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HMDB01586 HMDB ReactionCatalysis950 ACTIVATION 6022 PubChem-compound SMP00027 SMPDB 937 ChemSpider HMDB01341 HMDB Glucose-6-phosphatase 439278 PubChem-compound 439153 PubChem-compound Phosphoglycerate mutase 2 ReactionCatalysis949 ACTIVATION Phosphoglycerate mutase 1 Bisphosphoglycerate mutase ReactionCatalysis942 ACTIVATION ReactionCatalysis940 ACTIVATION Pyruvate kinase PKLR 58238 ChemSpider HMDB01112 HMDB PW000055 PathWhiz C6H14O12P2 Fructose 1,6-bisphosphate 339.99606 PW000054 PathWhiz SMP00039 SMPDB ATP BioCyc HMDB00263 HMDB HMDB01473 HMDB Reaction1242 false 2,3-Diphosphoglyceric acid + Water ↔ 3-Phosphoglyceric acid + Phosphate REVERSIBLE Reaction1243 false 2,3-Diphosphoglyceric acid + Water ↔ 3-Phosphoglyceric acid + Phosphate REVERSIBLE Reaction1240 false Glyceric acid 1,3-biphosphate ↔ 2,3-Diphosphoglyceric acid REVERSIBLE 2.7.2.3 false 2.7.2.3 Adenosine diphosphate + Glyceric acid 1,3-biphosphate → 3-Phosphoglyceric acid + Adenosine triphosphate LEFT_TO_RIGHT ReactionCatalysis939 ACTIVATION ReactionCatalysis937 ACTIVATION ReactionCatalysis936 ACTIVATION Reaction1246 false 3-Phosphoglyceric acid ↔ 2-Phospho-D-glyceric acid REVERSIBLE SMP00031 SMPDB SubPathwayInteraction178 SubPathway178Reaction SubPathwayReaction 5743 ChemSpider 5742 ChemSpider NADH 2280-44-6 CAS SMP00040 SMPDB ALPHA-GLUCOSE-16-BISPHOSPHATE BioCyc SubPathwayInteraction171 SubPathway171Reaction SubPathwayReaction SubPathwayInteraction170 SubPathwayReaction SubPathway170Reaction SubPathwayInteraction173 SubPathwayReaction SubPathway173Reaction SubPathwayInteraction172 SubPathway172Reaction SubPathwayReaction SubPathwayInteraction175 SubPathway175Reaction SubPathwayReaction SubPathwayInteraction174 SubPathwayReaction SubPathway174Reaction SMILES OC1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@H]1O SMP00043 SMPDB SubPathwayInteraction177 SubPathway177Reaction SubPathwayReaction SubPathwayInteraction176 SubPathway176Reaction SubPathwayReaction HMDB00122 HMDB ReactionCatalysis960 ACTIVATION HMDB00243 HMDB SubPathwayInteraction168 SubPathwayReaction SubPathway168Reaction C6H13O9P Beta-D-Glucose 6-phosphate 260.02972 HMDB00124 HMDB PW000032 PathWhiz SubPathwayInteraction169 SubPathway169Reaction SubPathwayReaction PW000159 PathWhiz 709 ChemSpider PW000036 PathWhiz C00221 KEGG Compound 2,3-Diphosphoglyceric acid 704 ChemSpider 1.0 PW000031 PathWhiz C00103 KEGG Compound PW000150 PathWhiz 439165 PubChem-compound 488-69-7 CAS ReactionCatalysis958 ACTIVATION ReactionCatalysis713 ACTIVATION ReactionCatalysis955 ACTIVATION SMP00058 SMPDB ReactionCatalysis953 ACTIVATION ReactionCatalysis954 ACTIVATION ReactionCatalysis952 ACTIVATION C3H7O6P D-Glyceraldehyde 3-phosphate 169.99803 138-08-9 CAS 1.0 59-56-3 CAS C3H8O10P2 Glyceric acid 1,3-biphosphate 265.95926 C00111 KEGG Compound Cytosol Alpha-enolase C00236 