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Mitochondrial Electron Transport Chain HMDB00254 HMDB HMDB00134 HMDB 1.0 6022 PubChem-compound Adenosine triphosphate 439162 PubChem-compound HMDB01341 HMDB Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Glyceraldehyde-3-phosphate dehydrogenase 1.0 439153 PubChem-compound 110-17-8 CAS 21883788 PubChem-compound Glycerol 3-phosphate Succinate dehydrogenase cytochrome b560 subunit, mitochondrial C49H78O4 Ubiquinol 8 730.59 HMDB01112 HMDB ATP BioCyc HMDB01473 HMDB 1.0 1981-49-3 CAS C3H7O6P Dihydroxyacetone phosphate 169.99803 CHEBI:15846 ChEBI ADP BioCyc CHEBI:46245 ChEBI Ubiquinol 8 PW000165 PathWhiz SubPathwayInteraction734 SubPathwayReaction SubPathway734Reaction SubPathwayInteraction735 SubPathway735Reaction SubPathwayReaction P12235 UniProt SubPathwayInteraction733 SubPathwayReaction SubPathway733Reaction 5742 ChemSpider NADH SubPathwayInteraction736 SubPathwayReaction SubPathway736Reaction Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial GO:0005829 GENE ONTOLOGY 1.0 HMDB00902 HMDB 5281915 PubChem-compound CHEBI:16908 ChEBI 1.0 HMDB00126 HMDB 709 ChemSpider O4P Phosphate 94.95342 UBIQUINOL-8 BioCyc PW000152 PathWhiz O43826 UniProt Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial SMP00057 SMPDB C3H7O6P D-Glyceraldehyde 3-phosphate 169.99803 1.0 1.0 C3H8O10P2 Glyceric acid 1,3-biphosphate 265.95926 C00111 KEGG Compound Transport67 false Phosphate (→) Transport: Homo sapiens, Cell, Endoplasmic Reticulum to Homo sapiens, Cell, Cytosol LEFT_TO_RIGHT ADP/ATP translocase 1 Cytosol C00236 KEGG Compound 683 PubChem-compound 1.0 1.0 SUC BioCyc 58-68-4 CAS Glyceraldehyde-3-phosphate dehydrogenase SMILES [O-]P([O-])([O-])=O C00009 KEGG Compound C00008 KEGG Compound Succinate dehydrogenase 1.0 C00122 KEGG Compound 1.0 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial CHEBI:18367 ChEBI C00004 KEGG Compound 1032 ChemSpider C00003 KEGG Compound C00002 KEGG Compound C3H9O6P Glycerol 3-phosphate 172.01367 GO:0005758 GENE ONTOLOGY GO:0005759 GENE ONTOLOGY Mitochondrial Inner Membrane HMDB01429 HMDB SMP00355 SMPDB C4H4O4 Fumaric acid 116.010956 57-04-5 CAS C11378 KEGG Compound P31040 UniProt 1.0 Citric Acid Cycle SubPathway C59H90O4 Coenzyme Q10 862.6839 Gluconeogenesis SubPathway Gluconeogenesis SubPathway CHEBI:15741 ChEBI 1.0 C21H28N7O14P2 NAD 664.11694 SMP00128 SMPDB 1110 PubChem-compound 1.0 Reaction2164 false D-Glyceraldehyde 3-phosphate + NAD → Glyceric acid 1,3-biphosphate + NADH + Phosphate LEFT_TO_RIGHT 1.0 1.3.5.1 false 1.3.5.1 Coenzyme Q10 + Succinic acid → Fumaric acid + Ubiquinol 8 LEFT_TO_RIGHT C21H29N7O14P2 NADH 665.12476 5957 PubChem-compound 1.1.5.3 false 1.1.5.3 Coenzyme Q10 + Glycerol 3-phosphate → Dihydroxyacetone phosphate + Ubiquinol 8 LEFT_TO_RIGHT GO:0005743 GENE ONTOLOGY CHEBI:15978 ChEBI GO:0005741 GENE ONTOLOGY C4H6O4 Succinic acid 118.02661 1.0 Citric Acid Cycle SubPathway CHEBI:17138 ChEBI 388308 ChemSpider Phosphate 56-65-5 CAS 53-84-9 CAS Fumaric acid SubPathwayInput Adenosine triphosphate O14521 UniProt C10H15N5O10P2 Adenosine diphosphate 427.02942 D-Glyceraldehyde 3-phosphate SubPathwayOutput Ubiquinol 