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Histidine Metabolism CHEBI:16015 ChEBI 6022 PubChem-compound 7722-84-1 CAS 1.0 C00439 KEGG Compound 937 ChemSpider HMDB00250 HMDB L-Histidine CHEBI:16134 ChEBI HMDB01341 HMDB Carnosine 1.0 439153 PubChem-compound Amiloride-sensitive amine oxidase [copper-containing] 1.0 Tetrahydrofolic acid CHEBI:27398 ChEBI CHEBI:20506 ChEBI L-histidyl-tRNA(His) CHEBI:16027 ChEBI HMDB00148 HMDB Histidine decarboxylase Aldehyde dehydrogenase, mitochondrial ATP BioCyc 388363 ChemSpider C6H11N3 1-Methylhistamine 125.0953 Q96N76 UniProt 18714427 ChemSpider 559142 ChemSpider SMILES CN1C=NC(CC=O)=C1 CHEBI:27384 ChEBI 1.0 C6H8N2O3 4-Imidazolone-5-propionic acid 156.0535 PW000043 PathWhiz C15H23N6O5S S-Adenosylmethionine 399.14505 HMDB00479 HMDB Histamine 1.0 5742 ChemSpider 17340-16-8 CAS CHEBI:16474 ChEBI 952 ChemSpider CHEBI:28104 ChEBI Carbon dioxide Aldehyde dehydrogenase, mitochondrial Formimidoyltransferase-cyclodeaminase HMDB59597 HMDB Aldehyde dehydrogenase, dimeric NADP-preferring Amine oxidase [flavin-containing] A Carnosine synthase 1 64969 PubChem-compound SMP00044 SMPDB 5858 ChemSpider 6274 PubChem-compound Adenosine monophosphate CHEBI:16240 ChEBI 4-IMIDAZOLONE-5-PROPIONATE BioCyc 1.0 Carnosine synthase 1 58494 ChemSpider 1010 ChemSpider C00101 KEGG Compound PPI BioCyc Imidazoleacetic acid 1.0 643824 ChemSpider HMDB00217 HMDB SMILES C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C(N)N=CN=C12 979-92-0 CAS L-Glutamic acid SubPathwayInput Cytosol C6H8N2O2 Methylimidazoleacetic acid 140.05858 SMILES OC(=O)CCC1N=CNC1=O C14H20N6O5S S-Adenosylhomocysteine 384.12158 Q96NU7 UniProt A5YM72 UniProt P50135 UniProt 1.4.3.4 false 1.4.3.4 1-Methylhistamine + Oxygen + Water → Ammonia + Hydrogen peroxide + Methylimidazole acetaldehyde LEFT_TO_RIGHT Urocanic acid 3-Methylhistidine 193545 PubChem-compound C00009 KEGG Compound HMDB00221 HMDB C00008 KEGG Compound CHEBI:1606 ChEBI C00007 KEGG Compound 19639-03-3 CAS C00006 KEGG Compound CHEBI:18009 ChEBI C00001 KEGG Compound CHEBI:18361 ChEBI 1.0 C00005 KEGG Compound CHEBI:18367 ChEBI C00004 KEGG Compound CHEBI:7274 ChEBI 1032 ChemSpider C00003 KEGG Compound 135-16-0 CAS C00002 KEGG Compound NADP Q96KN2 UniProt 1.0 CHEBI:29009 ChEBI 4.0 HMDB01429 HMDB 1.0 C00019 KEGG Compound 3488 ChemSpider C21H28N7O14P2 NAD 664.11694 1.0 C05828 KEGG Compound C05827 KEGG Compound Adenosine triphosphate C00011 KEGG Compound Formimidoyltransferase-cyclodeaminase C00135 KEGG Compound C00014 KEGG Compound C00013 KEGG Compound NAD(P) BioCyc 11267158 ChemSpider H Hydrogen Ion 1.007825 388301 ChemSpider Beta-Ala-His dipeptidase HMDB01534 HMDB C00386 KEGG Compound 56-65-5 CAS C00021 KEGG Compound 53-84-9 CAS C00020 KEGG Compound C00027 KEGG Compound C00388 KEGG Compound C00025 KEGG Compound 501-75-7 CAS 104-98-3 CAS 8.0 HMDB00898 HMDB CL:0000000 CELL TYPE ONTOLOGY SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O AMP BioCyc P19801 UniProt 1.0 HYDROGEN-PEROXIDE BioCyc 645-65-8 CAS