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P2Y purinoceptor 12 Multidrug resistance protein 1 Cytochrome P450 2B6 Cytochrome P450 2C9 Cytochrome P450 2C19 Cytochrome P450 3A4 Cytochrome P450 3A5 Serum paraoxonase/arylesterase 1 Cytochrome P450 1A2 Cytochrome P450 2B6 Cytochrome P450 2C19 Active Metabolite of Clopidogrel Clopidogrel Clopidogrel Clopidogrel 2-Oxoclopidogrel O2 H2O H2O2 H2O ATP ADP Pi Heme Heme Heme Heme Heme Calcium Heme Heme Heme Platelet Cell Endoplasmic Reticulum Membrane
Endoplasmic Reticulum P2RY12 ABCB1 CYP2B6 CYP2C9 CYP2C19 CYP3A4 CYP3A5 PON1 CYP1A2 CYP2B6 CYP2C19 Active Metabolite of Clopidogrel Clopidogrel Clopidogrel Clopidogrel 2- Oxoclopidogrel Oxygen Water Hydrogen peroxide Water Adenosine triphosphate Adenosine diphosphate Phosphate
P2RY12 ABCB1 CYP2B6 CYP2C9 CYP2C19 CYP3A4 CYP3A5 PON1 CYP1A2 CYP2B6 CYP2C19 AMClop Clopid Clopid Clopid 2Oxocpg O2 H2O H2O2 H2O ATP ADP Pi Heme Heme Heme Heme Heme Ca2+ Heme Heme Heme Platelet Cell Endoplasmic Reticulum Membrane
Endoplasmic Reticulum P2RY12 ABCB1 CYP2B6 CYP2C9 CYP2C19 CYP3A4 CYP3A5 PON1 CYP1A2 CYP2B6 CYP2C19 AMClop Clopid Clopid Clopid 2Oxocpg O2 H2O H2O2 H2O ATP ADP Pi