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CHEBI:16015 ChEBI 30572 ChemSpider Glucose-Alanine Cycle 937 ChemSpider CHEBI:16134 ChEBI 439153 PubChem-compound SMILES O H3N Ammonia 17.026548 50 ChemSpider HMDB00148 HMDB 51 PubChem-compound CHEBI:15846 ChEBI P00367 UniProt C3H4O3 Pyruvic acid 88.016045 PW000046 PathWhiz ReactionCatalysis38 ACTIVATION CL:0000182 CELL TYPE ONTOLOGY BTO:0000759 BRENDA TISSUE ONTOLOGY 1.0 CL:0000187 CELL TYPE ONTOLOGY 1038 PubChem-compound PW000162 PathWhiz GO:0005829 GENE ONTOLOGY 2280-44-6 CAS SMP00040 SMPDB HMDB59597 HMDB BTO:0000887 BRENDA TISSUE ONTOLOGY C5H6O5 Oxoglutaric acid 146.02153 1.0 HMDB00902 HMDB CHEBI:16908 ChEBI HMDB00243 HMDB HMDB00122 HMDB Ammonia SubPathwayInput 5735 ChemSpider PW000152 PathWhiz 1010 ChemSpider SMP00059 SMPDB Solute carrier family 2, facilitated glucose transporter member 2 CHEBI:16977 ChEBI L-Glutamic acid SubPathwayOutput Cytosol 217 ChemSpider 58-68-4 CAS Neutral amino acid transporter A SMILES OC(=O)CCC(=O)C(O)=O Mitochondrial glutamate carrier 1 1.0 HMDB00208 HMDB CHEBI:30915 ChEBI C6H12O6 D-Glucose 180.06339 6.0 Q8TD30 UniProt 1.0 1.0 Hydrogen Ion ReactionCatalysis2 ACTIVATION L-ALPHA-ALANINE BioCyc GLC BioCyc C00001 KEGG Compound 1.0 56-41-7 CAS NADH C00004 KEGG Compound C00003 KEGG Compound 1031 ChemSpider Liver Sodium-coupled neutral amino acid transporter 4 Myocyte GO:0005759 GENE ONTOLOGY Solute carrier family 2, facilitated glucose transporter member 4 GLT BioCyc 1.0 7664-41-7 CAS Muscle Oxoglutaric acid 1.0 Pyruvic acid SubPathwayInput SMP00127 SMPDB C21H28N7O14P2 NAD 664.11694 SMP00128 SMPDB SMILES C[C@H](N)C(O)=O 1.0 5950 PubChem-compound 222 PubChem-compound C00014 KEGG Compound Hydrogen Ion 1.0 Alanine aminotransferase 1 C21H29N7O14P2 NADH 665.12476 Alanine aminotransferase 2 D-Glucose BiologicalState50 Hepatocyte Pyruvic acid SubPathwayOutput H Hydrogen Ion 1.007825 BiologicalState54 C00022 KEGG Compound 53-84-9 CAS L-Glutamic acid C00026 KEGG Compound C00025 KEGG Compound GO:0005737 GENE ONTOLOGY L-Glutamic acid BiologicalState26 1.4.1.3 false 1.4.1.3 L-Glutamic acid + NAD + Water → Ammonia + NADH + Oxoglutaric acid LEFT_TO_RIGHT TransportCatalysis13 ACTIVATION SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O C00031 KEGG Compound TransportCatalysis17 ACTIVATION 1.0 TransportCatalysis16 ACTIVATION TransportCatalysis15 ACTIVATION Alanine aminotransferase 2 TransportCatalysis14 ACTIVATION 5682 ChemSpider 328-50-7 CAS SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O C00041 KEGG Compound P43007 UniProt 2.0 D-Glucose SubPathwayOutput Mitochondrial Matrix Mitochondrial glutamate carrier 1 Neutral amino acid transporter A Q9H936 UniProt Alanine aminotransferase 1 1.0 1.0 Cytoplasm 5589 ChemSpider 1.0 Ammonia SubPathwayInteraction70 SubPathwayReaction SubPathway70Reaction Transport42 false D-Glucose (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel LEFT_TO_RIGHT 7732-18-5 CAS 388299 ChemSpider SubPathwayInteraction74 SubPathway74Reaction SubPathwayReaction Sodium-coupled neutral amino acid transporter 4 Transport41 false L-Alanine (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Liver, Hepatocyte, Cytosol LEFT_TO_RIGHT Solute carrier family 2, facilitated glucose transporter member 4 SubPathwayInteraction73 SubPathway73Reaction SubPathwayReaction Transport44 false L-Glutamic acid (→), Hydrogen Ion (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Liver, Hepatocyte, Mitochondrial Matrix LEFT_TO_RIGHT SubPathwayInteraction72 SubPathway72Reaction SubPathwayReaction Transport43 false D-Glucose (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Muscle, Myocyte, Cytoplasm LEFT_TO_RIGHT SubPathwayInteraction71 SubPathwayReaction SubPathway71Reaction 127-17-3 CAS 1.0 AMMONIA BioCyc SMILES N 56-86-0 CAS Q969I6 UniProt Glutamate dehydrogenase 1, mitochondrial C5H9NO4 L-Glutamic acid 147.05316 33032 PubChem-compound 1.0 1.0 P24298 UniProt NAD 2.6.1.2 false 2.6.1.2 L-Alanine + Oxoglutaric acid ↔ L-Glutamic acid + Pyruvic acid REVERSIBLE SMILES CC(=O)C(O)=O Transport40 false L-Alanine (→) Transport: Homo sapiens, Muscle, Myocyte, Cytoplasm to Homo sapiens, Blood Vessel LEFT_TO_RIGHT 9606 TAXONOMY 962 PubChem-compound Gluconeogenesis SubPathway Aspartate Metabolism SubPathway Glycolysis SubPathway C3H7NO2 L-Alanine 89.047676 2-KETOGLUTARATE BioCyc P11168 UniProt Protein Degradation SubPathway L-Alanine PW000146 PathWhiz Urea Cycle SubPathway HMDB00051 HMDB Oxoglutaric acid 5893 PubChem-compound HMDB02111 HMDB 1.0 C00080 KEGG Compound Water 1.0 P14672 UniProt L-Alanine Oxoglutaric acid SMP00067 SMPDB SMILES N[C@@H](CCC(O)=O)C(O)=O CHEBI:32816 ChEBI CHEBI:15377 ChEBI CHEBI:15378 ChEBI SMILES [H+] PYRUVATE BioCyc 1.0 Alanine aminotransferase 1 2.0 CHEBI:4167 ChEBI HMDB01487 HMDB PW000002 PathWhiz ReactionCatalysis499 ACTIVATION 5793 PubChem-compound SMILES OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O H2O Water 18.010565 NADH BioCyc Alanine aminotransferase 2 NAD BioCyc 1060 PubChem-compound L-Alanine Glutamate dehydrogenase 1, mitochondrial HMDB00161 HMDB D-Glucose SubPathwayInput Solute carrier family 2, facilitated glucose transporter member 2 Glutamate dehydrogenase 1, mitochondrial Sodium-coupled neutral amino acid transporter 4 Solute carrier family 2, facilitated glucose transporter member 2 Solute carrier family 2, facilitated glucose transporter member 4 Mitochondrial glutamate carrier 1 Neutral amino acid transporter A Alanine aminotransferase 2 Alanine aminotransferase 1 Glutamate dehydrogenase 1, mitochondrial D-Glucose Pyruvic acid Pyruvic acid D-Glucose NH 3 L-Glutamic acid L-Alanine L-Alanine D-Glucose L-Glutamic acid L-Glutamic acid H + H + L-Alanine Oxoglutaric acid Oxoglutaric acid H 2 O NAD Oxoglutaric acid NADH Pyridoxal 5'-phosphate Pyridoxal 5'-phosphate Glycolysis Aspartate Metabolism Gluconeogenesis Urea Cycle Protein Degradation Mitochondria Blood Vessel Myocyte Muscle Liver Hepatocyte Mitochondrial Matrix Mitochondrial Inner Membrane Mitochondrial Outer Membrane