8 Mitochondrial Outer Membrane Endoplasmic Reticulum CL:0000000 CELL TYPE ONTOLOGY HMDB01060 HMDB CPD-8587 BioCyc SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O 56275-39-9 CAS 1.0 SMILES COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O 5682 ChemSpider Dihydroxyacetone phosphate SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O SMILES OC(=O)CCC(O)=O Mitochondrial Matrix 4.0 1.0 ADP/ATP translocase 1 HMDB01072 HMDB 4445197 ChemSpider C00042 KEGG Compound Fumaric acid 648 ChemSpider 1.0 1078 ChemSpider 303-98-0 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Adenosine diphosphate SMILES OC(COP(O)(O)=O)C(=O)OP(O)(O)=O BiologicalState42 HMDB00538 HMDB 1.0 Cell 10197150 ChemSpider CHEBI:15422 ChEBI TransportCatalysis180 ACTIVATION 668 PubChem-compound Coenzyme Q10 FUM BioCyc Glucose-6-phosphate translocase Adenosine diphosphate Dihydroxyacetone phosphate 388299 ChemSpider 1.0 CHEBI:18012 ChEBI 591-59-3 CAS 22833558 PubChem-compound Coenzyme Q10 1.0 1.0 GO:0005783 GENE ONTOLOGY P21912 UniProt TransportCatalysis179 ACTIVATION Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial BiologicalState17 NAD C10H16N5O13P3 Adenosine triphosphate 506.99576 DPG BioCyc DIHYDROXY-ACETONE-PHOSPHATE BioCyc CHEBI:16761 ChEBI SMILES COC1=C(OC)C(O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1O Glycerol 3-phosphate Glycerol-3-phosphate dehydrogenase, mitochondrial 663 ChemSpider SMILES OCC(=O)COP(O)(O)=O Adenosine triphosphate 9606 TAXONOMY 5800 ChemSpider 5893 PubChem-compound Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial 1.0 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial 110-15-6 CAS 729 PubChem-compound Mitochondrial Intermembrane Space Adenosine diphosphate 1.0 BiologicalState2 14265-44-2 CAS 17989-41-2 CAS CHEBI:16108 ChEBI 58-64-0 CAS HMDB01270 HMDB SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Glyceric acid 1,3-biphosphate SubPathwayInput Phosphate GLYCEROL-3P BioCyc C00093 KEGG Compound Glycerol-3-phosphate dehydrogenase, mitochondrial Phosphate P04406 UniProt HMDB01487 HMDB PW000005 PathWhiz 1.0 Succinic acid SubPathwayOutput 1.0 SMILES OC(COP(O)(O)=O)C=O P43304 UniProt Transport217 false Adenosine diphosphate (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Mitochondrial Outer Membrane LEFT_TO_RIGHT Transport216 false Adenosine triphosphate (→) Transport: Homo sapiens, Cell, Mitochondrial Outer Membrane to Homo sapiens, Cell, Cytosol LEFT_TO_RIGHT Succinic acid Transport219 false Glycerol 3-phosphate (→) Transport: Homo sapiens, Cell, Mitochondrial Intermembrane Space to Homo sapiens, Cell, Cytosol LEFT_TO_RIGHT Transport218 false Adenosine diphosphate (→), Adenosine triphosphate (←) Transport: Homo sapiens, Cell, Mitochondrial Outer Membrane to Homo sapiens, Cell, Mitochondrial Matrix LEFT_TO_RIGHT NADH BioCyc Transport215 false Phosphate (→) Transport: Homo sapiens, Cell, Mitochondrial Outer Membrane to Homo sapiens, Cell, Mitochondrial Matrix LEFT_TO_RIGHT NAD BioCyc Transport220 false Dihydroxyacetone phosphate (→) Transport: Homo sapiens, Cell, Mitochondrial Intermembrane Space to Homo sapiens, Cell, Cytosol LEFT_TO_RIGHT GAP