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C6H14O12P2 D-Fructose 2,6-bisphosphate 339.99606 6022 PubChem-compound 388350 ChemSpider 937 ChemSpider 18186-48-6 CAS C3H6O3 Glyceraldehyde 90.03169 C00794 KEGG Compound Sorbitol 439153 PubChem-compound 1.0 1.0 P50053 UniProt C6H14O12P2 Fructose 1,6-bisphosphate 339.99606 C00325 KEGG Compound C02985 KEGG Compound ATP BioCyc 2.0 1.0 53188-23-1 CAS 559142 ChemSpider HMDB0001076 HMDB HMDB0001078 HMDB Triosephosphate isomerase 388338 ChemSpider D-Fructose 2,6-bisphosphate 5742 ChemSpider P34949 UniProt MANNOSE-1P BioCyc CHEBI:16474 ChEBI SMP00040 SMPDB ALPHA-GLUCOSE-16-BISPHOSPHATE BioCyc SMP00045 SMPDB Guanosine triphosphate SMP00043 SMPDB 1.0 PW000159 PathWhiz 709 ChemSpider 27251-84-9 CAS 488-69-7 CAS PPI BioCyc HMDB0001095 HMDB 2438-80-4 CAS 1.0 C3H7O6P D-Glyceraldehyde 3-phosphate 169.99803 Galactose Metabolism SubPathway 388554 ChemSpider Q13630 UniProt Amino Sugar Metabolism SubPathway C10H16N5O14P3 Guanosine triphosphate 522.99066 Glycolysis SubPathway C00111 KEGG Compound 1.0 Q00796 UniProt 50-70-4 CAS C00354 KEGG Compound P60174 UniProt P15121 UniProt 439198 PubChem-compound 94762 ChemSpider 7664-38-2 CAS Fructose 6-phosphate SubPathwayInput C6H12O6 D-Fructose 180.06339 C00009 KEGG Compound C00008 KEGG Compound C00006 KEGG Compound CHEBI:18009 ChEBI 2.0 Fructose-bisphosphate aldolase B Phosphomannomutase 1 C00001 KEGG Compound CHEBI:18361 ChEBI C00005 KEGG Compound C00004 KEGG Compound C6H13O9P Beta-D-Fructose 2-phosphate 260.02972 CHEBI:18367 ChEBI C00003 KEGG Compound 1032 ChemSpider NADP C00002 KEGG Compound 193537 PubChem-compound MANNOSE-6P BioCyc C6H12O6 Alpha-D-Glucose 180.06339 Q9NRX4 UniProt 1.0 Fructose and Mannose Degradation C6H13O9P Fructose 1-phosphate 260.02972 388775 ChemSpider C21H28N7O14P2 NAD 664.11694 1.0 CHEBI:17009 ChEBI Adenosine triphosphate C01222 KEGG Compound P16118 UniProt O14772 UniProt HMDB0000902 HMDB Q92871 UniProt FRUCTOSE-6P BioCyc Fucose-1-phosphate guanylyltransferase SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)C(=O)N1 C6H13O9P Mannose 6-phosphate 260.02972 C00013 KEGG Compound L-fucose kinase 105021 PubChem-compound Sorbitol dehydrogenase 4.2.1.47 false 4.2.1.47 Guanosine diphosphate mannose → GDP-4-Dehydro-6-deoxy-D-mannose + Water LEFT_TO_RIGHT GDP-L-fucose synthase L-fucose kinase NAD(P) BioCyc 2.0 HMDB0006330 HMDB CHEBI:17138 ChEBI C6H13O8P Fucose 1-phosphate 244.0348 1.0 56-65-5 CAS 53-84-9 CAS C00267 KEGG Compound 62713 ChemSpider 644175 PubChem-compound Mannose-1-phosphate guanyltransferase beta CHEBI:26078 ChEBI GDP-mannose 4,6 dehydratase 1.0 C16H25N5O15P2 GDP-L-fucose 589.0822 10400369 PubChem-compound 3672-15-9 CAS CL:0000000 CELL TYPE ONTOLOGY C00275 KEGG Compound C6H13O9P D-Mannose 1-phosphate 260.02972 C02336 KEGG Compound C00159 KEGG Compound 1.0 SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O Alpha-D-Glucose SubPathwayInput HMDB0001346 HMDB Adenosine diphosphate Beta-D-Fructose 2-phosphate Guanosine diphosphate mannose HMDB0000250 HMDB SMILES [O-]P([O-])(=O)OP([O-])([O-])=O HMDB0001341 HMDB 2.7.1.11 false 2.7.1.11 Adenosine triphosphate + Fructose 6-phosphate → Adenosine diphosphate + Fructose 1,6-bisphosphate LEFT_TO_RIGHT 3.1.3.11 