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CHEBI:16015 ChEBI C00437 KEGG Compound HMDB00134 HMDB 6022 PubChem-compound 6262 PubChem-compound C23H38N7O17P3S Acetyl-CoA 809.1258 Argininosuccinate lyase, chloroplastic 937 ChemSpider HMDB00250 HMDB Ornithine carbamoyltransferase, chloroplastic Carbamoyl-phosphate synthase large chain, chloroplastic Carbamoyl-phosphate synthase small chain, chloroplastic HMDB01341 HMDB Argininosuccinate synthase, chloroplastic Arginase 2, mitochondrial Arginine biosynthesis bifunctional protein ArgJ, chloroplastic Acetylornithine deacetylase 439153 PubChem-compound 110-17-8 CAS 50 ChemSpider 1.0 388369 ChemSpider C00327 KEGG Compound CHEBI:16027 ChEBI HMDB00148 HMDB NAD 1.0 ATP BioCyc Citrulline CHEBI:17232 ChEBI Acetylglutamate kinase, chloroplastic Probable N-acetyl-gamma-glutamyl-phosphate reductase, chloroplastic 1.0 Alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial 559142 ChemSpider PRO BioCyc Q9C5C4 UniProt HMDB00595 HMDB CHEBI:17203 ChEBI 1.0 5746 ChemSpider HCO3 BioCyc 5745 ChemSpider HMDB01206 HMDB 5742 ChemSpider L-ASPARTATE BioCyc 1143 ChemSpider CHEBI:16474 ChEBI 192878 PubChem-compound HMDB59597 HMDB UREA BioCyc Q9SCL7 UniProt 5858 ChemSpider ARG BioCyc L-CITRULLINE BioCyc Acetyl-CoA 16950 PubChem-compound 1010 ChemSpider SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCS PPI BioCyc 1.0 1.0 HMDB01423 HMDB HMDB01301 HMDB HMDB00214 HMDB Hydrogen Ion C5H10N2O3 L-Glutamine 146.06914 HMDB00217 HMDB CH4NO5P Carbamoyl phosphate 140.98271 Adenosine triphosphate 193305 PubChem-compound 1.0 Q9SZX3 UniProt HMDB00208 HMDB HMDB00221 HMDB C00009 KEGG Compound 1159 ChemSpider C00008 KEGG Compound 2.0 C00006 KEGG Compound P07991 UniProt 1.0 CHEBI:18009 ChEBI http://identifiers.org/smpdb/SMP02416 SMPDB C00001 KEGG Compound C00122 KEGG Compound N-Acetylornithine CHEBI:18361 ChEBI C00005 KEGG Compound CHEBI:18367 ChEBI C00004 KEGG Compound N-Acetylglutamic acid 1032 ChemSpider C00003 KEGG Compound C00002 KEGG Compound 6205-08-9 CAS 496-92-4 CAS HMDB01429 HMDB 2.0 1.0 C6H13N3O3 Citrulline 175.09569 372-75-8 CAS C03406 KEGG Compound C21H28N7O14P2 NAD 664.11694 44367445 PubChem-compound Q93Z70 UniProt C00010 KEGG Compound C00013 KEGG Compound NAD(P) BioCyc 1.0 O50039 UniProt H Hydrogen Ion 1.007825 2.0 1.0 4.0 L-Glutamine 56-65-5 CAS Carbamoyl phosphate C00020 KEGG Compound 53-84-9 CAS C00148 KEGG Compound C00026 KEGG Compound C00025 KEGG Compound C00024 KEGG Compound ACET BioCyc 1.0 769 PubChem-compound 1.0 C00033 KEGG Compound 9367 ChemSpider 1.0 328-50-7 CAS SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O Water AMP BioCyc C01250 KEGG Compound 1.0 SMILES [O-]P([O-])(=O)OP([O-])([O-])=O L-Glutamic gamma-semialdehyde 128566 ChemSpider N-Acetyl-L-glutamyl 5-phosphate C00049 KEGG Compound C00169 KEGG Compound C00288 KEGG Compound 56-85-9 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 1.0 Urea HMDB00538 HMDB CH4N2O Urea 60.032364 10197150 ChemSpider C7H11NO5 N-Acetylglutamic acid 189.06372 ReactionCatalysis6197 ACTIVATION FUM BioCyc SMILES CC(O)=O C7H14N2O3 N-Acetylornithine 174.10045 7732-18-5 CAS CHEBI:18012 ChEBI CHEBI:16199 ChEBI 61-19-8 CAS SMILES