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HMDB00254 HMDB 454-29-5 CAS 17215925 ChemSpider 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 439161 PubChem-compound SMILES N[C@@H](CS)C(O)=O Methionine synthase CYS BioCyc Cystathionine gamma-synthase C30H35N9O12 N5-methyl--tetrahydropteroyl tri-L-glutamate 713.24274 Succinic acid C05330 KEGG Compound SMILES N[C@@H](CCO)C(O)=O CHEBI:58207 ChEBI CHEBI:58020 ChEBI HMDB12249 HMDB 1.0 SMP00834 SMPDB Homoserine O-succinyltransferase SMILES C[S+](C)CCC(N)C(O)=O C00441 KEGG Compound CHEBI:17230 ChEBI 6137 PubChem-compound Homocysteine S-methyltransferase 6816 PubChem-compound 2.0 49791978 PubChem-compound SMILES NC(=C)C([O-])=O 53-59-8 CAS SMILES N[C@@H](CCOC(=O)CCC(O)=O)C(O)=O CHEBI:15380 ChEBI SMILES [H][C@@](CCC([O-])=N[C@@]([H])(CCC([O-])=N[C@@]([H])(CCC([O-])=O)C(O)=O)C(O)=O)(NC(=O)C1=CC=C(NC[C@@]2([H])CNC3=C(N2C)C([O-])=NC(=N)N3)C=C1)C(O)=O L-Methionine C25H40N7O19P3S Succinyl-CoA 867.1312 1038 PubChem-compound CHEBI:17561 ChEBI SMILES CSCC[C@H](N)C(O)=O CHEBI:16474 ChEBI P00935 UniProt GO:0005829 GENE ONTOLOGY 1.0 C04144 KEGG Compound HMDB59597 HMDB L-CYSTATHIONINE BioCyc P23256 UniProt 1.0 1.0 2.1.1.10 false 2.1.1.10 Homocysteine + S-Methylmethionine ↔ Hydrogen Ion + 2 L-Methionine REVERSIBLE Bifunctional aspartokinase/homoserine dehydrogenase 2 Bifunctional aspartokinase/homoserine dehydrogenase 1 2.7.2.4 false 2.7.2.4 Hydrogen Ion + L-Aspartate-semialdehyde + NADPH → L-Homoserine + NADP LEFT_TO_RIGHT 1.0 NADPH 5862 PubChem-compound 1010 ChemSpider SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCS NADP 13065-25-3 CAS P25665 UniProt C21H30N7O17P3 NADPH 745.0911 CHEBI:58140 ChEBI C21H29N7O17P3 NADP 744.08325 SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(O)=O HMDB00574 HMDB 1.0 SubPathwayInteraction1649 SubPathway1649Reaction SubPathwayReaction P07623 UniProt HMDB01423 HMDB HMDB00696 HMDB NADPH BioCyc Hydrogen Ion C8H13NO6 O-succinyl-L-homoserine 219.07428 HMDB00217 HMDB C3H4NO2 2-aminoprop-2-enoate 86.02475 672-15-1 CAS Cytosol 2.0 C30H35N9O12 N5-methyl--tetrahydropteroyl tri-L-glutamate 713.24274 SUC BioCyc ReactionCatalysis2853 ACTIVATION ReactionCatalysis2855 ACTIVATION ReactionCatalysis2854 ACTIVATION ReactionCatalysis2857 ACTIVATION ReactionCatalysis2856 ACTIVATION ReactionCatalysis2859 ACTIVATION ReactionCatalysis2858 ACTIVATION HMDB38670 HMDB 1.0 HMDB00221 HMDB PW000771 PathWhiz Cystathionine gamma-synthase C00006 KEGG Compound P00561 UniProt CHEBI:18009 ChEBI Hydrogen Ion 16722112 PubChem-compound P00562 UniProt C29H37N9O12 Tetrahydropteroyltri-L-glutamate 703.25616 C00005 KEGG Compound SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O 445 ChemSpider SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O 53-57-6 CAS CHEBI:15741 ChEBI 1.0 Homocysteine S-methyltransferase CHEBI:17482 ChEBI 1.0 C00010 KEGG Compound Tetrahydropteroyltri-L-glutamate 1.0 1110 PubChem-compound 1.0 NAD(P) BioCyc