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ReactionCatalysis399 ACTIVATION ReactionCatalysis398 ACTIVATION HMDB02434 HMDB 6022 PubChem-compound 937 ChemSpider HMDB00250 HMDB HMDB01341 HMDB 431981 ChemSpider Tyrosinase SMILES O C10H14N5O7P Adenosine monophosphate 347.06308 Riboflavin kinase 1.0 CHEBI:16027 ChEBI Riboflavin Metabolism Melanosome Membrane ATP BioCyc CHEBI:17594 ChEBI 1.0 Reaction2332 false Riboflavin → Dimethylbenzimidazole LEFT_TO_RIGHT 2.0 Water 559142 ChemSpider 1.0 C17H20N4O6 Riboflavin 376.13828 ADP BioCyc CHEBI:16238 ChEBI 5742 ChemSpider Dimethylbenzimidazole SubPathwayInput 952 ChemSpider FMN BioCyc 1.0 PW000035 PathWhiz 5858 ChemSpider HMDB00244 HMDB 1.14.18.1 false 1.14.18.1 2 Hydroquinone + Oxygen → 2 Quinone + 2 Water LEFT_TO_RIGHT O4P Phosphate 94.95342 4650 PubChem-compound 582-60-5 CAS PPI BioCyc Riboflavin SubPathwayOutput GO:0033162 GENE ONTOLOGY Quinone 236-TRICHLOROHYDROQUINONE BioCyc C00472 KEGG Compound Low molecular weight phosphotyrosine protein phosphatase CPD-6641 BioCyc HMDB04256 HMDB C9H10N2 Dimethylbenzimidazole 146.0844 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 SMILES [O-]P([O-])([O-])=O GO:0005886 GENE ONTOLOGY C00009 KEGG Compound 1.0 5118-16-1 CAS C00008 KEGG Compound C00007 KEGG Compound 675 PubChem-compound Reaction845 true 6,7-Dimethyl-8-(1-D-ribityl)lumazine + Quinone → 7-Hydroxy-6-methyl-8-ribityl lumazine + Hydroquinone LEFT_TO_RIGHT 1.0 2.7.7.2 false 2.7.7.2 Adenosine triphosphate + Flavin Mononucleotide → FAD + Pyrophosphate LEFT_TO_RIGHT 2.0 C00001 KEGG Compound 559059 ChemSpider Hydroquinone 1.0 CHEBI:18361 ChEBI 672 PubChem-compound 493570 PubChem-compound CHEBI:15890 ChEBI CHEBI:18367 ChEBI 1032 ChemSpider C00002 KEGG Compound FAD 1.0 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 559060 ChemSpider HMDB01429 HMDB C17H21N4O9P Flavin Mononucleotide 456.1046 HMDB01520 HMDB C27H33N9O15P2 FAD 785.1571 1.0 1.0 HMDB03701 HMDB Adenosine triphosphate C12H16N4O7 7-Hydroxy-6-methyl-8-ribityl lumazine 328.1019 C00016 KEGG Compound C00013 KEGG Compound C00255 KEGG Compound O7P2 Pyrophosphate 173.91193 1.0 P24666 UniProt 1.0 5957 PubChem-compound Adenosine monophosphate ReactionCatalysis401 ACTIVATION ReactionCatalysis402 ACTIVATION ReactionCatalysis400 ACTIVATION Flavin Mononucleotide CHEBI:17015 ChEBI Intestinal Microflora SubPathway Quinone 56-65-5 CAS C00020 KEGG Compound C10H15N5O10P2 Adenosine diphosphate 427.02942 GO:0005737 GENE ONTOLOGY DIMETHYL-D-RIBITYL-LUMAZINE BioCyc 2.7.1.26 false 2.7.1.26 Adenosine triphosphate + Riboflavin → Adenosine diphosphate + Flavin Mononucleotide LEFT_TO_RIGHT HMDB03826 HMDB Q8NFF5 UniProt CHEBI:17621 ChEBI C6H6O2 Hydroquinone 110.03678 CL:0000000 CELL TYPE ONTOLOGY SMILES CC1=CC2=C(C=C1C)N(C[C@H](O)[C@H](O)[C@H](O)CO[P@](O)(=O)O[P@@](O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC3=C1N=CN=C3N)C1=NC(=O)NC(=O)C1=N2 CPD-8587 BioCyc HMDB03364 HMDB SMILES