false 3.1.3.11 Fructose 1,6-bisphosphate + Water → Fructose 6-phosphate + Phosphate LEFT_TO_RIGHT 2.7.7.13 false 2.7.7.13 D-Mannose 1-phosphate + Guanosine triphosphate → Guanosine diphosphate mannose + Pyrophosphate LEFT_TO_RIGHT C01019 KEGG Compound 751 PubChem-compound 1.1.1.271 false 1.1.1.271 GDP-L-fucose + NADP ↔ GDP-4-Dehydro-6-deoxy-D-mannose + NADPH REVERSIBLE 5.3.1.8 false 5.3.1.8 Mannose 6-phosphate ↔ Fructose 6-phosphate REVERSIBLE 5.4.2.8 false 5.4.2.8 D-Mannose 1-phosphate ↔ Mannose 6-phosphate REVERSIBLE 2.7.1.1 false 2.7.1.1 Adenosine triphosphate + D-Mannose → Adenosine diphosphate + Mannose 6-phosphate LEFT_TO_RIGHT C00044 KEGG Compound 648 ChemSpider 2.7.1.52 false 2.7.1.52 Adenosine triphosphate + L-Fucose → Adenosine diphosphate + Fucose 1-phosphate LEFT_TO_RIGHT 4.1.2.13 false 4.1.2.13 Fructose 1,6-bisphosphate ↔ D-Glyceraldehyde 3-phosphate + Dihydroxyacetone phosphate REVERSIBLE 2.7.7.30 false 2.7.7.30 Fucose 1-phosphate + Guanosine triphosphate ↔ GDP-L-fucose + Pyrophosphate REVERSIBLE SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O HMDB0001112 HMDB SMILES C[C@H]1O[C@H](OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=C(N)NC3=O)[C@@H](O)[C@@H](O)C1=O HMDB0006800 HMDB 6-phosphofructokinase, liver type 1.0 HMDB0001473 HMDB 5.3.1.1 false 5.3.1.1 Dihydroxyacetone phosphate ↔ D-Glyceraldehyde 3-phosphate REVERSIBLE 668 PubChem-compound GDP-L-fucose synthase 4.1.2.13 false 4.1.2.13 Fructose 1-phosphate ↔ Dihydroxyacetone phosphate + Glyceraldehyde REVERSIBLE 19046-69-6 CAS Hexokinase-1 7732-18-5 CAS 1.0 591-59-3 CAS HMDB0001487 HMDB Mannose 6-phosphate FRU1P BioCyc 492-62-6 CAS Adenosine diphosphate 1.0 C10H16N5O13P3 Adenosine triphosphate 506.99576 CPD-488 BioCyc DIHYDROXY-ACETONE-PHOSPHATE BioCyc 445557 PubChem-compound Pyrophosphate HMDB0000169 HMDB SMILES OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO SMILES OCC(=O)COP(O)(O)=O D-Fructose 962 PubChem-compound 5800 ChemSpider Fructose-1,6-bisphosphatase 1 GDP-L-fucose synthase 979 ChemSpider Fructose-1,6-bisphosphatase 1 Mannose-6-phosphate isomerase 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 731 ChemSpider H3O4P Phosphoric acid 97.9769 C00085 KEGG Compound 559210 ChemSpider C6H12O5 L-Fucose 164.06847 BiologicalState8 Homo sapiens, Cell, Cytoplasm 729 PubChem-compound C6H12O6 D-Mannose 180.06339 GUANOSINE_DIPHOSPHATE_FUCOSE BioCyc HMDB0002111 HMDB BiologicalState3 Homo sapiens, Cell, Mitochondrion HMDB0000174 HMDB Fructose-bisphosphate aldolase A HMDB0001265 HMDB Fructose-bisphosphate aldolase A 14265-44-2 CAS SubPathwayInteraction866 SubPathway866Reaction SubPathwayReaction SubPathwayInteraction867 SubPathway867Reaction SubPathwayReaction SubPathwayInteraction864 SubPathway864Reaction SubPathwayReaction SubPathwayInteraction865 SubPathway865Reaction SubPathwayReaction 58-64-0 CAS Fructose-1,6-bisphosphatase 1 GTP BioCyc GDP-mannose 4,6 dehydratase 71358 ChemSpider C00096 KEGG Compound CHEBI:704854 ChEBI HMDB0001273 HMDB 4.0 644102 PubChem-compound 1.0 C02154 KEGG Compound 17893 ChemSpider HMDB0001047 HMDB 22833512 PubChem-compound HMDB0003345 HMDB 18396 PubChem-compound H2O Water 18.010565 SMILES OCC(=O)[C@@H](O)[C@H](O)[C@H](O)COP(O)(O)=O 167949 ChemSpider