N[C@@H](CCCNC(N)=N)C(O)=O SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 SMILES N[C@@H](CCCNC(=N)N[C@@H](CC(O)=O)C(O)=O)C(O)=O C00062 KEGG Compound SMILES OC(=O)C1CCC=N1 56-86-0 CAS 590-55-6 CAS 1.0 HMDB00641 HMDB C10H16N5O13P3 Adenosine triphosphate 506.99576 CHEBI:17053 ChEBI 1.0 C00064 KEGG Compound 2387-71-5 CAS HMDB00517 HMDB 962 PubChem-compound C5H9NO2 L-Proline 115.06333 5800 ChemSpider 1.0 C00077 KEGG Compound C01165 KEGG Compound Phosphate 145742 PubChem-compound C00080 KEGG Compound ReactionCatalysis7109 ACTIVATION C7H11NO4 N-Acetyl-L-glutamate 5-semialdehyde 173.0688 2.0 Oxoglutaric acid 15383-57-0 CAS ReactionCatalysis7108 ACTIVATION SMILES N[C@@H](CCC(O)=O)C(O)=O ReactionCatalysis7107 ACTIVATION 14265-44-2 CAS ReactionCatalysis7111 ACTIVATION ReactionCatalysis7110 ACTIVATION Q9ZUR7 UniProt 58-64-0 CAS Q8VZC3 UniProt C00086 KEGG Compound C04322 KEGG Compound P54904 UniProt L-Aspartic acid C4H7NO4 L-Aspartic acid 133.0375 ReactionCatalysis7112 ACTIVATION L-GLUTAMATE_GAMMA-SEMIALDEHYDE BioCyc 644102 PubChem-compound 444493 PubChem-compound 6083 PubChem-compound C5H9NO3 L-Glutamic gamma-semialdehyde 131.05824 C7H12NO8P N-Acetyl-L-glutamyl 5-phosphate 269.03006 N-Acetyl-L-glutamate 5-semialdehyde 22833512 PubChem-compound ACETYL-COA BioCyc CHEBI:18050 ChEBI H2O Water 18.010565 NADH BioCyc ReactionCatalysis7129 ACTIVATION ReactionCatalysis7127 ACTIVATION NAD BioCyc SMILES CC(=O)N[C@@H](CCC(O)=O)C(O)=O ReactionCatalysis7133 ACTIVATION ReactionCatalysis7132 ACTIVATION ReactionCatalysis7131 ACTIVATION ReactionCatalysis7130 ACTIVATION 56-84-8 CAS 749 ChemSpider 71-52-3 CAS Q9ZPF5 UniProt Acetylornithine aminotransferase, chloroplastic/mitochondrial Arginase 1, mitochondrial Delta-1-pyrroline-5-carboxylate dehydrogenase 12A1, mitochondrial Pyrroline-5-carboxylate reductase L-Proline SMILES OC(=O)\C=C\C(O)=O Hydrogen carbonate 1.0 CHO3 Hydrogen carbonate 60.99257 ReactionCatalysis7135 ACTIVATION ReactionCatalysis7134 ACTIVATION 30572 ChemSpider 1.0 17215925 ChemSpider CHEBI:12575 ChEBI C2H4O2 Acetic acid 60.02113 SMILES CC(=O)N[C@@H](CCC(=O)OP(O)(O)=O)C(O)=O SMILES N[C@@H](CCC=O)C(O)=O NADH 13074-21-0 CAS 64-19-7 CAS 21883788 PubChem-compound Arginase, mitochondrial C5H7NO2 1-Pyrroline-5-carboxylic acid 113.047676 SMILES O C10H18N4O6 Argininosuccinic acid 290.12262 57-13-6 CAS C6H14N4O2 L-Arginine 174.11168 Pyrophosphate C10H14N5O7P Adenosine monophosphate 347.06308 2.6.1.13 false 2.6.1.13 Ornithine + Oxoglutaric acid ↔ L-Glutamic acid + L-Glutamic gamma-semialdehyde REVERSIBLE 6992098 PubChem-compound C7H11NO5 N-acetylglutamate semialdehyde 189.06372 5961 PubChem-compound HMDB06488 HMDB 1.0 C04133 KEGG Compound 6816 PubChem-compound 51 PubChem-compound SMILES OC([O-])=O CHEBI:15846 ChEBI ADP BioCyc CHEBI:15729 ChEBI 53-59-8 CAS 1.0 167744 ChemSpider 1038 PubChem-compound Argininosuccinic acid HMDB06456 HMDB 1-Pyrroline-5-carboxylic acid L-Arginine Adenosine monophosphate 4.3.2.1 false 4.3.2.1 Argininosuccinic acid → Fumaric acid + L-Arginine LEFT_TO_RIGHT C5H6O5 Oxoglutaric acid 146.02153 272 ChemSpider Reaction7132 false Adenosine triphosphate + Citrulline + L-Aspartic acid → Adenosine monophosphate + Argininosuccinic