Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
Your source for quantitative metabolomics technologies and bioinformatics.

Loading Pathway...

CHEBI:16015 ChEBI 79551-86-3 CAS C20H32O2 Arachidonic acid 304.24023 3.0 20559-16-4 CAS 1.0 HMDB0061118 HMDB HMDB0061119 HMDB 1.0 HMDB0061377 HMDB C04805 KEGG Compound 14,15-Epoxy-5,8,11-eicosatrienoic acid 24778634 PubChem-compound NADPH 1.0 Leukotriene B4 C22H46NO7P LysoPC(14:0/0:0) 467.30118 Cytochrome P450 4A11 Leukotriene A4 HMDB0003252 HMDB 5,6-Epoxy-8,11,14-eicosatrienoic acid P07203 UniProt 1.0 BTO:0000759 BRENDA TISSUE ONTOLOGY 1.0 C00219 KEGG Compound 1.0 60203-57-8 CAS C00696 KEGG Compound CHEBI:16474 ChEBI Q8TBF2 UniProt SMILES CCCCC\C=C/C[C@@H](OO)\C=C\C=C/C\C=C/CCCC(O)=O SMILES CCCCC\C=C/C\C=C/C\C=C/C=C/C(CCCC(O)=O)OO SMILES CCCCC\C=C/C\C=C/C\C=C/C=C/[C@@H](O)CCCC(O)=O SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@@H](O)CC(O)C1C\C=C/CCCC(O)=O SMILES C[C@H](O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O SMILES CCCCC\C=C/C\C=C/C=C/[C@@H](O)C\C=C/CCCC(O)=O SMILES CCCC[C@@H](O)\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O HMDB0001085 HMDB SMILES CCCCC[C@H](O)\C=C\C(O)C(O)C\C=C/C\C=C/CCCC(O)=O SMILES [H][C@](O)(CCCCC)\C=C\[C@@]1([H])C(=O)C[C@]([H])(O)[C@]1([H])C\C=C/CCCC(O)=O P16152 UniProt SMILES CCCCC\C=C\CC1OC1C\C=C\C\C=C\CCCC(O)=O HMDB0061111 HMDB C01312 KEGG Compound SMILES CCCCC\C=C/C\C=C/C=C/[C@H](C\C=C/CCCC(O)=O)OO SMILES CCCCCC1OC1\C=C\C(O)C\C=C/C\C=C/CCCC(O)=O 77667-09-5 CAS 1.0 SMILES CCCCCC(O)C(O)\C=C\C(O)C\C=C/C\C=C/CCCC(O)=O 58962-34-8 CAS 6-Ketoprostaglandin E1 5283154 PubChem-compound 5283155 PubChem-compound HMDB0002190 HMDB 5283156 PubChem-compound 124886 PubChem-compound L-Glutamic acid 2.0 P51589 UniProt 5283157 PubChem-compound 5283159 PubChem-compound 1.0 1.0 HMDB0007883 HMDB 9548884 PubChem-compound 9548883 PubChem-compound C00007 KEGG Compound C00006 KEGG Compound 9548885 PubChem-compound 5283142 PubChem-compound 1.0 CHEBI:18009 ChEBI 5283144 PubChem-compound C00001 KEGG Compound NADP C00005 KEGG Compound 9548880 PubChem-compound 1.0 C20H34O6 6-Keto-prostaglandin F1a 370.23553 NADP Aldo-keto reductase family 1 member C3 5283146 PubChem-compound 5283147 PubChem-compound 5283171 PubChem-compound 11954058 PubChem-compound ReactionCatalysis2192 ACTIVATION 11954059 PubChem-compound C05949 KEGG Compound C04853 KEGG Compound 17395793 PubChem-compound CHEBI:28269 ChEBI 17395792 PubChem-compound Cytochrome P450 2E1 1.0 1.0 1.0 SMILES CCCCC[C@H](O)\C=C\C1=CCC(=O)[C@@H]1C\C=C/CCCC(O)=O SMILES CCCCC[C@H](O)\C=C\C=C/C=C/C=C/[C@@H]1O[C@H]1CCCC(O)=O HMDB0061378 HMDB 11954060 PubChem-compound SMILES CCCCC\C=C/C[C@@H](O)\C=C\C=C/C\C=C/CCCC(O)=O 5283162 PubChem-compound SMILES CCCCC\C=C/C[C@H](O)\C=C\C=C/C\C=C/CCCC(O)=O C05958 KEGG Compound C20H32O4 Leukotriene B4 336.23007 C05957 KEGG Compound C06804 KEGG Compound 2.0 C05959 KEGG Compound C05954 KEGG Compound C05953 KEGG Compound C05956 KEGG Compound C05955 KEGG Compound C05950 KEGG Compound C00025 KEGG Compound C05951 KEGG Compound 12-KETE 1.0 SMILES CCCCC\C=C/CC(=O)\C=C\C=C/C\C=C/CCCC(O)=O 1.0 1.0 ALPHA11-ALPHA-EPOXY-15-HYDROXYTHROMBA BioCyc Arachidonic acid Cytosolic phospholipase A2 beta 15(S)-HPETE 