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Glutamine transporter, mitochondrial CHEBI:16015 ChEBI 6022 PubChem-compound Q9UI32 UniProt 4.0 PW002366 PathWhiz C23H38N7O17P3S Acetyl-CoA 809.1258 439161 PubChem-compound Mitochondrial pyruvate carrier 1 1.0 937 ChemSpider 1.0 96860 ChemSpider C00311 KEGG Compound CHEBI:16134 ChEBI Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial CHEBI:30797 ChEBI 439153 PubChem-compound 110-17-8 CAS HMDB0000094 HMDB 50 ChemSpider 1.0 1.0 H Hydrogen ion 1.007825 Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial NAD OXALACETIC_ACID BioCyc 1.0 ATP BioCyc Coenzyme Q10 FAD 1.0 4.0 Aspartate aminotransferase, mitochondrial HMDB0001072 HMDB 1.0 HMDB0001197 HMDB 1.0 Isocitrate dehydrogenase [NADP], mitochondrial PW000165 PathWhiz CHEBI:16238 ChEBI P09622 UniProt 5746 ChemSpider 1.0 HCO3 BioCyc 5745 ChemSpider CHEBI:15380 ChEBI L-lactate dehydrogenase A chain 5742 ChemSpider C25H40N7O19P3S Succinyl-CoA 867.1312 1.0 L-ASPARTATE BioCyc CHEBI:16474 ChEBI 1.0 1.0 Y+L amino acid transporter 1 1.0 Transport139 false L-Glutamine (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytoplasm LEFT_TO_RIGHT NADP-dependent malic enzyme 5281915 PubChem-compound 97-67-6 CAS Sodium-coupled neutral amino acid transporter 5 C27H35N9O15P2 FADH 787.1728 Carbon dioxide 5735 ChemSpider Aspartate aminotransferase, mitochondrial Acetyl-CoA 945 ChemSpider 1010 ChemSpider C10H15N5O11P2 Guanosine diphosphate 443.02432 SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)[C@@H](O)C(=O)NCCC(=O)NCCS 1.0 CHEBI:30769 ChEBI Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial CHEBI:30887 ChEBI 1.0 L-Leucine SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCSC(=O)CCC(O)=O 1.0 C10H16N5O14P3 Guanosine triphosphate 522.99066 C5H10N2O3 L-Glutamine 146.06914 Hydrogen Ion 1161 ChemSpider Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial Cytosol 6106 PubChem-compound 1.0 SUC BioCyc Adenosine triphosphate 5880 ChemSpider O43837 UniProt Neutral amino acid transporter A Reaction390 false L-Malic acid + NAD ↔ Hydrogen Ion + NADH + Oxalacetic acid REVERSIBLE Monocarboxylate transporter 1 1.0 C00009 KEGG Compound C00008 KEGG Compound C00006 KEGG Compound 1.0 CHEBI:18009 ChEBI 1.0 C00001 KEGG Compound C00122 KEGG Compound 559059 ChemSpider SMILES CC1=CC2=C(C=C1C)N(C[C@H](O)[C@H](O)[C@H](O)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC3=C1N=CN=C3N)C1=C(N2)C(=O)NC(=O)N1 L-ALPHA-ALANINE BioCyc Uncharacterized aminotransferase yfbQ 4.0 Transport280 false L-Lactic acid (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space LEFT_TO_RIGHT LEU BioCyc 56-41-7 CAS NADH SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial C00005 KEGG Compound C00004 KEGG Compound CHEBI:18367 ChEBI NADP-dependent malic enzyme C00003 KEGG Compound 1032 ChemSpider 1910-41-4 CAS 1031 ChemSpider C00002 KEGG Compound C00123 KEGG Compound 60.0 Coenzyme A Mitochondrial Inner Membrane C11378 KEGG Compound Hydrogen ion C59H90O4 Coenzyme Q10 862.6839 C27H33N9O15P2 FAD 785.1571 Pyruvic acid SubPathwayOutput C21H28N7O14P2 NAD 664.11694 1.0 107689 PubChem-compound P53985 UniProt 44367445 