BioCyc 1061 PubChem-compound Glucose-6-phosphate translocase Glyceraldehyde-3-phosphate dehydrogenase C00661 KEGG Compound 1.0 SMILES OC(=O)\C=C\C(O)=O ReactionCatalysis2005 ACTIVATION Q99643 UniProt Phosphate 17216048 ChemSpider UBIQUINONE-10 BioCyc ReactionCatalysis2002 ACTIVATION SMILES OC[C@@H](O)COP(O)(O)=O ReactionCatalysis2003 ACTIVATION Glucose-6- phosphate translocase ADP/ATP translocase 1 Glycerol-3- phosphate dehydrogenase, mitochondrial Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Succinate dehydrogenase cytochrome b560 subunit, mitochondrial Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial Glycerol-3- phosphate dehydrogenase [NAD(+)], cytoplasmic Glyceraldehyde- 3-phosphate dehydrogenase ATP synthase lipid-binding protein, mitochondrial ATP synthase subunit alpha, mitochondrial ATP synthase subunit epsilon, mitochondrial ATP synthase subunit beta, mitochondrial ATP synthase subunit b, mitochondrial ATP synthase subunit delta, mitochondrial ATP synthase subunit gamma, mitochondrial ATP synthase subunit a NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 Cytochrome c Cytochrome c Cytochrome b-c1 complex subunit 1, mitochondrial Cytochrome c oxidase subunit 1 Succinic acid Fumaric acid D- Glyceraldehyde 3-phosphate Glyceric acid 1,3-biphosphate P i P i P i ATP ATP ADP ADP ADP ATP Glycerol 3-phosphate Glycerol 3-phosphate Dihydroxyacetone phosphate Dihydroxyacetone phosphate Coenzyme Q10 Ubiquinol 8 Coenzyme Q10 Ubiquinol 8 NADH NAD P i H + H + H + NADH H + NAD H + H + H + H 2 O O 2 H + H + FAD FAD 2Fe-2S Heme Heme Citric Acid Cycle Citric Acid Cycle Gluconeogenesis Gluconeogenesis Fe2+ Fe3+ Extracellular Space Intracellular Space Mitochondrial Mitochondrial Matrix Mitochondrial inner membrane Mitochondrial outer membrane Mitochondrial intermembrane space
Mitochondrial Electron Transport Chain HMDB00254 HMDB HMDB00134 HMDB 1.0 6022 PubChem-compound Adenosine triphosphate 439162 PubChem-compound HMDB01341 HMDB Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Glyceraldehyde-3-phosphate dehydrogenase 1.0 439153 PubChem-compound 110-17-8 CAS 21883788 PubChem-compound Glycerol 3-phosphate Succinate dehydrogenase cytochrome b560 subunit, mitochondrial C49H78O4 Ubiquinol 8 730.59 HMDB01112 HMDB ATP BioCyc HMDB01473 HMDB 1.0 1981-49-3 CAS C3H7O6P Dihydroxyacetone phosphate 169.99803 CHEBI:15846 ChEBI ADP BioCyc CHEBI:46245 ChEBI Ubiquinol 8 PW000165 PathWhiz SubPathwayInteraction734 SubPathwayReaction SubPathway734Reaction SubPathwayInteraction735 SubPathway735Reaction SubPathwayReaction P12235 UniProt SubPathwayInteraction733 SubPathwayReaction SubPathway733Reaction 5742 ChemSpider NADH SubPathwayInteraction736 SubPathwayReaction SubPathway736Reaction Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial GO:0005829 GENE ONTOLOGY 1.0 HMDB00902 HMDB 5281915 PubChem-compound CHEBI:16908 ChEBI 1.0 HMDB00126 HMDB 709 ChemSpider O4P Phosphate 94.95342 UBIQUINOL-8 BioCyc PW000152 PathWhiz O43826 UniProt Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial http://identifiers.org/smpdb/SMP00057 SMPDB C3H7O6P D-Glyceraldehyde 3-phosphate 169.99803 1.0 1.0 C3H8O10P2 Glyceric