GO:0005620 GENE ONTOLOGY SMILES NC(CCS)C(O)=O C4H6O4 Succinic acid 118.02661 12126 ChemSpider H Hydrogen Ion 1.007825 388307 ChemSpider TransportCatalysis392 ACTIVATION 458 PubChem-compound CPD-1302 BioCyc CHEBI:16160 ChEBI C00263 KEGG Compound MET BioCyc N5-methyl--tetrahydropteroyl tri-L-glutamate 2.0 5653 ChemSpider 56-88-2 CAS 1.0 L-Cystathionine 1.0 SMILES N[C@@H](CC=O)C(O)=O C7H14N2O4S L-Cystathionine 222.06743 1.0 ReactionCatalysis2884 ACTIVATION S-Methylmethionine C5H11NO2S L-Methionine 149.05106 1.0 52-90-4 CAS HMDB00099 HMDB L-Homoserine CHEBI:1146900 ChEBI SMILES OC(=O)CCC(O)=O Protein malY CHEBI:15699 ChEBI CO-A BioCyc C00042 KEGG Compound 5675 ChemSpider Uncharacterized protein YbjE 1078 ChemSpider L-Cysteine 1.0 Coenzyme A 1.0 604-98-8 CAS C21H36N7O16P3S Coenzyme A 767.11523 2.0 SMILES N[C@@H](CCSC[C@H](N)C(O)=O)C(O)=O SMP00794 SMPDB 4.0 aspartate kinase / homoserine dehydrogenase 6557 ChemSpider Cystathionine beta-lyase metC 12647 PubChem-compound 17625690 ChemSpider 2.3.1.46 false 2.3.1.46 L-Homoserine + Succinyl-CoA → Coenzyme A + O-succinyl-L-homoserine LEFT_TO_RIGHT 63-68-3 CAS 5907 ChemSpider CHEBI:16643 ChEBI 1.0 N5-methyl--tetrahydropteroyl tri-L-glutamate HMDB12290 HMDB Methionine synthase 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase O-succinyl-L-homoserine 2-aminoprop-2-enoate L-Methionine 1.0 C00073 KEGG Compound Lysine Biosynthesis SubPathway 4.0 1.0 388392 ChemSpider CHEBI:17420 ChEBI L-Methionine Homoserine O-succinyltransferase HMDB01022 HMDB 439235 PubChem-compound C00080 KEGG Compound 110-15-6 CAS Periplasmic Space 4.0 15106-57-7 CAS Uncharacterized protein YbjE PW000814 PathWhiz C4H9NO2S Homocysteine 135.0354 ReactionCatalysis5840 ACTIVATION CHEBI:15378 ChEBI SMILES [H+] HMDB00742 HMDB Succinyl-CoA Protein malY 5886 PubChem-compound HOMO-CYS BioCyc 2.1.1.13 false 2.1.1.13 Homocysteine + N5-methyl--tetrahydropteroyl tri-L-glutamate → L-Methionine + Tetrahydropteroyltri-L-glutamate LEFT_TO_RIGHT C00091 KEGG Compound 2.1.1.13 false 2.1.1.13 N5-methyl--tetrahydropteroyl tri-L-glutamate + Homocysteine → L-Methionine + Tetrahydropteroyltri-L-glutamate LEFT_TO_RIGHT P75826 UniProt 2.5.1.48 false 2.5.1.48 L-Cysteine + O-succinyl-L-homoserine → Hydrogen Ion + L-Cystathionine + Succinic acid LEFT_TO_RIGHT 4.4.1.8 false 4.4.1.8 L-Cystathionine → 2-aminoprop-2-enoate + Homocysteine + Hydrogen Ion LEFT_TO_RIGHT L-Aspartate-semialdehyde C4H7NO3 L-Aspartate-semialdehyde 117.042595 C3H7NO2S L-Cysteine 121.01975 25243997 PubChem-compound 388372 ChemSpider SMILES CN1C(CNC2=CC=C(C=C2)C(=O)NC(CCC(=O)NC(CCC(=O)NC(CCC([O-])=O)C([O-])=O)C([O-])=O)C([O-])=O)CNC2=C1C(=O)NC(N)=N2 C00097 KEGG Compound Bifunctional aspartokinase/homoserine dehydrogenase 1 757 ChemSpider P13009 UniProt Bifunctional aspartokinase/homoserine dehydrogenase 2 L-ASPARTATE-SEMIALDEHYDE BioCyc 22833512 PubChem-compound HOMO-SER BioCyc Homocysteine CHEBI:18051 ChEBI 3-METHYLBENZYLSUCCINYL-COA