KEGG Compound 388311 ChemSpider 1.0 C00597 KEGG Compound C00354 KEGG Compound Aldose 1-epimerase Glyceraldehyde-3-phosphate dehydrogenase 7664-38-2 CAS Fructose 1,6-bisphosphate 5.3.1.9 false 5.3.1.9 Fructose 6-phosphate ↔ Glucose 6-phosphate REVERSIBLE 5.1.3.3 false 5.1.3.3 Alpha-D-Glucose ↔ Beta-D-Glucose REVERSIBLE C00009 KEGG Compound C00008 KEGG Compound SMILES O[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@H]1O 1.0 C3H8O10P2 2,3-Diphosphoglyceric acid 265.95926 C00001 KEGG Compound P15259 UniProt Fructose 6-phosphate SubPathwayInput CHEBI:18367 ChEBI C00004 KEGG Compound 1032 ChemSpider C00003 KEGG Compound C00002 KEGG Compound 1031 ChemSpider C6H12O6 Alpha-D-Glucose 180.06339 GLC-1-P BioCyc HMDB01429 HMDB Pyruvate Metabolism SubPathway Pantothenate and CoA Biosynthesis SubPathway HMDB01401 HMDB 388411 ChemSpider 388538 ChemSpider Pyruvic acid SubPathwayInput C21H28N7O14P2 NAD 664.11694 SMP00006 SMPDB 2.0 161681 ChemSpider FRUCTOSE-6P BioCyc Glucose-6-phosphatase Tyrosine Metabolism SubPathway Galactose Metabolism SubPathway Nucleotide Sugars Metabolism SubPathway Starch and Sucrose Metabolism SubPathway Fructose and Mannose Degradation SubPathway Pentose Phosphate Pathway SubPathway Galactose Metabolism SubPathway Thiamine Metabolism SubPathway Glycerolipid Metabolism SubPathway CHEBI:17138 ChEBI P52789 UniProt C00022 KEGG Compound 56-65-5 CAS P18669 UniProt 53-84-9 CAS C00267 KEGG Compound 62713 ChemSpider CHEBI:26078 ChEBI 1.0 ReactionCatalysis513 ACTIVATION SMP00010 SMPDB P06733 UniProt CL:0000000 CELL TYPE ONTOLOGY C00031 KEGG Compound 186004 PubChem-compound SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O D-Glucose SubPathwayOutput 492-61-5 CAS 4.0 3.1.3.9 false 3.1.3.9 Glucose 1-phosphate + Water → D-Glucose + Phosphate LEFT_TO_RIGHT P06744 UniProt 648 ChemSpider SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O PHOSPHO-ENOL-PYRUVATE BioCyc Pyruvate kinase isozymes R/L HMDB00538 HMDB SMILES OC(=O)C(=C)OP(O)(O)=O 64689 PubChem-compound Reaction812 false D-Glyceraldehyde 3-phosphate + NAD + Phosphoric acid ↔ Glyceric acid 1,3-biphosphate + NADH REVERSIBLE C3H7O7P 3-Phosphoglyceric acid 185.99294 668 PubChem-compound Hexokinase-2 CHEBI:16077 ChEBI 7732-18-5 CAS CHEBI:4170 ChEBI 591-59-3 CAS SMILES OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O 492-62-6 CAS 1.0 NAD BiologicalState14 C10H16N5O13P3 Adenosine triphosphate 506.99576 Phosphoric acid DPG BioCyc DIHYDROXY-ACETONE-PHOSPHATE BioCyc P30613 UniProt C01159 KEGG Compound 445557 PubChem-compound SMILES CC(=O)C(O)=O 663 ChemSpider Alpha-D-Glucose C3H7O7P 2-Phospho-D-glyceric acid 185.99294 C00074 KEGG Compound CHEBI:17050 ChEBI SMILES OCC(=O)COP(O)(O)=O HMDB00516 HMDB 3-Phosphoglyceric acid SubPathwayOutput P07738 UniProt 962 PubChem-compound 724 PubChem-compound P11168 UniProt 5800 ChemSpider Fructose-bisphosphate aldolase A 979 