NADH BioCyc 393165 ChemSpider HMDB0001163 HMDB NAD BioCyc L-Fucose 1.0 P17858 UniProt 1.0 HMDB0001058 HMDB NAD HMDB0001051 HMDB Fructose 6-phosphate HMDB0002142 HMDB 2.7.1.1 false 2.7.1.1 Adenosine triphosphate + D-Fructose → Adenosine diphosphate + Fructose 6-phosphate LEFT_TO_RIGHT 17215925 ChemSpider CPD-535 BioCyc 6-phosphofructokinase, liver type 388911 ChemSpider 2.0 MANNOSE BioCyc Mannose 6-phosphate C03267 KEGG Compound CHEBI:5445 ChEBI Triosephosphate isomerase SMILES O C01094 KEGG Compound 439709 PubChem-compound HMDB0000538 HMDB 4.0 1004 PubChem-compound CHEBI:2181 ChEBI 643-13-0 CAS Water C3H7O6P Dihydroxyacetone phosphate 169.99803 C6H14O6 Sorbitol 182.07904 CHEBI:15846 ChEBI D-Fructose ADP BioCyc Phosphomannomutase 1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 HMDB0000660 HMDB L-FUCOSE BioCyc 53-59-8 CAS CHEBI:15820 ChEBI SMILES OC[C@H]1OC(OP(O)(O)=O)[C@@H](O)[C@@H](O)[C@@H]1O Mannose-6-phosphate isomerase Fructose 1,6-bisphosphate 56-82-6 CAS D-Mannose 1-phosphate CHEBI:16905 ChEBI CHEBI:16908 ChEBI D-Glyceraldehyde 3-phosphate Sorbitol dehydrogenase O4P Phosphate 94.95342 6830 PubChem-compound 15978-08-2 CAS Adenosine triphosphate Q9Y5P6 UniProt C21H30N7O17P3 NADPH 745.0911 CHEBI:15946 ChEBI 16562-58-6 CAS C21H29N7O17P3 NADP 744.08325 Mitochondrion NADPH BioCyc C16H23N5O15P2 GDP-4-Dehydro-6-deoxy-D-mannose 587.0666 16190 ChemSpider CHEBI:35374 ChEBI Triosephosphate isomerase 58-68-4 CAS SMILES [O-]P([O-])([O-])=O CHEBI:28602 ChEBI HMDB0000217 HMDB 1.0 439871 PubChem-compound Sorbitol dehydrogenase Ketohexokinase C6H13O9P Fructose 6-phosphate 260.02972 GDP-MANNOSE BioCyc 79082-92-1 CAS Fructose-bisphosphate aldolase A 4.0 Fructose-bisphosphate aldolase B 1.0 HMDB0001429 HMDB 6-phosphofructokinase, liver type 17106 PubChem-compound SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O HMDB0000221 HMDB Fucose-1-phosphate guanylyltransferase Ketohexokinase SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE BioCyc 57-04-5 CAS CHEBI:4208 ChEBI 69507 PubChem-compound 53-57-6 CAS CHEBI:17924 ChEBI CHEBI:16955 ChEBI Ketohexokinase 1.0 Phosphomannomutase 1 CHEBI:12350 ChEBI SMILES OP(O)(O)=O 1.0 O7P2 Pyrophosphate 173.91193 Fucose 1-phosphate 1.0 C21H29N7O14P2 NADH 665.12476 17372 ChemSpider SMILES C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O 1.0 5957 PubChem-compound SMILES OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O Hexokinase-1 530-26-7 CAS CHEBI:15996 ChEBI CHEBI:49728 ChEBI ReactionCatalysis1315 ACTIVATION GO:0005739 GENE ONTOLOGY HMDB0000124 HMDB GDP-4-Dehydro-6-deoxy-D-mannose C10H15N5O10P2 Adenosine diphosphate 427.02942 GO:0005737 GENE ONTOLOGY HMDB0000247 HMDB 4.0 CHEBI:17925 ChEBI 15839-70-0 CAS Fructose 1-phosphate Mannose-1-phosphate guanyltransferase beta NADH SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O CPD-8587 BioCyc SMILES O[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@@H]1O SMILES OC[C@H]1O[C@](O)(COP(O)(O)=O)[C@@H](O)[C@@H]1O 5682 ChemSpider P19367 UniProt CHEBI:28645 ChEBI 1.0 D-Mannose 14000-31-8 CAS 5675 ChemSpider SMILES C[C@@H]1OC(OP(O)(O)=O)[C@@H](O)[C@H](O)[C@@H]1O SMILES C[C@@H]1OC(OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=C(N)NC3=O)[C@@H](O)[C@H](O)[C@@H]1O