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CHEBI:16015 ChEBI 6022 PubChem-compound ReactionCatalysis6693 ACTIVATION HMDB01227 HMDB 365-07-1 CAS 937 ChemSpider 964-26-1 CAS HMDB00250 HMDB 58580 ChemSpider HMDB01342 HMDB HMDB01341 HMDB ReactionCatalysis6697 ACTIVATION ReactionCatalysis6696 ACTIVATION ReactionCatalysis6695 ACTIVATION pyrimidine metabolism ReactionCatalysis6694 ACTIVATION 1.0 ReactionCatalysis6699 ACTIVATION ReactionCatalysis6698 ACTIVATION 6133 PubChem-compound CHEBI:16389 ChEBI 6132 PubChem-compound HMDB00148 HMDB C19H21N7O6 Dihydrofolic acid 443.15533 CHEBI:17239 ChEBI C10H15N2O8P 5-Thymidylic acid 322.0566 dCDP ATP BioCyc CHEBI:17111 ChEBI H4N Ammonium 18.034374 1.0 559142 ChemSpider Unknown 63-38-7 CAS HMDB00595 HMDB C00459 KEGG Compound PW002469 PathWhiz C00337 KEGG Compound C00458 KEGG Compound 5746 ChemSpider 1.0 HCO3 BioCyc 5745 ChemSpider Dihydrofolic acid 365-08-2 CAS 5742 ChemSpider 5-Thymidylic acid L-ASPARTATE BioCyc C9H15N2O14P3 Deoxyuridine triphosphate 467.9736 SMILES O[C@H]1C[C@@H](O[C@@H]1COP(O)(O)=O)N1C=CC(=O)NC1=O 7540-64-9 CAS HMDB59597 HMDB 64968 PubChem-compound 1.0 C00105 KEGG Compound 6030 PubChem-compound 6031 PubChem-compound 800-73-7 CAS 58493 ChemSpider C00460 KEGG Compound 1010 ChemSpider 942 ChemSpider CHEBI:15033 ChEBI HMDB41827 HMDB PPI BioCyc 21960964 PubChem-compound C00119 KEGG Compound 160617 PubChem-compound SMILES O[C@H]1C[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)N1C=CC(=O)NC1=O C10H16N2O11P2 dTDP 402.02292 Ammonium P30402 UniProt HMDB01546 HMDB C5H10N2O3 L-Glutamine 146.06914 Hydrogen Ion CH4NO5P Carbamoyl phosphate 140.98271 Adenosine triphosphate C00112 KEGG Compound 3.6.1.23 false 3.6.1.23 Deoxyuridine triphosphate + Water → Hydrogen Ion + Phosphate + dUMP LEFT_TO_RIGHT Reaction6745 false Adenosine triphosphate + dTDP → Adenosine diphosphate + Thymidine 5'-triphosphate LEFT_TO_RIGHT Reaction6746 false Cytidine triphosphate + a reduced flavodoxin → Water + an oxidized flavodoxin + dCTP LEFT_TO_RIGHT 1.0 Reaction6747 false Uridine triphosphate + a reduced flavodoxin → Deoxyuridine triphosphate + Water + an oxidized flavodoxin LEFT_TO_RIGHT Reaction6748 false CDP + a reduced NrdH glutaredoxin-like protein → Water + an oxidized NrdH glutaredoxin-like protein + dCDP LEFT_TO_RIGHT Reaction6749 false Uridine 5'-diphosphate + a reduced NrdH glutaredoxin-like protein → Water + an oxidized NrdH glutaredoxin-like protein + dUDP LEFT_TO_RIGHT 1.17.4.1 false 1.17.4.1 CDP + reduced thioredoxin → Water + dCDP + oxidized thioredoxin LEFT_TO_RIGHT Reaction6741 false Adenosine triphosphate + dCDP → Adenosine diphosphate + dCTP LEFT_TO_RIGHT Reaction6742 false Uridine 5'-diphosphate + reduced thioredoxin ? Water + dUDP + oxidized thioredoxin Reaction6743 false Adenosine triphosphate + dUDP → Adenosine diphosphate + Deoxyuridine triphosphate LEFT_TO_RIGHT C00009 KEGG Compound 4307 ChemSpider C00008 KEGG Compound 1.0 HMDB00226 HMDB P06785 UniProt C00001 KEGG Compound C00364 KEGG Compound CTP BioCyc C00363 KEGG Compound CHEBI:18361 ChEBI 4,5-Dihydroorotic acid CHEBI:18367 ChEBI 1032 ChemSpider C00002 KEGG Compound C00365 KEGG Compound 2.1.3.2 false 2.1.3.2 Carbamoyl phosphate + L-Aspartic acid → N-carbamoyl-L-aspartate + Hydrogen Ion + Phosphate LEFT_TO_RIGHT 3.5.2.3 false 3.5.2.3 N-carbamoyl-L-aspartate + Hydrogen Ion → 4,5-Dihydroorotic acid + Water LEFT_TO_RIGHT 2.4.2.10 false 2.4.2.10 Orotic acid + Phosphoribosyl pyrophosphate → Orotidylic acid + Pyrophosphate LEFT_TO_RIGHT 4.1.1.23 false 4.1.1.23 Hydrogen Ion + Orotidylic acid → Carbon dioxide + Uridine 5'-monophosphate LEFT_TO_RIGHT 2.7.4.22 false 2.7.4.22 Adenosine triphosphate + Uridine 5'-monophosphate → Adenosine diphosphate + Uridine 5'-diphosphate LEFT_TO_RIGHT 2.7.4.6 false 2.7.4.6 Adenosine triphosphate + Uridine 5'-diphosphate → Adenosine diphosphate + Uridine triphosphate LEFT_TO_RIGHT 6.3.4.2 false 6.3.4.2 Adenosine triphosphate + L-Glutamine + Uridine triphosphate + Water → Adenosine diphosphate + Cytidine triphosphate + Hydrogen Ion + L-Glutamic acid + Phosphate LEFT_TO_RIGHT HMDB01429 HMDB HMDB00218 HMDB 2.0 1.0 1.0 65-86-1 CAS 6.3.5.5 false 6.3.5.5 2 Adenosine triphosphate + Hydrogen carbonate + L-Glutamine + Water → 2 Adenosine diphosphate + Carbamoyl phosphate + 2 Hydrogen Ion + L-Glutamic acid + Phosphate LEFT_TO_RIGHT SubPathwayInteraction3728 SubPathway3728Reaction SubPathwayReaction SubPathwayInteraction3729 SubPathway3729Reaction SubPathwayReaction C9H15N3O10P2 dCDP 387.02325 44367445 PubChem-compound 447920 PubChem-compound C00011 KEGG Compound C01342 KEGG Compound 7339 PubChem-compound C00015 KEGG Compound C01346 KEGG Compound C01103 KEGG Compound C00013 KEGG Compound H Hydrogen Ion 1.007825 1.0 58574 ChemSpider L-Glutamine 56-65-5 CAS Carbamoyl phosphate CHEBI:17013 ChEBI C00025 KEGG Compound dTDP 1.0 HMDB01409 HMDB 3.5.4.13 false 3.5.4.13 Hydrogen Ion + Water + dCTP → Ammonium + Deoxyuridine triphosphate LEFT_TO_RIGHT 1.3.5.2 false 1.3.5.2 4,5-Dihydroorotic acid + Ubiquinone-1 → Orotic acid + Ubiquinol-1 LEFT_TO_RIGHT 2.1.1.45 false 2.1.1.45 5,10-methenyltetrahydrofolate mono-L-glutamate + dUMP → 5-Thymidylic acid + Dihydrofolic acid LEFT_TO_RIGHT TTP BioCyc 1.0 1.0 1.0 769 PubChem-compound 648 PubChem-compound DCDP BioCyc C00399 KEGG Compound 1.0 128553 ChemSpider 46878371 PubChem-compound Water Ribonucleoside-diphosphate reductase small chain 2 Ribonucleoside-diphosphate reductase large chain 1 SMILES NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Dihydroorotase 1.0 Protein URA2 HMDB00528 HMDB Ribonucleoside-diphosphate reductase large