ChemSpider C00085 KEGG Compound H3O4P Phosphoric acid 97.9769 C01172 KEGG Compound 729 PubChem-compound Phosphoglycerate mutase 1 BiologicalState2 14265-44-2 CAS CHEBI:44897 ChEBI Glucose-6-phosphate isomerase PYRUVATE BioCyc 58-64-0 CAS C6H13O9P Glucose 1-phosphate 260.02972 C00092 KEGG Compound 71358 ChemSpider G3P BioCyc Glucose-6-phosphate isomerase CHEBI:4167 ChEBI P04406 UniProt Phosphoglycerate kinase 1 1.0 56-73-5 CAS 2-PG BioCyc 23-DIPHOSPHOGLYCERATE BioCyc SMILES OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O 1.0 H2O Water 18.010565 138-81-8 CAS SMILES OCC(=O)[C@@H](O)[C@H](O)[C@H](O)COP(O)(O)=O 1.0 393165 ChemSpider NADH BioCyc Beta-D-Glucose NAD BioCyc Glyceraldehyde-3-phosphate dehydrogenase 1.0 980 ChemSpider 1.0 CHEBI:15903 ChEBI Aldose 1-epimerase 820-11-1 CAS 2-Phospho-D-glyceric acid 1.0 6-phosphofructokinase, muscle type 4.0 Glyceraldehyde-3-phosphate dehydrogenase 1.0 1.0 SMILES O P35575 UniProt Q96C23 UniProt C6H12O6 Beta-D-Glucose 180.06339 1.0 HMDB00807 HMDB 1004 PubChem-compound 1005 PubChem-compound Pyruvate kinase isozymes R/L 643-13-0 CAS 1981-49-3 CAS C3H7O6P Dihydroxyacetone phosphate 169.99803 CHEBI:15846 ChEBI ADP BioCyc C3H4O3 Pyruvic acid 88.016045 GO:0005829 GENE ONTOLOGY CHEBI:16905 ChEBI HMDB00902 HMDB Solute carrier family 2, facilitated glucose transporter member 2 CHEBI:16908 ChEBI O4P Phosphate 94.95342 1.0 CHEBI:15946 ChEBI Hexokinase-2 Solute carrier family 2, facilitated glucose transporter member 2 Glucose 1-phosphate SubPathwayOutput SubPathwayInput 683 PubChem-compound Phosphoenolpyruvic acid SubPathwayInput 58-68-4 CAS SMILES [O-]P([O-])([O-])=O GO:0005886 GENE ONTOLOGY C6H13O9P Fructose 6-phosphate 260.02972 C6H12O6 D-Glucose 180.06339 P00558 UniProt Fructose-bisphosphate aldolase A CHEBI:17835 ChEBI GLC BioCyc 1.0 1.0 57-04-5 CAS 69507 PubChem-compound 4.0 SMILES OP(O)(O)=O 5958 PubChem-compound C21H29N7O14P2 NADH 665.12476 D-Glucose 5957 PubChem-compound SMILES OC[C@H]1OC(OP(O)(O)=O)[C@H](O)[C@@H](O)[C@@H]1O Alpha-enolase C3H5O6P Phosphoenolpyruvic acid 167.98238 Adenosine triphosphate C10H15N5O10P2 Adenosine diphosphate 427.02942 HMDB03391 HMDB D-Glyceraldehyde 3-phosphate SubPathwayOutput SubPathwayInput CHEBI:17925 ChEBI P08237 UniProt CPD-8587 BioCyc SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O TransportCatalysis15 ACTIVATION 5682 ChemSpider Dihydroxyacetone phosphate C6H13O9P Glucose 6-phosphate 260.02972 2.0 6-phosphofructokinase, muscle type HMDB03498 HMDB Phosphoglycerate mutase 2 Adenosine diphosphate SMILES OC(COP(O)(O)=O)C(=O)OP(O)(O)=O ReactionCatalysis659 ACTIVATION 4.2.1.11 false 4.2.1.11 2-Phospho-D-glyceric acid ↔ Phosphoenolpyruvic acid + Water REVERSIBLE 2.7.1.40 false 2.7.1.40 Adenosine triphosphate + Pyruvic acid ↔ Adenosine diphosphate + Phosphoenolpyruvic acid REVERSIBLE Cell 439427 PubChem-compound HMDB03345 HMDB 1.0 CHEBI:15422 ChEBI