acid + Pyrophosphate LEFT_TO_RIGHT HMDB00902 HMDB Q9LEU8 UniProt HMDB00904 HMDB CHEBI:16908 ChEBI 70-26-8 CAS 6.3.5.5 false 6.3.5.5 2 Adenosine triphosphate + Hydrogen carbonate + L-Glutamine + Water → 2 Adenosine diphosphate + Carbamoyl phosphate + 2 Hydrogen Ion + L-Glutamic acid + Phosphate LEFT_TO_RIGHT 2.6.1.11 false 2.6.1.11 L-Glutamic acid + N-Acetyl-L-glutamate 5-semialdehyde → N-Acetylornithine + Oxoglutaric acid LEFT_TO_RIGHT O4P Phosphate 94.95342 Q9LVW7 UniProt NADPH 6026 ChemSpider Acetic acid 1.2.1.38 false 1.2.1.38 Hydrogen Ion + N-Acetyl-L-glutamyl 5-phosphate + NADPH → N-acetylglutamate semialdehyde + NADP + Phosphate LEFT_TO_RIGHT Ornithine 2.0 NADP SMILES NC(N)=O C21H30N7O17P3 NADPH 745.0911 C21H29N7O17P3 NADP 744.08325 2.7.2.8 false 2.7.2.8 Adenosine triphosphate + N-Acetylglutamic acid → Adenosine diphosphate + N-Acetyl-L-glutamyl 5-phosphate LEFT_TO_RIGHT C5H12N2O2 Ornithine 132.08987 NADPH BioCyc 6857435 PubChem-compound 58-68-4 CAS L-Glutamic acid SMILES [O-]P([O-])([O-])=O SMILES OC(=O)CCC(=O)C(O)=O 1.2.1.88 false 1.2.1.88 L-Glutamic gamma-semialdehyde + NAD + Water → 2 Hydrogen Ion + L-Glutamic acid + NADH LEFT_TO_RIGHT CHEBI:30915 ChEBI 3.5.3.1 false 3.5.3.1 L-Arginine + Water → Ornithine + Urea LEFT_TO_RIGHT PW000779 PathWhiz l-delta(1)-pyrroline_5-carboxylate BioCyc 1.5.1.2 false 1.5.1.2 1-Pyrroline-5-carboxylic acid + 2 Hydrogen Ion + NADPH → L-Proline + NADP LEFT_TO_RIGHT Argininosuccinate lyase, chloroplastic Argininosuccinate synthase, chloroplastic Ornithine carbamoyltransferase, chloroplastic 2.1.3.3 false 2.1.3.3 Carbamoyl phosphate + Ornithine → Citrulline + Hydrogen Ion + Phosphate LEFT_TO_RIGHT Alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial 2.3.1.35,2.3.1.1 false 2.3.1.35,2.3.1.1 Acetyl-CoA + L-Glutamic acid → Coenzyme A + Hydrogen Ion + N-Acetylglutamic acid LEFT_TO_RIGHT Carbamoyl-phosphate synthase small chain, chloroplastic 2.6.1.11 false 2.6.1.11 L-Glutamic acid + N-Acetyl-L-glutamate 5-semialdehyde → N-Acetylornithine + Oxoglutaric acid LEFT_TO_RIGHT Carbamoyl-phosphate synthase large chain, chloroplastic Reaction7152 false L-Glutamic acid + N-Acetylornithine → N-Acetylglutamic acid + Ornithine LEFT_TO_RIGHT ACETYL-GLU BioCyc Probable N-acetyl-gamma-glutamyl-phosphate reductase, chloroplastic Acetylglutamate kinase, chloroplastic SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O SMILES NCCC[C@H](N)C(O)=O SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O Fumaric acid GLN BioCyc GLT BioCyc C4H4O4 Fumaric acid 116.010956 acetylornithine aminotransferase / N-succinyldiaminopimelate aminotransferase Reaction7148 false N-Acetylornithine + Water → Acetic acid + Ornithine LEFT_TO_RIGHT acetylglutamate kinase 53-57-6 CAS 1.0 Pyrroline-5-carboxylate reductase http://identifiers.org/smpdb/SMP00802 SMPDB Acetylornithine aminotransferase, chloroplastic/mitochondrial Acetylornithine deacetylase Delta-1-pyrroline-5-carboxylate dehydrogenase 12A1, mitochondrial Arginase 1, mitochondrial Arginase 2, mitochondrial SMILES OC(=O)[C@@H]1CCCN1 Arginine biosynthesis bifunctional protein ArgJ, chloroplastic N-acetylglutamate semialdehyde O7P2 Pyrophosphate 173.91193 