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CHEBI:16015 ChEBI C10H14N5O7P 3'-AMP 347.06308 1.0 1.0 439153 PubChem-compound 16597-58-3 CAS 492-27-3 CAS 50 ChemSpider HMDB01476 HMDB HMDB00148 HMDB HMDB01238 HMDB 1118 ChemSpider 910 PubChem-compound HMDB00142 HMDB false L-Tryptophan + Oxygen → N'-Formylkynurenine LEFT_TO_RIGHT N-ACETYL-5-METHOXY-TRYPTAMINE BioCyc 559142 ChemSpider HMDB01200 HMDB HMDB01206 HMDB 5742 ChemSpider C03722 KEGG Compound NADH PW000163 PathWhiz 5-Hydroxyindoleacetaldehyde CHEBI:16474 ChEBI CHEBI:995 ChEBI Transport138 false L-Tryptophan (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytosol LEFT_TO_RIGHT C02406 KEGG Compound 5735 ChemSpider L-Kynurenine PW000151 PathWhiz SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCS C10H12N2O4 L-3-Hydroxykynurenine 224.07971 708-23-6 CAS 37610 ChemSpider 1.0 HMDB01423 HMDB Tryptophan--tRNA ligase, mitochondrial Serotonin N-acetyltransferase 1.0 979-92-0 CAS 1.0 CHEBI:5086 ChEBI CHEBI:17380 ChEBI CHEBI:48294 ChEBI C00007 KEGG Compound C7H7NO2 2-Aminobenzoic acid 137.04768 C00006 KEGG Compound CHEBI:18009 ChEBI C00001 KEGG Compound L-ALPHA-ALANINE BioCyc 56-41-7 CAS C00005 KEGG Compound C00004 KEGG Compound NADPH C00003 KEGG Compound C00002 KEGG Compound SMILES N[C@@H](CC(=O)C1=CC=CC(O)=C1N)C(O)=O 1.0 Tryptophan--tRNA ligase, mitochondrial 1.0 1.0 Q9UGM6 UniProt 84 ChemSpider 67261 ChemSpider SubPathwayInteraction461 SubPathway461Reaction SubPathwayReaction C00019 KEGG Compound Coenzyme A C00011 KEGG Compound C00010 KEGG Compound tRNA(Ala) C10H9NO3 5-Hydroxyindoleacetic acid 191.05824 C00013 KEGG Compound 903 PubChem-compound 59-00-7 CAS 56-65-5 CAS C00021 KEGG Compound 53-84-9 CAS L-Glutamic acid C00026 KEGG Compound CHEBI:50157 ChEBI Q8N5Z0 UniProt C00025 KEGG Compound C01598 KEGG Compound C00024 KEGG Compound C00272 KEGG Compound Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial NADP 1022-31-7 CAS 4a-Hydroxytetrahydrobiopterin CHEBI:29170 ChEBI CL:0000000 CELL TYPE ONTOLOGY 1760 ChemSpider C01367 KEGG Compound 1.0 Formic acid Tryptophan--tRNA ligase, cytoplasmic 2-Aminomuconic acid semialdehyde C00041 KEGG Compound SMILES N\C(C(O)=O)=C(\C=C/C=O)/C(O)=O TETRA-H-BIOPTERIN BioCyc SMILES NCCC1=CNC2=CC=C(O)C=C12 SMILES COC1=CC(C(=O)CCNC(C)=O)=C(NC=O)C=C1 C15522 KEGG Compound 3,4-Dihydroxyphenylacetaldehyde P04798 UniProt 6-Hydroxymelatonin SMILES [O-]P([O-])(=O)OP([O-])([O-])=O HMDB00303 HMDB C04409 KEGG Compound 1.0 606-59-7 CAS Kynureninase 886 ChemSpider C02470 KEGG Compound 52450-38-1 CAS 1.0 1.0 tRNA(Tyr) HMDB00538 HMDB 2-AMINO-3-CARBOXYMUCONATE_SEMIAL BioCyc L-tryptophyl-tRNA(Trp) Xanthurenic acid C00058 KEGG Compound CHEBI:29159 ChEBI SMILES OC(=O)C1=CC=CN=C1C(O)=O FORMATE BioCyc C10H12N2O3 Formyl-5-hydroxykynurenamine 208.0848 3712 ChemSpider HMDB00763 HMDB C10H16N5O13P3 Adenosine triphosphate 506.99576 1.0 Kynurenine formamidase Indolethylamine N-methyltransferase 41211 PubChem-compound 962 PubChem-compound 31983 ChemSpider Kynureninase 17528-72-2 CAS L-Alanine C00078 KEGG Compound 114908 ChemSpider HMDB04096 HMDB CO2 Carbon dioxide 43.98983 SMILES O=O Melatonin 54-16-0 CAS HMDB11631 HMDB BiologicalState2 1794 ChemSpider HMDB12948 HMDB Aldehyde dehydrogenase, mitochondrial CHEBI:18086 ChEBI 1892-21-3 CAS 1.0 Catalase 1.0 2-AMINOMUCONATE_SEMIALDEHYDE BioCyc HMDB00978 HMDB SMILES COC1=CC2=C(NC=C2CCNC(C)=O)C=C1 Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial C10H12N2 Tryptamine 160.10005 644102 PubChem-compound Kynurenine formamidase HMDB04076 HMDB HMDB04077 HMDB 64-18-6 CAS 879 ChemSpider HMDB04078 HMDB 872 ChemSpider C9H15N5O4 4a-Hydroxytetrahydrobiopterin 257.1124 HMDB04073 HMDB SMILES CNCCC1=CNC2=C1C=C(O)C=C2 SMILES CNCCC1=CNC2=CC=CC=C12 NADH BioCyc 29908-03-0 CAS 3517-61-1 CAS 141580 ChemSpider 977 PubChem-compound CHEBI:29182 ChEBI HMDB04086 HMDB HMDB04089 HMDB Tryptophan--tRNA ligase, cytoplasmic HMDB04083 HMDB HMDB04081 HMDB HMDB00715 HMDB 30572 ChemSpider 17215925 ChemSpider 144400 ChemSpider SMILES NCCC1=CNC2=CC=CC=C12 SMILES CC(O)C(O)C1CNC2=NC(N)=NC(=O)C2(O)N1 101399 PubChem-compound 1.0 1125 PubChem-compound Cytochrome P450 1A1 CHEBI:2065 ChEBI 6816 PubChem-compound 51 PubChem-compound CHEBI:235589 ChEBI 1.0 1150 PubChem-compound 144 PubChem-compound 278 ChemSpider 274 ChemSpider 86 PubChem-compound tRNA(Tyr) C9H15N5O3 Tetrahydrobiopterin 241.1175 Pyrophosphate C06212 KEGG Compound 1.0 NADPH BioCyc Reaction1619 false L-3-Hydroxykynurenine + Oxoglutaric acid → 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid + L-Glutamic acid LEFT_TO_RIGHT false L-3-Hydroxykynurenine + Water → 3-Hydroxyanthranilic acid + L-Alanine LEFT_TO_RIGHT false 2 3-Hydroxyanthranilic acid + Oxygen → Cinnavalininate + 2 Water LEFT_TO_RIGHT Reaction1615 false 4-(2-Aminophenyl)-2,4-dioxobutanoic acid → Kynurenic acid LEFT_TO_RIGHT false L-Kynurenine + NADPH + Oxygen → L-3-Hydroxykynurenine + NADP + Water LEFT_TO_RIGHT