87893-54-7 CAS C20H32O3 8,9-Epoxyeicosatrienoic acid 320.23514 C05965 KEGG Compound C05964 KEGG Compound O75342 UniProt C05966 KEGG Compound C42H76NO8P PC(14:0/20:4(5Z,8Z,11Z,14Z)) 753.5309 SMILES CCCCC[C@H](OO)\C=C\C=C/C\C=C/C\C=C/CCCC(O)=O C05961 KEGG Compound C05963 KEGG Compound C05962 KEGG Compound SMILES CCCCCC1OC1C\C=C/C\C=C/C\C=C/CCCC(O)=O HMDB0002314 HMDB PC(14:0/20:4(5Z,8Z,11Z,14Z)) HMDB0002311 HMDB Prostamide/prostaglandin F synthase HMDB0001220 HMDB 1.0 Leukotriene C4 synthase SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)C[C@@H]2OC(C[C@H]12)=CCCCC(O)=O 1.0 C20H32O3 20-Hydroxyeicosatetraenoic acid 320.23514 460604 PubChem-compound C20H34O4 14,15-DiHETrE 338.2457 Reaction2296 false Arachidonic acid + NADPH + Oxygen → 20-Hydroxyeicosatetraenoic acid + NADP + Water LEFT_TO_RIGHT 1.0 C00051 KEGG Compound HMDB0000148 HMDB 1.0 SMILES CCCCC\C=C/C\C=C/C=C/C=C/[C@@H]1O[C@H]1CCCC(O)=O C20H34O5 Prostaglandin F2a 354.24063 67675-13-2 CAS 1.0 Prostaglandin F2a Leukotriene A4 12-Keto-leukotriene B4 Prostacyclin synthase 1.0 5283137 PubChem-compound SMP0000710 SMPDB BiologicalState10 Homo sapiens, Liver 1.0 C20H32O3 15(S)-HETE 320.23514 1.0 Prostaglandin E2 SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1CC(=O)CCCCC(O)=O SMILES CCCCC[C@H](O)\C=C\[C@H]1OC(=O)C[C@H](O)[C@@H]1C\C=C\CCCC(O)=O SMILES CCCCC\C=C/C[C@H](OO)\C=C\C=C/C\C=C/CCCC(O)=O 1.0 SMILES CCCCC[C@H](O)C\C=C1/[C@@H](C\C=C/CCCC(O)=O)C=CC1=O 8-Isoprostane HMDB0002343 HMDB Oxidized glutathione P20813 UniProt 962 PubChem-compound 11-Epi-PGF2a 1.0 C20H30O6 20-Carboxy-leukotriene B4 366.20422 SMILES O=O C20H34O4 8,9-DiHETrE 338.2457 C20H34O4 11,12-DiHETrE 338.2457 Prostaglandin I2 SMILES CCCCC\C=C\C=C1/[C@@H](C\C=C/CCCC(O)=O)C=CC1=O SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H]2C[C@H](OO2)[C@@H]1C\C=C/CCCC(O)=O HMDB0002111 HMDB 5,6-Epoxy-8,11,14-eicosatrienoic acid 81246-85-7 CAS Leukotriene C4 synthase CHEBI:34306 ChEBI SMILES [H][C@@]1(CCCCCCC)CCC[C@]1([H])CCCCCCCC Arachidonate 15-lipoxygenase C25H40N2O6S Leukotriene D4 496.2607 20-Hydroxy-leukotriene B4 HMDB0001043 HMDB 506-32-1 CAS Prostaglandin G2 977 PubChem-compound 1.0 1983 PubChem-compound C04230 KEGG Compound SMILES CCCCC[C@H](O)\C=C\C1OC1C\C=C/C\C=C/CCCC(O)=O HMDB0003235 HMDB Glutathione peroxidase 1 1.0 CHEBI:28099 ChEBI 73836-78-9 CAS 4444399 ChemSpider 30572 ChemSpider 17215925 ChemSpider PROSTAGLANDIN-H2 BioCyc Cytochrome P450 2U1 Thromboxane A2 CHEBI:34487 ChEBI HMDB0001859 HMDB Cytochrome P450 2E1 6-Keto-prostaglandin F1a CHEBI:34486 ChEBI 11,12-Epoxyeicosatrienoic acid 19(S)-HETE HMDB0002710 HMDB Cytochrome P450 4F8 C20H32O5 Thromboxane A2 352.22498 Prostaglandin G/H synthase 1 4446324 ChemSpider 4446326 ChemSpider 74581-83-2 CAS 4446323 ChemSpider Cytochrome P450 2B6 CHEBI:34230 ChEBI Acetaminophen SubPathwayInhibitor LysoPC(14:0/0:0) SMILES O[C@@H](CCCC(O)=O)\C=C/C=C/C=C/[C@H](O)C\C=C/CCCCC(O)=O Water 5282411 PubChem-compound CHEBI:34229 ChEBI 4444133 ChemSpider 4444132 ChemSpider 4444137 ChemSpider 1.0 Cytochrome P450 4F8 C20H34O4 5,6-DHET 338.2457 Cytochrome P450 2J2 SMILES CCCCCCCCCCCCCC(=O)OC[C@]([H])(COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC Cytochrome P450 2C8 HMDB0001403 HMDB 