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CHEBI:16015 ChEBI C23H33N4O20P2 UDP-N-Acetylmuramyl-L-Ala 747.11633 Transport351 false L-Alanine (→), Hydrogen Ion (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT 388356 ChemSpider 2.0 6022 PubChem-compound HMDB01469 HMDB Phosphocarrier protein HPr 923 PubChem-compound C23H38N7O17P3S Acetyl-CoA 809.1258 ReactionCoupledTransportCatalysis178 ACTIVATION HMDB00250 HMDB HMDB01341 HMDB 1.0 1.3.1.98 false 1.3.1.98 Hydrogen ion + NADPH + UDP-N-acetyl-α-D-glucosamine-enolpyruvate → NADP + UDP-N-acetyl-α-D-muramate LEFT_TO_RIGHT 2.5.1.7 false 2.5.1.7 Phosphoenolpyruvic acid + Uridine diphosphate-N-acetylglucosamine → Phosphate + UDP-N-acetyl-α-D-glucosamine-enolpyruvate LEFT_TO_RIGHT Reaction3314 false Hydrogen Ion + N-Acetyl-glucosamine 1-phosphate + Uridine triphosphate → Pyrophosphate + Uridine diphosphate-N-acetylglucosamine LEFT_TO_RIGHT 2.7.7.23 false 2.7.7.23 Acetyl-CoA + Glucosamine-1P → Coenzyme A + Hydrogen Ion + N-Acetyl-glucosamine 1-phosphate LEFT_TO_RIGHT 1.0 C94H156N8O26P2 N-Acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine 1875.0605 5.4.2.10 false 5.4.2.10 Glucosamine 6-phosphate ↔ Glucosamine-1P REVERSIBLE 6133 PubChem-compound Glucosamine 6-phosphate H Hydrogen ion 1.007825 HMDB00148 HMDB Peptidoglycan synthase ftsI UDP-N-acetylmuramoylalanine--D-glutamate ligase ATP BioCyc CHEBI:16264 ChEBI PTS system mannose-specific EIIAB component Bifunctional protein glmU HMDB00263 HMDB 1.0 559142 ChemSpider 2.6.1.16 false 2.6.1.16 L-Glutamine + β-D-fructofuranose 6-phosphate ↔ Glucosamine 6-phosphate + L-Glutamic acid REVERSIBLE HMDB01109 HMDB CHEBI:42560 ChEBI C87H143N7O23P2 N-Acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 1715.9711 ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine Transport369 false L-Glutamic acid (→), Sodium (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT N-Acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 2.0 P0AD65 UniProt C00217 KEGG Compound P0AA04 UniProt P0AD68 UniProt 31867-59-1 CAS 5746 ChemSpider 1.0 D-Alanine HMDB01206 HMDB Transport371 false Hydrogen Ion (→), L-Glutamic acid (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT 5742 ChemSpider CHEBI:16474 ChEBI 6.3.2.13 false 6.3.2.13 Adenosine triphosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + meso-diaminopimelate → Adenosine diphosphate + Hydrogen Ion + Phosphate + UDP-N-Acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminopimelate LEFT_TO_RIGHT HMDB59597 HMDB Penicillin-binding protein 1A Penicillin-binding protein 1B 8140645 ChemSpider Reaction3455 false a peptidoglycan dimer (meso-diaminopimelate containing) → D-Alanine + a peptidoglycan with D,D cross-links (meso-diaminopimelate containing) LEFT_TO_RIGHT C00105 KEGG Compound 6030 PubChem-compound 6031 PubChem-compound 5735 ChemSpider Acetyl-CoA D-alanine--D-alanine ligase A C6H12N2O3 D-Alanyl-D-alanine 160.0848 Proton glutamate symport protein 1010 ChemSpider UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCS Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1.0 GLUCOSAMINE-1P BioCyc 440272 PubChem-compound PPI BioCyc biosynthetic peptidoglycan transglycosylase SMILES [H]C(N)(CCCC([H])(N=C(O)CC[C@@]([H])(N=C(O)[C@]([H])(C)N=C(O)C([H])(C)O[C@@]1([H])[C@]([H])(O)[C@@]([H])(CO)O[C@]([H])(OP(O)(=O)OP(O)(=O)OC[C@@]2([H])O[C@@]([H])(N3C=CC(O)=NC3=O)[C@]([H])(O)[C@]2([H])O)[C@]1([H])N=C(C)O)C(O)=O)C(O)=O)C(O)=O SMILES OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O 138-08-9 CAS BiologicalState109 Escherichia coli, Inner Membrane 2.0 C6H14NO8P Glucosamine-1P 259.04572 1.0 HMDB01423 HMDB 1.0 C5H10N2O3 L-Glutamine 146.06914 Hydrogen Ion HMDB00217 HMDB P07862 UniProt C00352 KEGG Compound Cytosol UDP-N-acetylmuramate--L-alanine ligase β-D-fructofuranose Adenosine triphosphate Glucose-6-phosphate isomerase 1.0 1.0 2.0 C00009 KEGG Compound UDP-N-acetyl-α-D-glucosamine-enolpyruvate HMDB00221 HMDB C5H9NO4 D-Glutamic acid 147.05316 3616-42-0 CAS UDP-N-acetyl-α-D-muramate C00008 KEGG Compound HMDB01310 HMDB C00006 KEGG Compound Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutaminyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine ReactionCatalysis3271 ACTIVATION HMDB00588 HMDB 1.0 UDP-N-Acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminopimelate CHEBI:18009 ChEBI Hydrogen Ion SMILES C[C@@H](N)C(=O)N[C@H](C)C(O)=O L-ALPHA-ALANINE BioCyc Phospho-N-acetylmuramoyl-pentapeptide-transferase C01330 KEGG Compound CHEBI:18361 ChEBI 56-41-7 CAS C00005 KEGG Compound 1.0 CHEBI:18367 ChEBI SMILES CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C(C)=C/CC\C(C)=C/CC\C(C)=C/CC\C(C)=C/CC\C(C)=C/CC\C(C)=C/CC\C(C)=C/CC\C(C)=C/COP(O)(O)=O 1032 ChemSpider C00002 KEGG Compound Phosphocarrier protein HPr P0A6W3 UniProt D-serine/D-alanine/glycine transporter Phosphoglucosamine mutase HMDB01429 HMDB 1.0 ReactionCatalysis3276 ACTIVATION 1.0 CHEBI:61388 ChEBI ReactionCatalysis3277 ACTIVATION ReactionCatalysis3278 ACTIVATION Hydrogen ion C35H55N7O26P2 UDP-N-Acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminopimelate 1051.2672 C6H12O6 β-D-fructofuranose 180.06339 C20H26N3O19P2 UDP-N-acetyl-α-D-glucosamine-enolpyruvate 674.06525 ReactionCatalysis3282 ACTIVATION C20H28N3O19P2 UDP-N-acetyl-α-D-muramate 676.0809 D-Glutamic acid N-Acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine C95H157N9O27P2 Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutaminyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine 1918.0664 ReactionCatalysis3281 ACTIVATION C00133 KEGG Compound C00010 KEGG Compound C00015 KEGG Compound C6H14NO8P Glucosamine 6-phosphate 259.04572 C00013 KEGG Compound CHEBI:7125 ChEBI P17443 UniProt UDP-N-acetylglucosamine 1-carboxyvinyltransferase NAD(P) BioCyc D-GLUCOSAMINE-6-P BioCyc 562 TAXONOMY H Hydrogen Ion 1.007825 2.0 UDP-N-Acetylmuramyl-L-Ala L-Glutamine 56-65-5 CAS UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase Glucosamine-1P L-Glutamic acid 1.0 338-69-2 CAS C00025 KEGG Compound Penicillin-binding protein 1C C00024 KEGG Compound 4573916 ChemSpider 23327 PubChem-compound 1.0 CHEBI:29101 ChEBI SMILES OC[C@@]1([H])O[C@]([H])(O[C@]2([H])[C@@]([H])(CO)O[C@]([H])(OP(O)(=O)OP(O)(=O)OC\C([H])=C(\C)CC\C([H])=C(\C)CC\C([H])=C(\C)CC\C([H])=C(\C)CC\C([H])=C(\C)CC\C([H])=C(\C)CC\C([H])=C(\C)CC\C([H])=C(\C)CC\C([H])=C(/C)CC\C([H])=C(/C)CCC=C(C)C)[C@]([H])(N=C(C)[O-])[C@@]2([H])O[C@@](C)([H])C(O)=N[C@](C)([H])C(O)=N[C@]([H])(CCC([O-])=N[C@@]([H])(CCC[C@](N)([H])C(=O)O)C(O)=N[C@@](C)([H])C([O-])=N[C@@](C)([H])C(=O)O)C(=O)O)[C@]([H])(N=C(C)[O-])[C@](O)([H])[C@@]1(O)[H] 