CHEBI:29178 ChEBI SMILES [O-]P([O-])(=O)OP([O-])([O-])=O P49590 UniProt HMDB00301 HMDB 1.0 132948 ChemSpider P30838 UniProt SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 1.0 C03680 KEGG Compound 763 ChemSpider Histamine L-histidyl-tRNA(His) HMDB00538 HMDB 1.0 tRNA(His) C6H10N2O4 Formiminoglutamic acid 174.06406 HMDB00870 HMDB 784 PubChem-compound 7732-18-5 CAS 61-19-8 CAS SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 C01152 KEGG Compound 3614 PubChem-compound AMMONIA BioCyc SMILES N 56-86-0 CAS 1.0 Adenosine diphosphate CHEBI:29155 ChEBI HMDB02820 HMDB 774 PubChem-compound C10H16N5O13P3 Adenosine triphosphate 506.99576 1.0 Probable histidine--tRNA ligase, mitochondrial Protein arginine N-methyltransferase 3 Beta-Ala-His dipeptidase 530 PubChem-compound Pyrophosphate P12081 UniProt 1.0 1.0 C5H6N2O Imidazole-4-acetaldehyde 110.04801 HMDB03905 HMDB HMDB01967 HMDB Ammonia HMDB01846 HMDB SMILES NCCC(O)=O UROCANATE BioCyc Amiloride-sensitive amine oxidase [copper-containing] 962 PubChem-compound 31983 ChemSpider 86856 ChemSpider HMDB00854 HMDB 5800 ChemSpider CO2 Carbon dioxide 43.98983 Hydrogen peroxide C00080 KEGG Compound SMILES O=O Histidine ammonia-lyase BiologicalState8 SMILES N[C@@H](CCC(O)=O)C(O)=O BiologicalState3 BiologicalState2 14265-44-2 CAS C6H9N3O2 L-Histidine 155.06947 58-64-0 CAS HISTAMINE BioCyc Aldehyde dehydrogenase, dimeric NADP-preferring C7H11N3O2 3-Methylhistidine 169.08513 644102 PubChem-compound C6H6N2O2 Urocanic acid 138.04292 6083 PubChem-compound 1.0 C00099 KEGG Compound Histidine ammonia-lyase CHEBI:18295 ChEBI 25246222 PubChem-compound 753 ChemSpider 22833512 PubChem-compound CARNOSINE BioCyc H2O Water 18.010565 H2O2 Hydrogen peroxide 34.005478 C5H9N3 Histamine 111.07965 NADH BioCyc 5-Formiminotetrahydrofolic acid 29908-03-0 CAS NAD BioCyc 977 PubChem-compound Histamine N-methyltransferase Formimidoyltransferase-cyclodeaminase 167957 ChemSpider SMILES NC1=NC2=C(N(C=N)C(CNC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)CN2)C(=O)N1 NAD ReactionCatalysis157 ACTIVATION 30572 ChemSpider 17215925 ChemSpider Histidine decarboxylase Aldehyde dehydrogenase, mitochondrial 128 PubChem-compound tRNA(His) C5H6N2O2 Imidazoleacetic acid 126.04293 L-histidyl-tRNA(His) SMILES OC(=O)\C=C\C1=CNC=N1 Histidine decarboxylase SMILES NCCC1=CNC=N1 1.0 SMILES O SMILES OO 1.0 H3N Ammonia 17.026548 6.1.1.21 false 6.1.1.21 Adenosine triphosphate + L-Histidine + tRNA(His) → Adenosine monophosphate + L-histidyl-tRNA(His) + Pyrophosphate LEFT_TO_RIGHT C10H14N5O7P Adenosine monophosphate 347.06308 CHEBI:15971 ChEBI 239 PubChem-compound 4.3.1.3 false 4.3.1.3 L-Histidine ↔ Ammonia + Urocanic acid REVERSIBLE 1.0 125 ChemSpider Water HMDB04181 HMDB CHEBI:15846 ChEBI CHEBI:15727 ChEBI ADP BioCyc HMDB00939 HMDB C3H7NO2 Beta-Alanine 89.047676 28305488 PubChem-compound 53-59-8 CAS Probable histidine--tRNA ligase, mitochondrial 1.0 6038 ChemSpider 1038 PubChem-compound GO:0005829 GENE ONTOLOGY C19H23N7O6 Tetrahydrofolic acid 445.171 274 ChemSpider 1.0 Beta-Alanine HMDB00902 HMDB CHEBI:16908 ChEBI Imidazole-4-acetaldehyde 2.1.1.