1.0 5.3.99.5 false 5.3.99.5 Prostaglandin H2 → Thromboxane A2 LEFT_TO_RIGHT P35354 UniProt 20-Hydroxy-leukotriene B4 Leukotriene C4 Cytochrome P450 4A11 1.0 5Z13E-15S-9-ALPHA11-ALPHA15-TRIHY BioCyc 8(S)-HPETE HMDB0013633 HMDB 5280493 PubChem-compound Prostaglandin-H2 D-isomerase 551-11-1 CAS 5280492 PubChem-compound SMILES CCCCCC(O)C(O)C\C=C/C\C=C/C\C=C/CCCC(O)=O CHEBI:34450 ChEBI CPD-8892 BioCyc SMILES OCCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O 2,3-Dinor-8iso prostaglandin F1alpha SMILES CCCCC\C=C/C\C=C/C=C/C=C/[C@@H](SC[C@H](N)C(=O)NCC(O)=O)[C@@H](O)CCCC(O)=O 5280497 PubChem-compound 1.0 1.0 C00909 KEGG Compound NADPH BioCyc Leukotriene A4 CHEBI:16856 ChEBI CHEBI:64095 ChEBI SMILES CCCCC\C=C/C\C=C/C\C=C/CC(O)C(O)CCCC(O)=O HMDB0010379 HMDB CPD-6641 BioCyc Bifunctional epoxide hydrolase 2 Thromboxane-A synthase C20H32O5 20-Hydroxy-leukotriene B4 352.22498 HMDB0002752 HMDB 42935-17-1 CAS 1.0 1.0 Prostaglandin G/H synthase 2 Prostaglandin-c2 16(R)-HETE NADPH Liver C10H17N3O6S Glutathione 307.0838 11-Dehydro-thromboxane B2 97008 ChemSpider Acetaminophen inhibition of Prostaglandin G/H synthase 2 InhibitorySubPathway Acetaminophen inhibition of Prostaglandin G/H synthase 1 InhibitorySubPathway CHEBI:607727 ChEBI 2.0 Cytochrome P450 2U1 448457 PubChem-compound Leukotriene A-4 hydrolase C18H32O5 2,3-Dinor-8iso prostaglandin F2alpha 328.22498 SMILES CCCCC\C=C/CC(O)C(O)C\C=C/C\C=C/CCCC(O)=O C18H32O5 2,3-Dinor-8iso prostaglandin F1alpha 328.22498 SMILES CCCCC\C=C/C\C=C/CC(O)C(O)C\C=C/CCCC(O)=O 1.0 Aldo-keto reductase family 1 member C3 Thromboxane A2 1.0 1.0 1.0 CHEBI:34490 ChEBI 1.0 1.0 79516-82-8 CAS HMDB0003876 HMDB HMDB0000125 HMDB Arachidonic acid GO:0005737 GENE ONTOLOGY 15(S)-HPETE 4510033 ChemSpider HMDB0001452 HMDB 70-18-8 CAS 4444314 ChemSpider 1.0 1.0 81276-03-1 CAS 5280884 PubChem-compound CHEBI:27555 ChEBI 14,15-DiHETrE 5280885 PubChem-compound 5280882 PubChem-compound 5280883 PubChem-compound 5Z13E-15S-9-ALPHA15-DIHYDROXY-11-O BioCyc 5280880 PubChem-compound 1.0 392692 ChemSpider 1.14.99.1 false 1.14.99.1 Prostaglandin G2 → Prostaglandin H2 + Water LEFT_TO_RIGHT 5280888 PubChem-compound 5280889 PubChem-compound 11954043 PubChem-compound Prostaglandin E synthase 11954042 PubChem-compound Glutathione peroxidase 1 Carbonyl reductase [NADPH] 1 1.0 SMILES CCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O 5675 ChemSpider 5280876 PubChem-compound Water 12(R)-HPETE 5280877 PubChem-compound Prostaglandin G/H synthase 1 5280878 PubChem-compound 4444307 ChemSpider Thromboxane-A synthase 5288144 PubChem-compound PW000687 PathWhiz 70981-96-3 CAS SMILES CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O C13809 KEGG Compound Cytosolic phospholipase A2 beta 8,9-DiHETrE 1.0 GO:0005789 GENE ONTOLOGY Prostaglandin G/H synthase 1 SubPathwayInhibition 15(S)-HPETE Reaction377 false Arachidonic acid + Oxygen → 12(S)-HPETE LEFT_TO_RIGHT Reaction378 false Arachidonic acid + Oxygen → 15(S)-HPETE LEFT_TO_RIGHT GO:0005783 GENE ONTOLOGY 3.3.2.6 false 3.3.2.6 Leukotriene A4 + Water → Leukotriene B4 LEFT_TO_RIGHT C5H9NO4 L-Glutamic acid 147.05316 33032 PubChem-compound CHEBI:15553 ChEBI CHEBI:15552 ChEBI CHEBI:15555 ChEBI CHEBI:15554 ChEBI 1.0 