATP-binding cassette sub-family C member 9 Sodium/potassium-transporting ATPase subunit beta-3 Potassium voltage-gated channel subfamily A member 5 Disks large homolog 1 1.0 1.0 HMDB0001429 HMDB Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 Sodium/calcium exchanger 1 Potassium voltage-gated channel subfamily KQT member 1 P13637 UniProt Q9NY47 UniProt P09493 UniProt HMDB0000464 HMDB HMDB0000586 HMDB HMDB0000588 HMDB PW000647 PathWhiz Calcium Voltage-dependent T-type calcium channel subunit alpha-1G Voltage-dependent T-type calcium channel subunit alpha-1H Cardiac phospholamban Muscarinic acetylcholine receptor M2 P08172 UniProt SMILES [Ca++] 5957 PubChem-compound 1.0 1.0 HMDB0010042 HMDB Voltage-dependent L-type calcium channel subunit beta-1 Beta-1 adrenergic receptor SubPathwayInhibition cAMP-dependent protein kinase catalytic subunit alpha GO:0005615 GENE ONTOLOGY C6H15O15P3 Inositol 1,4,5-trisphosphate 419.96237 C10H15N5O10P2 Adenosine diphosphate 427.02942 1.0 3.0 Potassium voltage-gated channel subfamily E member 2 Q14643 UniProt Inositol 1,4,5-trisphosphate receptor type 1 3.1.4.11 false 3.1.4.11 PIP2(16:0/20:3(8Z,11Z,14Z)) → DG(14:0/14:1(9Z)/0:0) + Inositol 1,4,5-trisphosphate LEFT_TO_RIGHT Endoplasmic Reticulum Sodium/potassium-transporting ATPase subunit beta-1 Kv channel-interacting protein 2 1.0 CPD-8587 BioCyc TransportCatalysis10 ACTIVATION Sodium/potassium-transporting ATPase subunit beta-2 B7ZKV8 UniProt Potassium voltage-gated channel subfamily E member 1 Bupranolol Action Pathway Bupranolol SubPathwayInhibitor Q14524 UniProt Potassium channel subfamily K member 1 G protein-activated inward rectifier potassium channel 4 Q14654 UniProt 1.0 3.0 1.0 2.0 1.0 TransportCatalysis23 ACTIVATION Beta-2-syntrophin Potassium voltage-gated channel subfamily D member 3 Inward rectifier potassium channel 4 Alpha-1-syntrophin G protein-activated inward rectifier potassium channel 1 Q02641 UniProt Q15746 UniProt Troponin, cardiac muscle SubPathwayActivation Troponin T, cardiac muscle CHEBI:15422 ChEBI Sodium/potassium-transporting ATPase subunit alpha-4 Homo sapiens Sodium/potassium-transporting ATPase subunit alpha-2 Cardiac phospholamban Ryanodine receptor 2 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Sodium/potassium-transporting ATPase subunit alpha-1 Troponin C, slow skeletal and cardiac muscles 439456 PubChem-compound ATP-sensitive inward rectifier potassium channel 8 GO:0005783 GENE ONTOLOGY Beta-1 adrenergic receptor SubPathwayActivator Q15842 UniProt C00626 KEGG Compound Transport35 false Calcium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cardiomyocyte , Cytosol LEFT_TO_RIGHT ATP-sensitive inward rectifier potassium channel 11 Transport36 false Calcium (?) Transport: Homo sapiens, Cardiomyocyte , sarcoplasmic reticulum to Homo sapiens, Cardiomyocyte , Cytosol LEFT_TO_RIGHT Sodium/potassium-transporting ATPase subunit alpha-3 CHEBI:16761 ChEBI Q9Y6J6 UniProt cAMP-dependent protein kinase catalytic subunit alpha SubPathwayActivation SubPathwayActivator Myosin light chain kinase, smooth muscle SubPathwayActivation SubPathwayActivator Q13424 UniProt Q13425 UniProt 9606 TAXONOMY 1.0 CA%2b2 BioCyc SubPathwayControl906 SubPathway906Control InhibitorySubPathwayControl HMDB0007009 HMDB C31H58O5 DG(14:0/14:1(9Z)/0:0) 510.42844 CHEBI:15377 ChEBI Cell Membrane P10644 UniProt SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 271 PubChem-compound Adenosine triphosphate P32418 UniProt ATP-binding cassette sub-family C member 8 SMILES CCCCCCCCCCCCCCCC(=O)OC[C@]([H])(COP(O)(=O)O[C@H]1C(O)C(O)C(OP(=O)(O)O)[C@@H](OP(=O)(O)O)C1O)OC(=O)CCCCCC\C=C/C\C=C/C\C=C/CCCCC P13805 UniProt ATPase, (Na+)/K+ transporting, beta 4 polypeptide Water Troponin C, skeletal muscle Troponin C, slow skeletal and cardiac muscles Troponin I, slow skeletal muscle C14H22ClNO2 Bupranolol 271.1339 ReactionCatalysis1269 ACTIVATION Troponin I, cardiac muscle Troponin I, fast skeletal muscle Troponin T, cardiac muscle BTO:0000562 BRENDA TISSUE ONTOLOGY Troponin T, slow skeletal muscle 1061 PubChem-compound 1.0 Calcium Bupranolol Inhibition of Beta-1 adrenergic receptor InhibitorySubPathway P08588 UniProt TransportCatalysis89 ACTIVATION TransportCatalysis88 ACTIVATION 1.0 TransportCatalysis87 ACTIVATION 1.0 Troponin T, fast skeletal muscle TransportCatalysis82 ACTIVATION Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase Beta-1-syntrophin Tropomyosin beta chain TransportCatalysis86 ACTIVATION Muscarinic acetylcholine receptor M2 SubPathwayActivator TransportCatalysis85 ACTIVATION 1.0 Sodium/potassium-transporting ATPase subunit gamma TransportCatalysis84 ACTIVATION Tropomyosin alpha-1 chain TransportCatalysis83 ACTIVATION P19237 UniProt 5.0 Troponin, fast skeletal muscle SubPathwayActivation Cardiac phospholamban SubPathwayInhibitor ADRB1 ITPR1 ADRB1 PRKACA PRKAR1A AGTR1 PLCB1 TNNC2 TNNI1 TNNT1 TNNC1 TNNI3 TNNT2 TNNC2 TNNI2 TNNT3 TPM1 TPM2 CALM1 MYLK CACNA1C CACNA2D2 CACNB1 RYR2 CHRM2 KCNJ3 KCNJ5 PLN ATP2A2 ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1B1 ATP1B2 ATP1B3 Unknown FXYD2 KCNJ2 KCNJ4 KCND3 KCNIP2 Unknown Unknown KCNQ1 KCNE1 KCNE2 KCNH2 ALG10B ABCC8 KCNJ8 KCNJ11 Unknown KCNK1 SLC8A1 HCN4 SCN5A SNTB2 SNTB1 SNTA1 CACNA1H CACNA1G Bupranolol Inositol 1,4,5- trisphosphate Calcium Calcium Sodium Sodium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Calcium Calcium Sodium Sodium Sodium Sodium Potassium Potassium Sodium Sodium Calcium Calcium Calcium Calcium PIP2(16:0/20:3(8Z,11Z,14Z)) DG(14:0/14:1(9Z)/0:0) Adenosine triphosphate Water Calcium Adenosine diphosphate Phosphate Calcium G-protein signalling cascade G-protein signalling cascade G-protein signalling cascade Muscle Contraction Created with Snap