CC1=C(O)N(C[C@H](O)[C@H](O)[C@H](O)CO)C2=NC(=O)NC(=O)C2=N1 655 ChemSpider AMP BioCyc 652 ChemSpider Hydroquinone 1.0 Q969G6 UniProt 1.0 Reaction479 false Flavin Mononucleotide + Water → Phosphate + Riboflavin LEFT_TO_RIGHT SMILES [O-]P([O-])(=O)OP([O-])([O-])=O 14000-31-8 CAS Water BiologicalState33 Water FAD SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 764 ChemSpider P22413 UniProt Cytoplasm HMDB00538 HMDB Reaction246 false FAD + Water → Adenosine monophosphate + Flavin Mononucleotide LEFT_TO_RIGHT Cell CHEBI:17601 ChEBI 785 PubChem-compound CHEBI:15422 ChEBI 643976 PubChem-compound 1.0 2184-54-5 CAS 643975 PubChem-compound C13H18N4O6 6,7-Dimethyl-8-(1-D-ribityl)lumazine 326.12262 7732-18-5 CAS FAD synthase 61-19-8 CAS SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 SubPathwayInteraction66 SubPathway66Reaction SubPathwayReaction O2 Oxygen 31.98983 SubPathwayInteraction65 SubPathwayReaction SubPathway65Reaction 83-88-5 CAS C6H4O2 Quinone 108.021126 C00061 KEGG Compound CHEBI:16509 ChEBI Adenosine diphosphate BiologicalState14 146-17-8 CAS C10H16N5O13P3 Adenosine triphosphate 506.99576 4489 ChemSpider CPD-8130 BioCyc CHEBI:16761 ChEBI 7782-44-7 CAS C05995 KEGG Compound Pyrophosphate RIBOFLAVIN BioCyc SMILES CC1=C(C)C=C2N(C[C@H](O)[C@H](O)[C@H](O)CO)C3=NC(=O)NC(=O)C3=NC2=C1 123-31-9 CAS 9606 TAXONOMY 962 PubChem-compound 5800 ChemSpider P14679 UniProt 1.0 HMDB02111 HMDB SMILES O=O Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 SMILES O=C1C=CC(=O)C=C1 BiologicalState8 Oxygen CHEBI:15377 ChEBI Cell Membrane CHEBI:15379 ChEBI 146-14-5 CAS 14265-44-2 CAS Intestinal Microflora SubPathway 58-64-0 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Intestinal Microflora SubPathway SubPathwayInteraction869 SubPathwayReaction SubPathway869Reaction Riboflavin kinase 1.0 Phosphate C03114 KEGG Compound SMP00070 SMPDB SMILES OC1=CC=C(O)C=C1 2.0 CHEBI:27581 ChEBI 644102 PubChem-compound HMDB01248 HMDB Tyrosinase 6083 PubChem-compound C04332 KEGG Compound SMILES CC1=CC2=C(C=C1C)N=CN2 C00530 KEGG Compound H2O Water 18.010565 FAD BioCyc Low molecular weight phosphotyrosine protein phosphatase 6,7-Dimethyl-8-(1-D-ribityl)lumazine SubPathwayOutput HMDB01377 HMDB 7-Hydroxy-6-methyl-8-ribityl lumazine HMDB00045 HMDB FAD synthase 1061 PubChem-compound 977 PubChem-compound Flavin Mononucleotide 106-51-4 CAS 20100757 ChemSpider 1.0 SMILES CC1=C(C)N(CC(O)C(O)C(O)CO)C2=NC(=O)NC(=O)C2=N1 2.0 SMILES CC1=CC2=C(C=C1C)N(C[C@H](O)[C@H](O)[C@H](O)COP(O)(O)=O)C1=NC(=O)NC(=O)C1=N2 Tyrosinase Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 FAD synthase Low molecular weight phosphotyrosine protein phosphatase Riboflavin kinase 6,7-Dimethyl-8-(1-D- ribityl)lumazine Riboflavin Dimethylbenzimidazole Hydroquinone O 2 Quinone H 2 O 7-Hydroxy-6-methyl-8-ribityl lumazine FAD H 2 O AMP Flavin Mononucleotide ATP PP i H 2 O P i ATP ADP Copper Calcium Magnesium Zinc Intestinal Microflora Intestinal Microflora Intestinal Microflora Melanosome Intracellular Space Extracellular Space