CHEBI:15558 ChEBI Prostacyclin synthase CHEBI:15551 ChEBI 7782-44-7 CAS 5280893 PubChem-compound 5-HETE SMILES [H][C@@](O)(COC(=O)CCCCCCCCCCCCC)COP([O-])(=O)OCC[N+](C)(C)C 5280892 PubChem-compound 4.4.1.20 false 4.4.1.20 Glutathione + Leukotriene A4 → Leukotriene C4 LEFT_TO_RIGHT Reaction385 false Arachidonic acid + Oxygen → 8(S)-HPETE LEFT_TO_RIGHT 9606 TAXONOMY ReactionCatalysis476 ACTIVATION ReactionCatalysis477 ACTIVATION ReactionCatalysis474 ACTIVATION P10632 UniProt ReactionCatalysis475 ACTIVATION ReactionCatalysis473 ACTIVATION ReactionCatalysis470 ACTIVATION ReactionCatalysis471 ACTIVATION 1.0 192461-96-4 CAS SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C\CCCC(O)=O C20H30O4 12-Keto-leukotriene B4 334.21442 C20H30O4 Prostaglandin B2 334.21442 CHEBI:28209 ChEBI 51982-36-6 CAS ReactionCatalysis469 ACTIVATION P19440 UniProt CHEBI:27595 ChEBI ReactionCatalysis467 ACTIVATION ReactionCatalysis468 ACTIVATION CHEBI:15377 ChEBI ReactionCatalysis465 ACTIVATION ReactionCatalysis466 ACTIVATION CHEBI:15379 ChEBI ReactionCatalysis463 ACTIVATION 70608-72-9 CAS ReactionCatalysis464 ACTIVATION ReactionCatalysis461 ACTIVATION ReactionCatalysis462 ACTIVATION Reaction326 false 8,9-Epoxyeicosatrienoic acid + Water → 8,9-DiHETrE LEFT_TO_RIGHT Reaction327 false 5,6-Epoxy-8,11,14-eicosatrienoic acid + Water → 5,6-DHET LEFT_TO_RIGHT Epoxide hydratase 2 SMILES CCCCC[C@H](O)\C=C\C=C/C\C=C/C\C=C/CCCC(O)=O SMILES CCCCC\C=C/C\C=C/CC1OC1C\C=C/CCCC(O)=O C20H30O3 5-KETE 318.21948 C05356 KEGG Compound Reaction325 false 14,15-Epoxy-5,8,11-eicosatrienoic acid + Water → 14,15-DiHETrE LEFT_TO_RIGHT 111188 ChemSpider ReactionCatalysis498 ACTIVATION 80434-82-8 CAS ReactionCatalysis496 ACTIVATION 30776537 ChemSpider ReactionCatalysis497 ACTIVATION 72025-60-6 CAS ReactionCatalysis494 ACTIVATION 27025-41-8 CAS ReactionCatalysis495 ACTIVATION ReactionCatalysis492 ACTIVATION ReactionCatalysis493 ACTIVATION ReactionCatalysis490 ACTIVATION 1.0 ReactionCatalysis491 ACTIVATION 1.0 1.0 CHEBI:28666 ChEBI CHEBI:28667 ChEBI 1906 ChemSpider HMDB0006059 HMDB ReactionCatalysis489 ACTIVATION ReactionCatalysis487 ACTIVATION ReactionCatalysis485 ACTIVATION ReactionCatalysis486 ACTIVATION ReactionCatalysis484 ACTIVATION 4444320 ChemSpider ReactionCatalysis481 ACTIVATION ReactionCatalysis482 ACTIVATION ReactionCatalysis480 ACTIVATION SMILES CCCCCC(O)C=CC1C(O)CC(O)C1CC(=O)CCCCC(O)=O Prostaglandin G/H synthase 1 CHEBI:27562 ChEBI ReactionCatalysis478 ACTIVATION ReactionCatalysis479 ACTIVATION 57576-52-0 CAS P09960 UniProt 5283078 PubChem-compound 937 ChemSpider 53477781 PubChem-compound C20H32O5 Prostaglandin E2 352.22498 12(S)-HPETE P41222 UniProt HMDB0004699 HMDB C14717 KEGG Compound P0C869 UniProt HMDB0004693 HMDB HMDB0004692 HMDB Acetaminophen Action Pathway 5353269 PubChem-compound HMDB0004694 HMDB 3.0 1.0 Q02928 UniProt 71160-24-2 CAS P34913 UniProt Prostaglandin G/H synthase 2 SubPathwayInhibition 1.0 1.0 HMDB0001198 HMDB Q7Z449 UniProt 67910-12-7 CAS 1.0 1.0 Prostaglandin D2 192461-95-3 CAS 952 ChemSpider HMDB0004238 HMDB 950 ChemSpider 4450370 ChemSpider HMDB0004236 HMDB HMDB0004234 HMDB C14732 KEGG Compound Leukotriene-B(4) omega-hydroxylase 1 Leukotriene D4 C30H47N3O9S Leukotriene