1.0 N-ACETYL-D-GLUCOSAMINE-1-P BioCyc peptidoglycan biosynthesis I 2 899 ChemSpider C03543 KEGG Compound L-Alanine C00041 KEGG Compound Glutamate racemase 1.0 SMILES [O-]P([O-])(=O)OP([O-])([O-])=O 5460362 PubChem-compound P0AF16 UniProt C00043 KEGG Compound 11953874 PubChem-compound Uridine 5'-diphosphate Mannose permease IID component Mannose permease IIC component 56-85-9 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 58-97-9 CAS 1.0 PHOSPHO-ENOL-PYRUVATE BioCyc ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine C9H14N2O12P2 Uridine 5'-diphosphate 404.0022 HMDB00538 HMDB UTP BioCyc SMILES OC(=O)C(=C)OP(O)(O)=O 17341-25-2 CAS CHEBI:70757 ChEBI 5903 ChemSpider UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase CHEBI:17047 ChEBI PW002062 PathWhiz 56-86-0 CAS Penicillin-binding protein 2 P0A749 UniProt 1.0 HMDB00641 HMDB C10H16N5O13P3 Adenosine triphosphate 506.99576 CHEBI:57791 ChEBI 445675 PubChem-compound SMILES C[C@@H](N)C(O)=O P0AER8 UniProt C00064 KEGG Compound 6866-69-9 CAS 1.0 Sodium/glutamate symport carrier protein SubPathwayInteraction3136 SubPathwayReaction SubPathway3136Reaction 3960 PubChem-compound L-Glutamic acid P0A6T1 UniProt SMILES CC(C)=CCC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\CC\C(C)=C\COP(O)(=O)OP(O)(O)=O C00074 KEGG Compound 71080 PubChem-compound Transport426 false ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine (→) Transport: Escherichia coli, Cytosol to Escherichia coli, Periplasmic Space LEFT_TO_RIGHT Transport425 false ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine (→) Transport: Escherichia coli, Cytosol to Escherichia coli, Periplasmic Space LEFT_TO_RIGHT Transport424 false D-Alanine (→), Hydrogen Ion (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT D-Alanine C3H7NO2 L-Alanine 89.047676 SMILES OCC1(O)OC(COP([O-])([O-])=O)C(O)C1O 5800 ChemSpider L-Alanine SMILES OC1OC(COP([O-])([O-])=C)C(O)C(O)C1O 58-98-0 CAS P22188 UniProt Peptidoglycan synthase ftsI C00075 KEGG Compound Sodium Phosphate SMILES CCCCCN(CCCCC)C(=O)C(CCC(O)=O)N=C(O)C1=CC(Cl)=C(Cl)C=C1 Bifunctional protein glmU C00080 KEGG Compound Periplasmic Space 9965052 PubChem-compound 1.0 1.0 UDP-N-acetylmuramoylalanine--D-glutamate ligase TransportCatalysis317 ACTIVATION 1.0 TransportCatalysis315 ACTIVATION SMILES N[C@@H](CCC(O)=O)C(O)=O 5809 ChemSpider 5808 ChemSpider CHEBI:44897 ChEBI 14265-44-2 CAS 58-64-0 CAS 2.0 52940208 PubChem-compound 25200588 PubChem-compound 1.0 P17952 UniProt 21814 ChemSpider 2.0 644102 PubChem-compound 444493 PubChem-compound SMILES [H][C@](N)(CCC[C@@]([H])(N)C(O)=O)C(O)=O P0AAE1 UniProt P0ABG4 UniProt 22833512 PubChem-compound SMILES CC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=CC(=O)NC1=O ACETYL-COA BioCyc CHEBI:18050 ChEBI Proton glutamate symport protein 23724481 PubChem-compound SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(O)=O)N1C=CC(=O)NC1=O SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)N1C=CC(=O)NC1=O 1.0 Na Sodium 22.989769 UMP BioCyc L-Alanine CHEBI:57634 ChEBI 1.0 P46022 UniProt SMILES CC(=O)N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)OC1OP(O)(O)=O UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase 980 ChemSpider ReactionCatalysis2925 ACTIVATION UDP-N-acetylmuramate--L-alanine