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Ca+ Na+ Ca+ Ca+ Na+ K+ K+ Sodium- dependent serotonin transporter Cytochrome P450 2D6 Cytochrome P450 3A5 Cytochrome P450 3A4 Cytochrome P450 2C9 Cytochrome P450 2C19 Cytochrome P450 2D6 Alpha-1A adrenergic receptor 5- hydroxytryptamine receptor 1A D(1A) dopamine receptor Beta-endorphin Mu-type opioid receptor Neuronal acetylcholine receptor subunit beta-2 Neuronal acetylcholine receptor subunit beta-2 Neuronal acetylcholine receptor subunit beta-2 Neuronal acetylcholine receptor subunit alpha-4 Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Potassium voltage-gated channel subfamily D member 2 Kv channel- interacting protein 2 Beta-endorphin Glutamate [NMDA] receptor subunit zeta-1 Glutamate [NMDA] receptor subunit epsilon-1 Glutamate [NMDA] receptor subunit 3A Sodium- dependent noradrenaline transporter Sodium- dependent serotonin transporter Sodium- dependent dopamine transporter Pro- opiomelanocortin Neuroendocrine convertase 2 Sodium/potassium- transporting ATPase subunit alpha-1 Fluoxetine Norfluoxetine Fluoxetine Fluoxetine glucuronide Norfluoxetine glucuronide O2 NADH H2O Formaldehyde NAD Heme Heme Heme Heme Heme Heme Norepinephrine Serotonin Dopamine Ca+ Na+ K+ Ca+ Ca+ Norepinephrine Serotonin Na+ Na+ Na+ Na+ Dopamine Na+ Na+ ATP H2O Na+ K+ ADP Pi Na+ K+ Sodium channel protein type 10 subunit alpha Neuronal acetylcholine receptor subunit alpha-4 Sodium channel subunit beta-1 Sodium/potassium- transporting ATPase subunit alpha-3 Sodium/potassium- transporting ATPase subunit beta-2 Sodium/potassium- transporting ATPase subunit alpha-2 Sodium/potassium- transporting ATPase subunit alpha-4 Sodium/potassium- transporting ATPase subunit beta-1 Sodium/potassium- transporting ATPase subunit gamma Neuronal acetylcholine receptor subunit alpha-4 Sodium/potassium- transporting ATPase subunit beta-3 ATPase, (Na+)/K+ transporting, beta 4 polypeptide Axon Terminal Synaptic Vesicle Presynaptic Neuron Postsynaptic Neuron Synaptic Cleft Neuron Neuron Axon Action Potential Membrane Potential (mV) Resting Potential -70 Time +40 0 Depolarization Peak Action Potential Repolarization Hyperpolarization
Chloroplast Vacuole Calcium Sodium Calcium Calcium Sodium Potassium Potassium SLC6A4 CYP2D6 CYP3A5 CYP3A4 CYP2C9 CYP2C19 CYP2D6 ADRA1A HTR1A DRD1 Unknown OPRM1 Unknown Unknown Unknown Unknown CACNA1A CACNB1 CACNA2D2 KCND2 KCNIP2 Unknown GRIN1 GRIN2A GRIN3A SLC6A2 SLC6A4 SLC6A3 Unknown Unknown ATP1A1 Fluoxetine Norfluoxetine Fluoxetine Fluoxetine glucuronide Norfluoxetine glucuronide Oxygen NADH Water Formaldehyde NAD Norepinephrine Serotonin Dopamine Calcium Sodium Potassium Calcium Calcium Norepinephrine Serotonin Sodium Sodium Sodium Sodium Dopamine Sodium Sodium Adenosine triphosphate Water Sodium Potassium Adenosine diphosphate Phosphate Sodium Potassium SCN10A Unknown SCN1B ATP1A3 ATP1B2 ATP1A2 ATP1A4 ATP1B1 FXYD2 Unknown ATP1B3 Unknown Created with Snap
Ca+ Na+ Ca+ Ca+ Na+ K+ K+ SLC6A4 CYP2D6 CYP3A5 CYP3A4 CYP2C9 CYP2C19 CYP2D6 ADRA1A HTR1A DRD1 OPRM1 CACNA1A CACNB1 CACNA2D2 KCND2 KCNIP2 GRIN1 GRIN2A GRIN3A SLC6A2 SLC6A4 SLC6A3 ATP1A1 Fluox Norfluo Fluox FluGlu NFluGlu O2 NADH H2O Formol NAD Heme Heme Heme Heme Heme Heme Norpp 5-HT LDP Ca+ Na+ K+ Ca+ Ca+ Norpp 5-HT Na+ Na+ Na+ Na+ LDP Na+ Na+ ATP H2O Na+ K+ ADP Pi Na+ K+ SCN10A SCN1B ATP1A3 ATP1B2 ATP1A2 ATP1A4 ATP1B1 FXYD2 ATP1B3 Axon Terminal Synaptic Vesicle Presynaptic Neuron Postsynaptic Neuron Synaptic Cleft Neuron Neuron Axon Action Potential Membrane Potential (mV) Resting Potential -70 Time +40 0 Depolarization Peak Action Potential Repolarization Hyperpolarization
Chloroplast Vacuole Ca2+ Na+ Ca2+ Ca2+ Na+ K+ K+ SLC6A4 CYP2D6 CYP3A5 CYP3A4 CYP2C9 CYP2C19 CYP2D6 ADRA1A HTR1A DRD1 OPRM1 CACNA1A CACNB1 CACNA2D2 KCND2 KCNIP2 GRIN1 GRIN2A GRIN3A SLC6A2 SLC6A4 SLC6A3 ATP1A1 Fluox Norfluo Fluox FluGlu NFluGlu O2 NADH H2O Formol NAD Norpp 5-HT LDP Ca2+ Na+ K+ Ca2+ Ca2+ Norpp 5-HT Na+ Na+ Na+ Na+ LDP Na+ Na+ ATP H2O Na+ K+ ADP Pi Na+ K+ SCN10A SCN1B ATP1A3 ATP1B2 ATP1A2 ATP1A4 ATP1B1 FXYD2 ATP1B3 Created with Snap