CHEBI:16015 ChEBI 30572 ChemSpider Glucose-Alanine Cycle 937 ChemSpider CHEBI:16134 ChEBI 439153 PubChem-compound SMILES O H3N Ammonia 17.026548 50 ChemSpider HMDB00148 HMDB 51 PubChem-compound CHEBI:15846 ChEBI P00367 UniProt C3H4O3 Pyruvic acid 88.016045 PW000046 PathWhiz ReactionCatalysis38 ACTIVATION CL:0000182 CELL TYPE ONTOLOGY BTO:0000759 BRENDA TISSUE ONTOLOGY 1.0 CL:0000187 CELL TYPE ONTOLOGY 1038 PubChem-compound PW000162 PathWhiz GO:0005829 GENE ONTOLOGY 2280-44-6 CAS SMP00040 SMPDB HMDB59597 HMDB BTO:0000887 BRENDA TISSUE ONTOLOGY C5H6O5 Oxoglutaric acid 146.02153 1.0 HMDB00902 HMDB CHEBI:16908 ChEBI HMDB00243 HMDB HMDB00122 HMDB Ammonia SubPathwayInput 5735 ChemSpider PW000152 PathWhiz 1010 ChemSpider SMP00059 SMPDB Solute carrier family 2, facilitated glucose transporter member 2 CHEBI:16977 ChEBI L-Glutamic acid SubPathwayOutput Cytosol 217 ChemSpider 58-68-4 CAS Neutral amino acid transporter A SMILES OC(=O)CCC(=O)C(O)=O Mitochondrial glutamate carrier 1 1.0 HMDB00208 HMDB CHEBI:30915 ChEBI C6H12O6 D-Glucose 180.06339 6.0 Q8TD30 UniProt 1.0 1.0 Hydrogen Ion ReactionCatalysis2 ACTIVATION L-ALPHA-ALANINE BioCyc GLC BioCyc C00001 KEGG Compound 1.0 56-41-7 CAS NADH C00004 KEGG Compound C00003 KEGG Compound 1031 ChemSpider Liver Sodium-coupled neutral amino acid transporter 4 Myocyte GO:0005759 GENE ONTOLOGY Solute carrier family 2, facilitated glucose transporter member 4 GLT BioCyc 1.0 7664-41-7 CAS Muscle Oxoglutaric acid 1.0 Pyruvic acid SubPathwayInput SMP00127 SMPDB C21H28N7O14P2 NAD 664.11694 SMP00128 SMPDB SMILES C[C@H](N)C(O)=O 1.0 5950 PubChem-compound 222 PubChem-compound C00014 KEGG Compound Hydrogen Ion 1.0 Alanine aminotransferase 1 C21H29N7O14P2 NADH 665.12476 Alanine aminotransferase 2 D-Glucose BiologicalState50 Hepatocyte Pyruvic acid SubPathwayOutput H Hydrogen Ion 1.007825 BiologicalState54 C00022 KEGG Compound 53-84-9 CAS L-Glutamic acid C00026 KEGG Compound C00025 KEGG Compound GO:0005737 GENE ONTOLOGY L-Glutamic acid BiologicalState26 1.4.1.3 false 1.4.1.3 L-Glutamic acid + NAD + Water → Ammonia + NADH + Oxoglutaric acid LEFT_TO_RIGHT TransportCatalysis13 ACTIVATION SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O C00031 KEGG Compound TransportCatalysis17 ACTIVATION 1.0 TransportCatalysis16 ACTIVATION TransportCatalysis15 ACTIVATION Alanine aminotransferase 2 TransportCatalysis14 ACTIVATION 5682 ChemSpider 328-50-7 CAS SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O C00041 KEGG Compound P43007 UniProt 2.0 D-Glucose SubPathwayOutput Mitochondrial Matrix Mitochondrial glutamate carrier 1 Neutral amino acid transporter A Q9H936 UniProt Alanine aminotransferase 