ligase a peptidoglycan dimer (meso-diaminopimelate containing) a peptidoglycan with D,D cross-links (meso-diaminopimelate containing) Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 30572 ChemSpider 17215925 ChemSpider 1.0 C7H14N2O4 meso-diaminopimelate 190.09535 CHEBI:15966 ChEBI 2.0 Phospho-N-acetylmuramoyl-pentapeptide-transferase Reaction6022 false N-Acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine + di-trans,octa-cis-undecaprenyl phosphate → N-Acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol + Uridine 5'-monophosphate LEFT_TO_RIGHT Reaction6023 false Adenosine triphosphate + D-Alanyl-D-alanine + UDP-N-Acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminopimelate → Adenosine diphosphate + Hydrogen Ion + N-Acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine + Phosphate LEFT_TO_RIGHT Reaction6024 false 2 Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutaminyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine → a peptidoglycan dimer (meso-diaminopimelate containing) + Hydrogen Ion + Undecaprenyl diphosphate LEFT_TO_RIGHT Pyrophosphate Glucose-6-phosphate isomerase GAMMA-GLUTAMYL-D-GLUTAMATE BioCyc P0A6J8 UniProt SMILES [Na+] 1005 PubChem-compound 5961 PubChem-compound C3H7NO2 D-Alanine 89.047676 D-fructose-6-phosphate aminotransferase C55H92O7P2 Undecaprenyl diphosphate 926.63184 1.0 528-04-1 CAS P0ACC7 UniProt 6816 PubChem-compound 1.0 64234 ChemSpider Undecaprenyl diphosphate TransportCatalysis369 ACTIVATION ADP BioCyc TransportCatalysis368 ACTIVATION TransportCatalysis367 ACTIVATION Reaction6016 false N-Acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol + Uridine diphosphate-N-acetylglucosamine → Hydrogen Ion + Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutaminyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + Uridine 5'-diphosphate LEFT_TO_RIGHT 53-59-8 CAS D-alanine--D-alanine ligase B C95H152N8O28P2 ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine 1915.0192 1.0 D-Alanine penicillin-binding protein 1B 1038 PubChem-compound C04256 KEGG Compound penicillin-binding protein 1A Penicillin-binding protein 1C GO:0005829 GENE ONTOLOGY fused N-acetylglucosamine-1-phosphate uridyltransferase and glucosamine-1-phosphate acetyltransferase UDP-N-acetylmuramate-alanine ligase 1.0 393240 ChemSpider 1.0 UDP-N-acetylglucosamine 1-carboxyvinyltransferase UDP-N-acetylenolpyruvoylglucosamine reductase CHEBI:15713 ChEBI O4P Phosphate 94.95342 NADPH CHEBI:58247 ChEBI GO:0070258 GENE ONTOLOGY 25246252 PubChem-compound SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(O)=O)N1C=CC(=O)NC1=O NADP C21H30N7O17P3 NADPH 745.0911 Reaction6033 false Adenosine triphosphate + D-Glutamic acid + UDP-N-Acetylmuramyl-L-Ala → Adenosine diphosphate + Phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate LEFT_TO_RIGHT Reaction6034 false Adenosine triphosphate + L-Alanine + UDP-N-acetyl-α-D-muramate → Adenosine diphosphate + Hydrogen Ion + Phosphate + UDP-N-Acetylmuramyl-L-Ala LEFT_TO_RIGHT C21H29N7O17P3 NADP 744.08325 glycolysis and pyruvate dehydrogenase SubPathway mannose PTS permease NADPH BioCyc PW000785 PathWhiz CHEBI:16977 ChEBI C9H15N2O15P3 Uridine triphosphate 483.96854 P69797 UniProt L-Glutamic acid Mannose permease IID component SMILES [O-]P([O-])([O-])=O