Cytoplasm GDP-L-fucose NADPH Cell ReactionCatalysis333 ACTIVATION ReactionCatalysis334 ACTIVATION ReactionCatalysis331 ACTIVATION SMILES OCC(O)C=O ReactionCatalysis332 ACTIVATION CHEBI:15422 ChEBI P09467 UniProt Homo sapiens 388299 ChemSpider 1.0 SMILES OC[C@@]1(OP(O)(O)=O)O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O 1.0 439211 PubChem-compound 1.0 Dihydroxyacetone phosphate SubPathwayInput FRUCTOSE-16-DIPHOSPHATE BioCyc Aldose reductase SMILES O[C@H]1[C@H](O)[C@](O)(COP(O)(O)=O)O[C@@H]1COP(O)(O)=O 5576 ChemSpider Phosphoric acid CHEBI:16761 ChEBI 439446 PubChem-compound Reaction260 false D-Fructose 2,6-bisphosphate + Water → Fructose 6-phosphate + Phosphate LEFT_TO_RIGHT O60547 UniProt Glyceraldehyde GLYCERALD BioCyc 8575807 ChemSpider 1.0 9606 TAXONOMY C00636 KEGG Compound C16H25N5O16P2 Guanosine diphosphate mannose 605.07715 P04075 UniProt 1.0 2.7.1.3 false 2.7.1.3 Adenosine triphosphate + D-Fructose → Adenosine diphosphate + Fructose 1-phosphate LEFT_TO_RIGHT PW000025 PathWhiz PW000146 PathWhiz 1.0 5893 PubChem-compound Q8N0W3 UniProt 1.0 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 1.1.1.14 false 1.1.1.14 NAD + Sorbitol ↔ D-Fructose + NADH REVERSIBLE 3.1.3.- false 3.1.3.- Beta-D-Fructose 2-phosphate + Water → D-Fructose + Phosphoric acid LEFT_TO_RIGHT 1.1.1.21 false 1.1.1.21 NADP + Sorbitol ↔ Alpha-D-Glucose + NADPH REVERSIBLE ReactionCatalysis348 ACTIVATION SMP00064 SMPDB ReactionCatalysis346 ACTIVATION ReactionCatalysis347 ACTIVATION CHEBI:15377 ChEBI ReactionCatalysis344 ACTIVATION ReactionCatalysis345 ACTIVATION ReactionCatalysis342 ACTIVATION 1.0 ReactionCatalysis343 ACTIVATION ReactionCatalysis340 ACTIVATION ReactionCatalysis341 ACTIVATION 6569 ChemSpider CHEBI:16108 ChEBI 18950 PubChem-compound SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound 2.0 1.0 Phosphate 9606 Taxonomy 3123-67-9 CAS CHEBI:28319 ChEBI 79025 PubChem-compound ReactionCatalysis339 ACTIVATION PW000008 PathWhiz ReactionCatalysis337 ACTIVATION ReactionCatalysis338 ACTIVATION ReactionCatalysis335 ACTIVATION 14 kDa phosphohistidine phosphatase ReactionCatalysis336 ACTIVATION Aldose reductase SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1 SMILES OC(COP(O)(O)=O)C=O P05062 UniProt 1.0 86-01-1 CAS GAP BioCyc 1061 PubChem-compound ReactionCatalysis122 ACTIVATION 5780 PubChem-compound SMILES OC[C@H]1O[C@@](CO)(OP(O)(O)=O)[C@@H](O)[C@@H]1O C00661 KEGG Compound 14 kDa phosphohistidine phosphatase C00665 KEGG Compound SMILES OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O SMILES OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O 1.0 Aldose reductase Sorbitol dehydrogenase 14 kDa phosphohistidine phosphatase Hexokinase-1 Mannose-6- phosphate isomerase Hexokinase-1 Phosphomannomutase 1 6- phosphofructokinase, liver type Fructose-1,6- bisphosphatase 1 Mannose-1- phosphate guanyltransferase beta Fructose- bisphosphate aldolase A Fructose- bisphosphate aldolase B GDP-mannose 4,6 dehydratase GDP-L-fucose synthase Fucose-1- phosphate guanylyltransferase L-fucose kinase Ketohexokinase Triosephosphate isomerase Fructose- bisphosphate aldolase A 6- phosphofructo- 2- kinase/fructose- 2,6- bisphosphatase 1 Alpha-D-Glucose Fructose 6-phosphate Dihydroxyacetone