C4 625.3033 11,14,15-THETA C00584 KEGG Compound 1.0 Q08477 UniProt O14684 UniProt 363-24-6 CAS C14749 KEGG Compound C14748 KEGG Compound 1.0 11H-14,15-EETA HMDB0004242 HMDB HMDB0004241 HMDB 1.0 HMDB0004244 HMDB CHEBI:27485 ChEBI 1.0 HMDB0004243 HMDB 1.0 Cytosol 1.0 PHOSPHATIDYLCHOLINE BioCyc C00127 KEGG Compound C14770 KEGG Compound 136696-10-1 CAS 11,12-DiHETrE 1.0 C20H32N6O12S2 Oxidized glutathione 612.152 SMILES CCCCC\C=C/C\C=C/C=C/C=C/[C@@H](SC[C@H](NC(=O)CC[C@H](N)C(O)=O)C(=O)NCC(O)=O)[C@@H](O)CCCC(O)=O CHEBI:28158 ChEBI C14769 KEGG Compound C14768 KEGG Compound HMDB0004264 HMDB ReactionCatalysis738 ACTIVATION Oxygen 79551-85-2 CAS C14781 KEGG Compound Gamma-glutamyltranspeptidase 1 5-HPETE 11,12,15-THETA 444899 PubChem-compound C20H32O6 Prostaglandin G2 368.21988 NAD(P) BioCyc SMILES CCCCC\C=C/CC(=O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O SMILES CCCCC[C@@H](O)\C=C\C1=C(C\C=C/CCCC(O)=O)C(=O)CC1 CHEBI:52449 ChEBI Cytochrome P450 2J2 C14774 KEGG Compound C14773 KEGG Compound C14772 KEGG Compound C14771 KEGG Compound 1.0 C14778 KEGG Compound 21467087 ChemSpider C14777 KEGG Compound C14776 KEGG Compound C14775 KEGG Compound P98187 UniProt 392800 ChemSpider C20H34O6 Thromboxane B2 370.23553 C04742 KEGG Compound SMILES CCCCC\C=C/C\C=C/C\C=C/C=C/C(=O)CCCC(O)=O CHEBI:28130 ChEBI C14782 KEGG Compound Reaction915 true 12(S)-HPETE → 12(S)-HETE LEFT_TO_RIGHT 3.1.1.4 false 3.1.1.4 PC(14:0/20:4(5Z,8Z,11Z,14Z)) + Water ↔ Arachidonic acid + LysoPC(14:0/0:0) REVERSIBLE 1.14.15.3 false 1.14.15.3 Arachidonic acid + Oxygen → 20-Hydroxyeicosatetraenoic acid + Water LEFT_TO_RIGHT Reaction914 true 12(S)-HPETE → 12-KETE LEFT_TO_RIGHT OXIDIZED-GLUTATHIONE BioCyc Reaction911 true 8-Isoprostane → 2,3-Dinor-8iso prostaglandin F1alpha LEFT_TO_RIGHT 1.0 Reaction912 true 8-Isoprostane → 2,3-Dinor-8iso prostaglandin F2alpha LEFT_TO_RIGHT Reaction910 true Arachidonic acid → 8-Isoprostane LEFT_TO_RIGHT 4446295 ChemSpider C00157 KEGG Compound 67786-53-2 CAS 103-90-2 CAS 4446283 ChemSpider 4446286 ChemSpider 4446280 ChemSpider 4446281 ChemSpider 5311211 PubChem-compound 4.0 Bifunctional epoxide hydrolase 2 87893-55-8 CAS 4446278 ChemSpider 4446279 ChemSpider 1.0 7732-18-5 CAS 13367-85-6 CAS 4446270 ChemSpider 126432-17-5 CAS 4446271 ChemSpider Water SMILES CCCCC[C@H](O)\C=C\[C@H]1O[C@H]2C[C@H](O2)[C@@H]1C\C=C/CCCC(O)=O 56-86-0 CAS Prostaglandin B2 Prostaglandin D2 4446266 ChemSpider 4446268 ChemSpider 4446261 ChemSpider 1.0 HMDB0001377 HMDB Gamma-glutamyltranspeptidase 1 5Z13E-15S-69-ALPHA-EPOXY-11-ALPHA BioCyc HMDB0001139 HMDB Prostaglandin H2 P09917 UniProt Leukotriene B4 8-HETE 1.0 12(R)-HETE SMILES CCCCCC(O)\C=C\[C@H]1C(O)CC(O)[C@H]1CCCCC(O)=O SMILES CCCCCC(O)\C=C\[C@H]1C(O)CC(O)[C@H]1CCCCC(O)=O 20-Hydroxyeicosatetraenoic acid HMDB0004659 HMDB 5Z13E-15S-1115-DIHYDROXY-9-OXOPROS BioCyc HMDB0001381 HMDB SMILES N[C@@H](CCC(O)=O)C(O)=O Glutathione HMDB0002232 HMDB 8,9-Epoxyeicosatrienoic acid CHEBI:64489 ChEBI 12(S)-HETE 7827808 ChemSpider 7827807 ChemSpider 7827806 ChemSpider C20H30O4 Prostaglandin J2 334.21442 HMDB0003337 HMDB HMDB0005998 HMDB 395250 ChemSpider 2.0 7827803 ChemSpider 54845-95-3 CAS 20-Hydroxyeicosatetraenoic acid Prostaglandin I2 Leukotriene C4 synthase HMDB0004679 HMDB 22833512 PubChem-compound 81246-84-6 CAS H2O Water 18.010565 SMILES OCCCCC\C=C/C[C@@H](O)\C=C\C=C\C=C/[C@@H](O)CCCC(O)=O 35121-78-9 CAS HMDB0004673 HMDB 1.14.13.