CHEBI:17720 ChEBI 5589 ChemSpider Beta-D-Glucose 6-phosphate Transport42 false D-Glucose (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel LEFT_TO_RIGHT 388299 ChemSpider 1.0 1.0 127-17-3 CAS CHEBI:17719 ChEBI Water HMDB01058 HMDB FRUCTOSE-16-DIPHOSPHATE BioCyc 1.0 SMILES O[C@H]1[C@H](O)[C@](O)(COP(O)(O)=O)O[C@@H]1COP(O)(O)=O HMDB01294 HMDB HMDB02142 HMDB CHEBI:16761 ChEBI GLC-6-P BioCyc 1.0 1.0 9606 TAXONOMY PW000144 PathWhiz P04075 UniProt Glucose 6-phosphate PW000142 PathWhiz PW000146 PathWhiz PW000025 PathWhiz SMILES OC(COP(O)(O)=O)C(O)=O C00631 KEGG Compound 5893 PubChem-compound HMDB02111 HMDB SMP00060 SMPDB Fructose-bisphosphate aldolase A 2.7.1.1 false 2.7.1.1 Adenosine triphosphate + Beta-D-Glucose → Adenosine diphosphate + Beta-D-Glucose 6-phosphate LEFT_TO_RIGHT Phosphoglycerate kinase 1 CHEBI:32816 ChEBI ReactionCatalysis349 ACTIVATION SMP00064 SMPDB Cell Membrane CHEBI:15377 ChEBI Glucose-6-phosphate isomerase CHEBI:16108 ChEBI HMDB01270 HMDB SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Glyceric acid 1,3-biphosphate Phosphate SMILES OC[C@@H](OP(O)(O)=O)C(O)=O 79025 PubChem-compound SMP00076 SMPDB HMDB01487 HMDB 5793 PubChem-compound Glycolysis SMILES OC(COP(O)(O)=O)C=O 2.7.1.1 false 2.7.1.1 Adenosine triphosphate + D-Glucose → Adenosine diphosphate + Glucose 6-phosphate LEFT_TO_RIGHT 2.7.1.1 false 2.7.1.1 Adenosine triphosphate + Alpha-D-Glucose → Adenosine diphosphate + Glucose 6-phosphate LEFT_TO_RIGHT 2.7.1.11 false 2.7.1.11 Adenosine triphosphate + Fructose 6-phosphate → Adenosine diphosphate + Fructose 1,6-bisphosphate LEFT_TO_RIGHT 4.1.2.13 false 4.1.2.13 Fructose 1,6-bisphosphate → D-Glyceraldehyde 3-phosphate + Dihydroxyacetone phosphate LEFT_TO_RIGHT 5.3.1.9 false 5.3.1.9 Beta-D-Glucose 6-phosphate ↔ Fructose 6-phosphate REVERSIBLE GAP BioCyc 1060 PubChem-compound 1061 PubChem-compound Bisphosphoglycerate mutase C00661 KEGG Compound SMILES OC(=O)[C@@H](COP(O)(O)=O)OP(O)(O)=O Bisphosphoglycerate mutase SMILES OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O Solute carrier family 2, facilitated glucose transporter member 2 Hexokinase-2 Hexokinase-2 Aldose 1-epimerase Hexokinase-2 Glucose-6- phosphate isomerase Glucose-6- phosphate isomerase 6- phosphofructokinase, muscle type Fructose- bisphosphate aldolase A Triosephosphate isomerase Glucose-6- phosphatase Glyceraldehyde- 3-phosphate dehydrogenase Bisphosphoglycerate mutase Pantothenate kinase 1 Phosphoglycerate mutase 1 Bisphosphoglycerate mutase Phosphoglycerate mutase 2 Alpha-enolase Pyruvate kinase isozymes R/L Pyruvic acid D-Glucose Glucose 1-phosphate Fructose 6-phosphate D-Glyceraldehyde 3-phosphate Phosphoenolpyruvic acid 3- Phosphoglyceric acid D-Glucose ATP Glucose 6-phosphate ADP Alpha-D-Glucose ATP ADP Beta-D-Glucose ATP ADP Beta-D-Glucose 6-phosphate ATP Fructose 1,6-bisphosphate ADP Dihydroxyacetone phosphate H 2 