- false 2.1.1.- L-Histidine + S-Adenosylmethionine → 3-Methylhistidine + S-Adenosylhomocysteine LEFT_TO_RIGHT Ammonia ADENOSYL-HOMO-CYS BioCyc SubPathwayInteraction845 SubPathway845Reaction SubPathwayReaction Methylimidazole acetaldehyde O4P Phosphate 94.95342 Urocanate hydratase 305-84-0 CAS Histidine--tRNA ligase, cytoplasmic 1.0 SMILES OC(=O)CC[C@H](NC=N)C(O)=O Adenosine triphosphate C21H30N7O17P3 NADPH 745.0911 C9H14N4O3 Carnosine 226.1066 3.4.13.20 false 3.4.13.20 Carnosine + Water → Beta-Alanine + L-Histidine LEFT_TO_RIGHT C21H29N7O17P3 NADP 744.08325 Mitochondrion THF BioCyc N-FORMIMINO-L-GLUTAMATE BioCyc NADPH BioCyc CHEBI:16974 ChEBI 1.0 S-Adenosylhomocysteine CPD-6641 BioCyc 71-00-1 CAS Probable imidazolonepropionase C05127 KEGG Compound 217 ChemSpider O95954 UniProt 58-68-4 CAS SMILES NC1=NC(=O)C2=C(NC[C@H](CNC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)N2)N1 SMILES [O-]P([O-])([O-])=O 1.0 C05130 KEGG Compound 124-38-9 CAS CHEBI:15639 ChEBI Glutamate Metabolism SubPathway CHEBI:15414 ChEBI tRNA(His) 1.4.3.22 false 1.4.3.22 Histamine + Oxygen + Water → Ammonia + Hydrogen peroxide + Imidazole-4-acetaldehyde LEFT_TO_RIGHT SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O SMILES OC(=O)CC1=CN=CN1 SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O C20H24N8O6 5-Formiminotetrahydrofolic acid 472.1819 1.0 SMILES NCCC(=O)N[C@@H](CC1=CN=CN1)C(O)=O 7664-41-7 CAS GLT BioCyc 107-95-9 CAS Oxygen 53-57-6 CAS S-ADENOSYLMETHIONINE BioCyc SMILES O=C=O 1-Methylhistamine 222 PubChem-compound O7P2 Pyrophosphate 173.91193 234 ChemSpider Hydrogen peroxide C21H29N7O14P2 NADH 665.12476 P21397 UniProt 1.0 5-FORMIMINO-THF BioCyc 5957 PubChem-compound 1.0 Reaction869 false Formiminoglutamic acid + Tetrahydrofolic acid ↔ 5-Formiminotetrahydrofolic acid + L-Glutamic acid REVERSIBLE 4.2.1.49 false 4.2.1.49 4-Imidazolone-5-propionic acid ↔ Urocanic acid + Water REVERSIBLE SMILES N[C@@H](CC1=CN=CN1)C(O)=O 1.0 816-90-0 CAS Amiloride-sensitive amine oxidase [copper-containing] GO:0005739 GENE ONTOLOGY C10H15N5O10P2 Adenosine diphosphate 427.02942 GO:0005737 GENE ONTOLOGY SMILES CN1C=NC=C1C[C@H](N)C(O)=O CHEBI:16958 ChEBI 1.0 Imidazole-4-acetaldehyde HMDB03125 HMDB NADH CPD-8587 BioCyc SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O 51-45-6 CAS L-Histidine HMDB01185 HMDB 5682 ChemSpider Beta-Ala-His dipeptidase 2.0 1.0 14000-31-8 CAS 1.0 P05091 UniProt B-ALANINE BioCyc 5675 ChemSpider N-METHYL-HISTAMINE BioCyc 68319 ChemSpider 1.0 Cytoplasm 1.2.1.5 false 1.2.1.5 Methylimidazole acetaldehyde + NADP + Water → Hydrogen Ion + Methylimidazoleacetic acid + NADPH LEFT_TO_RIGHT 150841 PubChem-compound Urocanate hydratase NADPH Cell ReactionCatalysis454 ACTIVATION ReactionCatalysis455 ACTIVATION ReactionCatalysis452 ACTIVATION CHEBI:15422 ChEBI ReactionCatalysis453 ACTIVATION ReactionCatalysis450 ACTIVATION ReactionCatalysis451 ACTIVATION 388299 ChemSpider Protein