BioCyc C4H9NO3 L-Homoserine 119.05824 Transport457 false L-Methionine (→), Hydrogen Ion (←) Transport: Escherichia coli, Cytosol to Escherichia coli, Periplasmic Space LEFT_TO_RIGHT 1.0 C6H14NO2S S-Methylmethionine 164.07452 Cystathionine beta-lyase metC P06721 UniProt Hydrogen Ion SMILES NC1=NC(=O)C2=C(NC[C@H](CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)N[C@@H](CCC(=O)N[C@@H](CCC(O)=O)C(O)=O)C(O)=O)C(O)=O)N2)N1 O-succinylhomoserine(thiol)-lyase / O-succinylhomoserine lyase homoserine O-succinyltransferase C02291 KEGG Compound 1.0 85-61-0 CAS cystathionine-β-lyase / L-cysteine desulfhydrase methionine biosynthesis bifunctional β-cystathionase, PLP-dependent and regulator of maltose regulon HMDB00719 HMDB Q47690 UniProt Uncharacterized protein YbjE Homoserine O- succinyltransferase Cystathionine gamma-synthase Cystathionine beta-lyase metC Protein malY 5- methyltetrahydropteroyltriglutamate- -homocysteine methyltransferase Bifunctional aspartokinase/homoserine dehydrogenase 2 Bifunctional aspartokinase/homoserine dehydrogenase 1 Methionine synthase Homocysteine S- methyltransferase L-Methionine L-Methionine H + H + L-Homoserine Succinyl-CoA CoA O-succinyl-L- homoserine L-Cysteine Succinic acid H + L-Cystathionine H + Homocysteine 2-aminoprop- 2-enoate N5-methyl-- tetrahydropteroyl tri-L-glutamate L-Methionine Tetrahydropteroyltri- L-glutamate L-Aspartate- semialdehyde H + NADPH NADP N5-methyl-- tetrahydropteroyl tri-L-glutamate Tetrahydropteroyltri- L-glutamate L-Methionine S- Methylmethionine L-Methionine H + Lysine Biosynthesis Methionine synthase
HMDB00254 HMDB 454-29-5 CAS 17215925 ChemSpider 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase 439161 PubChem-compound SMILES N[C@@H](CS)C(O)=O Methionine synthase CYS BioCyc Cystathionine gamma-synthase C30H35N9O12 N5-methyl--tetrahydropteroyl tri-L-glutamate 713.24274 Succinic acid C05330 KEGG Compound SMILES N[C@@H](CCO)C(O)=O CHEBI:58207 ChEBI CHEBI:58020 ChEBI HMDB12249 HMDB 1.0 http://identifiers.org/smpdb/SMP00834 SMPDB Homoserine O-succinyltransferase SMILES C[S+](C)CCC(N)C(O)=O C00441 KEGG Compound CHEBI:17230 ChEBI 6137 PubChem-compound Homocysteine S-methyltransferase 6816 PubChem-compound 2.0 49791978 PubChem-compound SMILES NC(=C)C([O-])=O 53-59-8 CAS SMILES N[C@@H](CCOC(=O)CCC(O)=O)C(O)=O CHEBI:15380 ChEBI SMILES [H][C@@](CCC([O-])=N[C@@]([H])(CCC([O-])=N[C@@]([H])(CCC([O-])=O)C(O)=O)C(O)=O)(NC(=O)C1=CC=C(NC[C@@]2([H])CNC3=C(N2C)C([O-])=NC(=N)N3)C=C1)C(O)=O L-Methionine C25H40N7O19P3S Succinyl-CoA 867.1312 1038 PubChem-compound CHEBI:17561 ChEBI SMILES CSCC[C@H](N)C(O)=O CHEBI:16474 ChEBI P00935 UniProt GO:0005829 GENE ONTOLOGY 1.0 C04144 KEGG Compound HMDB59597 HMDB L-CYSTATHIONINE BioCyc P23256 UniProt 1.0 1.0 Lysine Biosynthesis SubPathway 2.1.1.10 false 2.1.1.10 Homocysteine + S-Methylmethionine ↔ Hydrogen Ion + 2 L-Methionine REVERSIBLE Bifunctional aspartokinase/homoserine dehydrogenase 