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Type-1 angiotensin II receptor Type-1 angiotensin II receptor Renin Angiotensin- converting enzyme Angiotensinogen Renin Angiotensin- converting enzyme Angiotensinogen des(AngI)AGT Angiotensin II Eprosartan Angiotensin I Angiotensin II H2O Na+ H2O K+ H+ Zinc (II) ion Chloride ion Zinc (II) ion Chloride ion Gαq Angiotensin- converting enzyme GDP Angiotensin II Aldosterone Angiotensin II H2O Vasopressin Eprosartan blocks angiotensin II from binding to type-1 angiotensin II receptor. Angiotensin II is unable to activate the receptor, Gαq, Gβγ, and GDP. From liver From kidney Into circulation From capillaries of lungs and endothelial cells of kidney Hypothalmus Posterior Pituitary Gland Angiotensin II binds directly to AT1 receptors on the smooth muscle cells of the tunica media layer to induce vasoconstriction of the blood vessel Adrenal Cortex Vasopressin is released from the posterior pituitary gland where it changes the permeability of the collecting ducts to allow for water reabsorption back into the blood circulation Water reabsorption into blood circulation Increase in blood pressure Increase in circulating blood volume Triggers thirst sensation Increase in oral water uptake Reabsorption of Na+ into the blood stream subsequently causes water to follow, thus water retention occurs Potassium and hydrogen ions are simultaneously excreted into the urine Angiotensin binds to receptors in the adrenal cortex to trigger a series of reactions that leads to the synthesis of aldosterone from cholesterol
AGTR1 GNG2 AGTR1 REN ACE AGT REN ACE AGT Unknown GNB1 Angiotensin II Eprosartan Angiotensin I Angiotensin II Water Sodium Water Potassium Hydrogen GNAQ ACE Guanosine diphosphate Angiotensin II Aldosterone Angiotensin II Water Vasopressin
AGTR1 GNG2 AGTR1 REN ACE AGT REN ACE AGT GNB1 Ang II Eprosar Angio1 Ang II H2O Na+ H2O K+ H+ Zinc Cl Zinc Cl GNAQ ACE GDP Ang II Aldostr Ang II H2O ADH Eprosartan blocks angiotensin II from binding to type-1 angiotensin II receptor. Angiotensin II is unable to activate the receptor, Gαq, Gβγ, and GDP. From liver From kidney Into circulation From capillaries of lungs and endothelial cells of kidney Hypothalmus Posterior Pituitary Gland Angiotensin II binds directly to AT1 receptors on the smooth muscle cells of the tunica media layer to induce vasoconstriction of the blood vessel Adrenal Cortex Vasopressin is released from the posterior pituitary gland where it changes the permeability of the collecting ducts to allow for water reabsorption back into the blood circulation Water reabsorption into blood circulation Increase in blood pressure Increase in circulating blood volume Triggers thirst sensation Increase in oral water uptake Reabsorption of Na+ into the blood stream subsequently causes water to follow, thus water retention occurs Potassium and hydrogen ions are simultaneously excreted into the urine Angiotensin binds to receptors in the adrenal cortex to trigger a series of reactions that leads to the synthesis of aldosterone from cholesterol
AGTR1 GNG2 AGTR1 REN ACE AGT REN ACE AGT GNB1 Ang II Eprosar Angio1 Ang II H2O Na+ H2O K+ H2 GNAQ ACE GDP Ang II Aldostr Ang II H2O ADH