C21H29N7O14P2 NADH 665.12476 6082 ChemSpider SMILES CC(=O)N[C@@H](CCC=O)C(O)=O carbamoyl phosphate synthetase 5957 PubChem-compound argininosuccinate synthase 1188-37-0 CAS Q42601 UniProt Reaction2717 false L-Glutamic gamma-semialdehyde → 1-Pyrroline-5-carboxylic acid + Hydrogen Ion + Water LEFT_TO_RIGHT HMDB01096 HMDB acetylornithine deacetylase Adenosine diphosphate C10H15N5O10P2 Adenosine diphosphate 427.02942 SMILES N[C@@H](CC(O)=O)C(O)=O 16059 ChemSpider 147-85-3 CAS PW002522 PathWhiz 1.0 1.0 SMILES N[C@@H](CCCNC(N)=O)C(O)=O CPD-8587 BioCyc SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O CHEBI:15682 ChEBI 5682 ChemSpider CHEBI:1146900 ChEBI P46637 UniProt 14000-31-8 CAS CHEBI:16543 ChEBI CARBAMOYL-P BioCyc CO-A BioCyc Ornithine aminotransferase, mitochondrial 5675 ChemSpider 72-89-9 CAS Coenzyme A C21H36N7O16P3S Coenzyme A 767.11523 CHEBI:1372 ChEBI SMILES NC(=O)OP(O)(O)=O 1.0 CHEBI:15422 ChEBI Arginine Metabolism 6557 ChemSpider CHEBI:16878 ChEBI HMDB00191 HMDB SMILES CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N 388299 ChemSpider 2.0 1.0 TCA cycle SubPathway 28782 PubChem-compound 1.0 C5H9NO4 L-Glutamic acid 147.05316 33032 PubChem-compound C00624 KEGG Compound HMDB03357 HMDB SubPathwayInteraction3814 SubPathway3814Reaction SubPathwayReaction 1.0 Q940M2 UniProt 1.0 1.0 CHEBI:16761 ChEBI N-ALPHA-ACETYLORNITHINE BioCyc CHEBI:15366 ChEBI Ornithine aminotransferase, mitochondrial CHEBI:17544 ChEBI 2-KETOGLUTARATE BioCyc 392413 ChemSpider SMILES CC(=O)NC(CCC(O)=O)C(O)=O SMILES CC(=O)N[C@@H](CCCN)C(O)=O HMDB00052 HMDB HMDB00294 HMDB 1.0 1176 PubChem-compound 5893 PubChem-compound HMDB02111 HMDB 439232 PubChem-compound 171 ChemSpider CHEBI:15377 ChEBI 278 PubChem-compound CHEBI:15378 ChEBI SMILES [H+] CHEBI:16467 ChEBI CHEBI:16349 ChEBI N-ACETYL-GLUTAMYL-P BioCyc SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound CHEBI:17672 ChEBI 1.0 HMDB01487 HMDB 167387 ChemSpider 389220 ChemSpider 185 PubChem-compound SMILES N[C@@H](CCC(N)=O)C(O)=O 1196 PubChem-compound 2.0 2.0 HMDB00045 HMDB 1061 PubChem-compound Q9M8M7 UniProt HMDB02104 HMDB HMDB01138 HMDB 74-79-3 CAS CHEBI:15351 ChEBI HMDB00162 HMDB HMDB00042 HMDB 440236 PubChem-compound 176 PubChem-compound 2906-39-0 CAS CHEBI:16319 ChEBI 85-61-0 CAS L-ORNITHINE BioCyc 180 ChemSpider Acetylglutamate kinase, chloroplastic Probable N-acetyl- gamma- glutamyl- phosphate reductase, chloroplastic Alanine-- glyoxylate aminotransferase 2 homolog 1, mitochondrial Carbamoyl- phosphate synthase large chain, chloroplastic Carbamoyl- phosphate synthase small chain, chloroplastic Argininosuccinate synthase, chloroplastic Argininosuccinate lyase, chloroplastic Arginine biosynthesis bifunctional protein ArgJ, chloroplastic Acetylornithine deacetylase Ornithine carbamoyltransferase, chloroplastic Arginine biosynthesis bifunctional protein ArgJ, chloroplastic Acetylglutamate kinase, chloroplastic Probable N-acetyl- gamma- glutamyl- phosphate reductase, chloroplastic Acetylornithine aminotransferase, chloroplastic/mitochondrial Arginase 2, mitochondrial Arginase 1, mitochondrial Ornithine aminotransferase, mitochondrial Delta-1- pyrroline-5- carboxylate dehydrogenase 