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Pathway Description
Amino Sugar and Nucleotide Sugar Metabolism
Saccharomyces cerevisiae
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2016-01-14
Last Updated: 2019-08-14
The metabolism of aminosugars begins with D-fructose being phosphorylated resulting in the release of Beta-D-fructose 6-phosphate.
Beta-D-fructose 6-phosphate can react in 3 different paths:
1.-Beta-D-fructose 6-phosphate reacts with glucosamine 6-phosphate synthase resulting in the release of glucosamine 6-phosphate. This compound then reacts with glucosamine phosphate N-acetyltransferase resulting in the releaase of N-acetyl-D-Glucosamine 6-phosphate. This compound then reacts with a phosphoacetylglucosamine mutase resulting in the release of N-acetyl-glucosamine 1-phosphate. The latter compound reacts with a UTP through a UDP-N-acetylglucosamine pyrophosphorylase resulting in the release of UDP-N-acetylglucosamine. This compound is then used to produce chiting
2.-Beta-D-fructose 6-phosphate reacts with a mannose isomerase to release mannose 6-phosphate. The latter compound then reacts with a phosphomutase resulting in the release of mannose 1-phosphate. This in turn reacts with a GTP through a PSA1 resulting in the release of a guanosine diphosphate mannose.
3.-Beta-D-fructose 6-phosphate reacts with a glucose isomerase to release a beta-d-glucose 6 phosphate. This compound reacts wth phosphoglucomutase resulting in the release of glucose 1phosphate. This compound then reacts with a UTP through a uridinephosphoglucose pyrophosphorylase resulting in the release of UDP and a UDP-glucose.
UDP-glucose reacts with a bifunctional protein GAL10 resulting in the release of Uridine diphosphategalactose. This compound reacts in a reversible reaction with glucose 1-phosphate through a Galactose 1-phosphate uridylyltransferase resulting in the release of UDP-glucose and galactose 1-phosphate.
References
Amino Sugar and Nucleotide Sugar Metabolism References
Hashimoto H, Sakakibara A, Yamasaki M, Yoda K: Saccharomyces cerevisiae VIG9 encodes GDP-mannose pyrophosphorylase, which is essential for protein glycosylation. J Biol Chem. 1997 Jun 27;272(26):16308-14.
Pubmed: 9195935
Kepes F, Schekman R: The yeast SEC53 gene encodes phosphomannomutase. J Biol Chem. 1988 Jul 5;263(19):9155-61.
Pubmed: 3288631
Orlean P, Albright C, Robbins PW: Cloning and sequencing of the yeast gene for dolichol phosphate mannose synthase, an essential protein. J Biol Chem. 1988 Nov 25;263(33):17499-507.
Pubmed: 3053713
Warit S, Zhang N, Short A, Walmsley RM, Oliver SG, Stateva LI: Glycosylation deficiency phenotypes resulting from depletion of GDP-mannose pyrophosphorylase in two yeast species. Mol Microbiol. 2000 Jun;36(5):1156-66.
Pubmed: 10844699
Ball S, Colleoni C, Cenci U, Raj JN, Tirtiaux C: The evolution of glycogen and starch metabolism in eukaryotes gives molecular clues to understand the establishment of plastid endosymbiosis. J Exp Bot. 2011 Mar;62(6):1775-801. doi: 10.1093/jxb/erq411. Epub 2011 Jan 10.
Pubmed: 21220783
Bulik DA, Olczak M, Lucero HA, Osmond BC, Robbins PW, Specht CA: Chitin synthesis in Saccharomyces cerevisiae in response to supplementation of growth medium with glucosamine and cell wall stress. Eukaryot Cell. 2003 Oct;2(5):886-900.
Pubmed: 14555471
Milewski S, Gabriel I, Olchowy J: Enzymes of UDP-GlcNAc biosynthesis in yeast. Yeast. 2006 Jan 15;23(1):1-14. doi: 10.1002/yea.1337.
Pubmed: 16408321
Hofmann M, Boles E, Zimmermann FK: Characterization of the essential yeast gene encoding N-acetylglucosamine-phosphate mutase. Eur J Biochem. 1994 Apr 15;221(2):741-7.
Pubmed: 8174553
Albig W, Entian KD: Structure of yeast glucokinase, a strongly diverged specific aldo-hexose-phosphorylating isoenzyme. Gene. 1988 Dec 15;73(1):141-52. doi: 10.1016/0378-1119(88)90320-4.