phosphate NADP Sorbitol NADPH NAD D-Fructose NADH Beta-D-Fructose 2-phosphate H 2 O P i ATP ADP Mannose 6-phosphate D-Mannose ATP ADP D-Mannose 1-phosphate ATP Fructose 1,6-bisphosphate ADP H 2 O P i GTP Guanosine diphosphate mannose PP i D- Glyceraldehyde 3-phosphate GDP-4-Dehydro-6-deoxy-D- mannose H 2 O GDP-L-fucose NADP NADPH Fucose 1-phosphate GTP PP i L-Fucose ATP ADP ATP Fructose 1-phosphate ADP Glyceraldehyde D-Fructose 2,6- bisphosphate H 2 O P i Zinc (II) ion Zinc (II) ion Magnesium Magnesium Magnesium NADP Galactose Metabolism Glycolysis Glycolysis Amino Sugar Metabolism Mitochondrial Membrane Mitochondria Intracellular Space Liver
C6H14O12P2 D-Fructose 2,6-bisphosphate 339.99606 6022 PubChem-compound 388350 ChemSpider 937 ChemSpider 18186-48-6 CAS C3H6O3 Glyceraldehyde 90.03169 C00794 KEGG Compound Sorbitol 439153 PubChem-compound 1.0 1.0 P50053 UniProt C6H14O12P2 Fructose 1,6-bisphosphate 339.99606 C00325 KEGG Compound C02985 KEGG Compound ATP BioCyc 2.0 1.0 53188-23-1 CAS 559142 ChemSpider HMDB0001076 HMDB HMDB0001078 HMDB Triosephosphate isomerase 388338 ChemSpider D-Fructose 2,6-bisphosphate 5742 ChemSpider P34949 UniProt MANNOSE-1P BioCyc CHEBI:16474 ChEBI SMP00040 SMPDB ALPHA-GLUCOSE-16-BISPHOSPHATE BioCyc SMP00045 SMPDB Guanosine triphosphate SMP00043 SMPDB 1.0 PW000159 PathWhiz 709 ChemSpider 27251-84-9 CAS 488-69-7 CAS PPI BioCyc HMDB0001095 HMDB 2438-80-4 CAS 1.0 C3H7O6P D-Glyceraldehyde 3-phosphate 169.99803 Galactose Metabolism SubPathway 388554 ChemSpider Q13630 UniProt Amino Sugar Metabolism SubPathway C10H16N5O14P3 Guanosine triphosphate 522.99066 Glycolysis SubPathway C00111 KEGG Compound 1.0 Q00796 UniProt 50-70-4 CAS C00354 KEGG Compound P60174 UniProt P15121 UniProt 439198 PubChem-compound 94762 ChemSpider 7664-38-2 CAS Fructose 6-phosphate SubPathwayInput C6H12O6 D-Fructose 180.06339 C00009 KEGG Compound C00008 KEGG Compound C00006 KEGG Compound CHEBI:18009 ChEBI 2.0 Fructose-bisphosphate aldolase B Phosphomannomutase 1 C00001 KEGG Compound CHEBI:18361 ChEBI C00005 KEGG Compound C00004 KEGG Compound C6H13O9P Beta-D-Fructose 2-phosphate 260.02972 CHEBI:18367 ChEBI C00003 KEGG Compound 1032 ChemSpider NADP C00002 KEGG Compound 193537 PubChem-compound MANNOSE-6P BioCyc C6H12O6 Alpha-D-Glucose 180.06339 Q9NRX4 UniProt 1.0 Fructose and Mannose Degradation C6H13O9P Fructose 1-phosphate 260.02972 388775 ChemSpider C21H28N7O14P2 NAD 664.11694 1.0 CHEBI:17009 ChEBI Adenosine triphosphate C01222 KEGG Compound P16118 UniProt O14772 UniProt HMDB0000902 HMDB Q92871 UniProt FRUCTOSE-6P BioCyc Fucose-1-phosphate guanylyltransferase SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]3O)[C@@H](O)[C@H]2O)C(=O)N1 C6H13O9P Mannose 6-phosphate 260.02972 C00013 KEGG Compound L-fucose kinase 105021 PubChem-compound Sorbitol dehydrogenase 4.2.1.47 false 4.2.1.47 Guanosine diphosphate mannose → GDP-4-Dehydro-6-deoxy-D-mannose + Water LEFT_TO_RIGHT GDP-L-fucose synthase L-fucose kinase NAD(P) BioCyc 2.0 HMDB0006330 HMDB CHEBI:17138 ChEBI C6H13O8P Fucose 1-phosphate 244.0348 1.0 56-65-5 CAS 53-84-9 CAS C00267 KEGG Compound 62713 ChemSpider 644175 PubChem-compound Mannose-1-phosphate guanyltransferase beta CHEBI:26078 ChEBI GDP-mannose 4,6 dehydratase 1.0 