O P i NAD P i Glyceric acid 1,3-biphosphate NADH 2,3-Diphosphoglyceric acid ADP ATP H 2 O P i H 2 O P i 2-Phospho-D- glyceric acid H 2 O ATP ADP Magnesium Magnesium Magnesium Potassium Pyruvate Metabolism Pantothenate and CoA Biosynthesis Tyrosine Metabolism Galactose Metabolism Nucleotide Sugars Metabolism Starch and Sucrose Metabolism Fructose and Mannose Degradation Pentose Phosphate Pathway Galactose Metabolism Thiamine Metabolism Glycerolipid Metabolism Capillary Bed Intracellular space Extracellular Space
HMDB01586 HMDB ReactionCatalysis950 ACTIVATION 6022 PubChem-compound http://identifiers.org/smpdb/SMP00027 SMPDB 937 ChemSpider HMDB01341 HMDB Glucose-6-phosphatase 439278 PubChem-compound 439153 PubChem-compound Phosphoglycerate mutase 2 ReactionCatalysis949 ACTIVATION Phosphoglycerate mutase 1 Bisphosphoglycerate mutase ReactionCatalysis942 ACTIVATION ReactionCatalysis940 ACTIVATION Pyruvate kinase PKLR 58238 ChemSpider HMDB01112 HMDB PW000055 PathWhiz C6H14O12P2 Fructose 1,6-bisphosphate 339.99606 PW000054 PathWhiz http://identifiers.org/smpdb/SMP00039 SMPDB ATP BioCyc HMDB00263 HMDB HMDB01473 HMDB Reaction1242 false 2,3-Diphosphoglyceric acid + Water ↔ 3-Phosphoglyceric acid + Phosphate REVERSIBLE Reaction1243 false 2,3-Diphosphoglyceric acid + Water ↔ 3-Phosphoglyceric acid + Phosphate REVERSIBLE Reaction1240 false Glyceric acid 1,3-biphosphate ↔ 2,3-Diphosphoglyceric acid REVERSIBLE 2.7.2.3 false 2.7.2.3 Adenosine diphosphate + Glyceric acid 1,3-biphosphate → 3-Phosphoglyceric acid + Adenosine triphosphate LEFT_TO_RIGHT ReactionCatalysis939 ACTIVATION ReactionCatalysis937 ACTIVATION ReactionCatalysis936 ACTIVATION Reaction1246 false 3-Phosphoglyceric acid ↔ 2-Phospho-D-glyceric acid REVERSIBLE http://identifiers.org/smpdb/SMP00031 SMPDB SubPathwayInteraction178 SubPathway178Reaction SubPathwayReaction 5743 ChemSpider 5742 ChemSpider NADH 2280-44-6 CAS http://identifiers.org/smpdb/SMP00040 SMPDB ALPHA-GLUCOSE-16-BISPHOSPHATE BioCyc SubPathwayInteraction171 SubPathway171Reaction SubPathwayReaction SubPathwayInteraction170 SubPathwayReaction SubPathway170Reaction SubPathwayInteraction173 SubPathwayReaction SubPathway173Reaction SubPathwayInteraction172 SubPathway172Reaction SubPathwayReaction SubPathwayInteraction175 SubPathway175Reaction SubPathwayReaction SubPathwayInteraction174 SubPathwayReaction SubPathway174Reaction SMILES OC1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@H]1O http://identifiers.org/smpdb/SMP00043 SMPDB SubPathwayInteraction177 SubPathway177Reaction SubPathwayReaction SubPathwayInteraction176 SubPathway176Reaction SubPathwayReaction HMDB00122 HMDB ReactionCatalysis960 ACTIVATION HMDB00243 HMDB SubPathwayInteraction168 SubPathwayReaction SubPathway168Reaction C6H13O9P Beta-D-Glucose 6-phosphate 260.02972 HMDB00124 HMDB PW000032 PathWhiz SubPathwayInteraction169 SubPathway169Reaction