PubChem-compound C00011 KEGG Compound C00010 KEGG Compound Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial HMDB0000902 HMDB C00016 KEGG Compound C00014 KEGG Compound Extracellular Space 1.0 NAD(P) BioCyc FADH SubPathwayInput Pyruvate dehydrogenase E1 component subunit beta, mitochondrial H Hydrogen Ion 1.007825 C00149 KEGG Compound ATP-citrate synthase 388307 ChemSpider Phosphate Neutral amino acid transporter B(0) C00022 KEGG Compound L-Glutamine Pyruvate carboxylase, mitochondrial 56-65-5 CAS C01352 KEGG Compound 53-84-9 CAS P48163 UniProt C00026 KEGG Compound C00025 KEGG Compound C00024 KEGG Compound mutant succinate dehydrogenase Fumaric acid O14521 UniProt C00390 KEGG Compound 1.0 ReactionCatalysis6171 ACTIVATION 1.0 ReactionCatalysis6170 ACTIVATION 769 PubChem-compound Pyruvate carboxylase, mitochondrial 56275-39-9 CAS C00158 KEGG Compound C00036 KEGG Compound Transport1 false Pyruvic acid (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Mitochondrial Matrix LEFT_TO_RIGHT C00035 KEGG Compound SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O 328-50-7 CAS HMDB0000134 HMDB HMDB0000254 HMDB SMILES OC(=O)CCC(O)=O 1.0 C00041 KEGG Compound L-Lactic acid Uncharacterized aminotransferase yfdZ Transport519 false L-Glutamine (→) Transport: Homo sapiens, Cytosol to Homo sapiens, Cell, Mitochondrion LEFT_TO_RIGHT P50213 UniProt L-Lactic acid 1.0 SMILES OC(=O)C\C(=C\C(O)=O)C(O)=O Glutaminolysis and Cancer HMDB0001341 HMDB P07954 UniProt 1.0 C00044 KEGG Compound C00042 KEGG Compound 4445197 ChemSpider L-Glutamine C00049 KEGG Compound C00288 KEGG Compound 303-98-0 CAS 56-85-9 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O SMILES OC(=O)CC(O)(CC(O)=O)C(O)=O 604-98-8 CAS HMDB0000148 HMDB P51553 UniProt cis-Aconitic acid Glutaminase liver isoform, mitochondrial Transport520 false L-Glutamine (→), L-Leucine (←) Transport: Homo sapiens, Cytosol to Homo sapiens, Extracellular Space LEFT_TO_RIGHT Succinyl-CoA 10197150 ChemSpider FUM BioCyc SMILES OC(=O)CC(=O)C(O)=O 7732-18-5 CAS Aconitate hydratase, mitochondrial Q8WUX1 UniProt 1.0 CHEBI:18012 ChEBI HMDB0001487 HMDB HMDB0000156 HMDB Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial Q99798 UniProt HMDB0001248 HMDB Pyruvic acid AMMONIA BioCyc SMILES N 56-86-0 CAS 1.0 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial P21912 UniProt 1.0 24.0 C10H16N5O13P3 Adenosine triphosphate 506.99576 CHEBI:17053 ChEBI C00186 KEGG Compound SMILES COC1=C(O)C(C)=C(C\C=C(/C)CCC=C(C)C)C(O)=C1OC C00064 KEGG Compound NAD 305 ChemSpider SMILES CC(=O)C(O)=O Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial Mitochondrial pyruvate carrier 1 6.4.1.1 false 6.4.1.1 Adenosine triphosphate + Hydrogen carbonate + Pyruvic acid → Adenosine diphosphate + Oxalacetic acid + Phosphate LEFT_TO_RIGHT 1.0 HMDB0000161 HMDB C6H13NO2 L-Leucine 131.09464 Glutamate dehydrogenase 1, mitochondrial 962 PubChem-compound 1.0 C3H7NO2 L-Alanine 89.047676 5800 ChemSpider CO2 Carbon dioxide 43.98983 C00080 KEGG Compound 1.3.5.1 false 1.3.5.1 Coenzyme Q10 + FAD + Succinic acid ↔ FADH + Fumaric acid + QH2 REVERSIBLE Water Oxoglutaric acid 1.0 1.0 Q99417 