arginine N-methyltransferase 3 Hydrogen Ion O2 Oxygen 31.98983 O60678 UniProt CHEBI:30817 ChEBI 1.0 ReactionCatalysis449 ACTIVATION HIS BioCyc ReactionCatalysis448 ACTIVATION 1.2.1.3 false 1.2.1.3 Imidazole-4-acetaldehyde + NAD + Water → Hydrogen Ion + Imidazoleacetic acid + NADH LEFT_TO_RIGHT C5H9NO4 L-Glutamic acid 147.05316 Water 33032 PubChem-compound SMILES CN1C=NC(CCN)=C1 Probable imidazolonepropionase CHEBI:16526 ChEBI Adenosine monophosphate Histidine--tRNA ligase, cytoplasmic CHEBI:16761 ChEBI HMDB02024 HMDB 7782-44-7 CAS Carnosine synthase 1 2.0 4-Imidazolone-5-propionic acid 1.0 9606 TAXONOMY HMDB00056 HMDB HMDB00177 HMDB 1.0 Formiminoglutamic acid 4-IMIDAZOLEACETATE BioCyc 1.0 HMDB00051 HMDB 1.0 5893 PubChem-compound HMDB02111 HMDB 439233 PubChem-compound P42357 UniProt 2.1.1.8 false 2.1.1.8 Histamine + S-Adenosylmethionine → 1-Methylhistamine + S-Adenosylhomocysteine LEFT_TO_RIGHT 1.0 CHEBI:27596 ChEBI 1.0 CHEBI:15377 ChEBI 368-16-1 CAS Pyrophosphate 6.3.2.11 false 6.3.2.11 Adenosine triphosphate + Beta-Alanine + L-Histidine → Adenosine diphosphate + Carnosine + Phosphate LEFT_TO_RIGHT CHEBI:15379 ChEBI CHEBI:15378 ChEBI SMILES [H+] Amine oxidase [flavin-containing] A 2625-49-2 CAS ReactionCatalysis460 ACTIVATION SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound 1.0 Phosphate 439224 PubChem-compound Oxygen SMP00072 SMPDB 1.0 280 PubChem-compound SMILES O=CCC1=CN=CN1 645-14-7 CAS ReactionCatalysis458 ACTIVATION 3.5.2.7 false 3.5.2.7 4-Imidazolone-5-propionic acid + Water → Formiminoglutamic acid LEFT_TO_RIGHT ReactionCatalysis459 ACTIVATION ReactionCatalysis456 ACTIVATION 736715 PubChem-compound ReactionCatalysis457 ACTIVATION HMDB01487 HMDB ReactionCatalysis131 ACTIVATION C02835 KEGG Compound PW000003 PathWhiz SMILES CN1C=NC(CC(O)=O)=C1 Methylimidazoleacetic acid 388370 ChemSpider SMILES N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C(N)N=CN=C12)C(O)=O HMDB00033 HMDB 2311-81-1 CAS 75810 PubChem-compound 4.0 4.1.1.22 false 4.1.1.22 L-Histidine → Carbon dioxide + Histamine LEFT_TO_RIGHT 1.0 HMDB01377 HMDB HMDB01014 HMDB HMDB00045 HMDB 1061 PubChem-compound Histamine N-methyltransferase 2.0 CHEBI:16680 ChEBI C00785 KEGG Compound C00664 KEGG Compound 24762165 PubChem-compound P19113 UniProt 1.0 13781857 PubChem-compound S-Adenosylmethionine C6H8N2O Methylimidazole acetaldehyde 124.06366 Beta-Ala-His dipeptidase Carnosine synthase 1 Protein arginine N- methyltransferase 3 Histidine decarboxylase Histamine N- methyltransferase Amine oxidase [flavin- containing] A Aldehyde dehydrogenase, dimeric NADP-preferring Aldehyde dehydrogenase, mitochondrial Histidine ammonia-lyase Urocanate hydratase Probable imidazolonepropionase Formimidoyltransferase- cyclodeaminase Probable histidine--tRNA ligase, mitochondrial Histidine--tRNA ligase, cytoplasmic Amiloride- sensitive amine oxidase [copper- containing] L-Glutamic acid Carnosine H 2 O Beta-Alanine L-Histidine ATP Beta-Alanine ADP P i S-Adenosylmethionine 3- Methylhistidine