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Pathway Description
L-Alanine Metabolism
Saccharomyces cerevisiae
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2015-12-02
Last Updated: 2019-08-14
L-alanine metabolized from pyruvate and glutamate reacting through a Alanine aminotransferase resulting in the release of a oxoglutaric acid and a alanine. Alanine is degraded by alanine aminotransferase to form pyruvic acid. Meanwhile, oxoglutaric acid is converted to L-glutamic acid also by alanine aminotransferase. Pyruvate is transported into mitochondria for further metabolism.
References
L-Alanine Metabolism References
Garcia-Campusano F, Anaya VH, Robledo-Arratia L, Quezada H, Hernandez H, Riego L, Gonzalez A: ALT1-encoded alanine aminotransferase plays a central role in the metabolism of alanine in Saccharomyces cerevisiae. Can J Microbiol. 2009 Apr;55(4):368-74. doi: 10.1139/w08-150.
Pubmed: 19396236
Galibert F, Alexandraki D, Baur A, Boles E, Chalwatzis N, Chuat JC, Coster F, Cziepluch C, De Haan M, Domdey H, Durand P, Entian KD, Gatius M, Goffeau A, Grivell LA, Hennemann A, Herbert CJ, Heumann K, Hilger F, Hollenberg CP, Huang ME, Jacq C, Jauniaux JC, Katsoulou C, Karpfinger-Hartl L, et al.: Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X. EMBO J. 1996 May 1;15(9):2031-49.
Pubmed: 8641269
Engel SR, Dietrich FS, Fisk DG, Binkley G, Balakrishnan R, Costanzo MC, Dwight SS, Hitz BC, Karra K, Nash RS, Weng S, Wong ED, Lloyd P, Skrzypek MS, Miyasato SR, Simison M, Cherry JM: The reference genome sequence of Saccharomyces cerevisiae: then and now. G3 (Bethesda). 2014 Mar 20;4(3):389-98. doi: 10.1534/g3.113.008995.
Pubmed: 24374639
Huh WK, Falvo JV, Gerke LC, Carroll AS, Howson RW, Weissman JS, O'Shea EK: Global analysis of protein localization in budding yeast. Nature. 2003 Oct 16;425(6959):686-91. doi: 10.1038/nature02026.
Pubmed: 14562095
Johnston M, Hillier L, Riles L, Albermann K, Andre B, Ansorge W, Benes V, Bruckner M, Delius H, Dubois E, Dusterhoft A, Entian KD, Floeth M, Goffeau A, Hebling U, Heumann K, Heuss-Neitzel D, Hilbert H, Hilger F, Kleine K, Kotter P, Louis EJ, Messenguy F, Mewes HW, Hoheisel JD, et al.: The nucleotide sequence of Saccharomyces cerevisiae chromosome XII. Nature. 1997 May 29;387(6632 Suppl):87-90.
Pubmed: 9169871
Grandier-Vazeille X, Bathany K, Chaignepain S, Camougrand N, Manon S, Schmitter JM: Yeast mitochondrial dehydrogenases are associated in a supramolecular complex. Biochemistry. 2001 Aug 21;40(33):9758-69. doi: 10.1021/bi010277r.
Pubmed: 11502169
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