UniProt Q9Y5U8 UniProt HMDB0000051 HMDB HMDB0002111 HMDB SMILES N[C@@H](CCC(O)=O)C(O)=O HMDB0001022 HMDB Adenosine diphosphate 146-14-5 CAS L-Glutamine Q9UM01 UniProt 14265-44-2 CAS PYRUVATE BioCyc QH2 BioCyc 1.0 58-64-0 CAS SubPathwayInteraction3436 SubPathwayReaction SubPathway3436Reaction Glutaminase liver isoform, mitochondrial C-Myc-binding protein GTP BioCyc 585-84-2 CAS SubPathwayInteraction3431 SubPathway3431Reaction SubPathwayReaction C00091 KEGG Compound L-Aspartic acid L-Lactic acid 1.0 TransportCatalysis449 ACTIVATION P11177 UniProt TransportCatalysis448 ACTIVATION C4H7NO4 L-Aspartic acid 133.0375 L-Leucine C3H6O3 L-Lactic acid 90.03169 HMDB0001273 HMDB Isocitric acid 444493 PubChem-compound L-Glutamine Succinic acid HMDB0000190 HMDB ATP-citrate synthase Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial 22833512 PubChem-compound ACETYL-COA BioCyc CHEBI:18050 ChEBI H2O Water 18.010565 1.0 Reaction6241 false Hydrogen Ion + NADH + Pyruvic acid → L-Lactic acid + NAD LEFT_TO_RIGHT ReactionCatalysis6157 ACTIVATION FADH2 BioCyc HMDB0000191 HMDB Reaction6242 false Carbon dioxide + Oxoglutaric acid → Citric acid LEFT_TO_RIGHT HMDB0000193 HMDB Hydrogen carbonate HMDB0000072 HMDB NADH BioCyc NAD BioCyc 1.0 ReactionCatalysis6165 ACTIVATION HMDB0059597 HMDB Reaction6240 false L-Malic acid + NADP → Carbon dioxide + Hydrogen Ion + NADPH + Pyruvic acid LEFT_TO_RIGHT L-Alanine Carbon dioxide Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial Glutamate dehydrogenase 1, mitochondrial 56-84-8 CAS 749 ChemSpider 71-52-3 CAS 970 PubChem-compound CIS-ACONITATE BioCyc SubPathwayInteraction3453 SubPathway3453Reaction SubPathwayReaction SMILES OC(=O)\C=C\C(O)=O Reaction6238 false L-Glutamic acid + NAD → Hydrogen ion + NADH + Oxoglutaric acid LEFT_TO_RIGHT Reaction6239 false L-Glutamic acid + Oxalacetic acid → L-Aspartic acid + Oxoglutaric acid LEFT_TO_RIGHT Acetyl-CoA Q99643 UniProt O75390 UniProt SubPathwayInteraction3460 SubPathway3460Reaction SubPathwayReaction L-Malic acid 146-91-8 CAS ReactionCatalysis6169 ACTIVATION Citrate synthase, mitochondrial C4H6O5 L-Malic acid 134.02153 1.0 ReactionCatalysis6168 ACTIVATION CHO3 Hydrogen carbonate 60.99257 ReactionCatalysis6167 ACTIVATION P0A959 UniProt ReactionCatalysis6166 ACTIVATION Reaction6237 false L-Glutamine → Ammonia + L-Glutamic acid LEFT_TO_RIGHT 30572 ChemSpider 17215925 ChemSpider 446013 PubChem-compound C4H4O5 Oxalacetic acid 132.00587 L-Malic acid CHEBI:15603 ChEBI Succinyl-CoA ligase Adenosine triphosphate 1.0 Succinic acid NADH 2.0 Uncharacterized aminotransferase yfbQ 21883788 PubChem-compound Citric acid SMILES O CIT BioCyc Guanosine triphosphate H3N Ammonia 17.026548 ReactionCatalysis2653 ACTIVATION P11498 UniProt HMDB0000538 HMDB Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial (C5H8)nC14H20O4 QH2 glutamate-pyruvate aminotransferase TransportCatalysis6 ACTIVATION 5961 PubChem-compound Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial 1.0 1.0 6816 PubChem-compound 328-42-7 CAS 51 PubChem-compound Glycolysis SubPathway 2.0 SMILES O[C@@H](CC(O)=O)C(O)=O SMILES OC([O-])=O Pyruvic acid 1.0 CHEBI:15846 