S-Adenosylhomocysteine Histamine CO 2 S-Adenosylmethionine S-Adenosylhomocysteine 1-Methylhistamine H 2 O O 2 Methylimidazole acetaldehyde NH 3 H 2 O 2 NADP H 2 O Methylimidazoleacetic acid NADPH H + Imidazole-4-acetaldehyde NAD H 2 O Imidazoleacetic acid NADH H + NH 3 Urocanic acid 4-Imidazolone-5-propionic acid H 2 O H 2 O Formiminoglutamic acid Tetrahydrofolic acid 5-Formiminotetrahydrofolic acid ATP AMP PP i ATP AMP PP i H 2 O O 2 NH 3 H 2 O 2 Zinc (II) ion Manganese Pyridoxal 5'-phosphate FAD NAD Zinc (II) ion Pyridoxal 5'-phosphate Copper Calcium Topaquinone tRNA(His) L- histidyl- tRNA(His) tRNA(His) Glutamate Metabolism Intracellular Space Extracellular Space
Histidine Metabolism CHEBI:16015 ChEBI 6022 PubChem-compound 7722-84-1 CAS 1.0 C00439 KEGG Compound 937 ChemSpider HMDB00250 HMDB L-Histidine CHEBI:16134 ChEBI HMDB01341 HMDB Carnosine 1.0 439153 PubChem-compound Amiloride-sensitive amine oxidase [copper-containing] 1.0 Tetrahydrofolic acid CHEBI:27398 ChEBI CHEBI:20506 ChEBI L-histidyl-tRNA(His) CHEBI:16027 ChEBI HMDB00148 HMDB Histidine decarboxylase Aldehyde dehydrogenase, mitochondrial ATP BioCyc 388363 ChemSpider C6H11N3 1-Methylhistamine 125.0953 Q96N76 UniProt 18714427 ChemSpider 559142 ChemSpider SMILES CN1C=NC(CC=O)=C1 CHEBI:27384 ChEBI 1.0 C6H8N2O3 4-Imidazolone-5-propionic acid 156.0535 PW000043 PathWhiz C15H23N6O5S S-Adenosylmethionine 399.14505 HMDB00479 HMDB Histamine 1.0 5742 ChemSpider 17340-16-8 CAS CHEBI:16474 ChEBI 952 ChemSpider CHEBI:28104 ChEBI Carbon dioxide Aldehyde dehydrogenase, mitochondrial Formimidoyltransferase-cyclodeaminase HMDB59597 HMDB Aldehyde dehydrogenase, dimeric NADP-preferring Amine oxidase [flavin-containing] A Carnosine synthase 1 64969 PubChem-compound http://identifiers.org/smpdb/SMP00044 SMPDB 5858 ChemSpider 6274 PubChem-compound Adenosine monophosphate CHEBI:16240 ChEBI 4-IMIDAZOLONE-5-PROPIONATE BioCyc 1.0 Carnosine synthase 1 58494 ChemSpider 1010 ChemSpider C00101 KEGG Compound PPI BioCyc Imidazoleacetic acid 1.0 643824 ChemSpider HMDB00217 HMDB SMILES C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C(N)N=CN=C12 979-92-0 CAS L-Glutamic acid SubPathwayInput Cytosol C6H8N2O2 Methylimidazoleacetic acid 140.05858 SMILES OC(=O)CCC1N=CNC1=O C14H20N6O5S S-Adenosylhomocysteine 384.12158 Q96NU7 UniProt A5YM72 UniProt P50135 UniProt 1.4.3.4 false 1.4.3.4 1-Methylhistamine + Oxygen + Water &rarr; Ammonia + Hydrogen peroxide + Methylimidazole acetaldehyde LEFT_TO_RIGHT Urocanic acid 3-Methylhistidine 193545 PubChem-compound C00009 KEGG Compound HMDB00221 HMDB C00008 KEGG Compound CHEBI:1606 ChEBI C00007 KEGG Compound 19639-03-3 CAS C00006 KEGG Compound CHEBI:18009 ChEBI C00001 KEGG Compound CHEBI:18361 ChEBI 1.0 C00005 KEGG Compound CHEBI:18367 ChEBI C00004 KEGG Compound CHEBI:7274 ChEBI 1032 ChemSpider C00003 KEGG Compound 135-16-0 CAS C00002 KEGG Compound NADP Q96KN2 UniProt 1.0 CHEBI:29009 ChEBI 4.0 HMDB01429 HMDB 1.0 C00019 KEGG Compound 3488 ChemSpider C21H28N7O14P2 NAD 664.11694 1.0 C05828 