C16H25N5O15P2 GDP-L-fucose 589.0822 10400369 PubChem-compound 3672-15-9 CAS CL:0000000 CELL TYPE ONTOLOGY C00275 KEGG Compound C6H13O9P D-Mannose 1-phosphate 260.02972 C02336 KEGG Compound C00159 KEGG Compound 1.0 SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O Alpha-D-Glucose SubPathwayInput HMDB0001346 HMDB Adenosine diphosphate Beta-D-Fructose 2-phosphate Guanosine diphosphate mannose HMDB0000250 HMDB SMILES [O-]P([O-])(=O)OP([O-])([O-])=O HMDB0001341 HMDB 2.7.1.11 false 2.7.1.11 Adenosine triphosphate + Fructose 6-phosphate → Adenosine diphosphate + Fructose 1,6-bisphosphate LEFT_TO_RIGHT 3.1.3.11 false 3.1.3.11 Fructose 1,6-bisphosphate + Water → Fructose 6-phosphate + Phosphate LEFT_TO_RIGHT 2.7.7.13 false 2.7.7.13 D-Mannose 1-phosphate + Guanosine triphosphate → Guanosine diphosphate mannose + Pyrophosphate LEFT_TO_RIGHT C01019 KEGG Compound 751 PubChem-compound 1.1.1.271 false 1.1.1.271 GDP-L-fucose + NADP ↔ GDP-4-Dehydro-6-deoxy-D-mannose + NADPH REVERSIBLE 5.3.1.8 false 5.3.1.8 Mannose 6-phosphate ↔ Fructose 6-phosphate REVERSIBLE 5.4.2.8 false 5.4.2.8 D-Mannose 1-phosphate ↔ Mannose 6-phosphate REVERSIBLE 2.7.1.1 false 2.7.1.1 Adenosine triphosphate + D-Mannose → Adenosine diphosphate + Mannose 6-phosphate LEFT_TO_RIGHT C00044 KEGG Compound 648 ChemSpider 2.7.1.52 false 2.7.1.52 Adenosine triphosphate + L-Fucose → Adenosine diphosphate + Fucose 1-phosphate LEFT_TO_RIGHT 4.1.2.13 false 4.1.2.13 Fructose 1,6-bisphosphate ↔ D-Glyceraldehyde 3-phosphate + Dihydroxyacetone phosphate REVERSIBLE 2.7.7.30 false 2.7.7.30 Fucose 1-phosphate + Guanosine triphosphate ↔ GDP-L-fucose + Pyrophosphate REVERSIBLE SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O HMDB0001112 HMDB SMILES C[C@H]1O[C@H](OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=C(N)NC3=O)[C@@H](O)[C@@H](O)C1=O HMDB0006800 HMDB 6-phosphofructokinase, liver type 1.0 HMDB0001473 HMDB 5.3.1.1 false 5.3.1.1 Dihydroxyacetone phosphate ↔ D-Glyceraldehyde 3-phosphate REVERSIBLE 668 PubChem-compound GDP-L-fucose synthase 4.1.2.13 false 4.1.2.13 Fructose 1-phosphate ↔ Dihydroxyacetone phosphate + Glyceraldehyde REVERSIBLE 19046-69-6 CAS Hexokinase-1 7732-18-5 CAS 1.0 591-59-3 CAS HMDB0001487 HMDB Mannose 6-phosphate FRU1P BioCyc 492-62-6 CAS Adenosine diphosphate 1.0 C10H16N5O13P3 Adenosine triphosphate 506.99576 CPD-488 BioCyc DIHYDROXY-ACETONE-PHOSPHATE BioCyc 445557 PubChem-compound Pyrophosphate HMDB0000169 HMDB SMILES OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO SMILES OCC(=O)COP(O)(O)=O D-Fructose 962 PubChem-compound 5800 ChemSpider Fructose-1,6-bisphosphatase 1 GDP-L-fucose synthase 979 ChemSpider Fructose-1,6-bisphosphatase 1 Mannose-6-phosphate isomerase 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 731 ChemSpider H3O4P Phosphoric acid 97.9769 C00085 KEGG Compound 559210 ChemSpider C6H12O5 L-Fucose 164.06847 BiologicalState8 Homo sapiens, Cell, Cytoplasm 729 PubChem-compound C6H12O6 D-Mannose 180.06339 GUANOSINE_DIPHOSPHATE_FUCOSE BioCyc HMDB0002111 HMDB BiologicalState3 Homo sapiens, Cell, Mitochondrion HMDB0000174 HMDB Fructose-bisphosphate aldolase A HMDB0001265 HMDB Fructose-bisphosphate aldolase A 14265-44-2 CAS SubPathwayInteraction866 SubPathway866Reaction