Transport1212
false
Thyroxine (→) Transport: Homo sapiens, Cell, Endocytic Vesicle to Homo sapiens, Cell, Cytosol
LEFT_TO_RIGHT
Transport1214
false
Thyroxine (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Exocytic Vesicle
LEFT_TO_RIGHT
7722-84-1
CAS
28015
ChemSpider
923
PubChem-compound
937
ChemSpider
GO:0030139
GENE ONTOLOGY
Transport1216
false
Liothyronine (→) Transport: Homo sapiens, Cell, Exocytic Vesicle to Homo sapiens, Cell, Extracellular Space
LEFT_TO_RIGHT
20461-54-5
CAS
Transport1215
false
Thyroxine (→) Transport: Homo sapiens, Cell, Exocytic Vesicle to Homo sapiens, Cell, Extracellular Space
LEFT_TO_RIGHT
25201348
PubChem-compound
P04839
UniProt
1.0
HMDB0003125
HMDB
SMILES
OO
SMILES
O
GO:0070382
GENE ONTOLOGY
Thyroid peroxidase
L-THYROXINE
BioCyc
1.0
Thyroid Hormone Synthesis
SMILES
[Na+]
NADPH oxidase 4
CHEBI:16382
ChEBI
Transport249
false
Iodide (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space
LEFT_TO_RIGHT
Thyroid peroxidase
Transport248
false
Sodium (→), Iodide (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Cell, Cytosol
LEFT_TO_RIGHT
1.0
Transport255
false
[thyroglobulin]-thyroxine (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol
LEFT_TO_RIGHT
Transport254
false
[thyroglobulin]-3,5,3'-triiodo-L-thyronine (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol
LEFT_TO_RIGHT
Endocytic Vesicle
P07202
UniProt
1.0
GO:0005829
GENE ONTOLOGY
TransportCatalysis215
ACTIVATION
NADPH oxidase 4
TransportCatalysis214
ACTIVATION
1.0
Cytochrome b-245 heavy chain
5614
ChemSpider
30165
PubChem-compound
CHEBI:16240
ChEBI
Liothyronine
1.0
Iodide
Q9HBY0
UniProt
Transport1539
false
Liothyronine (→) Transport: Homo sapiens, Cell, Endocytic Vesicle to Homo sapiens, Cell, Cytosol
LEFT_TO_RIGHT
Cytosol
Thyroxine
1.0
1.0
Sodium/iodide cotransporter
Liothyronine
C00001
KEGG Compound
C01330
KEGG Compound
5920
PubChem-compound
1.11.1.8
false
1.11.1.8
Hydrogen peroxide + Iodide + [thyroglobulin]-3-iodo-L-tyrosine → 2 Water + [thyroglobulin]-3,5-diiodo-L-tyrosine
LEFT_TO_RIGHT
HMDB0000588
HMDB
1.0
GO:0005634
GENE ONTOLOGY
Iodide
Dual oxidase 2
Reaction2258
false
[thyroglobulin]-3,5,3'-triiodo-L-thyronine → Liothyronine + Thyroglobulin
LEFT_TO_RIGHT
Reaction2259
false
[thyroglobulin]-thyroxine → Thyroglobulin + Thyroxine
LEFT_TO_RIGHT
1.11.1.8
false
1.11.1.8
Hydrogen peroxide + 2 [thyroglobulin]-3,5-diiodo-L-tyrosine → 2 Water + [thyroglobulin]-3,5,3'-triiodo-L-thyronine + [thyroglobulin]-aminoacrylate
LEFT_TO_RIGHT
1.11.1.8
false
1.11.1.8
Hydrogen peroxide + Iodide + [thyroglobulin]-3,5,3'-triiodo-L-thyronine → 2 Water + [thyroglobulin]-thyroxine
