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1.0 CHEBI:42147 ChEBI SMILES O[C@H]1CSSC[C@@H]1O 17215925 ChemSpider Vitamin K Metabolism 2.0 Endoplasmic Reticulum C05849 KEGG Compound C02059 KEGG Compound CHEBI:583972 ChEBI 3483-12-3 CAS CL:0000000 CELL TYPE ONTOLOGY 5280483 PubChem-compound 937 ChemSpider BiologicalState29 5284607 PubChem-compound SMILES O 3-HYDROXY-2-METHYL-3-PHYTYL-23-DIHYDRONA BioCyc Prothrombin 82688 ChemSpider 388524 ChemSpider 4447652 ChemSpider 5675 ChemSpider C05850 KEGG Compound C31H46O2 Vitamin K1 450.3498 NAD(P)H dehydrogenase [quinone] 1 1.0 1.0 Water SMILES CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC\C(C)=C\CC1=C(C)C(=O)C2=C(C=CC=C2)C1=O Reduced Vitamin K (phylloquinone) P38435 UniProt Cell 388336 ChemSpider Vitamin K1 2,3-epoxide C4H8O2S2 Oxidized dithiothreitol 151.99657 1,4-Dithiothreitol Prothrombin 53-59-8 CAS BTO:0000759 BRENDA TISSUE ONTOLOGY Vitamin K epoxide reductase complex subunit 1 PW000047 PathWhiz NAD(P)H dehydrogenase [quinone] 1 Vitamin K1 7732-18-5 CAS CHEBI:16474 ChEBI 952 ChemSpider 1.0 GO:0005829 GENE ONTOLOGY O2 Oxygen 31.98983 Vitamin K-dependent gamma-carboxylase 274 ChemSpider GO:0005783 GENE ONTOLOGY Q9BQB6 UniProt 1.0 BiologicalState15 ReactionCatalysis563 ACTIVATION 1.0 4444124 ChemSpider CHEBI:16526 ChEBI Transport261 false [Prothrombin]-Methylmalonic acid (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space LEFT_TO_RIGHT 23-EPOXY-23-DIHYDRO-2-METHYL-14-NAPHTHOQ BioCyc NADPH C31H46O3 Vitamin K1 2,3-epoxide 466.3447 SMILES CC(C)CCCC(C)CCCC(C)CCC\C(C)=C\CC1=C(C)C(=O)C2=CC=CC=C2C1=O BiologicalState18 1.0 7782-44-7 CAS NADP C21H30N7O17P3 NADPH 745.0911 HMDB01967 HMDB C21H29N7O17P3 NADP 744.08325 1.0 9606 TAXONOMY 962 PubChem-compound 1.0 CHEBI:42106 ChEBI NADPH BioCyc HMDB00217 HMDB 1.0 C4H10O2S2 1,4-Dithiothreitol 154.01222 Vitamin K1 Cytosol CPD-6641 BioCyc CO2 Carbon dioxide 43.98983 84-80-0 CAS HMDB02111 HMDB 4.1.1.90 false 4.1.1.90 Carbon dioxide + Oxygen + Reduced Vitamin K (phylloquinone) + [Prothrombin]-Propionic acid → Vitamin K1 2,3-epoxide + Water + [Prothrombin]-Methylmalonic acid LEFT_TO_RIGHT SMILES O=O SMP00464 SMPDB 124-38-9 CAS BiologicalState2 HMDB00221 HMDB CHEBI:15377 ChEBI C00007 KEGG Compound CHEBI:15379 ChEBI C00006 KEGG Compound 91577 PubChem-compound CHEBI:18009 ChEBI SMILES CC(C)CCCC(C)CCCC(C)CCCC(C)=CCC12OC1(C)C(=O)C1=CC=CC=C1C2=O C00001 KEGG Compound 5886 PubChem-compound 439196 PubChem-compound 51621-02-4 CAS C00005 KEGG Compound Vitamin K epoxide reductase complex subunit 1 Liver SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O Prothrombin 25486-55-9 CAS SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O 280 PubChem-compound Oxidized dithiothreitol 1.6.5.2 false 1.6.5.2 NADPH + Vitamin K1 → NADP + Reduced Vitamin K (phylloquinone) LEFT_TO_RIGHT Oxygen 53-57-6 CAS HMDB02972 HMDB 1.0 HMDB04198 HMDB C00011 KEGG Compound SMILES O=C=O 1.0 SMILES O[C@@H](CS)[C@@H](O)CS Extracellular Space 22833512 PubChem-compound NAD(P) BioCyc H2O Water 18.010565 Prothrombin HMDB13593 HMDB 1.1.4.1 false 1.1.4.1 Oxidized dithiothreitol + Vitamin K1 → 1,4-Dithiothreitol + Vitamin K1 2,3-epoxide LEFT_TO_RIGHT P00734 UniProt HMDB01377 HMDB C01119 KEGG Compound HMDB03555 HMDB NAD(P)H dehydrogenase [quinone] 1 977 PubChem-compound Carbon dioxide Vitamin K-dependent gamma-carboxylase 1.0 C00265 KEGG Compound P15559 UniProt CHEBI:18067 ChEBI 1.0 Reduced Vitamin K (phylloquinone) ReactionCatalysis2127 ACTIVATION C31H46O2 Reduced Vitamin K (phylloquinone) 450.3498 ReactionCatalysis2128 ACTIVATION HMDB59664 HMDB GO:0005615 GENE ONTOLOGY 439407 PubChem-compound CHEBI:28371 ChEBI 1.0 Prothrombin NAD(P)H dehydrogenase [quinone] 1 Vitamin K epoxide reductase complex subunit 1 Prothrombin Prothrombin Vitamin K-dependent gamma- carboxylase Vitamin K1 NADPH Reduced Vitamin K (phylloquinone) NADP Oxidized dithiothreitol Vitamin K1 2,3-epoxide 1,4- Dithiothreitol O 2 CO 2 H 2 O Methylmalonic acid FAD Propionic acid Methylmalonic acid Liver Intracellular SPace Extracellular Space Endoplasmic reticulum