chain 1 Orotate phosphoribosyltransferase 2 C9H14N2O11P2 dUDP 388.0073 98792 PubChem-compound C9H16N3O13P3 dCTP 466.9896 Protein URA2 SMILES [O-]P([O-])(=O)OP([O-])([O-])=O Protein URA2 Uridine 5'-diphosphate C00049 KEGG Compound SMILES OC(=N)NC(CC([O-])=O)C([O-])=O C00169 KEGG Compound C00288 KEGG Compound 56-85-9 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 58-97-9 CAS DIHYDROFOLATE BioCyc 7062 ChemSpider 1.0 SMILES CC1=CN([C@H]2C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)C(=O)NC1=O C9H14N2O12P2 Uridine 5'-diphosphate 404.0022 HMDB00538 HMDB UTP BioCyc 5902 ChemSpider C5H6N2O4 4,5-Dihydroorotic acid 158.03276 DI-H-OROTATE BioCyc 5903 ChemSpider HMDB00998 HMDB C00295 KEGG Compound 7732-18-5 CAS SMILES COC1=C(O)C(C)=C(CC=C(C)C)C(O)=C1OC dCTP SMILES OC(=O)C1=CC(=O)NC(=O)N1 C00063 KEGG Compound 145729 PubChem-compound dUDP 56-86-0 CAS 590-55-6 CAS 1.0 HMDB00641 HMDB DUDP BioCyc C10H16N5O13P3 Adenosine triphosphate 506.99576 CHEBI:17053 ChEBI C00064 KEGG Compound 1.0 1.0 4033-27-6 CAS 65-47-4 CAS 132961 ChemSpider HMDB01967 HMDB 1.0 962 PubChem-compound 1.0 967 PubChem-compound OROTATE BioCyc 5800 ChemSpider 58-98-0 CAS CHEBI:18077 ChEBI Unknown CO2 Carbon dioxide 43.98983 C00075 KEGG Compound CHEBI:18075 ChEBI Phosphate Ubiquinone-1 C00080 KEGG Compound SMILES NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 1.0 SMILES N[C@@H](CCC(O)=O)C(O)=O 1.0 5809 ChemSpider 5808 ChemSpider TMP BioCyc 14265-44-2 CAS 6176 PubChem-compound 58-64-0 CAS L-Aspartic acid C4H7NO4 L-Aspartic acid 133.0375 644102 PubChem-compound 5941 ChemSpider 1.0 SMILES [H][C@@](CCC([O-])=O)(N=C(O)C1=CC=C(C=C1)[N+]1=CN2C3=C(NC[C@]2([H])C1)NC(=N)N=C3O)C([O-])=O 1.0 CHEBI:18050 ChEBI H2O Water 18.010565 Thymidylate synthase SMILES O[C@H]1[C@@H](O)[C@@H](O[P@](O)(=O)OP(O)(O)=O)O[C@@H]1COP(O)(O)=O SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(O)=O)N1C=CC(=O)NC1=O SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)N1C=CC(=O)NC1=O 2.0 UMP BioCyc Carbon dioxide 56-84-8 CAS 749 ChemSpider 628 ChemSpider 71-52-3 CAS PW000909 PathWhiz Hydrogen carbonate CHO3 Hydrogen carbonate 60.99257 2149-82-8 CAS 30572 ChemSpider CHEBI:15842 ChEBI C20H20N7O6 5,10-methenyltetrahydrofolate mono-L-glutamate 454.14804 N-carbamoyl-L-aspartate 4.0 Cytidine triphosphate SMILES O 1.0 Pyrophosphate C5H4N2O4 Orotic acid 156.0171 5961 PubChem-compound 1.0 SMILES OC([O-])=O ADP BioCyc 1038 PubChem-compound SMILES O[C@H]1C[C@@H](O[C@@H]1COP(O)(=O)OP(O)(O)=O)N1C=CC(=O)NC1=O Orotic acid SMILES NC1=NC(=O)N(C=C1)[C@H]1C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O1 P49723 UniProt 274 ChemSpider 272 ChemSpider 155-54-4 CAS 4208-67-7 CAS DUMP BioCyc L-glutamate metabolism SubPathway 141140 ChemSpider CHEBI:15713 ChEBI 164628 PubChem-compound O4P Phosphate 94.95342 C5H6N2O5 