12A1, mitochondrial Pyrroline-5- carboxylate reductase N- Acetylglutamic acid ATP ADP N-Acetyl-L- glutamyl 5-phosphate NADPH H + N- acetylglutamate semialdehyde P i NADP N-Acetyl-L- glutamate 5-semialdehyde L-Glutamic acid Oxoglutaric acid N- Acetylornithine HCO 3 - H 2 O L-Glutamine ATP ADP P i L-Glutamic acid H + Carbamoyl phosphate ATP Citrulline L-Aspartic acid PP i AMP Argininosuccinic acid Fumaric acid L-Arginine L-Glutamic acid Acetyl-CoA CoA H + H 2 O Ornithine Acetic acid Carbamoyl phosphate P i H + Citrulline L-Glutamic acid N- Acetylornithine N- Acetylglutamic acid ATP ADP N-Acetyl-L- glutamyl 5-phosphate NADPH H + N- acetylglutamate semialdehyde P i NADP N-Acetyl-L- glutamate 5-semialdehyde L-Glutamic acid Oxoglutaric acid N- Acetylornithine H 2 O Ornithine Urea Oxoglutaric acid L-Glutamic acid L-Glutamic gamma- semialdehyde H 2 O H + 1-Pyrroline- 5-carboxylic acid NAD H 2 O NADH H + L-Glutamic acid H + NADPH NADP L-Proline
CHEBI:16015 ChEBI C00437 KEGG Compound HMDB00134 HMDB 6022 PubChem-compound 6262 PubChem-compound C23H38N7O17P3S Acetyl-CoA 809.1258 Argininosuccinate lyase, chloroplastic 937 ChemSpider HMDB00250 HMDB Ornithine carbamoyltransferase, chloroplastic Carbamoyl-phosphate synthase large chain, chloroplastic Carbamoyl-phosphate synthase small chain, chloroplastic HMDB01341 HMDB Argininosuccinate synthase, chloroplastic Arginase 2, mitochondrial Arginine biosynthesis bifunctional protein ArgJ, chloroplastic Acetylornithine deacetylase 439153 PubChem-compound 110-17-8 CAS 50 ChemSpider 1.0 388369 ChemSpider C00327 KEGG Compound CHEBI:16027 ChEBI HMDB00148 HMDB NAD 1.0 ATP BioCyc Citrulline CHEBI:17232 ChEBI Acetylglutamate kinase, chloroplastic Probable N-acetyl-gamma-glutamyl-phosphate reductase, chloroplastic 1.0 Alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial 559142 ChemSpider PRO BioCyc Q9C5C4 UniProt HMDB00595 HMDB CHEBI:17203 ChEBI 1.0 5746 ChemSpider HCO3 BioCyc 5745 ChemSpider HMDB01206 HMDB 5742 ChemSpider L-ASPARTATE BioCyc 1143 ChemSpider CHEBI:16474 ChEBI 192878 PubChem-compound HMDB59597 HMDB UREA BioCyc Q9SCL7 UniProt 5858 ChemSpider ARG BioCyc L-CITRULLINE BioCyc Acetyl-CoA 16950 PubChem-compound 1010 ChemSpider SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCS PPI BioCyc 1.0 1.0 HMDB01423 HMDB HMDB01301 HMDB HMDB00214 HMDB Hydrogen Ion C5H10N2O3 L-Glutamine 146.06914 HMDB00217 HMDB CH4NO5P Carbamoyl phosphate 140.98271 Adenosine triphosphate 193305 PubChem-compound 1.0 Q9SZX3 UniProt HMDB00208 HMDB HMDB00221 HMDB C00009 KEGG Compound 1159 ChemSpider C00008 KEGG Compound 2.0 C00006 KEGG Compound P07991 UniProt 1.0 CHEBI:18009 ChEBI http://identifiers.org/smpdb/SMP02416 SMPDB C00001 KEGG Compound C00122 KEGG Compound N-Acetylornithine CHEBI:18361 ChEBI C00005 KEGG Compound CHEBI:18367 ChEBI C00004 KEGG Compound N-Acetylglutamic acid 1032 ChemSpider C00003 KEGG Compound C00002 KEGG Compound 6205-08-9 CAS 496-92-4 CAS HMDB01429 HMDB 2.0 1.0 C6H13N3O3 Citrulline 175.09569 372-75-8 CAS C03406 KEGG Compound C21H28N7O14P2 NAD 664.11694 44367445 PubChem-compound Q93Z70 UniProt C00010 KEGG Compound C00013 KEGG Compound NAD(P) BioCyc 1.0 O50039 UniProt H Hydrogen Ion 1.007825 2.0 