- false 1.14.13.- Arachidonic acid + Oxygen → 5,6-Epoxy-8,11,14-eicosatrienoic acid + Water LEFT_TO_RIGHT 1.11.1.9 false 1.11.1.9 5-HPETE + 2 Glutathione → 5-HETE + Oxidized glutathione + Water LEFT_TO_RIGHT 1.14.13.- false 1.14.13.- Arachidonic acid + Oxygen → 8,9-Epoxyeicosatrienoic acid + Water LEFT_TO_RIGHT 1.13.11.34 false 1.13.11.34 5-HPETE + Oxygen → Leukotriene A4 + Water LEFT_TO_RIGHT Glutathione 1.13.11.34 false 1.13.11.34 Arachidonic acid + Oxygen → 5-HPETE + Water LEFT_TO_RIGHT 219535-29-2 CAS 12(R)-HPETE 1.0 8,9-Epoxyeicosatrienoic acid C02165 KEGG Compound 5,6-DHET Reaction908 true 8(S)-HPETE → 8-HETE LEFT_TO_RIGHT C02166 KEGG Compound Reaction909 true 12(R)-HPETE → 12(R)-HETE LEFT_TO_RIGHT Reaction906 false Arachidonic acid + Oxygen → 19(S)-HETE + Water LEFT_TO_RIGHT 1.13.11.- false 1.13.11.- Arachidonic acid + Oxygen → 12(R)-HPETE LEFT_TO_RIGHT 1.0 ARACHIDONIC_ACID BioCyc SMILES N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O)C(O)=O 5283202 PubChem-compound HMDB0004680 HMDB 5283203 PubChem-compound 5283205 PubChem-compound HMDB0002265 HMDB HMDB0004684 HMDB Reaction878 true Delta-12-Prostaglandin J2 → 15-Deoxy-d-12,14-PGJ2 LEFT_TO_RIGHT CHEBI:15843 ChEBI Reaction879 true 6-Keto-prostaglandin F1a → 6-Ketoprostaglandin E1 LEFT_TO_RIGHT Reaction876 true 15(S)-HPETE → 5,6-Epoxytetraene LEFT_TO_RIGHT 1.11.1.9 false 1.11.1.9 15(S)-HPETE + 2 Glutathione → 15(S)-HETE + Oxidized glutathione + Water LEFT_TO_RIGHT 6Z8E10E14Z-5S12R-512-DIHYDROXYI BioCyc 445049 PubChem-compound 5280360 PubChem-compound 155976-51-5 CAS SMILES O 72059-45-1 CAS Reaction874 false Leukotriene C4 + Water → L-Glutamic acid + Leukotriene D4 LEFT_TO_RIGHT Reaction875 true 5,6-Epoxytetraene → Leukotriene A4 LEFT_TO_RIGHT Reaction872 false Leukotriene B4 + NADPH + Oxygen → 20-Hydroxy-leukotriene B4 + NADP + Water LEFT_TO_RIGHT Reaction873 true Leukotriene B4 → 12-Keto-leukotriene B4 LEFT_TO_RIGHT Reaction871 true 20-Hydroxy-leukotriene B4 → 20-Carboxy-leukotriene B4 LEFT_TO_RIGHT 4446204 ChemSpider Reaction889 true Prostaglandin-c2 → Prostaglandin B2 LEFT_TO_RIGHT Reaction887 true Prostaglandin A2 → Prostaglandin-c2 LEFT_TO_RIGHT LEUKOTRIENE-C4 BioCyc Reaction888 true Thromboxane A2 → Thromboxane B2 LEFT_TO_RIGHT CHEBI:27814 ChEBI Leukotriene-B(4) omega-hydroxylase 2 HMDB0001509 HMDB Leukotriene-B(4) omega-hydroxylase 1 20-Carboxy-leukotriene B4 Leukotriene A-4 hydrolase CHEBI:33023 ChEBI C20H30O4 Delta-12-Prostaglandin J2 334.21442 CHEBI:27820 ChEBI 15-Deoxy-d-12,14-PGJ2 P24557 UniProt C20H32O6 6-Ketoprostaglandin E1 368.21988 HMDB0010217 HMDB 1.0 C20H32O6 11-Dehydro-thromboxane B2 368.21988 Reaction885 false NADPH + Prostaglandin E2 → NADP + Prostaglandin F2a LEFT_TO_RIGHT Reaction886 true Prostaglandin E2 → Prostaglandin A2 LEFT_TO_RIGHT Reaction883 true Prostaglandin D2 → Prostaglandin J2 LEFT_TO_RIGHT Reaction884 false NADPH + Prostaglandin D2 → 11-Epi-PGF2a + NADP LEFT_TO_RIGHT Reaction881 true Prostaglandin J2 → Delta-12-Prostaglandin J2 LEFT_TO_RIGHT Reaction882 true Prostaglandin I2 → 6-Keto-prostaglandin F1a LEFT_TO_RIGHT 877878-78-9 CAS Reaction880 true 5-HETE → 5-KETE LEFT_TO_RIGHT 53-59-8 CAS 1.14.13.