N-carbamoyl-L-aspartate 174.02876 CTP synthase ribonucleoside diphosphate reductase 1 C14H18O4 Ubiquinone-1 250.12051 Ubiquinol-1 nucleoside diphosphate kinase orotidine-5'-phosphate decarboxylase UMP kinase dihydroorotase 2.0 orotate phosphoribosyltransferase carbamoyl phosphate synthetase aspartate transcarbamylase Orotidylic acid SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(=O)OP(O)(O)=O)N1C=CC(=O)NC1=O 2.0 C10H13N2O11P Orotidylic acid 368.0257 1.0 2056-98-6 CAS 144320 ChemSpider oxidized thioredoxin reduced thioredoxin 218 ChemSpider C9H15N2O15P3 Uridine triphosphate 483.96854 L-Glutamic acid CDP C5H13O14P3 Phosphoribosyl pyrophosphate 389.9518 SMILES [O-]P([O-])([O-])=O CHEBI:28846 ChEBI 1.0 124-38-9 CAS 6.0 C9H13N2O9P Uridine 5'-monophosphate 324.03586 Dihydroorotase Orotate phosphoribosyltransferase 2 Ribonucleoside-diphosphate reductase large chain 1 CHEBI:16742 ChEBI Ribonucleoside-diphosphate reductase large chain 1 Protein URA2 Protein URA2 9319 ChemSpider Protein URA2 a reduced NrdH glutaredoxin-like protein SMILES COC1=C(OC)C(=O)C(CC=C(C)C)=C(C)C1=O an oxidized flavodoxin an oxidized NrdH glutaredoxin-like protein CHEBI:57455 ChEBI 2.0 a reduced flavodoxin GLN BioCyc SMILES O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(O)(O)=O)N1C(=O)NC(=O)C=C1C(O)=O GLT BioCyc CDP BioCyc Ribonucleoside-diphosphate reductase small chain 2 an oxidized flavodoxin 1.0 a reduced flavodoxin an oxidized NrdH glutaredoxin-like protein a reduced NrdH glutaredoxin-like protein SMILES O=C=O CHEBI:28938 ChEBI http://identifiers.org/smpdb/SMP00926 SMPDB TDP BioCyc O7P2 Pyrophosphate 173.91193 Uridine 5'-monophosphate 5,10-methenyltetrahydrofolate mono-L-glutamate 5957 PubChem-compound C9H16N3O14P3 Cytidine triphosphate 482.9845 1.0 Uridine triphosphate Phosphoribosyl pyrophosphate Thymidylate synthase C00705 KEGG Compound CHEBI:15633 ChEBI http://identifiers.org/smpdb/SMP00811 SMPDB P20051 UniProt HMDB01096 HMDB reduced thioredoxin Adenosine diphosphate Thymidine 5'-triphosphate C10H15N5O10P2 Adenosine diphosphate 427.02942 C10H17N2O14P3 Thymidine 5'-triphosphate 481.98926 SMILES N[C@@H](CC(O)=O)C(O)=O 1.0 CHEBI:17622 ChEBI OROTIDINE-5-PHOSPHATE BioCyc 1.0 CHEBI:17625 ChEBI CPD-8587 BioCyc SMILES NC1=NC(=O)N(C=C1)[C@H]1C[C@H](O)[C@@H](COP(O)(=O)OP(O)(O)=O)O1 1.0 UDP BioCyc oxidized thioredoxin C9H13N2O8P dUMP 308.04095 150855 PubChem-compound DCTP BioCyc 14000-31-8 CAS CARBAMOYL-P BioCyc 65063 PubChem-compound 1.0 65070 PubChem-compound SMILES NC(=O)OP(O)(O)=O 14798-03-9 CAS HMDB01191 HMDB CHEBI:15422 ChEBI 1.0 HMDB00191 HMDB 1.0 HMDB02012 HMDB 1.0 SMILES CC1=CN([C@H]2C[C@H](O)[C@@H](COP(O)(O)=O)O2)C(=O)NC1=O C9H15N3O11P2 CDP 403.0182 dUMP C5H9NO4 L-Glutamic acid 147.05316 33032 PubChem-compound SMILES [NH4+] 9700 PubChem-compound CHEBI:16526 ChEBI