LEFT_TO_RIGHT
Transport1552
false
Thyroglobulin with L-Tyrosine (↔) Transport: Homo sapiens, Cell, Endocytic Vesicle to Homo sapiens, Cell, Cytosol
LEFT_TO_RIGHT
ReactionCatalysis2190
ACTIVATION
Q9NRD8
UniProt
LIOTHYRONINE
BioCyc
Q9NRD9
UniProt
1.0
C15H11I4NO4
Thyroxine
776.6867
Transport1550
false
Thyroglobulin with L-Tyrosine (←) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Exocytic Vesicle
LEFT_TO_RIGHT
SubPathwayInteraction816
SubPathwayReaction
SubPathway816Reaction
Extracellular Space
CHEBI:18332
ChEBI
2.0
SMILES
[I-]
1.0
Transport1544
false
Thyroglobulin with L-Tyrosine (←) Transport: Homo sapiens, Cell, Endocytic Vesicle to Homo sapiens, Cell, Cytosol
LEFT_TO_RIGHT
Cytochrome b-245 light chain
Dual oxidase 2
Transport1540
false
Liothyronine (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Exocytic Vesicle
LEFT_TO_RIGHT
NADPH oxidase 3
Transport1549
false
Thyroglobulin with L-Tyrosine (←) Transport: Homo sapiens, Cell, Exocytic Vesicle to Homo sapiens, Cell, Nucleus
LEFT_TO_RIGHT
Pendrin
C00027
KEGG Compound
1.0
C15H12I3NO4
Liothyronine
650.79004
GO:0005615
GENE ONTOLOGY
HMDB0000248
HMDB
C00708
KEGG Compound
CHEBI:29101
ChEBI
Thyroglobulin
Cytochrome b-245 heavy chain
HMDB0012238
HMDB
Thyroid peroxidase
899
ChemSpider
Sodium
1.0
Thyroglobulin
SubPathwayOutput
HYDROGEN-PEROXIDE
BioCyc
1.0
1.0
PW000693
PathWhiz
CPD-387
BioCyc
Sodium/iodide cotransporter
Thyroglobulin
Cytochrome b-245 light chain
Dual oxidase 1
C02465
KEGG Compound
HMDB0000265
HMDB
763
ChemSpider
1.0
1.11.1.8
false
1.11.1.8
Hydrogen peroxide + Iodide + Thyroglobulin with L-Tyrosine → Water + [thyroglobulin]-3-iodo-L-tyrosine
LEFT_TO_RIGHT
2.0
SMILES
N[C@@H](CC1=CC(I)=C(OC2=CC(I)=C(O)C=C2)C(I)=C1)C(O)=O
17341-25-2
CAS
784
PubChem-compound
CHEBI:18258
ChEBI
Thyroglobulin secretion
SubPathway
Homo sapiens
1.0
7732-18-5
CAS
1.0
6893-02-3
CAS
Exocytic Vesicle
1.0
2.0
Liothyronine
C01829
KEGG Compound
Water
SMP0000716
SMPDB
1.0
F5H104
UniProt
SMILES
N[C@@H](CC1=CC(I)=C(OC2=CC(I)=C(O)C(I)=C2)C(I)=C1)C(O)=O
1.0
9606
TAXONOMY
962
PubChem-compound
1.0
Thyroglobulin
Pendrin
Sodium
Hydrogen peroxide
1.0
Thyroxine
I
Iodide
126.904465
Dual oxidase 1
1.0
HMDB0002111
HMDB
CHEBI:15377
ChEBI
Q92911
UniProt
1.0
P01266
UniProt
Liothyronine
Thyroglobulin
Thyroxine
Q9NPH5
UniProt
51-48-9
CAS
H2O2
Hydrogen peroxide
34.005478
H2O
Water
18.010565
Iodide
NADPH oxidase 3
5707
ChemSpider
1.0
Thyroxine
Nucleus
Thyroglobulin
Na
Sodium
22.989769
P13498
UniProt
ReactionCatalysis2121
ACTIVATION
ReactionCatalysis2120
ACTIVATION
ReactionCatalysis2122
ACTIVATION