1.0 4.0 L-Glutamine 56-65-5 CAS Carbamoyl phosphate C00020 KEGG Compound 53-84-9 CAS C00148 KEGG Compound C00026 KEGG Compound C00025 KEGG Compound C00024 KEGG Compound ACET BioCyc 1.0 769 PubChem-compound 1.0 C00033 KEGG Compound 9367 ChemSpider 1.0 328-50-7 CAS SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O Water AMP BioCyc C01250 KEGG Compound 1.0 SMILES [O-]P([O-])(=O)OP([O-])([O-])=O L-Glutamic gamma-semialdehyde 128566 ChemSpider N-Acetyl-L-glutamyl 5-phosphate C00049 KEGG Compound C00169 KEGG Compound C00288 KEGG Compound 56-85-9 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 1.0 Urea HMDB00538 HMDB CH4N2O Urea 60.032364 10197150 ChemSpider C7H11NO5 N-Acetylglutamic acid 189.06372 ReactionCatalysis6197 ACTIVATION FUM BioCyc SMILES CC(O)=O C7H14N2O3 N-Acetylornithine 174.10045 7732-18-5 CAS CHEBI:18012 ChEBI CHEBI:16199 ChEBI 61-19-8 CAS SMILES N[C@@H](CCCNC(N)=N)C(O)=O SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 SMILES N[C@@H](CCCNC(=N)N[C@@H](CC(O)=O)C(O)=O)C(O)=O C00062 KEGG Compound SMILES OC(=O)C1CCC=N1 56-86-0 CAS 590-55-6 CAS 1.0 HMDB00641 HMDB C10H16N5O13P3 Adenosine triphosphate 506.99576 CHEBI:17053 ChEBI 1.0 C00064 KEGG Compound 2387-71-5 CAS HMDB00517 HMDB 962 PubChem-compound C5H9NO2 L-Proline 115.06333 5800 ChemSpider 1.0 C00077 KEGG Compound C01165 KEGG Compound Phosphate 145742 PubChem-compound C00080 KEGG Compound ReactionCatalysis7109 ACTIVATION C7H11NO4 N-Acetyl-L-glutamate 5-semialdehyde 173.0688 2.0 Oxoglutaric acid 15383-57-0 CAS ReactionCatalysis7108 ACTIVATION SMILES N[C@@H](CCC(O)=O)C(O)=O ReactionCatalysis7107 ACTIVATION 14265-44-2 CAS ReactionCatalysis7111 ACTIVATION ReactionCatalysis7110 ACTIVATION Q9ZUR7 UniProt 58-64-0 CAS Q8VZC3 UniProt C00086 KEGG Compound C04322 KEGG Compound P54904 UniProt L-Aspartic acid C4H7NO4 L-Aspartic acid 133.0375 ReactionCatalysis7112 ACTIVATION L-GLUTAMATE_GAMMA-SEMIALDEHYDE BioCyc 644102 PubChem-compound 444493 PubChem-compound 6083 PubChem-compound C5H9NO3 L-Glutamic gamma-semialdehyde 131.05824 C7H12NO8P N-Acetyl-L-glutamyl 5-phosphate 269.03006 N-Acetyl-L-glutamate 5-semialdehyde 22833512 PubChem-compound ACETYL-COA BioCyc CHEBI:18050 ChEBI H2O Water 18.010565 NADH BioCyc ReactionCatalysis7129 ACTIVATION ReactionCatalysis7127 ACTIVATION NAD BioCyc SMILES CC(=O)N[C@@H](CCC(O)=O)C(O)=O ReactionCatalysis7133 ACTIVATION ReactionCatalysis7132 ACTIVATION ReactionCatalysis7131 ACTIVATION ReactionCatalysis7130 ACTIVATION 56-84-8 CAS 749 ChemSpider 71-52-3 CAS Q9ZPF5 UniProt Acetylornithine aminotransferase, chloroplastic/mitochondrial Arginase 1, mitochondrial Delta-1-pyrroline-5-carboxylate dehydrogenase 12A1, mitochondrial Pyrroline-5-carboxylate reductase L-Proline SMILES OC(=O)\C=C\C(O)=O Hydrogen carbonate 1.0 CHO3 Hydrogen carbonate 60.99257 ReactionCatalysis7135 ACTIVATION ReactionCatalysis7134 ACTIVATION 30572 ChemSpider 1.0 17215925 ChemSpider CHEBI:12575 ChEBI C2H4O2 Acetic acid 60.02113 SMILES CC(=O)N[C@@H](CCC(=O)OP(O)(O)=O)C(O)=O SMILES N[C@@H](CCC=O)C(O)=O NADH 13074-21-0 CAS 64-19-7 CAS 21883788 PubChem-compound Arginase, mitochondrial C5H7NO2 1-Pyrroline-5-carboxylic acid 113.047676 SMILES O C10H18N4O6 Argininosuccinic