acid 1,3-biphosphate 265.95926 C00111 KEGG Compound Transport67 false Phosphate (→) Transport: Homo sapiens, Cell, Endoplasmic Reticulum to Homo sapiens, Cell, Cytosol LEFT_TO_RIGHT ADP/ATP translocase 1 Cytosol C00236 KEGG Compound 683 PubChem-compound 1.0 1.0 SUC BioCyc 58-68-4 CAS Glyceraldehyde-3-phosphate dehydrogenase SMILES [O-]P([O-])([O-])=O C00009 KEGG Compound C00008 KEGG Compound Succinate dehydrogenase 1.0 C00122 KEGG Compound 1.0 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial CHEBI:18367 ChEBI C00004 KEGG Compound 1032 ChemSpider C00003 KEGG Compound C00002 KEGG Compound C3H9O6P Glycerol 3-phosphate 172.01367 GO:0005758 GENE ONTOLOGY GO:0005759 GENE ONTOLOGY Mitochondrial Inner Membrane HMDB01429 HMDB http://identifiers.org/smpdb/SMP00355 SMPDB C4H4O4 Fumaric acid 116.010956 57-04-5 CAS C11378 KEGG Compound P31040 UniProt 1.0 Citric Acid Cycle SubPathway C59H90O4 Coenzyme Q10 862.6839 Gluconeogenesis SubPathway Gluconeogenesis SubPathway CHEBI:15741 ChEBI 1.0 C21H28N7O14P2 NAD 664.11694 http://identifiers.org/smpdb/SMP00128 SMPDB 1110 PubChem-compound 1.0 Reaction2164 false D-Glyceraldehyde 3-phosphate + NAD → Glyceric acid 1,3-biphosphate + NADH + Phosphate LEFT_TO_RIGHT 1.0 1.3.5.1 false 1.3.5.1 Coenzyme Q10 + Succinic acid → Fumaric acid + Ubiquinol 8 LEFT_TO_RIGHT C21H29N7O14P2 NADH 665.12476 5957 PubChem-compound 1.1.5.3 false 1.1.5.3 Coenzyme Q10 + Glycerol 3-phosphate → Dihydroxyacetone phosphate + Ubiquinol 8 LEFT_TO_RIGHT GO:0005743 GENE ONTOLOGY CHEBI:15978 ChEBI GO:0005741 GENE ONTOLOGY C4H6O4 Succinic acid 118.02661 1.0 Citric Acid Cycle SubPathway CHEBI:17138 ChEBI 388308 ChemSpider Phosphate 56-65-5 CAS 53-84-9 CAS Fumaric acid SubPathwayInput Adenosine triphosphate O14521 UniProt C10H15N5O10P2 Adenosine diphosphate 427.02942 D-Glyceraldehyde 3-phosphate SubPathwayOutput Ubiquinol 8 Mitochondrial Outer Membrane Endoplasmic Reticulum CL:0000000 CELL TYPE ONTOLOGY HMDB01060 HMDB CPD-8587 BioCyc SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C2N=CN=C3N)[C@@H](O)[C@H]1O 56275-39-9 CAS 1.0 SMILES COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O 5682 ChemSpider Dihydroxyacetone phosphate SMILES NC(=O)C1=CN(C=CC1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O SMILES OC(=O)CCC(O)=O Mitochondrial Matrix 4.0 1.0 ADP/ATP translocase 1 HMDB01072 HMDB 4445197 ChemSpider C00042 KEGG Compound Fumaric acid 648 ChemSpider 1.0 1078 ChemSpider 303-98-0 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Adenosine diphosphate SMILES OC(COP(O)(O)=O)C(=O)OP(O)(O)=O BiologicalState42 Homo sapiens, Cell, Mitochondrial Intermembrane Space HMDB00538 HMDB 1.0 Cell 10197150 ChemSpider CHEBI:15422 ChEBI TransportCatalysis180 ACTIVATION 668 PubChem-compound Coenzyme Q10 FUM BioCyc Glucose-6-phosphate translocase Adenosine diphosphate Dihydroxyacetone phosphate 388299 ChemSpider 1.0 CHEBI:18012 ChEBI 591-59-3 CAS 22833558 PubChem-compound Coenzyme Q10 1.0 1.0 GO:0005783 GENE ONTOLOGY P21912 UniProt TransportCatalysis179 ACTIVATION Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial BiologicalState17 Homo sapiens, Cell, Mitochondrial Inner Membrane NAD