Q92934
UniProt
E3 ubiquitin-protein ligase CBL
5291
PubChem-compound
Interaction214
Ras activates RAF
Interaction213
BCR-ABL/GRB2/GAB2/SOS1 complex activates Ras
Tyrosine-protein kinase JAK2
Interaction216
MEK activates MAPK
Imatinib Inhibition of BCR-ABL
Interaction215
RAF activates MEK
Q9UQC2
UniProt
Interaction218
BCR-ABL/CRK/CRKL/CBL/PI3K complex activates Akt
RAF
Interaction217
BCR-ABL/GRB2/GAB2/SOS1 complex activates BCR-ABL/CRK/CRKL/CBL/PI3K complex
Ras
RAF
MEK
Interaction219
Akt inhibits FOXO
direct_interaction
MEK
MAPK
Akt
Bcl-2-like protein 1
S-phase kinase-associated protein 2
CHEBI:45783
ChEBI
E3 ubiquitin-protein ligase CBL
TransportCatalysis1455
ACTIVATION
Interaction221
S-phase kinase-associated protein 2 inhibits cyclin-dependent kinase inhibitor 1B
Serine/threonine-protein kinase mTOR
Interaction220
Akt activates S-phase kinase-associated protein 2
Interaction223
Serine/threonine-protein kinase mTOR activates 70 kDa ribosomal protein S6 kinase
Ribosomal protein S6 kinase beta-1
E3 ubiquitin-protein ligase Mdm2
TransportCatalysis1454
ACTIVATION
Interaction222
Akt activates Serine/threonine-protein kinase mTOR
Interaction225
Bcl2-associated agonist of cell death inhibits Bcl-2-like protein 1
Q00987
UniProt
MAPK
Interaction224
Akt inhibits Bcl2-associated agonist of cell death
Imatinib
Interaction227
E3 ubiquitin-protein ligase Mdm2 inhibits Cellular tumor antigen p53
Interaction226
Akt activates E3 ubiquitin-protein ligase Mdm2
Interaction229
BCR-ABL/GRB2/GAB2/SOS1 complex activates Tyrosine-protein kinase JAK2
Interaction228
BCR-ABL/GRB2/GAB2/SOS1 complex activates STAT5A homodimer complex
Ras
Transport10274
false
Imatinib (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytoplasm
LEFT_TO_RIGHT
P46527
UniProt
Transport10275
false
Imatinib (→) Transport: Homo sapiens, Cell, Cytoplasm to Homo sapiens, Extracellular Space
LEFT_TO_RIGHT
Cytoplasm
Bcl2-associated agonist of cell death
Interaction230
Tyrosine-protein kinase JAK2 activates STAT5A homodimer complex
Interaction232
Imatinib inhibits BCR-ABL
S-phase kinase-associated protein 2
Interaction231
Tyrosine-protein kinase JAK2 activates Myc proto-oncogene protein
Homo sapiens
5101
ChemSpider
GRB2-associated-binding protein 2
P22681
UniProt
Phosphatidylinositol 3-kinase regulatory subunit alpha
Multidrug resistance protein 1
Bcl2-associated agonist of cell death
O60674
UniProt
C29H31N7O
Imatinib
493.259
Q07817
UniProt
Adapter molecule crk
P01106
UniProt
A8E194
UniProt
GRB2-associated-binding protein 2
Akt
Cyclin-dependent kinase inhibitor 1B
P46109
UniProt
P46108
UniProt
S-phase kinase-associated protein 2
152459-95-5
CAS
Q13309
UniProt
PW032592
PathWhiz
9606
TAXONOMY
Solute carrier family 22 member 1
E3 ubiquitin-protein ligase Mdm2
O15245
UniProt
P62993
UniProt
Bcl-2-like protein 1
Growth factor receptor-bound protein 2
Ribosomal protein S6 kinase beta-1
FOXO
BCR-ABL/CRK/CRKL/CBL/PI3K complex
SMILES
CN1CCN(CC2=CC=C(C=C2)C(=O)NC2=CC(NC3=NC=CC(=N3)C3=CN=CC=C3)=C(C)C=C2)CC1
P04637
UniProt
Crk-like protein
Cellular tumor antigen p53
Tyrosine-protein kinase JAK2
Signal transducer and activator of transcription 5A
Q07889
UniProt
Myc proto-oncogene protein
Myc proto-oncogene protein
Growth factor receptor-bound protein 2
P27986
UniProt
GO:0005634
GENE ONTOLOGY
Son of sevenless homolog 1
HMDB0014757
HMDB
Son of sevenless homolog 1
1.0
SMP0031694
SMPDB
Extracellular Space
Adapter molecule crk
BCR-ABL/GRB2/GAB2/SOS1 complex
Bcr-abl1 fusion protein
Bcr-abl1 fusion protein
Phosphatidylinositol 3-kinase regulatory subunit alpha
Nucleus
Cellular tumor antigen p53
E3 ubiquitin-protein ligase Mdm2
Multidrug resistance protein 1
FOXO
Signal transducer and activator of transcription 5A
Tyrosine-protein kinase JAK2
Solute carrier family 22 member 1
P08183
UniProt
Imatinib
GO:0005615
GENE ONTOLOGY
GO:0005737
GENE ONTOLOGY
P42345
UniProt
P23443
UniProt
Crk-like protein
P42229
UniProt
Serine/threonine-protein kinase mTOR
1.0
Cyclin-dependent kinase inhibitor 1B