SubPathwayReaction SubPathwayInteraction867 SubPathway867Reaction SubPathwayReaction SubPathwayInteraction864 SubPathway864Reaction SubPathwayReaction SubPathwayInteraction865 SubPathway865Reaction SubPathwayReaction 58-64-0 CAS Fructose-1,6-bisphosphatase 1 GTP BioCyc GDP-mannose 4,6 dehydratase 71358 ChemSpider C00096 KEGG Compound CHEBI:704854 ChEBI HMDB0001273 HMDB 4.0 644102 PubChem-compound 1.0 C02154 KEGG Compound 17893 ChemSpider HMDB0001047 HMDB 22833512 PubChem-compound HMDB0003345 HMDB 18396 PubChem-compound H2O Water 18.010565 SMILES OCC(=O)[C@@H](O)[C@H](O)[C@H](O)COP(O)(O)=O 167949 ChemSpider NADH BioCyc 393165 ChemSpider HMDB0001163 HMDB NAD BioCyc L-Fucose 1.0 P17858 UniProt 1.0 HMDB0001058 HMDB NAD HMDB0001051 HMDB Fructose 6-phosphate HMDB0002142 HMDB 2.7.1.1 false 2.7.1.1 Adenosine triphosphate + D-Fructose → Adenosine diphosphate + Fructose 6-phosphate LEFT_TO_RIGHT 17215925 ChemSpider CPD-535 BioCyc 6-phosphofructokinase, liver type 388911 ChemSpider 2.0 MANNOSE BioCyc Mannose 6-phosphate C03267 KEGG Compound CHEBI:5445 ChEBI Triosephosphate isomerase SMILES O C01094 KEGG Compound 439709 PubChem-compound HMDB0000538 HMDB 4.0 1004 PubChem-compound CHEBI:2181 ChEBI 643-13-0 CAS Water C3H7O6P Dihydroxyacetone phosphate 169.99803 C6H14O6 Sorbitol 182.07904 CHEBI:15846 ChEBI D-Fructose ADP BioCyc Phosphomannomutase 1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 HMDB0000660 HMDB L-FUCOSE BioCyc 53-59-8 CAS CHEBI:15820 ChEBI SMILES OC[C@H]1OC(OP(O)(O)=O)[C@@H](O)[C@@H](O)[C@@H]1O Mannose-6-phosphate isomerase Fructose 1,6-bisphosphate 56-82-6 CAS D-Mannose 1-phosphate CHEBI:16905 ChEBI CHEBI:16908 ChEBI D-Glyceraldehyde 3-phosphate Sorbitol dehydrogenase O4P Phosphate 94.95342 6830 PubChem-compound 15978-08-2 CAS Adenosine triphosphate Q9Y5P6 UniProt C21H30N7O17P3 NADPH 745.0911 CHEBI:15946 ChEBI 16562-58-6 CAS C21H29N7O17P3 NADP 744.08325 Mitochondrion NADPH BioCyc C16H23N5O15P2 GDP-4-Dehydro-6-deoxy-D-mannose 587.0666 16190 ChemSpider CHEBI:35374 ChEBI Triosephosphate isomerase 58-68-4 CAS SMILES [O-]P([O-])([O-])=O CHEBI:28602 ChEBI HMDB0000217 HMDB 1.0 439871 PubChem-compound Sorbitol dehydrogenase Ketohexokinase C6H13O9P Fructose 6-phosphate 260.02972 GDP-MANNOSE BioCyc 79082-92-1 CAS Fructose-bisphosphate aldolase A 4.0 Fructose-bisphosphate aldolase B 1.0 HMDB0001429 HMDB 6-phosphofructokinase, liver type 17106 PubChem-compound SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O HMDB0000221 HMDB Fucose-1-phosphate guanylyltransferase Ketohexokinase SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE BioCyc 57-04-5 CAS CHEBI:4208 ChEBI 69507 PubChem-compound 53-57-6 CAS CHEBI:17924 ChEBI CHEBI:16955 ChEBI Ketohexokinase 1.0 Phosphomannomutase 1 CHEBI:12350 ChEBI SMILES OP(O)(O)=O 1.0 O7P2 Pyrophosphate 173.91193 Fucose 1-phosphate 1.0 C21H29N7O14P2 NADH 665.12476 17372 ChemSpider SMILES C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O 1.0 5957 PubChem-compound SMILES OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O Hexokinase-1 530-26-7 CAS CHEBI:15996 ChEBI CHEBI:49728 ChEBI ReactionCatalysis1315 ACTIVATION GO:0005739 GENE ONTOLOGY HMDB0000124 HMDB GDP-4-Dehydro-6-deoxy-D-mannose C10H15N5O10P2 Adenosine