C10H16N5O13P3 Adenosine triphosphate 506.99576 DPG BioCyc DIHYDROXY-ACETONE-PHOSPHATE BioCyc CHEBI:16761 ChEBI SMILES COC1=C(OC)C(O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1O Glycerol 3-phosphate Glycerol-3-phosphate dehydrogenase, mitochondrial 663 ChemSpider SMILES OCC(=O)COP(O)(O)=O Adenosine triphosphate 9606 TAXONOMY 5800 ChemSpider 5893 PubChem-compound Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial 1.0 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial 110-15-6 CAS 729 PubChem-compound Mitochondrial Intermembrane Space Adenosine diphosphate 1.0 BiologicalState2 Homo sapiens, Cell, Cytosol 14265-44-2 CAS 17989-41-2 CAS CHEBI:16108 ChEBI 58-64-0 CAS HMDB01270 HMDB SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Glyceric acid 1,3-biphosphate SubPathwayInput Phosphate GLYCEROL-3P BioCyc C00093 KEGG Compound Glycerol-3-phosphate dehydrogenase, mitochondrial Phosphate P04406 UniProt HMDB01487 HMDB PW000005 PathWhiz 1.0 Succinic acid SubPathwayOutput 1.0 SMILES OC(COP(O)(O)=O)C=O P43304 UniProt Transport217 false Adenosine diphosphate (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Cell, Mitochondrial Outer Membrane LEFT_TO_RIGHT Transport216 false Adenosine triphosphate (→) Transport: Homo sapiens, Cell, Mitochondrial Outer Membrane to Homo sapiens, Cell, Cytosol LEFT_TO_RIGHT Succinic acid Transport219 false Glycerol 3-phosphate (→) Transport: Homo sapiens, Cell, Mitochondrial Intermembrane Space to Homo sapiens, Cell, Cytosol LEFT_TO_RIGHT Transport218 false Adenosine diphosphate (→), Adenosine triphosphate (←) Transport: Homo sapiens, Cell, Mitochondrial Outer Membrane to Homo sapiens, Cell, Mitochondrial Matrix LEFT_TO_RIGHT NADH BioCyc Transport215 false Phosphate (→) Transport: Homo sapiens, Cell, Mitochondrial Outer Membrane to Homo sapiens, Cell, Mitochondrial Matrix LEFT_TO_RIGHT NAD BioCyc Transport220 false Dihydroxyacetone phosphate (→) Transport: Homo sapiens, Cell, Mitochondrial Intermembrane Space to Homo sapiens, Cell, Cytosol LEFT_TO_RIGHT GAP BioCyc 1061 PubChem-compound Glucose-6-phosphate translocase Glyceraldehyde-3-phosphate dehydrogenase C00661 KEGG Compound 1.0 SMILES OC(=O)\C=C\C(O)=O ReactionCatalysis2005 ACTIVATION Q99643 UniProt Phosphate 17216048 ChemSpider UBIQUINONE-10 BioCyc ReactionCatalysis2002 ACTIVATION SMILES OC[C@@H](O)COP(O)(O)=O ReactionCatalysis2003 ACTIVATION Mitochondria SLC37A4 SLC25A4 GPD2 SDHA SDHB SDHC SDHD GPD1 GAPDH ATP5G2 ATP5A1 ATP5E ATP5B ATP5F1 ATP5D ATP5C1 MT-ATP6 NDUFA1 CYCS CYCS UQCRC1 COX1 Succinic acid Fumaric acid D- Glyceraldehyde 3-phosphate Glyceric acid 1,3-biphosphate Phosphate Phosphate Phosphate Adenosine triphosphate Adenosine triphosphate Adenosine diphosphate Adenosine diphosphate Adenosine diphosphate Adenosine triphosphate Glycerol 3-phosphate Glycerol 3-phosphate Dihydroxyacetone phosphate Dihydroxyacetone phosphate Coenzyme Q10 Ubiquinol 8 Coenzyme Q10 Ubiquinol 8 NADH NAD Phosphate Hydrogen Ion Hydrogen Ion Hydrogen Ion NADH Hydrogen Ion NAD Hydrogen Ion Hydrogen Ion Hydrogen Ion Water Oxygen Hydrogen Ion Hydrogen Ion Citric Acid Cycle Citric Acid Cycle Gluconeogenesis Gluconeogenesis