UDP-N-acetylmuramoyl-L-alanyl-D-glutamate a peptidoglycan with D,D cross-links (meso-diaminopimelate containing) C17H27N3O17P2 Uridine diphosphate-N-acetylglucosamine 607.08154 a peptidoglycan dimer (meso-diaminopimelate containing) C9H13N2O9P Uridine 5'-monophosphate 324.03586 D-ALANINE BioCyc TransportCatalysis297 ACTIVATION β-D-fructofuranose 6-phosphate β-D-glucose 6-phosphate 1.0 Inner Membrane 25203452 PubChem-compound N-Acetyl-glucosamine 1-phosphate SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O C8H16NO9P N-Acetyl-glucosamine 1-phosphate 301.05627 1.0 SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O GLN BioCyc GLT BioCyc 53-57-6 CAS Mannose permease IIC component 1.0 C6H11O9P β-D-fructofuranose 6-phosphate 258.01517 SMILES C[C@H](N)C(O)=O C7H13O8P β-D-glucose 6-phosphate 256.0359 5950 PubChem-compound http://identifiers.org/smpdb/SMP00807 SMPDB C22H32Cl2N2O4 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate 458.17392 Uridine diphosphate-N-acetylglucosamine O7P2 Pyrophosphate 173.91193 Sodium/glutamate symport carrier protein 1.0 Uridine 5'-monophosphate CHEBI:68483 ChEBI 5957 PubChem-compound 1.0 GO:0005620 GENE ONTOLOGY Penicillin-binding protein 2 Uridine triphosphate meso-diaminopimelate CHEBI:15873 ChEBI 1.0 Reaction2958 false β-D-glucose 6-phosphate ↔ β-D-fructofuranose 6-phosphate REVERSIBLE Penicillin-binding protein 1B Penicillin-binding protein 1A Adenosine diphosphate C3H5O6P Phosphoenolpyruvic acid 167.98238 D-alanine ligase C10H15N5O10P2 Adenosine diphosphate 427.02942 phosphoglucose isomerase Phosphoenolpyruvic acid 1.0 1.0 CHEBI:28639 ChEBI D-alanine--D-alanine ligase A CPD-8587 BioCyc SMILES N[C@H]1[C@@H](O)O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O UDP BioCyc 6893-26-1 CAS CHEBI:1146900 ChEBI P11880 UniProt 14000-31-8 CAS CO-A BioCyc 5675 ChemSpider 72-89-9 CAS CHEBI:15570 ChEBI β-D-fructofuranose 6-phosphate lipid II flippase essential cell division protein FtsW; lipid II flippase Coenzyme A 1.0 1.0 C21H36N7O16P3S Coenzyme A 767.11523 1.0 ReactionCoupledTransport144 false HPr - phosphorylated + β-D-fructofuranose → HPr + β-D-fructofuranose 6-phosphate LEFT_TO_RIGHT P31120 UniProt biosynthetic peptidoglycan transglycosylase CHEBI:15422 ChEBI 6557 ChemSpider P08373 UniProt Phosphoglucosamine mutase SMILES CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N D-serine/D-alanine/glycine transporter 439217 PubChem-compound C5H9NO4 L-Glutamic acid 147.05316 33032 PubChem-compound 3.0 1.0 1.0 UDP-N-ACETYL-D-GLUCOSAMINE BioCyc CHEBI:16761 ChEBI http://identifiers.org/smpdb/SMP02074 SMPDB P21345 UniProt 5.1.1.3 false 5.1.1.3 L-Glutamic acid ↔ D-Glutamic acid REVERSIBLE 6.3.2.4 false 6.3.2.4 Adenosine triphosphate + 2 D-Alanine → Adenosine diphosphate + D-Alanyl-D-alanine + Phosphate LEFT_TO_RIGHT 923-16-0 CAS SMILES CC(OC1C(O)C(CO)OC(OP([O-])(=O)OP([O-])(=O)OCC2OC(C(O)C2O)N2C=CC(=O)NC2=O)C1NC(C)=O)C([O-])=O CHEBI:16576 ChEBI SMILES CC(=O)NC1C(OP([O-])(=O)OP([O-])(=O)OCC2OC(C(O)C2O)N2C=CC(=O)NC2=O)OC(CO)C(O)C1OC(=C)C([O-])=O essential cell division protein FtsW; lipid II flippase 389248 ChemSpider 1.0 lipid II flippase SMILES