ChEBI P00367 UniProt ADP BioCyc C3H4O3 Pyruvic acid 88.016045 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial CHEBI:46245 ChEBI 1.0 53-59-8 CAS C6H8O7 Isocitric acid 192.02701 1.0 1038 PubChem-compound Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial Neutral amino acid transporter B(0) Oxoglutarate dehydrogenase complex QH2 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial GO:0005829 GENE ONTOLOGY Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial Ammonia 1.0 274 ChemSpider C5H6O5 Oxoglutaric acid 146.02153 393487 ChemSpider Citric acid CHEBI:16908 ChEBI Pyruvate dehydrogenase complex Pyruvate dehydrogenase E1 component subunit beta, mitochondrial O4P Phosphate 94.95342 Oxalacetic acid NADPH 6830 PubChem-compound 77-92-9 CAS 558863 ChemSpider 1.0 HMDB0000687 HMDB NADP C21H30N7O17P3 NADPH 745.0911 TransportCatalysis228 ACTIVATION 4.0 L-LACTATE BioCyc Mitochondrion C21H29N7O17P3 NADP 744.08325 SMP0002298 SMPDB TransportCatalysis101 ACTIVATION NADPH BioCyc 643757 PubChem-compound Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial CHEBI:16977 ChEBI HMDB0000208 HMDB 217 ChemSpider 58-68-4 CAS SMP0000040 SMPDB HMDB0001423 HMDB Water L-Glutamic acid SMILES [O-]P([O-])([O-])=O HMDB0001304 HMDB SMILES OC(=O)CCC(=O)C(O)=O HMDB0000217 HMDB P48735 UniProt 1.0 124-38-9 CAS CHEBI:30915 ChEBI Q96HY7 UniProt Guanosine diphosphate Mitochondrial Electron Transport Chain SubPathway ReactionCatalysis69 ACTIVATION 4.2.1.3 false 4.2.1.3 Citric acid ↔ Water + cis-Aconitic acid REVERSIBLE 2.0 ReactionCatalysis4 ACTIVATION HMDB0001429 HMDB ReactionCatalysis63 ACTIVATION ReactionCatalysis64 ACTIVATION ReactionCatalysis62 ACTIVATION ReactionCatalysis67 ACTIVATION ReactionCatalysis68 ACTIVATION SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O HMDB0000221 HMDB HMDB0000223 HMDB GO:0005759 GENE ONTOLOGY GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE BioCyc 4.2.1.3 false 4.2.1.3 Water + cis-Aconitic acid ↔ Isocitric acid REVERSIBLE SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O Q96I99 UniProt Fumaric acid GLN BioCyc 1.0 GLT BioCyc 7664-41-7 CAS 1.0 C4H4O4 Fumaric acid 116.010956 P31040 UniProt Aconitate hydratase, mitochondrial 53-57-6 CAS 1.0 2.0 CHEBI:15741 ChEBI Fumarate hydratase, mitochondrial NADP-dependent malic enzyme SMILES O=C=O SMILES C[C@H](N)C(O)=O ReactionCatalysis78 ACTIVATION 5950 PubChem-compound 4444052 ChemSpider 222 PubChem-compound 1110 PubChem-compound Hydrogen Ion 1.0 HMDB0001201 HMDB HMDB0000595 HMDB C21H29N7O14P2 NADH 665.12476 ReactionCatalysis70 ACTIVATION 5280344 PubChem-compound HMDB0001206 HMDB 5957 PubChem-compound GO:0005743 GENE ONTOLOGY C4H6O4 Succinic acid 118.02661 Aconitate hydratase, mitochondrial P00338 UniProt C6H6O6 cis-Aconitic acid 174.01643 320-77-4 CAS threo-d(s)-iso-citrate BioCyc Isocitric acid CHEBI:15996 ChEBI L-lactate dehydrogenase A chain Y+L amino acid transporter 1 HMDB0000243 HMDB Citric acid Adenosine diphosphate GO:0005739 GENE ONTOLOGY 60.0 SMILES OC(C(CC(O)=O)C(O)=O)C(O)=O C10H15N5O10P2 Adenosine diphosphate 427.02942 GO:0005615 GENE ONTOLOGY 1.0 GO:0005737 GENE ONTOLOGY SMILES N[C@@H](CC(O)=O)C(O)=O