ReactionCatalysis399 ACTIVATION ReactionCatalysis398 ACTIVATION HMDB02434 HMDB 6022 PubChem-compound 937 ChemSpider HMDB00250 HMDB HMDB01341 HMDB 431981 ChemSpider Tyrosinase SMILES O C10H14N5O7P Adenosine monophosphate 347.06308 Riboflavin kinase 1.0 CHEBI:16027 ChEBI Riboflavin Metabolism Melanosome Membrane ATP BioCyc CHEBI:17594 ChEBI 1.0 Reaction2332 false Riboflavin → Dimethylbenzimidazole LEFT_TO_RIGHT 2.0 Water 559142 ChemSpider 1.0 C17H20N4O6 Riboflavin 376.13828 ADP BioCyc CHEBI:16238 ChEBI 5742 ChemSpider Dimethylbenzimidazole SubPathwayInput 952 ChemSpider FMN BioCyc 1.0 PW000035 PathWhiz 5858 ChemSpider HMDB00244 HMDB 1.14.18.1 false 1.14.18.1 2 Hydroquinone + Oxygen → 2 Quinone + 2 Water LEFT_TO_RIGHT O4P Phosphate 94.95342 4650 PubChem-compound 582-60-5 CAS PPI BioCyc Riboflavin SubPathwayOutput GO:0033162 GENE ONTOLOGY Quinone 236-TRICHLOROHYDROQUINONE BioCyc C00472 KEGG Compound Low molecular weight phosphotyrosine protein phosphatase CPD-6641 BioCyc HMDB04256 HMDB C9H10N2 Dimethylbenzimidazole 146.0844 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 SMILES [O-]P([O-])([O-])=O GO:0005886 GENE ONTOLOGY C00009 KEGG Compound 1.0 5118-16-1 CAS C00008 KEGG Compound C00007 KEGG Compound 675 PubChem-compound Reaction845 true 6,7-Dimethyl-8-(1-D-ribityl)lumazine + Quinone → 7-Hydroxy-6-methyl-8-ribityl lumazine + Hydroquinone LEFT_TO_RIGHT 1.0 2.7.7.2 false 2.7.7.2 Adenosine triphosphate + Flavin Mononucleotide → FAD + Pyrophosphate LEFT_TO_RIGHT 2.0 C00001 KEGG Compound 559059 ChemSpider Hydroquinone 1.0 CHEBI:18361 ChEBI 672 PubChem-compound 493570 PubChem-compound CHEBI:15890 ChEBI CHEBI:18367 ChEBI 1032 ChemSpider C00002 KEGG Compound FAD 1.0 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 559060 ChemSpider HMDB01429 HMDB C17H21N4O9P Flavin Mononucleotide 456.1046 HMDB01520 HMDB C27H33N9O15P2 FAD 785.1571 1.0 1.0 HMDB03701 HMDB Adenosine triphosphate C12H16N4O7 7-Hydroxy-6-methyl-8-ribityl lumazine 328.1019 C00016 KEGG Compound C00013 KEGG Compound C00255 KEGG Compound O7P2 Pyrophosphate 173.91193 1.0 P24666 UniProt 1.0 5957 PubChem-compound Adenosine monophosphate ReactionCatalysis401 ACTIVATION ReactionCatalysis402 ACTIVATION ReactionCatalysis400 ACTIVATION Flavin Mononucleotide CHEBI:17015 ChEBI Intestinal Microflora SubPathway Quinone 56-65-5 CAS C00020 KEGG Compound C10H15N5O10P2 Adenosine diphosphate 427.02942 GO:0005737 GENE ONTOLOGY DIMETHYL-D-RIBITYL-LUMAZINE BioCyc 2.7.1.26 false 2.7.1.26 Adenosine triphosphate + Riboflavin → Adenosine diphosphate + Flavin Mononucleotide LEFT_TO_RIGHT HMDB03826 HMDB Q8NFF5 UniProt CHEBI:17621 ChEBI C6H6O2 Hydroquinone 110.03678 CL:0000000 CELL TYPE ONTOLOGY SMILES CC1=CC2=C(C=C1C)N(C[C@H](O)[C@H](O)[C@H](O)CO[P@](O)(=O)O[P@@](O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC3=C1N=CN=C3N)C1=NC(=O)NC(=O)C1=N2 CPD-8587 BioCyc