- false 1.14.13.- Arachidonic acid + Oxygen → 11,12-Epoxyeicosatrienoic acid + Water LEFT_TO_RIGHT Arachidonic acid Reaction899 false 11,12-Epoxyeicosatrienoic acid + Water → 11,12-DiHETrE LEFT_TO_RIGHT 108437-64-5 CAS SubPathwayControl963 SubPathway963Control InhibitorySubPathwayControl 5280383 PubChem-compound SubPathwayControl962 SubPathway962Control InhibitorySubPathwayControl C20H30O4 Prostaglandin A2 334.21442 1.0 1.0 C02198 KEGG Compound 1.0 1.0 GO:0005829 GENE ONTOLOGY 1.0 1.14.14.1 false 1.14.14.1 Arachidonic acid + Oxygen → 16(R)-HETE + Water LEFT_TO_RIGHT 1.14.13.- false 1.14.13.- Arachidonic acid + Oxygen → 14,15-Epoxy-5,8,11-eicosatrienoic acid + Water LEFT_TO_RIGHT 1.14.14.1 false 1.14.14.1 15H-11,12-EETA + Oxygen → 11,12,15-THETA + Water LEFT_TO_RIGHT 1.14.14.1 false 1.14.14.1 11H-14,15-EETA + Oxygen → 11,14,15-THETA + Water LEFT_TO_RIGHT 1.14.14.1 false 1.14.14.1 15(S)-HPETE + Oxygen → 15H-11,12-EETA + Water LEFT_TO_RIGHT Reaction890 true Thromboxane B2 → 11-Dehydro-thromboxane B2 LEFT_TO_RIGHT Q16647 UniProt 1.14.14.1 false 1.14.14.1 15(S)-HPETE + Oxygen → 11H-14,15-EETA + Water LEFT_TO_RIGHT Carbonyl reductase [NADPH] 1 11,12-Epoxyeicosatrienoic acid Prostamide/prostaglandin F synthase 1.0 1.0 2.0 C8H9NO2 Acetaminophen 151.06332 54397-83-0 CAS C20H32O3 5,6-Epoxy-8,11,14-eicosatrienoic acid 320.23514 C21H30N7O17P3 NADPH 745.0911 C21H29N7O17P3 NADP 744.08325 1.0 CHEBI:34162 ChEBI CHEBI:15647 ChEBI CHEBI:16978 ChEBI 24766559 ChemSpider CHEBI:15646 ChEBI 5-KETE ReactionCatalysis191 ACTIVATION ReactionCatalysis192 ACTIVATION SMILES CCCCC[C@H](O)\C=C\[C@H]1C=CC(=O)[C@@H]1C\C=C/CCCC(O)=O 4444074 ChemSpider 1.0 Prostaglandin J2 Prostaglandin E2 HMDB0000217 HMDB 1.0 Prostaglandin A2 213382-49-1 CAS CHEBI:15651 ChEBI Oxygen ReactionCatalysis188 ACTIVATION CHEBI:34151 ChEBI ReactionCatalysis187 ACTIVATION Arachidonate 15-lipoxygenase Arachidonate 12-lipoxygenase, 12S-type CHEBI:34157 ChEBI Arachidonate 15-lipoxygenase B Prostaglandin G/H synthase 1 Prostaglandin G/H synthase 2 Arachidonate 5-lipoxygenase SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O HMDB0000221 HMDB HMDB0002886 HMDB Arachidonate 12-lipoxygenase, 12R-type SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O SMILES CCCCC\C=C/C\C=C/C\C=C/CC1OC1CCCC(O)=O C20H32O4 15H-11,12-EETA 336.23007 SMILES CC(=O)NC1=CC=C(O)C=C1 5,6-Epoxytetraene GLT BioCyc 53-57-6 CAS 1.0 Oxygen 4444059 ChemSpider C20H32O4 12(S)-HPETE 336.23007 C20H32O4 15(S)-HPETE 336.23007 CHEBI:34146 ChEBI ReactionCatalysis73 ACTIVATION Prostaglandin-H2 D-isomerase 13345-50-1 CAS ReactionCatalysis76 ACTIVATION CHEBI:34145 ChEBI ReactionCatalysis77 ACTIVATION Prostaglandin E2 CHEBI:34144 ChEBI P23219 UniProt Delta-12-Prostaglandin J2 SMILES CCCCC[C@H](O)\C=C\[C@@H]1[C@@H](C\C=C/CCCC(O)=O)C=CC1=O C20H32O3 14,15-Epoxy-5,8,11-eicosatrienoic acid 320.23514 1.0 Prostaglandin E synthase Cytochrome P450 2B6 126873-49-2 CAS 14,15-Epoxy-5,8,11-eicosatrienoic acid C20H32O5 Prostaglandin I2 352.22498 HMDB0011137 HMDB HMDB0011136 HMDB 405289 ChemSpider HMDB0011135 HMDB HMDB0011134 