diphosphate 427.02942 GO:0005737 GENE ONTOLOGY HMDB0000247 HMDB 4.0 CHEBI:17925 ChEBI 15839-70-0 CAS Fructose 1-phosphate Mannose-1-phosphate guanyltransferase beta NADH SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O CPD-8587 BioCyc SMILES O[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H](O)[C@@H]1O SMILES OC[C@H]1O[C@](O)(COP(O)(O)=O)[C@@H](O)[C@@H]1O 5682 ChemSpider P19367 UniProt CHEBI:28645 ChEBI 1.0 D-Mannose 14000-31-8 CAS 5675 ChemSpider SMILES C[C@@H]1OC(OP(O)(O)=O)[C@@H](O)[C@H](O)[C@@H]1O SMILES C[C@@H]1OC(OP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=C(N)NC3=O)[C@@H](O)[C@H](O)[C@@H]1O Cytoplasm GDP-L-fucose NADPH Cell ReactionCatalysis333 ACTIVATION ReactionCatalysis334 ACTIVATION ReactionCatalysis331 ACTIVATION SMILES OCC(O)C=O ReactionCatalysis332 ACTIVATION CHEBI:15422 ChEBI P09467 UniProt Homo sapiens 388299 ChemSpider 1.0 SMILES OC[C@@]1(OP(O)(O)=O)O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O 1.0 439211 PubChem-compound 1.0 Dihydroxyacetone phosphate SubPathwayInput FRUCTOSE-16-DIPHOSPHATE BioCyc Aldose reductase SMILES O[C@H]1[C@H](O)[C@](O)(COP(O)(O)=O)O[C@@H]1COP(O)(O)=O 5576 ChemSpider Phosphoric acid CHEBI:16761 ChEBI 439446 PubChem-compound Reaction260 false D-Fructose 2,6-bisphosphate + Water → Fructose 6-phosphate + Phosphate LEFT_TO_RIGHT O60547 UniProt Glyceraldehyde GLYCERALD BioCyc 8575807 ChemSpider 1.0 9606 TAXONOMY C00636 KEGG Compound C16H25N5O16P2 Guanosine diphosphate mannose 605.07715 P04075 UniProt 1.0 2.7.1.3 false 2.7.1.3 Adenosine triphosphate + D-Fructose → Adenosine diphosphate + Fructose 1-phosphate LEFT_TO_RIGHT PW000025 PathWhiz PW000146 PathWhiz 1.0 5893 PubChem-compound Q8N0W3 UniProt 1.0 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 1.1.1.14 false 1.1.1.14 NAD + Sorbitol ↔ D-Fructose + NADH REVERSIBLE 3.1.3.- false 3.1.3.- Beta-D-Fructose 2-phosphate + Water → D-Fructose + Phosphoric acid LEFT_TO_RIGHT 1.1.1.21 false 1.1.1.21 NADP + Sorbitol ↔ Alpha-D-Glucose + NADPH REVERSIBLE ReactionCatalysis348 ACTIVATION SMP00064 SMPDB ReactionCatalysis346 ACTIVATION ReactionCatalysis347 ACTIVATION CHEBI:15377 ChEBI ReactionCatalysis344 ACTIVATION ReactionCatalysis345 ACTIVATION ReactionCatalysis342 ACTIVATION 1.0 ReactionCatalysis343 ACTIVATION ReactionCatalysis340 ACTIVATION ReactionCatalysis341 ACTIVATION 6569 ChemSpider CHEBI:16108 ChEBI 18950 PubChem-compound SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound 2.0 1.0 Phosphate 9606 Taxonomy 3123-67-9 CAS CHEBI:28319 ChEBI 79025 PubChem-compound ReactionCatalysis339 ACTIVATION PW000008 PathWhiz ReactionCatalysis337 ACTIVATION ReactionCatalysis338 ACTIVATION ReactionCatalysis335 ACTIVATION 14 kDa phosphohistidine phosphatase ReactionCatalysis336 ACTIVATION Aldose reductase SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1 SMILES OC(COP(O)(O)=O)C=O P05062 UniProt 1.0 86-01-1 CAS GAP BioCyc 1061 PubChem-compound ReactionCatalysis122 ACTIVATION 5780 PubChem-compound SMILES OC[C@H]1O[C@@](CO)(OP(O)(O)=O)[C@@H](O)[C@@H]1O C00661 KEGG Compound 14 kDa phosphohistidine phosphatase C00665 KEGG Compound SMILES OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O SMILES OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O 1.0