Estrogen
sulfotransferase
Cytochrome P450
1A1
Catechol O-
methyltransferase
UDP-
glucuronosyltransferase
1-1
UDP-
glucuronosyltransferase
1-1
Estradiol
17-beta-
dehydrogenase 1
Cytochrome P450
3A5
Estradiol
17-beta-
dehydrogenase 1
Cytochrome P450
3A5
Estrone
Phosphoadenosine
phosphosulfate
Estrone sulfate
Adenosine
3',5'-
diphosphate
H+
O2
NADH
2-
Hydroxyestrone
NAD
H2O
S-
Adenosylmethionine
2-
Methoxyestrone
S-
Adenosylhomocysteine
Uridine
diphosphate
glucuronic acid
2-
Methoxyestrone
3-glucuronide
Uridine
5'-diphosphate
Uridine
diphosphate
glucuronic acid
Estrone
glucuronide
Uridine
5'-diphosphate
NADPH
H+
Estradiol
NADP
H+
O2
NADPH
NADP
H2O
16a-
Hydroxyestrone
NADH
H+
Estriol
NAD
H+
O2
NADPH
NADP
H2O
Heme
Magnesium
Heme
Heme
Cytosol
Endoplasmic Reticulum
Membrane