SubPathwayReaction PW000159 PathWhiz 709 ChemSpider PW000036 PathWhiz C00221 KEGG Compound 2,3-Diphosphoglyceric acid 704 ChemSpider 1.0 PW000031 PathWhiz C00103 KEGG Compound PW000150 PathWhiz 439165 PubChem-compound 488-69-7 CAS ReactionCatalysis958 ACTIVATION ReactionCatalysis713 ACTIVATION ReactionCatalysis955 ACTIVATION http://identifiers.org/smpdb/SMP00058 SMPDB ReactionCatalysis953 ACTIVATION ReactionCatalysis954 ACTIVATION ReactionCatalysis952 ACTIVATION C3H7O6P D-Glyceraldehyde 3-phosphate 169.99803 138-08-9 CAS 1.0 59-56-3 CAS C3H8O10P2 Glyceric acid 1,3-biphosphate 265.95926 C00111 KEGG Compound Cytosol Alpha-enolase C00236 KEGG Compound 388311 ChemSpider 1.0 C00597 KEGG Compound C00354 KEGG Compound Aldose 1-epimerase Glyceraldehyde-3-phosphate dehydrogenase 7664-38-2 CAS Fructose 1,6-bisphosphate 5.3.1.9 false 5.3.1.9 Fructose 6-phosphate ↔ Glucose 6-phosphate REVERSIBLE 5.1.3.3 false 5.1.3.3 Alpha-D-Glucose ↔ Beta-D-Glucose REVERSIBLE C00009 KEGG Compound C00008 KEGG Compound SMILES O[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@H]1O 1.0 C3H8O10P2 2,3-Diphosphoglyceric acid 265.95926 C00001 KEGG Compound P15259 UniProt Fructose 6-phosphate SubPathwayInput CHEBI:18367 ChEBI C00004 KEGG Compound 1032 ChemSpider C00003 KEGG Compound C00002 KEGG Compound 1031 ChemSpider C6H12O6 Alpha-D-Glucose 180.06339 GLC-1-P BioCyc HMDB01429 HMDB Pyruvate Metabolism SubPathway Pantothenate and CoA Biosynthesis SubPathway HMDB01401 HMDB 388411 ChemSpider 388538 ChemSpider Pyruvic acid SubPathwayInput C21H28N7O14P2 NAD 664.11694 http://identifiers.org/smpdb/SMP00006 SMPDB 2.0 161681 ChemSpider FRUCTOSE-6P BioCyc Glucose-6-phosphatase Tyrosine Metabolism SubPathway Galactose Metabolism SubPathway Nucleotide Sugars Metabolism SubPathway Starch and Sucrose Metabolism SubPathway Fructose and Mannose Degradation SubPathway Pentose Phosphate Pathway SubPathway Galactose Metabolism SubPathway Thiamine Metabolism SubPathway Glycerolipid Metabolism SubPathway CHEBI:17138 ChEBI P52789 UniProt C00022 KEGG Compound 56-65-5 CAS P18669 UniProt 53-84-9 CAS C00267 KEGG Compound 62713 ChemSpider CHEBI:26078 ChEBI 1.0 ReactionCatalysis513 ACTIVATION http://identifiers.org/smpdb/SMP00010 SMPDB P06733 UniProt CL:0000000 CELL TYPE ONTOLOGY C00031 KEGG Compound 186004 PubChem-compound SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O D-Glucose SubPathwayOutput 492-61-5 CAS 4.0 3.1.3.9 false 3.1.3.9 Glucose 1-phosphate + Water → D-Glucose + Phosphate LEFT_TO_RIGHT P06744 UniProt 648 ChemSpider SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O PHOSPHO-ENOL-PYRUVATE BioCyc Pyruvate kinase isozymes R/L HMDB00538 HMDB SMILES OC(=O)C(=C)OP(O)(O)=O 64689 PubChem-compound Reaction812 false D-Glyceraldehyde 3-phosphate + NAD + Phosphoric acid ↔ Glyceric acid 1,3-biphosphate + NADH REVERSIBLE C3H7O7P 3-Phosphoglyceric acid 185.99294 668 