HMDB O15296 UniProt C20H30O3 Leukotriene A4 318.21948 1.0 54397-85-2 CAS HMDB0001335 HMDB HMDB0001337 HMDB CHEBI:15627 ChEBI CHEBI:15626 ChEBI CHEBI:15628 ChEBI 98462-03-4 CAS 1.0 HMDB0003080 HMDB Endoplasmic Reticulum Endoplasmic Reticulum Membrane SMILES [H][C@@](CCCCC)(OO)\C=C\[C@@]1([H])[C@@]2([H])C[C@]([H])(OO2)[C@]1([H])C\C=C/CCCC(O)=O C20H34O5 11,12,15-THETA 354.24063 C20H32O4 5-HPETE 336.23007 CHEBI:46195 ChEBI C20H32O3 19(S)-HETE 320.23514 5255796 PubChem-compound C20H32O3 5-HETE 320.23514 C20H32O4 12(R)-HPETE 336.23007 C20H34O5 11-Epi-PGF2a 354.24063 1.0 C20H32O3 11,12-Epoxyeicosatrienoic acid 320.23514 C20H32O3 8-HETE 320.23514 Glutathione peroxidase 1 C20H32O3 16(R)-HETE 320.23514 C20H30O4 5,6-Epoxytetraene 334.21442 C20H32O5 Prostaglandin D2 352.22498 4470730 ChemSpider C20H30O4 Prostaglandin-c2 334.21442 C20H32O3 12(S)-HETE 320.23514 53480669 PubChem-compound 1.0 C20H32O3 12(R)-HETE 320.23514 1.0 SMILES CCCCC[C@H](O)\C=C\[C@H]1OC(O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O 1.0 Arachidonate 12-lipoxygenase, 12S-type Cytoplasm C20H32O4 11H-14,15-EETA 336.23007 C20H34O5 11,14,15-THETA 354.24063 10128355 ChemSpider NADPH 10128354 ChemSpider C20H32O4 8(S)-HPETE 336.23007 10128353 ChemSpider 4444411 ChemSpider Cytochrome P450 2C8 4444412 ChemSpider SMILES CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC(O)=O CHEBI:34185 ChEBI HMDB0060095 HMDB Homo sapiens Arachidonate 12-lipoxygenase, 12R-type O2 Oxygen 31.98983 C20H28O3 15-Deoxy-d-12,14-PGJ2 316.20386 C20H32O5 Prostaglandin H2 352.22498 P78329 UniProt Arachidonate 15-lipoxygenase B P18054 UniProt 4444415 ChemSpider 4444416 ChemSpider 4444400 ChemSpider 4444401 ChemSpider CHEBI:17858 ChEBI HMDB0005050 HMDB CHEBI:28728 ChEBI 107873 PubChem-compound 15H-11,12-EETA C20H40 8-Isoprostane 280.313 CHEBI:27647 ChEBI 4444407 ChemSpider 4444408 ChemSpider 4444403 ChemSpider 4444405 ChemSpider 4444406 ChemSpider 4445566 ChemSpider C00639 KEGG Compound 1.0 Thromboxane B2 5-HETE 1.0 Leukotriene-B(4) omega-hydroxylase 2 P16050 UniProt 5280724 PubChem-compound 15(S)-HETE CHEBI:63970 ChEBI Q16873 UniProt 12(S)-HPETE 8(S)-HPETE 5886 PubChem-compound C20H30O3 12-KETE 318.21948 1.0 1.0 C14807 KEGG Compound CHEBI:63969 ChEBI CHEBI:63966 ChEBI Leukotriene C4 HMDB0005079 HMDB P05181 UniProt 41598-07-6 CAS 81276-02-0 CAS C14815 KEGG Compound 5.3.99.4 false 5.3.99.4 Prostaglandin H2 → Prostaglandin I2 LEFT_TO_RIGHT 5.3.99.3 false 5.3.99.3 Prostaglandin H2 → Prostaglandin E2 LEFT_TO_RIGHT 1.0 C14814 KEGG Compound P42330 UniProt C14813 KEGG Compound C14812 KEGG Compound 1.0 Prostaglandin H2 Prostaglandin E synthase 1.14.99.1 false 1.14.99.1 Arachidonic acid + 2 Oxygen → Prostaglandin G2 LEFT_TO_RIGHT 5.3.99.2 false 5.3.99.2 Prostaglandin H2 → Prostaglandin D2 LEFT_TO_RIGHT CHEBI:63974 ChEBI 1.11.1.20 false 1.11.1.20 Prostaglandin H2 → Prostaglandin F2a LEFT_TO_RIGHT 5280745 PubChem-compound 20-OH-LTB4 BioCyc NADP C00427 KEGG Compound 1.0 1.0 SMILES NC(CCC(=O)NC(CSSCC(NC(=O)CCC(N)C(O)=O)C(=O)NCC(O)=O)C(=O)NCC(O)=O)C(O)=O 5280733 PubChem-compound C14823 KEGG Compound 10128338 ChemSpider Arachidonate 5-lipoxygenase 10128337 ChemSpider C14822 KEGG Compound 2,3-Dinor-8iso prostaglandin F2alpha