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Glycerol-3- phosphate dehydrogenase [NAD(+)], cytoplasmic glycerol-3- phosphate acyltransferase 1-acyl-sn- glycerol-3- phosphate acyltransferase phosphatidate phosphatase diacylglycerol O- acyltransferase Dihydroxyacetone phosphate NADH H + NAD Glycerol 3-phosphate γ-Linolenoyl- CoA CoA LPA(18:3(6Z,9Z,12Z)/0:0) LPA(18:3(6Z,9Z,12Z)/0:0) Osbondoyl-CoA CoA PA(18:3(6Z,9Z,12Z)/22:5(4Z,7Z,10Z,13Z,16Z)) H 2 O DG(18:3(6Z,9Z,12Z)/22:5(4Z,7Z,10Z,13Z,16Z)/0:0) P i α-Linolenoyl- CoA TG(18:3(6Z,9Z,12Z)/22:5(4Z,7Z,10Z,13Z,16Z)/18:3(9Z,12Z,15Z)) CoA Glycolysis Mitochondria Outer Membrane Endoplasmic Reticulum Membrane Cytosol
Mitochondria Endoplasmic Reticulum GPD1 GPAM AGPAT1 LPIN1 DGAT1 Dihydroxyacetone phosphate NADH Hydrogen Ion NAD Glycerol 3-phosphate γ-Linolenoyl- CoA Coenzyme A LPA(18:3(6Z,9Z,12Z)/0:0) LPA(18:3(6Z,9Z,12Z)/0:0) Osbondoyl-CoA Coenzyme A PA(18:3(6Z,9Z,12Z)/22:5(4Z,7Z,10Z,13Z,16Z)) Water DG(18:3(6Z,9Z,12Z)/22:5(4Z,7Z,10Z,13Z,16Z)/0:0) Phosphate α-Linolenoyl- CoA TG(18:3(6Z,9Z,12Z)/22:5(4Z,7Z,10Z,13Z,16Z)/18:3(9Z,12Z,15Z)) Coenzyme A Glycolysis