PubChem-compound Hexokinase-2 CHEBI:16077 ChEBI 7732-18-5 CAS CHEBI:4170 ChEBI 591-59-3 CAS SMILES OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O 492-62-6 CAS 1.0 NAD BiologicalState14 Homo sapiens, Cell Membrane C10H16N5O13P3 Adenosine triphosphate 506.99576 Phosphoric acid DPG BioCyc DIHYDROXY-ACETONE-PHOSPHATE BioCyc P30613 UniProt C01159 KEGG Compound 445557 PubChem-compound SMILES CC(=O)C(O)=O 663 ChemSpider Alpha-D-Glucose C3H7O7P 2-Phospho-D-glyceric acid 185.99294 C00074 KEGG Compound CHEBI:17050 ChEBI SMILES OCC(=O)COP(O)(O)=O HMDB00516 HMDB 3-Phosphoglyceric acid SubPathwayOutput P07738 UniProt 962 PubChem-compound 724 PubChem-compound P11168 UniProt 5800 ChemSpider Fructose-bisphosphate aldolase A 979 ChemSpider C00085 KEGG Compound H3O4P Phosphoric acid 97.9769 C01172 KEGG Compound 729 PubChem-compound Phosphoglycerate mutase 1 BiologicalState2 Homo sapiens, Cell, Cytosol 14265-44-2 CAS CHEBI:44897 ChEBI Glucose-6-phosphate isomerase PYRUVATE BioCyc 58-64-0 CAS C6H13O9P Glucose 1-phosphate 260.02972 C00092 KEGG Compound 71358 ChemSpider G3P BioCyc Glucose-6-phosphate isomerase CHEBI:4167 ChEBI P04406 UniProt Phosphoglycerate kinase 1 1.0 56-73-5 CAS 2-PG BioCyc 23-DIPHOSPHOGLYCERATE BioCyc SMILES OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O 1.0 H2O Water 18.010565 138-81-8 CAS SMILES OCC(=O)[C@@H](O)[C@H](O)[C@H](O)COP(O)(O)=O 1.0 393165 ChemSpider NADH BioCyc Beta-D-Glucose NAD BioCyc Glyceraldehyde-3-phosphate dehydrogenase 1.0 980 ChemSpider 1.0 CHEBI:15903 ChEBI Aldose 1-epimerase 820-11-1 CAS 2-Phospho-D-glyceric acid 1.0 6-phosphofructokinase, muscle type 4.0 Glyceraldehyde-3-phosphate dehydrogenase 1.0 1.0 SMILES O P35575 UniProt Q96C23 UniProt C6H12O6 Beta-D-Glucose 180.06339 1.0 HMDB00807 HMDB 1004 PubChem-compound 1005 PubChem-compound Pyruvate kinase isozymes R/L 643-13-0 CAS 1981-49-3 CAS C3H7O6P Dihydroxyacetone phosphate 169.99803 CHEBI:15846 ChEBI ADP BioCyc C3H4O3 Pyruvic acid 88.016045 GO:0005829 GENE ONTOLOGY CHEBI:16905 ChEBI HMDB00902 HMDB Solute carrier family 2, facilitated glucose transporter member 2 CHEBI:16908 ChEBI O4P Phosphate 94.95342 1.0 CHEBI:15946 ChEBI Hexokinase-2 Solute carrier family 2, facilitated glucose transporter member 2 Glucose 1-phosphate SubPathwayOutput SubPathwayInput 683 PubChem-compound Phosphoenolpyruvic acid SubPathwayInput 58-68-4 CAS SMILES [O-]P([O-])([O-])=O GO:0005886 GENE ONTOLOGY C6H13O9P Fructose 6-phosphate 260.02972 C6H12O6 D-Glucose 180.06339 P00558 UniProt Fructose-bisphosphate aldolase A CHEBI:17835 ChEBI GLC BioCyc 1.0 1.0 57-04-5 CAS 69507 PubChem-compound 4.0 SMILES OP(O)(O)=O 5958 PubChem-compound C21H29N7O14P2 NADH 665.12476 D-Glucose 5957 PubChem-compound SMILES OC[C@H]1OC(OP(O)(O)=O)[C@H](O)[C@@H](O)[C@@H]1O Alpha-enolase C3H5O6P Phosphoenolpyruvic acid 167.98238 Adenosine triphosphate C10H15N5O10P2 Adenosine diphosphate 427.02942 