Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
Your source for quantitative metabolomics technologies and bioinformatics.
You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on Small Molecule Pathway Database.
Loading Pathway...
SubPathwayInteraction796 SubPathwayReaction SubPathway796Reaction SubPathwayInteraction797 SubPathway797Reaction SubPathwayReaction 51-41-2 CAS C9H13N5O3 Dihydrobiopterin 239.10184 CL:0000000 CELL TYPE ONTOLOGY 937 ChemSpider CHEBI:28918 ChEBI HMDB01185 HMDB 1.0 Tyrosine 3-monooxygenase 1.0 SMILES NCCC1=CC(O)=C(O)C=C1 SMILES O 1.0 L-Tyrosine P11086 UniProt BIOPTERIN BioCyc HMDB00787 HMDB 5833 ChemSpider 1.0 Epinephrine Parasympathetic Nervous System InhibitorySubPathway S-Adenosylmethionine Sympathetic Nervous System ActivatingSubPathway Phenylethanolamine N-methyltransferase 247 ChemSpider Epinephrine SMILES N[C@@H](CC1=CC=C(O)C=C1)C(O)=O 59-92-7 CAS Aromatic-L-amino-acid decarboxylase Cytoplasm L-DOPA BioCyc HMDB00939 HMDB Cell ReactionCatalysis213 ACTIVATION C15H23N6O5S S-Adenosylmethionine 399.14505 51-61-6 CAS Epinephrine SubPathwayInput 1.0 SMILES CC(O)C(O)C1=NC2=C(NC1)N=C(N)NC2=O HMDB00073 HMDB 62989-33-7 CAS 1.0 7732-18-5 CAS 6047 PubChem-compound 952 ChemSpider GO:0005829 GENE ONTOLOGY O2 Oxygen 31.98983 Adrenal Medulla 274 ChemSpider 7991951 ChemSpider Dihydrobiopterin TYR BioCyc Water NOREPINEPHRINE BioCyc 1.14.16.2 false 1.14.16.2 L-Tyrosine + Oxygen + Sapropterin → Dihydrobiopterin + L-Dopa + Water LEFT_TO_RIGHT 60-18-4 CAS 1.0 ADENOSYL-HOMO-CYS BioCyc 5611 ChemSpider DOPAMINE BioCyc Transport262 false Epinephrine (→) Transport: Homo sapiens, Kidney to Homo sapiens, Brain, Cell, Cytoplasm LEFT_TO_RIGHT CHEBI:16526 ChEBI 252 PubChem-compound 7782-44-7 CAS Sapropterin SMP00170 SMPDB S-Adenosylhomocysteine SMILES CNC[C@H](O)C1=CC(O)=C(O)C=C1 661 ChemSpider BiologicalState20 HMDB01967 HMDB 1.0 Dopamine C8H11NO3 Norepinephrine 169.0739 9606 TAXONOMY C9H15N5O3 Sapropterin 241.1175 962 PubChem-compound 31983 ChemSpider CHEBI:18357 ChEBI SubPathwayControl27 SubPathway27Control ActivatingSubPathwayControl P07101 UniProt CHEBI:15765 ChEBI SubPathwayControl28 SubPathway28Control InhibitorySubPathwayControl HMDB00216 HMDB C9H11NO3 L-Tyrosine 181.0739 CHEBI:64491 ChEBI 51-43-4 CAS SMILES C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C(N)N=CN=C12 388394 ChemSpider 979-92-0 CAS Carbon dioxide Cytosol CPD-6641 BioCyc CO2 Carbon dioxide 43.98983 C00355 KEGG Compound 681 PubChem-compound HMDB02111 HMDB C14H20N6O5S S-Adenosylhomocysteine 384.12158 SMILES O=O 5816 PubChem-compound Phenylethanolamine N-methyltransferase C00082 KEGG Compound 124-38-9 CAS Sympathetic Nervous System SubPathway Parasympathetic Nervous System SubPathway CHEBI:15377 ChEBI 6057 PubChem-compound Norepinephrine HMDB00068 HMDB C00007 KEGG Compound CHEBI:15379 ChEBI C9H11NO4 L-Dopa 197.0688 CHEBI:15414 ChEBI C03758 KEGG Compound L-EPINEPHRINE BioCyc C00001 KEGG Compound HMDB00181 HMDB PW000090 PathWhiz 1.0 CHEBI:18243 ChEBI Oxygen SMILES NC[C@H](O)C1=CC(O)=C(O)C=C1 P20711 UniProt 280 PubChem-compound 9816201 PubChem-compound ReactionCatalysis218 ACTIVATION 1.0 ReactionCatalysis214 ACTIVATION 5824 ChemSpider CHEBI:64277 ChEBI C00019 KEGG Compound HMDB00158 HMDB 1.0 HMDB00038 HMDB C9H13NO3 Epinephrine 183.08954 439260 PubChem-compound C00011 KEGG Compound SMILES O=C=O S-ADENOSYLMETHIONINE BioCyc C02953 KEGG Compound SMILES N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C(N)N=CN=C12)C(O)=O SMILES C[C@H](O)[C@H](O)C1CNC2=C(N1)C(=O)N=C(N)N2 6779-87-9 CAS 25246222 PubChem-compound L-Dopa H2O Water 18.010565 1.0 C8H11NO2 Dopamine 153.07898 BTO:0000049 BRENDA TISSUE ONTOLOGY 29908-03-0 CAS HMDB01377 HMDB C00547 KEGG Compound CHEBI:17895 ChEBI 388301 ChemSpider C00788 KEGG Compound 977 PubChem-compound 1.0 Aromatic L-Aminoacid Decarboxylase Deficiency Tyrosine 3-monooxygenase SMILES N[C@@H](CC1=CC(O)=C(O)C=C1)C(O)=O C00021 KEGG Compound CHEBI:16680 ChEBI 24762165 PubChem-compound C00272 KEGG Compound GO:0005737 GENE ONTOLOGY 4.1.1.28 false 4.1.1.28 L-Dopa → Carbon dioxide + Dopamine LEFT_TO_RIGHT 2.1.1.28 false 2.1.1.28 Norepinephrine + S-Adenosylmethionine → Epinephrine + S-Adenosylhomocysteine LEFT_TO_RIGHT 1.0 Aromatic-L-amino-acid decarboxylase Tyrosine 3-monooxygenase Aromatic-L- amino-acid decarboxylase Dopamine beta- hydroxylase Phenylethanolamine N- methyltransferase Dissipation Epinephrine L-Tyrosine Sapropterin O 2 Accumulation L-Dopa Dihydrobiopterin H 2 O Dissipation Dopamine CO 2 Ascorbic acid O 2 Dissipation Norepinephrine Dehydroascorbic acid H 2 O