KEGG Compound C05827 KEGG Compound Adenosine triphosphate C00011 KEGG Compound Formimidoyltransferase-cyclodeaminase C00135 KEGG Compound C00014 KEGG Compound C00013 KEGG Compound NAD(P) BioCyc 11267158 ChemSpider H Hydrogen Ion 1.007825 388301 ChemSpider Beta-Ala-His dipeptidase HMDB01534 HMDB C00386 KEGG Compound 56-65-5 CAS C00021 KEGG Compound 53-84-9 CAS C00020 KEGG Compound C00027 KEGG Compound C00388 KEGG Compound C00025 KEGG Compound 501-75-7 CAS 104-98-3 CAS 8.0 HMDB00898 HMDB CL:0000000 CELL TYPE ONTOLOGY SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O AMP BioCyc P19801 UniProt 1.0 HYDROGEN-PEROXIDE BioCyc 645-65-8 CAS CHEBI:29178 ChEBI SMILES [O-]P([O-])(=O)OP([O-])([O-])=O P49590 UniProt HMDB00301 HMDB 1.0 132948 ChemSpider P30838 UniProt SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 1.0 C03680 KEGG Compound 763 ChemSpider Histamine L-histidyl-tRNA(His) HMDB00538 HMDB 1.0 tRNA(His) C6H10N2O4 Formiminoglutamic acid 174.06406 HMDB00870 HMDB 784 PubChem-compound 7732-18-5 CAS 61-19-8 CAS SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 C01152 KEGG Compound 3614 PubChem-compound AMMONIA BioCyc SMILES N 56-86-0 CAS 1.0 Adenosine diphosphate CHEBI:29155 ChEBI HMDB02820 HMDB 774 PubChem-compound C10H16N5O13P3 Adenosine triphosphate 506.99576 1.0 Probable histidine--tRNA ligase, mitochondrial Protein arginine N-methyltransferase 3 Beta-Ala-His dipeptidase 530 PubChem-compound Pyrophosphate P12081 UniProt 1.0 1.0 C5H6N2O Imidazole-4-acetaldehyde 110.04801 HMDB03905 HMDB HMDB01967 HMDB Ammonia HMDB01846 HMDB SMILES NCCC(O)=O UROCANATE BioCyc Amiloride-sensitive amine oxidase [copper-containing] 962 PubChem-compound 31983 ChemSpider 86856 ChemSpider HMDB00854 HMDB 5800 ChemSpider CO2 Carbon dioxide 43.98983 Hydrogen peroxide C00080 KEGG Compound SMILES O=O Histidine ammonia-lyase BiologicalState8 Homo sapiens, Cell, Cytoplasm SMILES N[C@@H](CCC(O)=O)C(O)=O BiologicalState3 Homo sapiens, Cell, Mitochondrion BiologicalState2 Homo sapiens, Cell, Cytosol 14265-44-2 CAS C6H9N3O2 L-Histidine 155.06947 58-64-0 CAS HISTAMINE BioCyc Aldehyde dehydrogenase, dimeric NADP-preferring C7H11N3O2 3-Methylhistidine 169.08513 644102 PubChem-compound C6H6N2O2 Urocanic acid 138.04292 6083 PubChem-compound 1.0 C00099 KEGG Compound Histidine ammonia-lyase CHEBI:18295 ChEBI 25246222 PubChem-compound 753 ChemSpider 22833512 PubChem-compound CARNOSINE BioCyc H2O Water 18.010565 H2O2 Hydrogen peroxide 34.005478 C5H9N3 Histamine 111.07965 NADH BioCyc 5-Formiminotetrahydrofolic acid 29908-03-0 CAS NAD BioCyc 977 PubChem-compound Histamine N-methyltransferase Formimidoyltransferase-cyclodeaminase 167957 ChemSpider SMILES NC1=NC2=C(N(C=N)C(CNC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)CN2)C(=O)N1 NAD ReactionCatalysis157 ACTIVATION 30572 ChemSpider 17215925 ChemSpider Histidine decarboxylase Aldehyde dehydrogenase, mitochondrial 128 PubChem-compound tRNA(His) C5H6N2O2 Imidazoleacetic acid 126.04293 L-histidyl-tRNA(His) SMILES OC(=O)\C=C\C1=CNC=N1 