HMDB00082 HMDB SMILES NC1=NC2=C(N=C(CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)CN2)C(=O)N1 CHEBI:16761 ChEBI HMDB01056 HMDB 65091 PubChem-compound DUTP BioCyc 1173-82-6 CAS PW000789 PathWhiz CHEBI:28850 ChEBI CHEBI:17544 ChEBI 2.0 dCTP deaminase C14H20O4 Ubiquinol-1 252.13615 HMDB00295 HMDB 1.0 SMILES OC(=O)C1CC(=O)NC(=O)N1 CHEBI:16695 ChEBI HMDB02111 HMDB 2.0 Ribonucleoside-diphosphate reductase 1 CHEBI:32814 ChEBI ribonucleoside-triphosphate reductase ribonucleoside-diphosphate reductase 2 deoxyuridine triphosphatase ribonucleoside diphosphate reductase 1 nucleoside triphosphate pyrophosphohydrolase CHEBI:15377 ChEBI CHEBI:17677 ChEBI Deoxyuridine triphosphate 278 PubChem-compound CHEBI:15378 ChEBI SMILES [H+] 2.0 SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O HMDB01274 HMDB CHEBI:17672 ChEBI http://identifiers.org/smpdb/SMP02370 SMPDB ReactionCatalysis6705 ACTIVATION ReactionCatalysis6704 ACTIVATION 1.0 1.0 ReactionCatalysis6703 ACTIVATION P21524 UniProt ReactionCatalysis6702 ACTIVATION ReactionCatalysis6709 ACTIVATION 280 PubChem-compound ReactionCatalysis6708 ACTIVATION ReactionCatalysis6707 ACTIVATION CHEBI:30865 ChEBI ReactionCatalysis6706 ACTIVATION ReactionCatalysis6701 ACTIVATION ReactionCatalysis6700 ACTIVATION 1.0 HMDB01245 HMDB 491-97-4 CAS CHEBI:16311 ChEBI C00415 KEGG Compound 4462 PubChem-compound 58601 ChemSpider 16741146 PubChem-compound SMILES CC1=CN([C@H]2C[C@H](O)[C@@H](COP(O)(=O)OP(O)(O)=O)O2)C(=O)NC1=O 89228 ChemSpider SMILES N[C@@H](CCC(N)=O)C(O)=O PRPP BioCyc HMDB01000 HMDB 3.0 ReactionCatalysis6715 ACTIVATION ReactionCatalysis6714 ACTIVATION ReactionCatalysis6713 ACTIVATION 727-81-1 CAS ReactionCatalysis6712 ACTIVATION Reaction3534 false Cytidine triphosphate + Water → CDP + Hydrogen Ion + Phosphate LEFT_TO_RIGHT ReactionCatalysis6711 ACTIVATION ReactionCatalysis6710 ACTIVATION 2.0 1.0 P07259 UniProt 1061 PubChem-compound HMDB00288 HMDB 63-39-8 CAS CHEBI:17659 ChEBI HMDB00280 HMDB PRPP Biosynthesis SubPathway 6.0 HMDB00285 HMDB Protein URA2 Protein URA2 Protein URA2 aspartate transcarbamylase Dihydroorotase Orotate phosphoribosyltransferase 2 orotidine-5'- phosphate decarboxylase UMP kinase nucleoside diphosphate kinase CTP synthase ribonucleoside diphosphate reductase 1 Ribonucleoside- diphosphate reductase large chain 1 nucleoside diphosphate kinase ribonucleoside diphosphate reductase 1 ribonucleoside diphosphate reductase 1 nucleoside diphosphate kinase deoxyuridine triphosphatase nucleoside triphosphate pyrophosphohydrolase pyrimidine deoxynucleoside triphosphate pyrophosphohydrolase nucleoside diphosphate kinase ribonucleoside- triphosphate reductase ribonucleoside- triphosphate reductase ribonucleoside- diphosphate reductase 2 ribonucleoside- diphosphate reductase 2 Ribonucleoside- diphosphate