SMILES C[C@H](O)C(O)=O 1.0 C6H8O7 Citric acid 192.02701 ATP-citrate synthase Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial 1.0 SMILES CC1=CC2=C(C=C1C)N(C[C@H](O)[C@H](O)[C@H](O)CO[P@](O)(=O)O[P@@](O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC3=C1N=CN=C3N)C1=NC(=O)NC(=O)C1=N2 SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial CPD-8587 BioCyc 19782904 PubChem-compound 1.0 SMILES COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O 5682 ChemSpider CHEBI:1146900 ChEBI 1.2.4.2 false 1.2.4.2 Coenzyme A + NAD + Oxoglutaric acid → Carbon dioxide + Hydrogen Ion + NADH + Succinyl-CoA LEFT_TO_RIGHT 2.3.3.1 false 2.3.3.1 Acetyl-CoA + Oxalacetic acid + Water → Citric acid + Coenzyme A LEFT_TO_RIGHT Oxalacetic acid P43007 UniProt Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Mitochondrial Matrix Reaction593 false Guanosine diphosphate + Phosphate + Succinyl-CoA ↔ Coenzyme A + Guanosine triphosphate + Succinic acid REVERSIBLE 1.2.4.1 false 1.2.4.1 Coenzyme A + NAD + Pyruvic acid → Acetyl-CoA + Carbon dioxide + NADH LEFT_TO_RIGHT Fumarate hydratase, mitochondrial CO-A BioCyc CHEBI:17877 ChEBI Monocarboxylate transporter 1 222656 PubChem-compound 5675 ChemSpider 72-89-9 CAS 2.0 1078 ChemSpider Neutral amino acid transporter A Coenzyme A C21H36N7O16P3S Coenzyme A 767.11523 Cytoplasm C-Myc-binding protein Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial CHEBI:15422 ChEBI Citrate synthase, mitochondrial 6557 ChemSpider 1.0 643975 PubChem-compound Homo sapiens SMILES CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N 388299 ChemSpider 79-33-4 CAS 127-17-3 CAS 1.0 ReactionCatalysis1067 ACTIVATION C5H9NO4 L-Glutamic acid 147.05316 33032 PubChem-compound P53396 UniProt P36957 UniProt Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial Dihydrolipoyl dehydrogenase, mitochondrial Sodium-coupled neutral amino acid transporter 5 1.0 CHEBI:16526 ChEBI Isocitrate dehydrogenase [NADP], mitochondrial 8977 PubChem-compound 1.0 1.0 1.0 CHEBI:16761 ChEBI 4.2.1.2 false 4.2.1.2 L-Malic acid ↔ Fumaric acid + Water REVERSIBLE 9606 TAXONOMY P08559 UniProt CHEBI:17544 ChEBI 2-KETOGLUTARATE BioCyc 392413 ChemSpider PW000146 PathWhiz 61-90-5 CAS 1.0 Oxoglutaric acid 8630 ChemSpider 5893 PubChem-compound FADH P10515 UniProt Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial 110-15-6 CAS 2.6.1.2 false 2.6.1.2 L-Glutamic acid + Pyruvic acid → L-Alanine + Oxoglutaric acid LEFT_TO_RIGHT Citrate synthase, mitochondrial CHEBI:32816 ChEBI CHEBI:15377 ChEBI Fumarate hydratase, mitochondrial CHEBI:15378 ChEBI SMILES [H+] Isocitrate dehydrogenase 6569 ChemSpider SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound 60.0 CHEBI:17552 ChEBI Uncharacterized aminotransferase yfdZ Pyruvate carboxylase, mitochondrial Aspartate aminotransferase, mitochondrial CHEBI:422 ChEBI 280 PubChem-compound CHEBI:30744 ChEBI SMILES CC(C)C[C@H](N)C(O)=O Dihydrolipoyl dehydrogenase, mitochondrial CHEBI:32805 ChEBI L-Glutamine 1.0 C00417 KEGG Compound SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1 SMILES N[C@@H](CCC(N)=O)C(O)=O 1198 PubChem-compound 1.0 2.3.3.8 false 