Histidine decarboxylase SMILES NCCC1=CNC=N1 1.0 SMILES O SMILES OO 1.0 H3N Ammonia 17.026548 6.1.1.21 false 6.1.1.21 Adenosine triphosphate + L-Histidine + tRNA(His) &rarr; Adenosine monophosphate + L-histidyl-tRNA(His) + Pyrophosphate LEFT_TO_RIGHT C10H14N5O7P Adenosine monophosphate 347.06308 CHEBI:15971 ChEBI 239 PubChem-compound 4.3.1.3 false 4.3.1.3 L-Histidine &harr; Ammonia + Urocanic acid REVERSIBLE 1.0 125 ChemSpider Water HMDB04181 HMDB CHEBI:15846 ChEBI CHEBI:15727 ChEBI ADP BioCyc HMDB00939 HMDB C3H7NO2 Beta-Alanine 89.047676 28305488 PubChem-compound 53-59-8 CAS Probable histidine--tRNA ligase, mitochondrial 1.0 6038 ChemSpider 1038 PubChem-compound GO:0005829 GENE ONTOLOGY C19H23N7O6 Tetrahydrofolic acid 445.171 274 ChemSpider 1.0 Beta-Alanine HMDB00902 HMDB CHEBI:16908 ChEBI Imidazole-4-acetaldehyde 2.1.1.- false 2.1.1.- L-Histidine + S-Adenosylmethionine &rarr; 3-Methylhistidine + S-Adenosylhomocysteine LEFT_TO_RIGHT Ammonia ADENOSYL-HOMO-CYS BioCyc SubPathwayInteraction845 SubPathway845Reaction SubPathwayReaction Methylimidazole acetaldehyde O4P Phosphate 94.95342 Urocanate hydratase 305-84-0 CAS Histidine--tRNA ligase, cytoplasmic 1.0 SMILES OC(=O)CC[C@H](NC=N)C(O)=O Adenosine triphosphate C21H30N7O17P3 NADPH 745.0911 C9H14N4O3 Carnosine 226.1066 3.4.13.20 false 3.4.13.20 Carnosine + Water &rarr; Beta-Alanine + L-Histidine LEFT_TO_RIGHT C21H29N7O17P3 NADP 744.08325 Mitochondrion THF BioCyc N-FORMIMINO-L-GLUTAMATE BioCyc NADPH BioCyc CHEBI:16974 ChEBI 1.0 S-Adenosylhomocysteine CPD-6641 BioCyc 71-00-1 CAS Probable imidazolonepropionase C05127 KEGG Compound 217 ChemSpider O95954 UniProt 58-68-4 CAS SMILES NC1=NC(=O)C2=C(NC[C@H](CNC3=CC=C(C=C3)C(=O)NC(CCC(O)=O)C(O)=O)N2)N1 SMILES [O-]P([O-])([O-])=O 1.0 C05130 KEGG Compound 124-38-9 CAS CHEBI:15639 ChEBI Glutamate Metabolism SubPathway CHEBI:15414 ChEBI tRNA(His) 1.4.3.22 false 1.4.3.22 Histamine + Oxygen + Water &rarr; Ammonia + Hydrogen peroxide + Imidazole-4-acetaldehyde LEFT_TO_RIGHT SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O SMILES OC(=O)CC1=CN=CN1 SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O C20H24N8O6 5-Formiminotetrahydrofolic acid 472.1819 1.0 SMILES NCCC(=O)N[C@@H](CC1=CN=CN1)C(O)=O 7664-41-7 CAS GLT BioCyc 107-95-9 CAS Oxygen 53-57-6 CAS S-ADENOSYLMETHIONINE BioCyc SMILES O=C=O 1-Methylhistamine 222 PubChem-compound O7P2 Pyrophosphate 173.91193 234 ChemSpider Hydrogen peroxide C21H29N7O14P2 NADH 665.12476 P21397 UniProt 1.0 5-FORMIMINO-THF BioCyc 5957 PubChem-compound 1.0 Reaction869 false Formiminoglutamic acid + Tetrahydrofolic acid &harr; 5-Formiminotetrahydrofolic acid + L-Glutamic acid REVERSIBLE 4.2.1.49 false 4.2.1.49 4-Imidazolone-5-propionic acid &harr; Urocanic acid + Water REVERSIBLE SMILES N[C@@H](CC1=CN=CN1)C(O)=O 1.0 816-90-0 CAS Amiloride-sensitive amine oxidase [copper-containing] GO:0005739 GENE ONTOLOGY C10H15N5O10P2 Adenosine diphosphate 427.02942 GO:0005737 GENE ONTOLOGY SMILES CN1C=NC=C1C[C@H](N)C(O)=O CHEBI:16958 