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Ca+ Na+ Ca+ Ca+ Na+ K+ K+ Neuronal acetylcholine receptor subunit beta-2 Neuronal acetylcholine receptor subunit alpha-4 Neuronal acetylcholine receptor subunit beta-2 Neuronal acetylcholine receptor subunit alpha-3 Dimethylaniline monooxygenase [N-oxide- forming] 3 UDP- glucuronosyltransferase 1-4 UDP- glucuronosyltransferase 1-9 Cytochrome P450 2A6 Cytochrome P450 2B6 Aldehyde oxidase Cytochrome P450 2A6 UDP- glucuronosyltransferase 1-4 UDP- glucuronosyltransferase 1-9 Cytochrome P450 2A6 Alpha-1A adrenergic receptor 5- hydroxytryptamine receptor 1A D(1A) dopamine receptor Beta-endorphin Mu-type opioid receptor Neuronal acetylcholine receptor subunit beta-2 Neuronal acetylcholine receptor subunit beta-2 Neuronal acetylcholine receptor subunit beta-2 Neuronal acetylcholine receptor subunit alpha-4 Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Potassium voltage-gated channel subfamily D member 2 Kv channel- interacting protein 2 Beta-endorphin Glutamate [NMDA] receptor subunit zeta-1 Glutamate [NMDA] receptor subunit epsilon-1 Glutamate [NMDA] receptor subunit 3A Sodium- dependent noradrenaline transporter Sodium- dependent serotonin transporter Sodium- dependent dopamine transporter Pro- opiomelanocortin Neuroendocrine convertase 2 Sodium/potassium- transporting ATPase subunit alpha-1 Nicotine Nicotine Nicotine Nornicotine Norcotinine Hydroxycotinine trans-3-Hydroxycotinine glucuronide Cotinine Cotinine N-oxide 5'-Hydroxycotinine O2 NADPH H+ Nicotine-1'-N-oxide H2O NADP Uridine diphosphate glucuronic acid Nicotine glucuronide Uridine 5'-diphosphate Nicotine imine H+ H2O O2 H2O2 H+ O2 NADPH H+ H2O NADP Uridine diphosphate glucuronic acid Cotinine glucuronide Uridine 5'-diphosphate O2 NADH H2O Formaldehyde NAD FAD Heme Heme FAD Molybdopterin 2Fe-2S Heme Heme Norepinephrine Serotonin Dopamine Ca+ Na+ K+ Ca+ Ca+ Norepinephrine Serotonin Na+ Na+ Na+ Na+ Dopamine Na+ Na+ ATP H2O Na+ K+ ADP Pi Na+ K+ Sodium channel protein type 10 subunit alpha Neuronal acetylcholine receptor subunit alpha-4 Sodium channel subunit beta-1 Sodium/potassium- transporting ATPase subunit alpha-3 Sodium/potassium- transporting ATPase subunit beta-2 Sodium/potassium- transporting ATPase subunit alpha-2 Sodium/potassium- transporting ATPase subunit alpha-4 Sodium/potassium- transporting ATPase subunit beta-1 Sodium/potassium- transporting ATPase subunit gamma Neuronal acetylcholine receptor subunit alpha-4 Sodium/potassium- transporting ATPase subunit beta-3 ATPase, (Na+)/K+ transporting, beta 4 polypeptide Dendrite Synaptic Vesicle Presynaptic Neuron Postsynaptic Neuron Synaptic Cleft Neuron Neuron Axon Action Potential Membrane Potential (mV) Resting Potential -70 Time +40 0 Depolarization Peak Action Potential Repolarization Hyperpolarization