reductase large chain 1 Ribonucleoside- diphosphate reductase small chain 2 dCTP deaminase dihydroorotate dehydrogenase, type 2 Thymidylate synthase HCO 3 - H 2 O L-Glutamine ATP ADP P i L-Glutamic acid H + Carbamoyl phosphate L-Aspartic acid P i H + N-carbamoyl- L-aspartate H + H 2 O 4,5- Dihydroorotic acid Orotic acid Phosphoribosyl pyrophosphate PP i Orotidylic acid H + CO 2 Uridine 5'- monophosphate ATP ADP Uridine 5'-diphosphate ATP Uridine triphosphate ADP L-Glutamine H 2 O ATP ADP H + P i L-Glutamic acid Cytidine triphosphate H 2 O P i H + CDP H 2 O dCDP ATP ADP dCTP H 2 O dUDP ATP ADP Deoxyuridine triphosphate H 2 O P i H + dUMP ATP dTDP ADP Thymidine 5'-triphosphate H 2 O dCTP H 2 O Deoxyuridine triphosphate H 2 O dCDP H 2 O dUDP H 2 O H + Ammonium Deoxyuridine triphosphate Ubiquinone-1 Ubiquinol-1 Orotic acid 5,10- methenyltetrahydrofolate mono-L- glutamate Dihydrofolic acid 5-Thymidylic acid Adenosine triphosphate Zinc Magnesium Guanosine triphosphate Magnesium Magnesium Adenosine triphosphate Fe2+ Magnesium Magnesium Magnesium Zinc Magnesium Magnesium Adenosine triphosphate dGTP Thymidine 5'-triphosphate Potassium Magnesium Zinc (II) ion 4Fe-4S Adenosine triphosphate dGTP Thymidine 5'-triphosphate Potassium Magnesium Zinc (II) ion 4Fe-4S Fe3+ Flavin Mononucleotide reduced thioredoxin oxidized thioredoxin reduced thioredoxin oxidized thioredoxin a reduced flavodoxin an oxidized flavodoxin a reduced flavodoxin an oxidized flavodoxin a reduced NrdH glutaredoxin- like protein an oxidized NrdH glutaredoxin- like protein a reduced NrdH glutaredoxin- like protein an oxidized NrdH glutaredoxin- like protein L-glutamate metabolism PRPP Biosynthesis
CHEBI:16015 ChEBI 6022 PubChem-compound ReactionCatalysis6693 ACTIVATION HMDB01227 HMDB 365-07-1 CAS 937 ChemSpider 964-26-1 CAS HMDB00250 HMDB 58580 ChemSpider HMDB01342 HMDB HMDB01341 HMDB ReactionCatalysis6697 ACTIVATION ReactionCatalysis6696 ACTIVATION ReactionCatalysis6695 ACTIVATION pyrimidine metabolism ReactionCatalysis6694 ACTIVATION 1.0 ReactionCatalysis6699 ACTIVATION ReactionCatalysis6698 ACTIVATION 6133 PubChem-compound CHEBI:16389 ChEBI 6132 PubChem-compound HMDB00148 HMDB C19H21N7O6 Dihydrofolic acid 443.15533 CHEBI:17239 ChEBI C10H15N2O8P 5-Thymidylic acid 322.0566 dCDP ATP BioCyc CHEBI:17111 ChEBI H4N Ammonium 18.034374 1.0 559142 ChemSpider Unknown 63-38-7 CAS HMDB00595 HMDB C00459 KEGG Compound PW002469 PathWhiz C00337 KEGG Compound C00458 KEGG Compound 5746 ChemSpider 1.0 HCO3 BioCyc 5745 ChemSpider Dihydrofolic acid 365-08-2 CAS 5742 ChemSpider 5-Thymidylic acid L-ASPARTATE BioCyc C9H15N2O14P3 Deoxyuridine triphosphate 467.9736 SMILES O[C@H]1C[C@@H](O[C@@H]1COP(O)(O)=O)N1C=CC(=O)NC1=O 7540-64-9 CAS HMDB59597 HMDB 64968 PubChem-compound 1.0 C00105 KEGG Compound 6030 PubChem-compound 