Pubmed: 3072253
Scherens B, Messenguy F, Gigot D, Dubois E: The complete sequence of a 9,543 bp segment on the left arm of chromosome III reveals five open reading frames including glucokinase and the protein disulfide isomerase. Yeast. 1992 Jul;8(7):577-85. doi: 10.1002/yea.320080709.
Pubmed: 1523890
Oliver SG, van der Aart QJ, Agostoni-Carbone ML, Aigle M, Alberghina L, Alexandraki D, Antoine G, Anwar R, Ballesta JP, Benit P, et al.: The complete DNA sequence of yeast chromosome III. Nature. 1992 May 7;357(6373):38-46. doi: 10.1038/357038a0.
Pubmed: 1574125
Jacq C, Alt-Morbe J, Andre B, Arnold W, Bahr A, Ballesta JP, Bargues M, Baron L, Becker A, Biteau N, Blocker H, Blugeon C, Boskovic J, Brandt P, Bruckner M, Buitrago MJ, Coster F, Delaveau T, del Rey F, Dujon B, Eide LG, Garcia-Cantalejo JM, Goffeau A, Gomez-Peris A, Zaccaria P, et al.: The nucleotide sequence of Saccharomyces cerevisiae chromosome IV. Nature. 1997 May 29;387(6632 Suppl):75-8.
Pubmed: 9169867
Engel SR, Dietrich FS, Fisk DG, Binkley G, Balakrishnan R, Costanzo MC, Dwight SS, Hitz BC, Karra K, Nash RS, Weng S, Wong ED, Lloyd P, Skrzypek MS, Miyasato SR, Simison M, Cherry JM: The reference genome sequence of Saccharomyces cerevisiae: then and now. G3 (Bethesda). 2014 Mar 20;4(3):389-98. doi: 10.1534/g3.113.008995.
Pubmed: 24374639
Lutfiyya LL, Iyer VR, DeRisi J, DeVit MJ, Brown PO, Johnston M: Characterization of three related glucose repressors and genes they regulate in Saccharomyces cerevisiae. Genetics. 1998 Dec;150(4):1377-91.
Pubmed: 9832517
Kopetzki E, Entian KD, Mecke D: Complete nucleotide sequence of the hexokinase PI gene (HXK1) of Saccharomyces cerevisiae. Gene. 1985;39(1):95-101. doi: 10.1016/0378-1119(85)90113-1.
Pubmed: 3908224
Stachelek C, Stachelek J, Swan J, Botstein D, Konigsberg W: Identification, cloning and sequence determination of the genes specifying hexokinase A and B from yeast. Nucleic Acids Res. 1986 Jan 24;14(2):945-63. doi: 10.1093/nar/14.2.945.
Pubmed: 3003701
Murakami Y, Naitou M, Hagiwara H, Shibata T, Ozawa M, Sasanuma S, Sasanuma M, Tsuchiya Y, Soeda E, Yokoyama K, et al.: Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae. Nat Genet. 1995 Jul;10(3):261-8. doi: 10.1038/ng0795-261.
Pubmed: 7670463
Frohlich KU, Entian KD, Mecke D: The primary structure of the yeast hexokinase PII gene (HXK2) which is responsible for glucose repression. Gene. 1985;36(1-2):105-11. doi: 10.1016/0378-1119(85)90074-5.
Pubmed: 3905511
Coissac E, Maillier E, Robineau S, Netter P: Sequence of a 39,411 bp DNA fragment covering the left end of chromosome VII of Saccharomyces cerevisiae. Yeast. 1996 Dec;12(15):1555-62. doi: 10.1002/(SICI)1097-0061(199612)12:15%3C1555::AID-YEA43%3E3.0.CO;2-Q.
Pubmed: 8972578
Johnston M, Hillier L, Riles L, Albermann K, Andre B, Ansorge W, Benes V, Bruckner M, Delius H, Dubois E, Dusterhoft A, Entian KD, Floeth M, Goffeau A, Hebling U, Heumann K, Heuss-Neitzel D, Hilbert H, Hilger F, Kleine K, Kotter P, Louis EJ, Messenguy F, Mewes HW, Hoheisel JD, et al.: The nucleotide sequence of Saccharomyces cerevisiae chromosome XII. Nature. 1997 May 29;387(6632 Suppl):87-90.
Pubmed: 9169871
Hu Y, Rolfs A, Bhullar B, Murthy TV, Zhu C, Berger MF, Camargo AA, Kelley F, McCarron S, Jepson D, Richardson A, Raphael J, Moreira D, Taycher E, Zuo D, Mohr S, Kane MF, Williamson J, Simpson A, Bulyk ML, Harlow E, Marsischky G, Kolodner RD, LaBaer J: Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae. Genome Res. 2007 Apr;17(4):536-43. doi: 10.1101/gr.6037607. Epub 2007 Feb 23.