HMDB03391 HMDB D-Glyceraldehyde 3-phosphate SubPathwayOutput SubPathwayInput CHEBI:17925 ChEBI P08237 UniProt CPD-8587 BioCyc SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O TransportCatalysis15 ACTIVATION 5682 ChemSpider Dihydroxyacetone phosphate C6H13O9P Glucose 6-phosphate 260.02972 2.0 6-phosphofructokinase, muscle type HMDB03498 HMDB Phosphoglycerate mutase 2 Adenosine diphosphate SMILES OC(COP(O)(O)=O)C(=O)OP(O)(O)=O ReactionCatalysis659 ACTIVATION 4.2.1.11 false 4.2.1.11 2-Phospho-D-glyceric acid ↔ Phosphoenolpyruvic acid + Water REVERSIBLE 2.7.1.40 false 2.7.1.40 Adenosine triphosphate + Pyruvic acid ↔ Adenosine diphosphate + Phosphoenolpyruvic acid REVERSIBLE Cell 439427 PubChem-compound HMDB03345 HMDB 1.0 CHEBI:15422 ChEBI CHEBI:17720 ChEBI 5589 ChemSpider Beta-D-Glucose 6-phosphate Transport42 false D-Glucose (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel LEFT_TO_RIGHT 388299 ChemSpider 1.0 1.0 127-17-3 CAS CHEBI:17719 ChEBI Water HMDB01058 HMDB FRUCTOSE-16-DIPHOSPHATE BioCyc 1.0 SMILES O[C@H]1[C@H](O)[C@](O)(COP(O)(O)=O)O[C@@H]1COP(O)(O)=O HMDB01294 HMDB HMDB02142 HMDB CHEBI:16761 ChEBI GLC-6-P BioCyc 1.0 1.0 9606 TAXONOMY PW000144 PathWhiz P04075 UniProt Glucose 6-phosphate PW000142 PathWhiz PW000146 PathWhiz PW000025 PathWhiz SMILES OC(COP(O)(O)=O)C(O)=O C00631 KEGG Compound 5893 PubChem-compound HMDB02111 HMDB http://identifiers.org/smpdb/SMP00060 SMPDB Fructose-bisphosphate aldolase A 2.7.1.1 false 2.7.1.1 Adenosine triphosphate + Beta-D-Glucose → Adenosine diphosphate + Beta-D-Glucose 6-phosphate LEFT_TO_RIGHT Phosphoglycerate kinase 1 CHEBI:32816 ChEBI ReactionCatalysis349 ACTIVATION http://identifiers.org/smpdb/SMP00064 SMPDB Cell Membrane CHEBI:15377 ChEBI Glucose-6-phosphate isomerase CHEBI:16108 ChEBI HMDB01270 HMDB SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Glyceric acid 1,3-biphosphate Phosphate SMILES OC[C@@H](OP(O)(O)=O)C(O)=O 79025 PubChem-compound http://identifiers.org/smpdb/SMP00076 SMPDB HMDB01487 HMDB 5793 PubChem-compound Glycolysis SMILES OC(COP(O)(O)=O)C=O 2.7.1.1 false 2.7.1.1 Adenosine triphosphate + D-Glucose → Adenosine diphosphate + Glucose 6-phosphate LEFT_TO_RIGHT 2.7.1.1 false 2.7.1.1 Adenosine triphosphate + Alpha-D-Glucose → Adenosine diphosphate + Glucose 6-phosphate LEFT_TO_RIGHT 2.7.1.11 false 2.7.1.11 Adenosine triphosphate + Fructose 6-phosphate → Adenosine diphosphate + Fructose 1,6-bisphosphate LEFT_TO_RIGHT 4.1.2.13 false 4.1.2.13 Fructose 1,6-bisphosphate → D-Glyceraldehyde 3-phosphate + Dihydroxyacetone phosphate LEFT_TO_RIGHT 5.3.1.9 false 5.3.1.9 Beta-D-Glucose 6-phosphate ↔ Fructose 6-phosphate REVERSIBLE GAP BioCyc 1060 PubChem-compound 1061 PubChem-compound Bisphosphoglycerate mutase C00661 KEGG Compound SMILES OC(=O)[C@@H](COP(O)(O)=O)OP(O)(O)=O Bisphosphoglycerate mutase SMILES OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O