OC[C@@]1([H])O[C@@]([H])(O[C@]2([H])[C@@]([H])(CO)OC([H])(OP(O)(=O)OP(O)(=O)OC\C([H])=C(/C)CC\C([H])=C(/C)CC\C([H])=C(/C)CC\C([H])=C(/C)CC\C([H])=C(/C)CC\C([H])=C(/C)CC\C([H])=C(/C)CC\C([H])=C(/C)CC\C([H])=C(/C)CC\C([H])=C(/C)CCC=C(C)C)[C@]([H])(N=C(C)O)[C@@]2([H])OC(C)([H])C(O)=N[C@](C)([H])C(O)=N[C@]([H])(CCC(=N)O)C(O)=N[C@]([H])(CCC[C@@](N)([H])C(=O)O)C(O)=N[C@@](C)([H])C(O)=N[C@@](C)([H])C(=O)O)[C@]([H])(N=C(C)O)[C@](O)([H])[C@@]1(O)[H] 392413 ChemSpider UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase HMDB00290 HMDB D-Alanyl-D-alanine 1.0 1.0 HMDB00295 HMDB 1.0 C00993 KEGG Compound CHEBI:16695 ChEBI di-trans,octa-cis-undecaprenyl phosphate ReactionCatalysis3428 ACTIVATION 1.0 ReactionCatalysis3429 ACTIVATION 5280604 PubChem-compound ReactionCatalysis3420 ACTIVATION Sodium CHEBI:15378 ChEBI SMILES [H+] HMDB03459 HMDB HMDB03339 HMDB SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound Glutamate racemase D-alanine--D-alanine ligase B ReactionCatalysis5977 ACTIVATION 1.0 ReactionCatalysis3430 ACTIVATION ReactionCatalysis3431 ACTIVATION HMDB01367 HMDB SMILES [H][C@](C)(O[C@@]1([H])[C@]([H])(O)[C@@]([H])(CO)OC([H])(OP(O)(=O)OP(O)(=O)OC[C@@]2([H])O[C@@]([H])(N3C=CC([O-])=NC3=O)[C@]([H])(O)[C@]2([H])O)[C@]1([H])N=C(C)[O-])C([O-])=N[C@]([H])(C)C(O)=O 4444213 ChemSpider 2.0 SMILES N[C@@H](CCC(N)=O)C(O)=O UDP-N-acetylenolpyruvoylglucosamine reductase SMILES N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OP(O)(O)=O ReactionCatalysis5988 ACTIVATION ReactionCatalysis5987 ACTIVATION P02919 UniProt P02918 UniProt 1.0 P17169 UniProt SMILES [H][C@](C)(O[C@@]1([H])[C@]([H])(O[C@@]2([H])O[C@]([H])(CO)[C@@]([H])(O)[C@]([H])(O)[C@@]2([H])N=C(C)O)[C@@]([H])(CO)O[C@]([H])(OP(O)(=O)OP(O)(=O)OCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)[C@]1([H])N=C(C)O)C(O)=N[C@@]([H])(C)C(O)=N[C@]([H])(CCC(O)=O)C(O)=N[C@@]([H])(CCCCN)C(O)=N[C@]([H])(C)C(O)=N[C@]([H])(C)C(O)=O ReactionCatalysis5986 ACTIVATION ReactionCatalysis5985 ACTIVATION ReactionCatalysis5984 ACTIVATION ReactionCatalysis5983 ACTIVATION 63-39-8 CAS 1061 PubChem-compound SMILES [H+] HMDB00288 HMDB CHEBI:17659 ChEBI 1.0 ReactionCatalysis2480 ACTIVATION Hydrogen Ion UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase UNDECAPRENYL-DIPHOSPHATE BioCyc D-ALA-D-ALA BioCyc HMDB00161 HMDB C55H91O4P di-trans,octa-cis-undecaprenyl phosphate 846.6655 CHEBI:15351 ChEBI SMILES N[C@H](CCC(O)=O)C(O)=O PTS system mannose-specific EIIAB component P14900 UniProt HMDB01254 HMDB HMDB00285 HMDB ReactionCatalysis5999 ACTIVATION P22634 UniProt ReactionCatalysis5998 ACTIVATION P69801 UniProt 1.0 ReactionCatalysis2482 ACTIVATION 85-61-0 CAS P69805 UniProt SMILES [H][C@@](N)(CCC[C@]([H])(N=C(O)CC[C@@]([H])(N=C(O)[C@]([H])(C)N=C(O)[C@@]([H])(C)O[C@@]1([H])[C@]([H])(O)[C@@]([H])(CO)O[C@@]([H])(OP(O)(=O)OP(O)(=O)OCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)[C@]1([H])N=C(C)O)C(O)=O)C(O)=N[C@]([H])(C)C(O)=N[C@]([H])(C)C(O)=O)C(O)=O P76577 UniProt D-serine/D- alanine/glycine transporter Sodium/glutamate symport carrier protein Proton glutamate symport protein D-serine/D- alanine/glycine transporter Unknown FtsW Glucose-6- phosphate isomerase Glucosamine-- fructose-6- phosphate aminotransferase [isomerizing] Phosphoglucosamine mutase Bifunctional protein glmU Bifunctional protein glmU UDP-N- acetylglucosamine 1- carboxyvinyltransferase UDP-N- acetylenolpyruvoylglucosamine reductase Glutamate racemase