Chloroplast Endoplasmic Reticulum Vacuole Calcium Sodium Calcium Calcium Sodium Potassium Potassium Unknown Unknown Unknown Unknown FMO3 UGT1A4 UGT1A9 CYP2A6 CYP2B6 AOX1 CYP2A6 UGT1A4 UGT1A9 CYP2A6 ADRA1A HTR1A DRD1 Unknown OPRM1 Unknown Unknown Unknown Unknown CACNA1A CACNB1 CACNA2D2 KCND2 KCNIP2 Unknown GRIN1 GRIN2A GRIN3A SLC6A2 SLC6A4 SLC6A3 Unknown Unknown ATP1A1 Nicotine Nicotine Nicotine Nornicotine Norcotinine Hydroxycotinine trans-3- Hydroxycotinine glucuronide Cotinine Cotinine N-oxide 5'- Hydroxycotinine Oxygen NADPH Hydrogen Ion Nicotine-1'- N-oxide Water NADP Uridine diphosphate glucuronic acid Nicotine glucuronide Uridine 5'-diphosphate Nicotine imine Hydrogen Ion Water Oxygen Hydrogen peroxide Hydrogen Ion Oxygen NADPH Hydrogen Ion Water NADP Uridine diphosphate glucuronic acid Cotinine glucuronide Uridine 5'-diphosphate Oxygen NADH Water Formaldehyde NAD Norepinephrine Serotonin Dopamine Calcium Sodium Potassium Calcium Calcium Norepinephrine Serotonin Sodium Sodium Sodium Sodium Dopamine Sodium Sodium Adenosine triphosphate Water Sodium Potassium Adenosine diphosphate Phosphate Sodium Potassium SCN10A Unknown SCN1B ATP1A3 ATP1B2 ATP1A2 ATP1A4 ATP1B1 FXYD2 Unknown ATP1B3 Unknown Created with Snap
Ca+ Na+ Ca+ Ca+ Na+ K+ K+ FMO3 UGT1A4 UGT1A9 CYP2A6 CYP2B6 AOX1 CYP2A6 UGT1A4 UGT1A9 CYP2A6 ADRA1A HTR1A DRD1 OPRM1 CACNA1A CACNB1 CACNA2D2 KCND2 KCNIP2 GRIN1 GRIN2A GRIN3A SLC6A2 SLC6A4 SLC6A3 ATP1A1 Nicot Nicot Nicot Nornico Norctin HCotin 3HCGluA Cotinin CotnN-O 5'-HCot O2 NADPH H+ Nc-1-NO H2O NADP UDPGlcA NictGlu UDP Nicotim H+ H2O O2 H2O2 H+ O2 NADPH H+ H2O NADP UDPGlcA CotGluA UDP O2 NADH H2O Formol NAD FAD Heme Heme FAD mlyBdpn 2Fe2S Heme Heme Norpp 5-HT LDP Ca+ Na+ K+ Ca+ Ca+ Norpp 5-HT Na+ Na+ Na+ Na+ LDP Na+ Na+ ATP H2O Na+ K+ ADP Pi Na+ K+ SCN10A SCN1B ATP1A3 ATP1B2 ATP1A2 ATP1A4 ATP1B1 FXYD2 ATP1B3 Dendrite Synaptic Vesicle Presynaptic Neuron Postsynaptic Neuron Synaptic Cleft Neuron Neuron Axon Action Potential Membrane Potential (mV) Resting Potential -70 Time +40 0 Depolarization Peak Action Potential Repolarization Hyperpolarization
Chloroplast Endoplasmic Reticulum Vacuole Ca2+ Na+ Ca2+ Ca2+ Na+ K+ K+ FMO3 UGT1A4 UGT1A9 CYP2A6 CYP2B6 AOX1 CYP2A6 UGT1A4 UGT1A9 CYP2A6 ADRA1A HTR1A DRD1 OPRM1 CACNA1A CACNB1 CACNA2D2 KCND2 KCNIP2 GRIN1 GRIN2A GRIN3A SLC6A2 SLC6A4 SLC6A3 ATP1A1 Nicot Nicot Nicot Nornico Norctin HCotin 3HCGluA Cotinin CotnN-O 5'-HCot O2 NADPH H+ Nc-1-NO H2O NADP UDPGlcA NictGlu UDP Nicotim H+ H2O O2 H2O2 H+ O2 NADPH H+ H2O NADP UDPGlcA CotGluA UDP O2 NADH H2O Formol NAD Norpp 5-HT LDP Ca2+ Na+ K+ Ca2+ Ca2+ Norpp 5-HT Na+ Na+ Na+ Na+ LDP Na+ Na+ ATP H2O Na+ K+ ADP Pi Na+ K+ SCN10A SCN1B ATP1A3 ATP1B2 ATP1A2 ATP1A4 ATP1B1 FXYD2 ATP1B3 Created with Snap