6031 PubChem-compound 800-73-7 CAS 58493 ChemSpider C00460 KEGG Compound 1010 ChemSpider 942 ChemSpider CHEBI:15033 ChEBI HMDB41827 HMDB PPI BioCyc 21960964 PubChem-compound C00119 KEGG Compound 160617 PubChem-compound SMILES O[C@H]1C[C@@H](O[C@@H]1COP(O)(=O)OP(O)(=O)OP(O)(O)=O)N1C=CC(=O)NC1=O C10H16N2O11P2 dTDP 402.02292 Ammonium P30402 UniProt HMDB01546 HMDB C5H10N2O3 L-Glutamine 146.06914 Hydrogen Ion CH4NO5P Carbamoyl phosphate 140.98271 Adenosine triphosphate C00112 KEGG Compound 3.6.1.23 false 3.6.1.23 Deoxyuridine triphosphate + Water → Hydrogen Ion + Phosphate + dUMP LEFT_TO_RIGHT Reaction6745 false Adenosine triphosphate + dTDP → Adenosine diphosphate + Thymidine 5'-triphosphate LEFT_TO_RIGHT Reaction6746 false Cytidine triphosphate + a reduced flavodoxin → Water + an oxidized flavodoxin + dCTP LEFT_TO_RIGHT 1.0 Reaction6747 false Uridine triphosphate + a reduced flavodoxin → Deoxyuridine triphosphate + Water + an oxidized flavodoxin LEFT_TO_RIGHT Reaction6748 false CDP + a reduced NrdH glutaredoxin-like protein → Water + an oxidized NrdH glutaredoxin-like protein + dCDP LEFT_TO_RIGHT Reaction6749 false Uridine 5'-diphosphate + a reduced NrdH glutaredoxin-like protein → Water + an oxidized NrdH glutaredoxin-like protein + dUDP LEFT_TO_RIGHT 1.17.4.1 false 1.17.4.1 CDP + reduced thioredoxin → Water + dCDP + oxidized thioredoxin LEFT_TO_RIGHT Reaction6741 false Adenosine triphosphate + dCDP → Adenosine diphosphate + dCTP LEFT_TO_RIGHT Reaction6742 false Uridine 5'-diphosphate + reduced thioredoxin ? Water + dUDP + oxidized thioredoxin Reaction6743 false Adenosine triphosphate + dUDP → Adenosine diphosphate + Deoxyuridine triphosphate LEFT_TO_RIGHT C00009 KEGG Compound 4307 ChemSpider C00008 KEGG Compound 1.0 HMDB00226 HMDB P06785 UniProt C00001 KEGG Compound C00364 KEGG Compound CTP BioCyc C00363 KEGG Compound CHEBI:18361 ChEBI 4,5-Dihydroorotic acid CHEBI:18367 ChEBI 1032 ChemSpider C00002 KEGG Compound C00365 KEGG Compound 2.1.3.2 false 2.1.3.2 Carbamoyl phosphate + L-Aspartic acid → N-carbamoyl-L-aspartate + Hydrogen Ion + Phosphate LEFT_TO_RIGHT 3.5.2.3 false 3.5.2.3 N-carbamoyl-L-aspartate + Hydrogen Ion → 4,5-Dihydroorotic acid + Water LEFT_TO_RIGHT 2.4.2.10 false 2.4.2.10 Orotic acid + Phosphoribosyl pyrophosphate → Orotidylic acid + Pyrophosphate LEFT_TO_RIGHT 4.1.1.23 false 4.1.1.23 Hydrogen Ion + Orotidylic acid → Carbon dioxide + Uridine 5'-monophosphate LEFT_TO_RIGHT 2.7.4.22 false 2.7.4.22 Adenosine triphosphate + Uridine 5'-monophosphate → Adenosine diphosphate + Uridine 5'-diphosphate LEFT_TO_RIGHT 2.7.4.6 false 2.7.4.6 Adenosine triphosphate + Uridine 5'-diphosphate → Adenosine diphosphate + Uridine triphosphate LEFT_TO_RIGHT 6.3.4.2 false 6.3.4.2 Adenosine triphosphate + L-Glutamine + Uridine triphosphate + Water → Adenosine diphosphate + Cytidine triphosphate + Hydrogen Ion + L-Glutamic acid + Phosphate LEFT_TO_RIGHT HMDB01429 HMDB HMDB00218 HMDB 2.0 1.0 1.0 65-86-1 CAS 6.3.5.5 false 6.3.5.5 2 Adenosine triphosphate + Hydrogen carbonate + L-Glutamine + Water → 2 Adenosine diphosphate + Carbamoyl phosphate + 2 Hydrogen Ion + L-Glutamic acid + Phosphate LEFT_TO_RIGHT SubPathwayInteraction3728 SubPathway3728Reaction SubPathwayReaction SubPathwayInteraction3729 SubPathway3729Reaction SubPathwayReaction C9H15N3O10P2 dCDP 387.02325 44367445 PubChem-compound 447920 PubChem-compound C00011 KEGG Compound C01342 KEGG Compound 7339 PubChem-compound C00015 KEGG Compound C01346 KEGG Compound C01103 KEGG Compound C00013 KEGG Compound H Hydrogen Ion 1.007825 1.0 58574 ChemSpider L-Glutamine 56-65-5 CAS Carbamoyl phosphate CHEBI:17013 ChEBI C00025 KEGG Compound dTDP 1.0 HMDB01409 HMDB 3.5.4.13 false 3.5.4.13 Hydrogen Ion + Water + dCTP → Ammonium + Deoxyuridine triphosphate LEFT_TO_RIGHT 1.3.5.2 false 1.3.5.2 4,5-Dihydroorotic acid + Ubiquinone-1 → Orotic acid + Ubiquinol-1 LEFT_TO_RIGHT 2.1.1.45 false 2.1.1.45 5,10-methenyltetrahydrofolate mono-L-glutamate + dUMP → 5-Thymidylic acid + Dihydrofolic acid LEFT_TO_RIGHT TTP BioCyc 1.0 1.0 1.0 769 PubChem-compound 648 PubChem-compound DCDP BioCyc C00399 KEGG Compound 1.0 128553 ChemSpider 46878371 PubChem-compound Water Ribonucleoside-diphosphate reductase small chain 2 Ribonucleoside-diphosphate reductase large chain 1 SMILES NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Dihydroorotase 1.0 Protein URA2 HMDB00528 HMDB Ribonucleoside-diphosphate reductase large chain 1 Orotate phosphoribosyltransferase 2 C9H14N2O11P2 dUDP 388.0073 98792 PubChem-compound C9H16N3O13P3 dCTP 466.9896 Protein URA2 SMILES [O-]P([O-])(=O)OP([O-])([O-])=O Protein URA2 Uridine 5'-diphosphate C00049 KEGG Compound SMILES OC(=N)NC(CC([O-])=O)C([O-])=O C00169 KEGG Compound C00288 KEGG Compound 56-85-9 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 58-97-9 CAS DIHYDROFOLATE BioCyc 7062 ChemSpider 1.0 SMILES CC1=CN([C@H]2C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O2)C(=O)NC1=O C9H14N2O12P2 Uridine 5'-diphosphate 404.0022 HMDB00538 HMDB UTP BioCyc 5902 ChemSpider C5H6N2O4 4,5-Dihydroorotic acid 158.03276 DI-H-OROTATE BioCyc 5903 ChemSpider HMDB00998 HMDB C00295 KEGG Compound 7732-18-5 CAS SMILES COC1=C(O)C(C)=C(CC=C(C)C)C(O)=C1OC dCTP SMILES OC(=O)C1=CC(=O)NC(=O)N1 C00063 KEGG Compound 145729 PubChem-compound dUDP 56-86-0 CAS 590-55-6 CAS 1.0 HMDB00641 HMDB DUDP BioCyc C10H16N5O13P3 Adenosine triphosphate 506.99576 CHEBI:17053 ChEBI C00064 KEGG Compound 1.0 1.0 4033-27-6 CAS 65-47-4 CAS 132961 ChemSpider HMDB01967 HMDB 1.0 962 PubChem-compound 1.0 967 PubChem-compound OROTATE BioCyc 5800 ChemSpider 58-98-0 CAS CHEBI:18077 ChEBI Unkn