HMDB03364 HMDB SMILES CC1=C(O)N(C[C@H](O)[C@H](O)[C@H](O)CO)C2=NC(=O)NC(=O)C2=N1 655 ChemSpider AMP BioCyc 652 ChemSpider Hydroquinone 1.0 Q969G6 UniProt 1.0 Reaction479 false Flavin Mononucleotide + Water → Phosphate + Riboflavin LEFT_TO_RIGHT SMILES [O-]P([O-])(=O)OP([O-])([O-])=O 14000-31-8 CAS Water BiologicalState33 Water FAD SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 764 ChemSpider P22413 UniProt Cytoplasm HMDB00538 HMDB Reaction246 false FAD + Water → Adenosine monophosphate + Flavin Mononucleotide LEFT_TO_RIGHT Cell CHEBI:17601 ChEBI 785 PubChem-compound CHEBI:15422 ChEBI 643976 PubChem-compound 1.0 2184-54-5 CAS 643975 PubChem-compound C13H18N4O6 6,7-Dimethyl-8-(1-D-ribityl)lumazine 326.12262 7732-18-5 CAS FAD synthase 61-19-8 CAS SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 SubPathwayInteraction66 SubPathway66Reaction SubPathwayReaction O2 Oxygen 31.98983 SubPathwayInteraction65 SubPathwayReaction SubPathway65Reaction 83-88-5 CAS C6H4O2 Quinone 108.021126 C00061 KEGG Compound CHEBI:16509 ChEBI Adenosine diphosphate BiologicalState14 146-17-8 CAS C10H16N5O13P3 Adenosine triphosphate 506.99576 4489 ChemSpider CPD-8130 BioCyc CHEBI:16761 ChEBI 7782-44-7 CAS C05995 KEGG Compound Pyrophosphate RIBOFLAVIN BioCyc SMILES CC1=C(C)C=C2N(C[C@H](O)[C@H](O)[C@H](O)CO)C3=NC(=O)NC(=O)C3=NC2=C1 123-31-9 CAS 9606 TAXONOMY 962 PubChem-compound 5800 ChemSpider P14679 UniProt 1.0 HMDB02111 HMDB SMILES O=O Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 SMILES O=C1C=CC(=O)C=C1 BiologicalState8 Oxygen CHEBI:15377 ChEBI Cell Membrane CHEBI:15379 ChEBI 146-14-5 CAS 14265-44-2 CAS Intestinal Microflora SubPathway 58-64-0 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Intestinal Microflora SubPathway SubPathwayInteraction869 SubPathwayReaction SubPathway869Reaction Riboflavin kinase 1.0 Phosphate C03114 KEGG Compound SMP00070 SMPDB SMILES OC1=CC=C(O)C=C1 2.0 CHEBI:27581 ChEBI 644102 PubChem-compound HMDB01248 HMDB Tyrosinase 6083 PubChem-compound C04332 KEGG Compound SMILES CC1=CC2=C(C=C1C)N=CN2 C00530 KEGG Compound H2O Water 18.010565 FAD BioCyc Low molecular weight phosphotyrosine protein phosphatase 6,7-Dimethyl-8-(1-D-ribityl)lumazine SubPathwayOutput HMDB01377 HMDB 7-Hydroxy-6-methyl-8-ribityl lumazine HMDB00045 HMDB FAD synthase 1061 PubChem-compound 977 PubChem-compound Flavin Mononucleotide 106-51-4 CAS 20100757 ChemSpider 1.0 SMILES CC1=C(C)N(CC(O)C(O)C(O)CO)C2=NC(=O)NC(=O)C2=N1 2.0 SMILES CC1=CC2=C(C=C1C)N(C[C@H](O)[C@H](O)[C@H](O)COP(O)(O)=O)C1=NC(=O)NC(=O)C1=N2 TYR ENPP1 FLAD1 ACP1 RFK 6,7-Dimethyl- 8-(1-D- ribityl)lumazine Riboflavin Dimethylbenzimidazole Hydroquinone Oxygen Quinone Water 7-Hydroxy-6- methyl-8- ribityl lumazine FAD Water Adenosine monophosphate Flavin Mononucleotide Adenosine triphosphate Pyrophosphate Water Phosphate Adenosine triphosphate Adenosine diphosphate Intestinal Microflora Intestinal Microflora Intestinal Microflora