UDP-N- acetylmuramoyl- L-alanyl-D- glutamate-- 2,6- diaminopimelate ligase D-alanine--D- alanine ligase B D-alanine--D- alanine ligase A UDP-N- acetylglucosamine- -N- acetylmuramyl- (pentapeptide) pyrophosphoryl- undecaprenol N- acetylglucosamine transferase Phospho-N- acetylmuramoyl- pentapeptide- transferase UDP-N- acetylmuramoyl- tripeptide-- D-alanyl-D- alanine ligase biosynthetic peptidoglycan transglycosylase Penicillin- binding protein 1A Penicillin- binding protein 1B Penicillin- binding protein 1C UDP-N- acetylmuramoylalanine- -D-glutamate ligase UDP-N- acetylmuramate- -L-alanine ligase Phosphocarrier protein HPr Phosphocarrier protein HPr Mannose permease IID component Mannose permease IIC component PTS system mannose- specific EIIAB component L-Alanine L-Alanine H + H + L-Glutamic acid L-Glutamic acid Na + Na + H + H + L-Glutamic acid L-Glutamic acid D-Alanine D-Alanine H + H + β-D-glucose 6-phosphate β-D- fructofuranose 6-phosphate L-Glutamine Glucosamine 6-phosphate L-Glutamic acid Glucosamine-1P Acetyl-CoA N-Acetyl- glucosamine 1-phosphate CoA H + Uridine triphosphate H + Uridine diphosphate- N- acetylglucosamine PP i Phosphoenolpyruvic acid P i UDP-N-acetyl- α-D- glucosamine- enolpyruvate NADPH Hydrogen ion NADP UDP-N-acetyl- α-D-muramate L-Glutamic acid D-Glutamic acid UDP-N- acetylmuramoyl- L-alanyl-D- glutamate meso- diaminopimelate ATP ADP P i H + UDP-N- Acetylmuramoyl- L-alanyl-D- gamma- glutamyl- meso-2,6- diaminopimelate D-Alanine ATP D-Alanyl-D- alanine ADP P i D-Alanine N- Acetylmuramoyl- L-alanyl-D- glutamyl- meso-2,6- diaminopimelyl- D-alanyl-D- alanine- diphosphoundecaprenol Uridine diphosphate- N- acetylglucosamine Undecaprenyl- diphospho-N- acetylmuramoyl- (N- acetylglucosamine)- L-alanyl-D- glutaminyl- meso-2,6- diaminopimeloyl- D-alanyl-D- alanine Uridine 5'-diphosphate H + N- Acetylmuramoyl- L-alanyl-D- glutamyl-L- lysyl-D- alanyl-D- alanine- diphosphoundecaprenyl- N- acetylglucosamine di- trans,octa- cis- undecaprenyl phosphate Uridine 5'- monophosphate D-Alanyl-D- alanine ATP ADP P i H + Undecaprenyl- diphospho-N- acetylmuramoyl- (N- acetylglucosamine)- L-alanyl-D- glutaminyl- meso-2,6- diaminopimeloyl- D-alanyl-D- alanine Undecaprenyl diphosphate H + UDP-N- Acetylmuramyl- L-Ala ATP ADP P i ATP ADP P i H + β-D- fructofuranose Undecaprenyl- diphospho-N- acetylmuramoyl- (N- acetylglucosamine)- L-alanyl-D- glutaminyl- meso-2,6- diaminopimeloyl- D-alanyl-D- alanine Calcium Cobalt Manganese Magnesium Manganese a peptidoglycan dimer (meso- diaminopimelate containing) a peptidoglycan with D,D cross-links (meso- diaminopimelate containing) glycolysis and pyruvate dehydrogenase Penicillin- binding protein 2 Peptidoglycan synthase ftsI Penicillin- binding protein 1A Penicillin- binding protein 1B
CHEBI:16015 ChEBI C23H33N4O20P2 UDP-N-Acetylmuramyl-L-Ala 747.11633 Transport351 false L-Alanine (→), Hydrogen Ion (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT 388356 ChemSpider 2.0 6022 PubChem-compound HMDB01469 HMDB Phosphocarrier protein HPr 923 PubChem-compound C23H38N7O17P3S Acetyl-CoA 809.1258 ReactionCoupledTransportCatalysis178 ACTIVATION HMDB00250 HMDB HMDB01341 HMDB 1.0 1.3.1.98 false 1.3.1.98 Hydrogen ion + NADPH + UDP-N-acetyl-α-D-glucosamine-enolpyruvate → NADP + UDP-N-acetyl-α-D-muramate