2 Bifunctional aspartokinase/homoserine dehydrogenase 1 2.7.2.4 false 2.7.2.4 Hydrogen Ion + L-Aspartate-semialdehyde + NADPH → L-Homoserine + NADP LEFT_TO_RIGHT 1.0 NADPH 5862 PubChem-compound 1010 ChemSpider SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCS NADP 13065-25-3 CAS P25665 UniProt C21H30N7O17P3 NADPH 745.0911 CHEBI:58140 ChEBI C21H29N7O17P3 NADP 744.08325 SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(O)=O HMDB00574 HMDB 1.0 SubPathwayInteraction1649 SubPathway1649Reaction SubPathwayReaction P07623 UniProt HMDB01423 HMDB HMDB00696 HMDB NADPH BioCyc Hydrogen Ion C8H13NO6 O-succinyl-L-homoserine 219.07428 HMDB00217 HMDB C3H4NO2 2-aminoprop-2-enoate 86.02475 672-15-1 CAS Cytosol 2.0 C30H35N9O12 N5-methyl--tetrahydropteroyl tri-L-glutamate 713.24274 SUC BioCyc ReactionCatalysis2853 ACTIVATION ReactionCatalysis2855 ACTIVATION ReactionCatalysis2854 ACTIVATION ReactionCatalysis2857 ACTIVATION ReactionCatalysis2856 ACTIVATION ReactionCatalysis2859 ACTIVATION ReactionCatalysis2858 ACTIVATION HMDB38670 HMDB 1.0 HMDB00221 HMDB PW000771 PathWhiz Cystathionine gamma-synthase C00006 KEGG Compound P00561 UniProt CHEBI:18009 ChEBI Hydrogen Ion 16722112 PubChem-compound P00562 UniProt C29H37N9O12 Tetrahydropteroyltri-L-glutamate 703.25616 C00005 KEGG Compound SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O 445 ChemSpider SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O 53-57-6 CAS CHEBI:15741 ChEBI 1.0 Homocysteine S-methyltransferase CHEBI:17482 ChEBI 1.0 C00010 KEGG Compound Tetrahydropteroyltri-L-glutamate 1.0 1110 PubChem-compound 1.0 NAD(P) BioCyc GO:0005620 GENE ONTOLOGY SMILES NC(CCS)C(O)=O C4H6O4 Succinic acid 118.02661 12126 ChemSpider H Hydrogen Ion 1.007825 388307 ChemSpider TransportCatalysis392 ACTIVATION 458 PubChem-compound CPD-1302 BioCyc CHEBI:16160 ChEBI C00263 KEGG Compound MET BioCyc N5-methyl--tetrahydropteroyl tri-L-glutamate 2.0 5653 ChemSpider 56-88-2 CAS 1.0 L-Cystathionine 1.0 SMILES N[C@@H](CC=O)C(O)=O C7H14N2O4S L-Cystathionine 222.06743 1.0 ReactionCatalysis2884 ACTIVATION S-Methylmethionine C5H11NO2S L-Methionine 149.05106 1.0 52-90-4 CAS HMDB00099 HMDB L-Homoserine CHEBI:1146900 ChEBI SMILES OC(=O)CCC(O)=O Protein malY CHEBI:15699 ChEBI CO-A BioCyc C00042 KEGG Compound 5675 ChemSpider Uncharacterized protein YbjE 1078 ChemSpider L-Cysteine 1.0 Coenzyme A 1.0 604-98-8 CAS C21H36N7O16P3S Coenzyme A 767.11523 2.0 SMILES N[C@@H](CCSC[C@H](N)C(O)=O)C(O)=O http://identifiers.org/smpdb/SMP00794 SMPDB 4.0 aspartate kinase / homoserine dehydrogenase 6557 ChemSpider Cystathionine beta-lyase metC 12647 PubChem-compound 17625690 ChemSpider 2.3.1.46 false 2.3.1.46 L-Homoserine + Succinyl-CoA → Coenzyme A + O-succinyl-L-homoserine LEFT_TO_RIGHT 63-68-3 CAS 5907 ChemSpider CHEBI:16643 ChEBI 1.0 N5-methyl--tetrahydropteroyl tri-L-glutamate HMDB12290 HMDB Methionine synthase 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase O-succinyl-L-homoserine 2-aminoprop-2-enoate L-Methionine 1.0 C00073 KEGG Compound 4.0 1.0 388392 ChemSpider CHEBI:17420 ChEBI L-Methionine Homoserine O-succinyltransferase HMDB01022 HMDB 439235 PubChem-compound C00080 KEGG Compound 110-15-6 CAS Periplasmic Space 4.0 15106-57-7 CAS Uncharacterized protein YbjE PW000814 PathWhiz C4H9NO2S Homocysteine 135.0354 ReactionCatalysis5840 ACTIVATION CHEBI:15378 ChEBI SMILES [H+] HMDB00742 HMDB Succinyl-CoA Protein malY 5886 PubChem-compound HOMO-CYS BioCyc 2.1.1.13 false 2.1.1.13 Homocysteine + N5-methyl--tetrahydropteroyl tri-L-glutamate → L-Methionine + Tetrahydropteroyltri-L-glutamate LEFT_TO_RIGHT C00091 KEGG Compound 2.1.1.13 false 2.1.1.13 N5-methyl--tetrahydropteroyl tri-L-glutamate + Homocysteine → L-Methionine + Tetrahydropteroyltri-L-glutamate LEFT_TO_RIGHT P75826 UniProt 2.5.1.48 false 2.5.1.48 L-Cysteine + O-succinyl-L-homoserine → Hydrogen Ion + L-Cystathionine + Succinic acid LEFT_TO_RIGHT 4.4.1.8 false 4.4.1.8 L-Cystathionine → 2-aminoprop-2-enoate + Homocysteine + Hydrogen Ion LEFT_TO_RIGHT L-Aspartate-semialdehyde C4H7NO3 L-Aspartate-semialdehyde 117.042595 C3H7NO2S L-Cysteine 121.01975 25243997 PubChem-compound 388372 ChemSpider SMILES CN1C(CNC2=CC=C(C=C2)C(=O)NC(CCC(=O)NC(CCC(=O)NC(CCC([O-])=O)C([O-])=O)C([O-])=O)C([O-])=O)CNC2=C1C(=O)NC(N)=N2 C00097 KEGG Compound Bifunctional aspartokinase/homoserine dehydrogenase 1 757 ChemSpider P13009 UniProt Bifunctional aspartokinase/homoserine dehydrogenase 2 L-ASPARTATE-SEMIALDEHYDE BioCyc 22833512 PubChem-compound HOMO-SER BioCyc Homocysteine CHEBI:18051 ChEBI 3-METHYLBENZYLSUCCINYL-COA BioCyc C4H9NO3 L-Homoserine 119.05824 Transport457 false L-Methionine (→), Hydrogen Ion (←) Transport: Escherichia coli, Cytosol to Escherichia coli, Periplasmic Space LEFT_TO_RIGHT 1.0 C6H14NO2S S-Methylmethionine 164.07452 Cystathionine beta-lyase metC P06721 UniProt Hydrogen Ion SMILES NC1=NC(=O)C2=C(NC[C@H](CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)N[C@@H](CCC(=O)N[C@@H](CCC(O)=O)C(O)=O)C(O)=O)C(O)=O)N2)N1 O-succinylhomoserine(thiol)-lyase / O-succinylhomoserine lyase homoserine O-succinyltransferase C02291 KEGG Compound 1.0 85-61-0 CAS cystathionine-β-lyase / L-cysteine desulfhydrase methionine biosynthesis bifunctional β-cystathionase, PLP-dependent and regulator of maltose regulon HMDB00719 HMDB Q47690 UniProt ybjE metA metB metC malY metE metL thrA metH mmuM L-Methionine L-Methionine Hydrogen Ion Hydrogen Ion L-Homoserine Succinyl-CoA Coenzyme A O-succinyl-L- homoserine L-Cysteine Succinic acid Hydrogen Ion L-Cystathionine Hydrogen Ion Homocysteine 2-aminoprop- 2-enoate N5-methyl-- tetrahydropteroyl tri-L-glutamate L-Methionine Tetrahydropteroyltri- L-glutamate L-Aspartate- semialdehyde Hydrogen Ion NADPH NADP N5-methyl-- tetrahydropteroyl tri-L-glutamate Tetrahydropteroyltri- L-glutamate L-Methionine S- Methylmethionine L-Methionine Hydrogen Ion Lysine Biosynthesis metH