acid 290.12262 57-13-6 CAS C6H14N4O2 L-Arginine 174.11168 Pyrophosphate C10H14N5O7P Adenosine monophosphate 347.06308 2.6.1.13 false 2.6.1.13 Ornithine + Oxoglutaric acid ↔ L-Glutamic acid + L-Glutamic gamma-semialdehyde REVERSIBLE 6992098 PubChem-compound C7H11NO5 N-acetylglutamate semialdehyde 189.06372 5961 PubChem-compound HMDB06488 HMDB 1.0 C04133 KEGG Compound 6816 PubChem-compound 51 PubChem-compound SMILES OC([O-])=O CHEBI:15846 ChEBI ADP BioCyc CHEBI:15729 ChEBI 53-59-8 CAS 1.0 167744 ChemSpider 1038 PubChem-compound Argininosuccinic acid HMDB06456 HMDB 1-Pyrroline-5-carboxylic acid L-Arginine Adenosine monophosphate 4.3.2.1 false 4.3.2.1 Argininosuccinic acid → Fumaric acid + L-Arginine LEFT_TO_RIGHT C5H6O5 Oxoglutaric acid 146.02153 272 ChemSpider Reaction7132 false Adenosine triphosphate + Citrulline + L-Aspartic acid → Adenosine monophosphate + Argininosuccinic acid + Pyrophosphate LEFT_TO_RIGHT HMDB00902 HMDB Q9LEU8 UniProt HMDB00904 HMDB CHEBI:16908 ChEBI 70-26-8 CAS 6.3.5.5 false 6.3.5.5 2 Adenosine triphosphate + Hydrogen carbonate + L-Glutamine + Water → 2 Adenosine diphosphate + Carbamoyl phosphate + 2 Hydrogen Ion + L-Glutamic acid + Phosphate LEFT_TO_RIGHT 2.6.1.11 false 2.6.1.11 L-Glutamic acid + N-Acetyl-L-glutamate 5-semialdehyde → N-Acetylornithine + Oxoglutaric acid LEFT_TO_RIGHT O4P Phosphate 94.95342 Q9LVW7 UniProt NADPH 6026 ChemSpider Acetic acid 1.2.1.38 false 1.2.1.38 Hydrogen Ion + N-Acetyl-L-glutamyl 5-phosphate + NADPH → N-acetylglutamate semialdehyde + NADP + Phosphate LEFT_TO_RIGHT Ornithine 2.0 NADP SMILES NC(N)=O TCA cycle SubPathway C21H30N7O17P3 NADPH 745.0911 C21H29N7O17P3 NADP 744.08325 2.7.2.8 false 2.7.2.8 Adenosine triphosphate + N-Acetylglutamic acid → Adenosine diphosphate + N-Acetyl-L-glutamyl 5-phosphate LEFT_TO_RIGHT C5H12N2O2 Ornithine 132.08987 NADPH BioCyc 6857435 PubChem-compound 58-68-4 CAS L-Glutamic acid SMILES [O-]P([O-])([O-])=O SMILES OC(=O)CCC(=O)C(O)=O 1.2.1.88 false 1.2.1.88 L-Glutamic gamma-semialdehyde + NAD + Water → 2 Hydrogen Ion + L-Glutamic acid + NADH LEFT_TO_RIGHT CHEBI:30915 ChEBI 3.5.3.1 false 3.5.3.1 L-Arginine + Water → Ornithine + Urea LEFT_TO_RIGHT PW000779 PathWhiz l-delta(1)-pyrroline_5-carboxylate BioCyc 1.5.1.2 false 1.5.1.2 1-Pyrroline-5-carboxylic acid + 2 Hydrogen Ion + NADPH → L-Proline + NADP LEFT_TO_RIGHT Argininosuccinate lyase, chloroplastic Argininosuccinate synthase, chloroplastic Ornithine carbamoyltransferase, chloroplastic 2.1.3.3 false 2.1.3.3 Carbamoyl phosphate + Ornithine → Citrulline + Hydrogen Ion + Phosphate LEFT_TO_RIGHT Alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial 2.3.1.35,2.3.1.1 false 2.3.1.35,2.3.1.1 Acetyl-CoA + L-Glutamic acid → Coenzyme A + Hydrogen Ion + N-Acetylglutamic acid LEFT_TO_RIGHT Carbamoyl-phosphate synthase small chain, chloroplastic 2.6.1.11 false 2.6.1.11 L-Glutamic acid + N-Acetyl-L-glutamate 5-semialdehyde → N-Acetylornithine + Oxoglutaric acid LEFT_TO_RIGHT Carbamoyl-phosphate synthase large chain, chloroplastic Reaction7152 false L-Glutamic acid + N-Acetylornithine → N-Acetylglutamic acid + Ornithine LEFT_TO_RIGHT ACETYL-GLU BioCyc Probable N-acetyl-gamma-glutamyl-phosphate