Pubmed: 17322287
Smith DJ, Proudfoot A, Friedli L, Klig LS, Paravicini G, Payton MA: PMI40, an intron-containing gene required for early steps in yeast mannosylation. Mol Cell Biol. 1992 Jul;12(7):2924-30. doi: 10.1128/mcb.12.7.2924.
Pubmed: 1377774
Dietrich FS, Mulligan J, Hennessy K, Yelton MA, Allen E, Araujo R, Aviles E, Berno A, Brennan T, Carpenter J, Chen E, Cherry JM, Chung E, Duncan M, Guzman E, Hartzell G, Hunicke-Smith S, Hyman RW, Kayser A, Komp C, Lashkari D, Lew H, Lin D, Mosedale D, Davis RW, et al.: The nucleotide sequence of Saccharomyces cerevisiae chromosome V. Nature. 1997 May 29;387(6632 Suppl):78-81.
Pubmed: 9169868
Watzele G, Tanner W: Cloning of the glutamine:fructose-6-phosphate amidotransferase gene from yeast. Pheromonal regulation of its transcription. J Biol Chem. 1989 May 25;264(15):8753-8.
Pubmed: 2656689
Cheret G, Pallier C, Valens M, Diagnan-Fornier B, Fukuhara H, Bolotin-Fukuhara M, Sor F: The DNA sequence analysis of the HAP4-LAP4 region on chromosome XI of Saccharomyces cerevisiae suggests the presence of a second aspartate aminotransferase gene in yeast. Yeast. 1993 Nov;9(11):1259-65. doi: 10.1002/yea.320091113.
Pubmed: 8109175
Dujon B, Alexandraki D, Andre B, Ansorge W, Baladron V, Ballesta JP, Banrevi A, Bolle PA, Bolotin-Fukuhara M, Bossier P, Bou G, Boyer J, Bultrago MJ, Cheret G, Colleaux L, Dalgnan-Fornler B, del Rey F, Dlon C, Domdey H, Dusterhoft A, Dusterhus S, Entlan KD, Erfle H, Esteban PF, Feldmann H, Fernandes L, Robo GM, Fritz C, Fukuhara H, Gabel C, Gaillon L, Carcia-Cantalejo JM, Garcia-Ramirez JJ, Gent NE, Ghazvini M, Goffeau A, Gonzalez A, Grothues D, Guerreiro P, Hegemann J, Hewitt N, Hilger F, Hollenberg CP, Horaitis O, Indge KJ, Jacquier A, James CM, Jauniaux C, Jimenez A, Keuchel H, Kirchrath L, Kleine K, Kotter P, Legrain P, Liebl S, Louis EJ, Maia e Silva A, Marck C, Monnier AL, Mostl D, Muller S, Obermaier B, Oliver SG, Pallier C, Pascolo S, Pfeiffer F, Philippsen P, Planta RJ, Pohl FM, Pohl TM, Pohlmann R, Portetelle D, Purnelle B, Puzos V, Ramezani Rad M, Rasmussen SW, Remacha M, Revuelta JL, Richard GF, Rieger M, Rodrigues-Pousada C, Rose M, Rupp T, Santos MA, Schwager C, Sensen C, Skala J, Soares H, Sor F, Stegemann J, Tettelin H, Thierry A, Tzermia M, Urrestarazu LA, van Dyck L, Van Vliet-Reedijk JC, Valens M, Vandenbo M, Vilela C, Vissers S, von Wettstein D, Voss H, Wiemann S, Xu G, Zimmermann J, Haasemann M, Becker I, Mewes HW: Complete DNA sequence of yeast chromosome XI. Nature. 1994 Jun 2;369(6479):371-8. doi: 10.1038/369371a0.
Pubmed: 8196765
Mio T, Yamada-Okabe T, Arisawa M, Yamada-Okabe H: Saccharomyces cerevisiae GNA1, an essential gene encoding a novel acetyltransferase involved in UDP-N-acetylglucosamine synthesis. J Biol Chem. 1999 Jan 1;274(1):424-9. doi: 10.1074/jbc.274.1.424.
Pubmed: 9867860
Boles E, Liebetrau W, Hofmann M, Zimmermann FK: A family of hexosephosphate mutases in Saccharomyces cerevisiae. Eur J Biochem. 1994 Feb 15;220(1):83-96. doi: 10.1111/j.1432-1033.1994.tb18601.x.
Pubmed: 8119301
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