1 1.0 1.0 Cytoplasm 5589 ChemSpider 1.0 Ammonia SubPathwayInteraction70 SubPathwayReaction SubPathway70Reaction Transport42 false D-Glucose (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Blood Vessel LEFT_TO_RIGHT 7732-18-5 CAS 388299 ChemSpider SubPathwayInteraction74 SubPathway74Reaction SubPathwayReaction Sodium-coupled neutral amino acid transporter 4 Transport41 false L-Alanine (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Liver, Hepatocyte, Cytosol LEFT_TO_RIGHT Solute carrier family 2, facilitated glucose transporter member 4 SubPathwayInteraction73 SubPathway73Reaction SubPathwayReaction Transport44 false L-Glutamic acid (→), Hydrogen Ion (→) Transport: Homo sapiens, Liver, Hepatocyte, Cytosol to Homo sapiens, Liver, Hepatocyte, Mitochondrial Matrix LEFT_TO_RIGHT SubPathwayInteraction72 SubPathway72Reaction SubPathwayReaction Transport43 false D-Glucose (→) Transport: Homo sapiens, Blood Vessel to Homo sapiens, Muscle, Myocyte, Cytoplasm LEFT_TO_RIGHT SubPathwayInteraction71 SubPathwayReaction SubPathway71Reaction 127-17-3 CAS 1.0 AMMONIA BioCyc SMILES N 56-86-0 CAS Q969I6 UniProt Glutamate dehydrogenase 1, mitochondrial C5H9NO4 L-Glutamic acid 147.05316 33032 PubChem-compound 1.0 1.0 P24298 UniProt NAD 2.6.1.2 false 2.6.1.2 L-Alanine + Oxoglutaric acid ↔ L-Glutamic acid + Pyruvic acid REVERSIBLE SMILES CC(=O)C(O)=O Transport40 false L-Alanine (→) Transport: Homo sapiens, Muscle, Myocyte, Cytoplasm to Homo sapiens, Blood Vessel LEFT_TO_RIGHT 9606 TAXONOMY 962 PubChem-compound Gluconeogenesis SubPathway Aspartate Metabolism SubPathway Glycolysis SubPathway C3H7NO2 L-Alanine 89.047676 2-KETOGLUTARATE BioCyc P11168 UniProt Protein Degradation SubPathway L-Alanine PW000146 PathWhiz Urea Cycle SubPathway HMDB00051 HMDB Oxoglutaric acid 5893 PubChem-compound HMDB02111 HMDB 1.0 C00080 KEGG Compound Water 1.0 P14672 UniProt L-Alanine Oxoglutaric acid SMP00067 SMPDB SMILES N[C@@H](CCC(O)=O)C(O)=O CHEBI:32816 ChEBI CHEBI:15377 ChEBI CHEBI:15378 ChEBI SMILES [H+] PYRUVATE BioCyc 1.0 Alanine aminotransferase 1 2.0 CHEBI:4167 ChEBI HMDB01487 HMDB PW000002 PathWhiz ReactionCatalysis499 ACTIVATION 5793 PubChem-compound SMILES OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O H2O Water 18.010565 NADH BioCyc Alanine aminotransferase 2 NAD BioCyc 1060 PubChem-compound L-Alanine Glutamate dehydrogenase 1, mitochondrial HMDB00161 HMDB D-Glucose SubPathwayInput Solute carrier family 2, facilitated glucose transporter member 2 Glutamate dehydrogenase 1, mitochondrial SLC38A4 SLC2A2 SLC2A4 SLC25A22 SLC1A4 GPT2 GPT GLUD1 D-Glucose Pyruvic acid Pyruvic acid D-Glucose Ammonia L-Glutamic acid L-Alanine L-Alanine D-Glucose L-Glutamic acid L-Glutamic acid Hydrogen Ion Hydrogen Ion L-Alanine Oxoglutaric acid Oxoglutaric acid Water NAD Oxoglutaric acid NADH Glycolysis Aspartate Metabolism Gluconeogenesis Urea Cycle Protein Degradation