reductase, chloroplastic Acetylglutamate kinase, chloroplastic SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O SMILES NCCC[C@H](N)C(O)=O SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O Fumaric acid GLN BioCyc GLT BioCyc C4H4O4 Fumaric acid 116.010956 acetylornithine aminotransferase / N-succinyldiaminopimelate aminotransferase Reaction7148 false N-Acetylornithine + Water → Acetic acid + Ornithine LEFT_TO_RIGHT acetylglutamate kinase 53-57-6 CAS 1.0 Pyrroline-5-carboxylate reductase http://identifiers.org/smpdb/SMP00802 SMPDB Acetylornithine aminotransferase, chloroplastic/mitochondrial Acetylornithine deacetylase Delta-1-pyrroline-5-carboxylate dehydrogenase 12A1, mitochondrial Arginase 1, mitochondrial Arginase 2, mitochondrial SMILES OC(=O)[C@@H]1CCCN1 Arginine biosynthesis bifunctional protein ArgJ, chloroplastic N-acetylglutamate semialdehyde O7P2 Pyrophosphate 173.91193 C21H29N7O14P2 NADH 665.12476 6082 ChemSpider SMILES CC(=O)N[C@@H](CCC=O)C(O)=O carbamoyl phosphate synthetase 5957 PubChem-compound argininosuccinate synthase 1188-37-0 CAS Q42601 UniProt Reaction2717 false L-Glutamic gamma-semialdehyde → 1-Pyrroline-5-carboxylic acid + Hydrogen Ion + Water LEFT_TO_RIGHT HMDB01096 HMDB acetylornithine deacetylase Adenosine diphosphate C10H15N5O10P2 Adenosine diphosphate 427.02942 SMILES N[C@@H](CC(O)=O)C(O)=O 16059 ChemSpider 147-85-3 CAS PW002522 PathWhiz 1.0 1.0 SMILES N[C@@H](CCCNC(N)=O)C(O)=O CPD-8587 BioCyc SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O CHEBI:15682 ChEBI 5682 ChemSpider CHEBI:1146900 ChEBI P46637 UniProt 14000-31-8 CAS CHEBI:16543 ChEBI CARBAMOYL-P BioCyc CO-A BioCyc Ornithine aminotransferase, mitochondrial 5675 ChemSpider 72-89-9 CAS Coenzyme A C21H36N7O16P3S Coenzyme A 767.11523 CHEBI:1372 ChEBI SMILES NC(=O)OP(O)(O)=O 1.0 CHEBI:15422 ChEBI Arginine Metabolism 6557 ChemSpider CHEBI:16878 ChEBI HMDB00191 HMDB SMILES CC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N 388299 ChemSpider 2.0 1.0 28782 PubChem-compound 1.0 C5H9NO4 L-Glutamic acid 147.05316 33032 PubChem-compound C00624 KEGG Compound HMDB03357 HMDB SubPathwayInteraction3814 SubPathway3814Reaction SubPathwayReaction 1.0 Q940M2 UniProt 1.0 1.0 CHEBI:16761 ChEBI N-ALPHA-ACETYLORNITHINE BioCyc CHEBI:15366 ChEBI Ornithine aminotransferase, mitochondrial CHEBI:17544 ChEBI 2-KETOGLUTARATE BioCyc 392413 ChemSpider SMILES CC(=O)NC(CCC(O)=O)C(O)=O SMILES CC(=O)N[C@@H](CCCN)C(O)=O HMDB00052 HMDB HMDB00294 HMDB 1.0 1176 PubChem-compound 5893 PubChem-compound HMDB02111 HMDB 439232 PubChem-compound 171 ChemSpider CHEBI:15377 ChEBI 278 PubChem-compound CHEBI:15378 ChEBI SMILES [H+] CHEBI:16467 ChEBI CHEBI:16349 ChEBI N-ACETYL-GLUTAMYL-P BioCyc SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound CHEBI:17672 ChEBI 1.0 HMDB01487 HMDB 167387 ChemSpider 389220 ChemSpider 185 PubChem-compound SMILES N[C@@H](CCC(N)=O)C(O)=O 1196 PubChem-compound 2.0 2.0 HMDB00045 HMDB 1061 PubChem-compound Q9M8M7 UniProt HMDB02104 HMDB HMDB01138 HMDB 74-79-3 CAS CHEBI:15351 ChEBI HMDB00162 HMDB HMDB00042 HMDB 440236 PubChem-compound 176 PubChem-compound 2906-39-0 CAS CHEBI:16319 ChEBI 85-61-0 CAS L-ORNITHINE BioCyc 180 ChemSpider