ChEBI 1.0 Imidazole-4-acetaldehyde HMDB03125 HMDB NADH CPD-8587 BioCyc SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O 51-45-6 CAS L-Histidine HMDB01185 HMDB 5682 ChemSpider Beta-Ala-His dipeptidase 2.0 1.0 14000-31-8 CAS 1.0 P05091 UniProt B-ALANINE BioCyc 5675 ChemSpider N-METHYL-HISTAMINE BioCyc 68319 ChemSpider 1.0 Cytoplasm 1.2.1.5 false 1.2.1.5 Methylimidazole acetaldehyde + NADP + Water &rarr; Hydrogen Ion + Methylimidazoleacetic acid + NADPH LEFT_TO_RIGHT 150841 PubChem-compound Urocanate hydratase NADPH Cell ReactionCatalysis454 ACTIVATION ReactionCatalysis455 ACTIVATION ReactionCatalysis452 ACTIVATION CHEBI:15422 ChEBI ReactionCatalysis453 ACTIVATION ReactionCatalysis450 ACTIVATION ReactionCatalysis451 ACTIVATION 388299 ChemSpider Protein arginine N-methyltransferase 3 Hydrogen Ion O2 Oxygen 31.98983 O60678 UniProt CHEBI:30817 ChEBI 1.0 ReactionCatalysis449 ACTIVATION HIS BioCyc ReactionCatalysis448 ACTIVATION 1.2.1.3 false 1.2.1.3 Imidazole-4-acetaldehyde + NAD + Water &rarr; Hydrogen Ion + Imidazoleacetic acid + NADH LEFT_TO_RIGHT C5H9NO4 L-Glutamic acid 147.05316 Water 33032 PubChem-compound SMILES CN1C=NC(CCN)=C1 Probable imidazolonepropionase CHEBI:16526 ChEBI Adenosine monophosphate Histidine--tRNA ligase, cytoplasmic CHEBI:16761 ChEBI HMDB02024 HMDB 7782-44-7 CAS Carnosine synthase 1 2.0 4-Imidazolone-5-propionic acid 1.0 9606 TAXONOMY HMDB00056 HMDB HMDB00177 HMDB 1.0 Formiminoglutamic acid 4-IMIDAZOLEACETATE BioCyc 1.0 HMDB00051 HMDB 1.0 5893 PubChem-compound HMDB02111 HMDB 439233 PubChem-compound P42357 UniProt 2.1.1.8 false 2.1.1.8 Histamine + S-Adenosylmethionine &rarr; 1-Methylhistamine + S-Adenosylhomocysteine LEFT_TO_RIGHT 1.0 CHEBI:27596 ChEBI 1.0 CHEBI:15377 ChEBI 368-16-1 CAS Pyrophosphate 6.3.2.11 false 6.3.2.11 Adenosine triphosphate + Beta-Alanine + L-Histidine &rarr; Adenosine diphosphate + Carnosine + Phosphate LEFT_TO_RIGHT CHEBI:15379 ChEBI CHEBI:15378 ChEBI SMILES [H+] Amine oxidase [flavin-containing] A 2625-49-2 CAS ReactionCatalysis460 ACTIVATION SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound 1.0 Phosphate 439224 PubChem-compound Oxygen http://identifiers.org/smpdb/SMP00072 SMPDB 1.0 280 PubChem-compound SMILES O=CCC1=CN=CN1 645-14-7 CAS ReactionCatalysis458 ACTIVATION 3.5.2.7 false 3.5.2.7 4-Imidazolone-5-propionic acid + Water &rarr; Formiminoglutamic acid LEFT_TO_RIGHT ReactionCatalysis459 ACTIVATION ReactionCatalysis456 ACTIVATION 736715 PubChem-compound ReactionCatalysis457 ACTIVATION HMDB01487 HMDB ReactionCatalysis131 ACTIVATION C02835 KEGG Compound PW000003 PathWhiz SMILES CN1C=NC(CC(O)=O)=C1 Methylimidazoleacetic acid 388370 ChemSpider SMILES N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C(N)N=CN=C12)C(O)=O HMDB00033 HMDB 2311-81-1 CAS 75810 PubChem-compound 4.0 4.1.1.22 false 4.1.1.22 L-Histidine &rarr; Carbon dioxide + Histamine LEFT_TO_RIGHT 1.0 HMDB01377 HMDB HMDB01014 HMDB HMDB00045 HMDB 1061 PubChem-compound Histamine N-methyltransferase 2.0 CHEBI:16680 ChEBI C00785<