2.3.3.8 Adenosine triphosphate + Citric acid + Coenzyme A → Acetyl-CoA + Adenosine diphosphate + Oxalacetic acid LEFT_TO_RIGHT 1.0 FAD BioCyc 193317 ChemSpider 3-METHYLBENZYLSUCCINYL-COA BioCyc 1.0 1.1.1.41 false 1.1.1.41 Isocitric acid + NAD → Carbon dioxide + Hydrogen Ion + NADH + Oxoglutaric acid LEFT_TO_RIGHT 86-01-1 CAS Q15758 UniProt P77434 UniProt 1060 PubChem-compound 1061 PubChem-compound SMILES [H+] P53597 UniProt HMDB0001967 HMDB 1.0 2.0 CHEBI:15351 ChEBI P00505 UniProt HMDB0000641 HMDB Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial SMP0000355 SMPDB 85-61-0 CAS UBIQUINONE-10 BioCyc 1.0 Malate dehydrogenase, mitochondrial Malate dehydrogenase, mitochondrial Serine/threonine- protein kinase mTOR Hypoxia- inducible factor 1-alpha inhibitor Myc proto-oncogene protein Mitochondrial pyruvate carrier 1 Mitochondrial pyruvate carrier 1 Neutral amino acid transporter B(0) Neutral amino acid transporter A Sodium-coupled neutral amino acid transporter 5 C-Myc-binding protein Monocarboxylate transporter 1 Y+L amino acid transporter 1 Pyruvate dehydrogenase complex Citrate synthase, mitochondrial Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial Oxoglutarate dehydrogenase complex Succinyl-CoA ligase Fumarate hydratase, mitochondrial Pyruvate carboxylase, mitochondrial Aconitate hydratase, mitochondrial Aconitate hydratase, mitochondrial Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial Succinate dehydrogenase cytochrome b560 subunit, mitochondrial Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Pyruvate dehydrogenase complex Citrate synthase, mitochondrial Fumarate hydratase, mitochondrial Pyruvate carboxylase, mitochondrial Aconitate hydratase, mitochondrial Aconitate hydratase, mitochondrial Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial Succinate dehydrogenase cytochrome b560 subunit, mitochondrial Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Glutaminase liver isoform, mitochondrial Glutamate dehydrogenase 1, mitochondrial Aspartate aminotransferase, mitochondrial Uncharacterized aminotransferase yfdZ Uncharacterized aminotransferase yfbQ NADP-dependent malic enzyme L-lactate dehydrogenase A chain Isocitrate dehydrogenase [NADP], mitochondrial ATP-citrate synthase ATP-citrate synthase Pyruvic acid FADH 2 Pyruvic acid FADH 2 Pyruvic acid Pyruvic acid L-Glutamine L-Glutamine L-Glutamine L-Glutamine L-Lactic acid L-Lactic acid L-Glutamine L-Glutamine L-Leucine L-Leucine CoA NAD Acetyl-CoA CO 2 NADH H 2 O Oxalacetic acid Citric acid CoA Isocitric acid NAD Oxoglutaric acid CO 2 NADH H + NAD CoA Succinyl-CoA NADH H + CO 2 P i GDP CoA GTP L-Malic acid Fumaric acid H 2 O NAD NADH H + ATP HCO 3 - ADP P i cis-Aconitic acid H 2 O H 2 O Q FAD FADH 2 Fumaric acid QH 2 CoA NAD Acetyl-CoA CO 2 NADH H 2 O Oxalacetic acid Citric acid CoA L-Malic acid Fumaric acid H 2 O NAD NADH H + ATP HCO 3 - ADP P i cis-Aconitic acid H 2 O H 2 O Isocitric acid Q FAD FADH 2 Fumaric acid QH 2 L-Glutamic acid NH 3 NAD NADH Hydrogen ion Oxoglutaric acid Oxalacetic acid Oxoglutaric acid L-Aspartic acid Pyruvic acid Oxoglutaric acid L-Alanine NADP NADPH H + CO 2 Pyruvic acid