LEFT_TO_RIGHT 2.5.1.7 false 2.5.1.7 Phosphoenolpyruvic acid + Uridine diphosphate-N-acetylglucosamine → Phosphate + UDP-N-acetyl-α-D-glucosamine-enolpyruvate LEFT_TO_RIGHT Reaction3314 false Hydrogen Ion + N-Acetyl-glucosamine 1-phosphate + Uridine triphosphate → Pyrophosphate + Uridine diphosphate-N-acetylglucosamine LEFT_TO_RIGHT 2.7.7.23 false 2.7.7.23 Acetyl-CoA + Glucosamine-1P → Coenzyme A + Hydrogen Ion + N-Acetyl-glucosamine 1-phosphate LEFT_TO_RIGHT 1.0 C94H156N8O26P2 N-Acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine-diphosphoundecaprenyl-N-acetylglucosamine 1875.0605 5.4.2.10 false 5.4.2.10 Glucosamine 6-phosphate ↔ Glucosamine-1P REVERSIBLE 6133 PubChem-compound Glucosamine 6-phosphate H Hydrogen ion 1.007825 HMDB00148 HMDB Peptidoglycan synthase ftsI UDP-N-acetylmuramoylalanine--D-glutamate ligase ATP BioCyc CHEBI:16264 ChEBI PTS system mannose-specific EIIAB component Bifunctional protein glmU HMDB00263 HMDB 1.0 559142 ChemSpider 2.6.1.16 false 2.6.1.16 L-Glutamine + β-D-fructofuranose 6-phosphate ↔ Glucosamine 6-phosphate + L-Glutamic acid REVERSIBLE HMDB01109 HMDB CHEBI:42560 ChEBI C87H143N7O23P2 N-Acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 1715.9711 ditrans,octacis-undecaprenyldiphospho-N-acetyl-(N-acetylglucosaminyl)muramoyl-L-alanyl-γ-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine Transport369 false L-Glutamic acid (→), Sodium (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT N-Acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 2.0 P0AD65 UniProt C00217 KEGG Compound P0AA04 UniProt P0AD68 UniProt 31867-59-1 CAS 5746 ChemSpider 1.0 D-Alanine HMDB01206 HMDB Transport371 false Hydrogen Ion (→), L-Glutamic acid (→) Transport: Escherichia coli, Periplasmic Space to Escherichia coli, Cytosol LEFT_TO_RIGHT 5742 ChemSpider CHEBI:16474 ChEBI 6.3.2.13 false 6.3.2.13 Adenosine triphosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + meso-diaminopimelate → Adenosine diphosphate + Hydrogen Ion + Phosphate + UDP-N-Acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminopimelate LEFT_TO_RIGHT HMDB59597 HMDB Penicillin-binding protein 1A Penicillin-binding protein 1B 8140645 ChemSpider Reaction3455 false a peptidoglycan dimer (meso-diaminopimelate containing) → D-Alanine + a peptidoglycan with D,D cross-links (meso-diaminopimelate containing) LEFT_TO_RIGHT C00105 KEGG Compound 6030 PubChem-compound 6031 PubChem-compound 5735 ChemSpider Acetyl-CoA D-alanine--D-alanine ligase A C6H12N2O3 D-Alanyl-D-alanine 160.0848 Proton glutamate symport protein 1010 ChemSpider UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCS Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 1.0 GLUCOSAMINE-1P BioCyc 440272 PubChem-compound PPI BioCyc biosynthetic peptidoglycan transglycosylase SMILES [H]C(N)(CCCC([H])(N=C(O)CC[C@@]([H])(N=C(O)[C@]([H])(C)N=C(O)C([H])(C)O[C@@]1([H])[C@]([H])(O)[C@@]([H])(CO)O[C@]([H])(OP(O)(=O)OP(O)(=O)OC[C@@]2([H])O[C@@]([H])(N3C=CC(O)=NC3=O)[C@]([H])(O)[C@]2([H])O)[C@]1([H])N=C(C)O)C(O)=O)C(O)=O)C(O)=O SMILES OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O 138-08-9 CAS BiologicalState109 Escherichia coli, Inner Membrane 2.0 C6H14NO8P Glucosamine-1P 259.04572 1.0 HMDB01423 HMDB 1.0 C5H10N2O3 L-Glutamine 146.06914 Hydrogen Ion HMDB00217 HMDB P07862