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Beta-1 adrenergic receptor Inositol 1,4,5- trisphosphate receptor type 1 Beta-1 adrenergic receptor cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase type I-alpha regulatory subunit Type-1 angiotensin II receptor 1- phosphatidylinositol 4,5- bisphosphate phosphodiesterase beta-1 Troponin C, skeletal muscle Troponin I, slow skeletal muscle Troponin T, slow skeletal muscle Troponin C, slow skeletal and cardiac muscles Troponin I, cardiac muscle Troponin T, cardiac muscle Troponin C, skeletal muscle Troponin I, fast skeletal muscle Troponin T, fast skeletal muscle Tropomyosin alpha-1 chain Tropomyosin beta chain Calmodulin Myosin light chain kinase, smooth muscle Voltage- dependent L-type calcium channel subunit alpha-1C Voltage- dependent calcium channel subunit alpha-2/delta-2 Voltage- dependent L-type calcium channel subunit beta-1 Ryanodine receptor 2 Muscarinic acetylcholine receptor M2 G protein- activated inward rectifier potassium channel 1 G protein- activated inward rectifier potassium channel 4 Cardiac phospholamban Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 Sodium/potassium- transporting ATPase subunit alpha-1 Sodium/potassium- transporting ATPase subunit alpha-2 Sodium/potassium- transporting ATPase subunit alpha-3 Sodium/potassium- transporting ATPase subunit alpha-4 Sodium/potassium- transporting ATPase subunit beta-1 Sodium/potassium- transporting ATPase subunit beta-2 Sodium/potassium- transporting ATPase subunit beta-3 ATPase, (Na+)/K+ transporting, beta 4 polypeptide Sodium/potassium- transporting ATPase subunit gamma Inward rectifier potassium channel 2 Inward rectifier potassium channel 4 Potassium voltage-gated channel subfamily D member 3 Kv channel- interacting protein 2 Potassium voltage-gated channel subfamily A member 5 Disks large homolog 1 Potassium voltage-gated channel subfamily KQT member 1 Potassium voltage-gated channel subfamily E member 1 Potassium voltage-gated channel subfamily E member 2 Potassium voltage-gated channel subfamily H member 2 Putative Dol-P- Glc:Glc(2)Man(9)GlcNAc(2)- PP-Dol alpha-1,2- glucosyltransferase ATP-binding cassette sub-family C member 8 ATP-sensitive inward rectifier potassium channel 8 ATP-sensitive inward rectifier potassium channel 11 ATP-binding cassette sub-family C member 9 Potassium channel subfamily K member 1 Sodium/calcium exchanger 1 Potassium/sodium hyperpolarization- activated cyclic nucleotide- gated channel 4 Sodium channel protein type 5 subunit alpha Beta-2- syntrophin Beta-1- syntrophin Alpha-1- syntrophin Voltage- dependent T-type calcium channel subunit alpha-1H Voltage- dependent T-type calcium channel subunit alpha-1G Bupranolol Inositol 1,4,5- trisphosphate Ca + Ca + Na + Na + K + K + K + K + K + K + K + K + K + K + K + K + K + K + K + K + K + K + Ca + Ca + Na + Na + Na + Na + K + K + Na + Na + Ca + Ca + Ca + Ca + PIP2(16:0/20:3(8Z,11Z,14Z)) DG(14:0/14:1(9Z)/0:0) ATP H 2 O Ca + ADP P i Ca + Calcium Magnesium Calcium G-protein signalling cascade G-protein signalling cascade G-protein signalling cascade Muscle Contraction MYOCYTE SARCOPLASMIC RETICULUM In smooth muscle In striated muscle
ADRB1 ITPR1 ADRB1 PRKACA PRKAR1A AGTR1 PLCB1 TNNC2 TNNI1 TNNT1 TNNC1 TNNI3 TNNT2 TNNC2 TNNI2 TNNT3 TPM1 TPM2 CALM1 MYLK CACNA1C CACNA2D2 CACNB1 RYR2 CHRM2 KCNJ3 KCNJ5 PLN ATP2A2 ATP1A1 ATP1A2 ATP1A3 ATP1A4 ATP1B1 ATP1B2 ATP1B3 Unknown FXYD2 KCNJ2 KCNJ4 KCND3 KCNIP2 Unknown Unknown KCNQ1 KCNE1 KCNE2 KCNH2 ALG10B ABCC8 KCNJ8 KCNJ11 Unknown KCNK1 SLC8A1 HCN4 SCN5A SNTB2 SNTB1 SNTA1 CACNA1H CACNA1G Bupranolol Inositol 1,4,5- trisphosphate Calcium Calcium Sodium Sodium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Potassium Calcium Calcium Sodium Sodium Sodium Sodium Potassium Potassium Sodium Sodium Calcium Calcium Calcium Calcium PIP2(16:0/20:3(8Z,11Z,14Z)) DG(14:0/14:1(9Z)/0:0) Adenosine triphosphate Water Calcium Adenosine diphosphate Phosphate Calcium G-protein signalling cascade G-protein signalling cascade G-protein signalling cascade Muscle Contraction Created with Snap