1.0 CHEBI:42147 ChEBI SMILES O[C@H]1CSSC[C@@H]1O 17215925 ChemSpider Vitamin K Metabolism 2.0 Endoplasmic Reticulum C05849 KEGG Compound C02059 KEGG Compound CHEBI:583972 ChEBI 3483-12-3 CAS CL:0000000 CELL TYPE ONTOLOGY 5280483 PubChem-compound 937 ChemSpider BiologicalState29 5284607 PubChem-compound SMILES O 3-HYDROXY-2-METHYL-3-PHYTYL-23-DIHYDRONA BioCyc Prothrombin 82688 ChemSpider 388524 ChemSpider 4447652 ChemSpider 5675 ChemSpider C05850 KEGG Compound C31H46O2 Vitamin K1 450.3498 NAD(P)H dehydrogenase [quinone] 1 1.0 1.0 Water SMILES CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC\C(C)=C\CC1=C(C)C(=O)C2=C(C=CC=C2)C1=O Reduced Vitamin K (phylloquinone) P38435 UniProt Cell 388336 ChemSpider Vitamin K1 2,3-epoxide C4H8O2S2 Oxidized dithiothreitol 151.99657 1,4-Dithiothreitol Prothrombin 53-59-8 CAS BTO:0000759 BRENDA TISSUE ONTOLOGY Vitamin K epoxide reductase complex subunit 1 PW000047 PathWhiz NAD(P)H dehydrogenase [quinone] 1 Vitamin K1 7732-18-5 CAS CHEBI:16474 ChEBI 952 ChemSpider 1.0 GO:0005829 GENE ONTOLOGY O2 Oxygen 31.98983 Vitamin K-dependent gamma-carboxylase 274 ChemSpider GO:0005783 GENE ONTOLOGY Q9BQB6 UniProt 1.0 BiologicalState15 ReactionCatalysis563 ACTIVATION 1.0 4444124 ChemSpider CHEBI:16526 ChEBI Transport261 false [Prothrombin]-Methylmalonic acid (→) Transport: Homo sapiens, Cell, Cytosol to Homo sapiens, Extracellular Space LEFT_TO_RIGHT 23-EPOXY-23-DIHYDRO-2-METHYL-14-NAPHTHOQ BioCyc NADPH C31H46O3 Vitamin K1 2,3-epoxide 466.3447 SMILES CC(C)CCCC(C)CCCC(C)CCC\C(C)=C\CC1=C(C)C(=O)C2=CC=CC=C2C1=O BiologicalState18 1.0 7782-44-7 CAS NADP C21H30N7O17P3 NADPH 745.0911 HMDB01967 HMDB C21H29N7O17P3 NADP 744.08325 1.0 9606 TAXONOMY 962 PubChem-compound 1.0 CHEBI:42106 ChEBI NADPH BioCyc HMDB00217 HMDB 1.0 C4H10O2S2 1,4-Dithiothreitol 154.01222 Vitamin K1 Cytosol CPD-6641 BioCyc CO2 Carbon dioxide 43.98983 84-80-0 CAS HMDB02111 HMDB 4.1.1.90 false 4.1.1.90 Carbon dioxide + Oxygen + Reduced Vitamin K (phylloquinone) + [Prothrombin]-Propionic acid → Vitamin K1 2,3-epoxide + Water + [Prothrombin]-Methylmalonic acid LEFT_TO_RIGHT SMILES O=O SMP00464 SMPDB 124-38-9 CAS BiologicalState2 HMDB00221 HMDB CHEBI:15377 ChEBI C00007 KEGG Compound CHEBI:15379 ChEBI C00006 KEGG Compound 91577 PubChem-compound CHEBI:18009 ChEBI SMILES CC(C)CCCC(C)CCCC(C)CCCC(C)=CCC12OC1(C)C(=O)C1=CC=CC=C1C2=O C00001 KEGG Compound 5886 PubChem-compound 439196 PubChem-compound 51621-02-4 CAS C00005 KEGG Compound Vitamin K epoxide reductase complex subunit 1 Liver SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O Prothrombin 25486-55-9 CAS SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O 280 PubChem-compound Oxidized dithiothreitol 1.6.5.2 false 1.6.5.2 NADPH + Vitamin K1 → NADP + Reduced Vitamin K (phylloquinone) LEFT_TO_RIGHT Oxygen 53-57-6 CAS HMDB02972 HMDB 1.0 HMDB04198 HMDB C00011 KEGG Compound SMILES O=C=O 1.0 SMILES O[C@@H](CS)[C@@H](O)CS Extracellular Space 22833512 PubChem-compound NAD(P) BioCyc H2O Water 18.010565 Prothrombin HMDB13593 HMDB 1.1.4.1 false 1.1.4.1 Oxidized dithiothreitol + Vitamin K1 → 1,4-Dithiothreitol + Vitamin K1 2,3-epoxide LEFT_TO_RIGHT P00734 UniProt HMDB01377 HMDB C01119 KEGG Compound HMDB03555 HMDB NAD(P)H dehydrogenase [quinone] 1 977 PubChem-compound Carbon dioxide Vitamin K-dependent gamma-carboxylase 1.0 C00265 KEGG Compound P15559 UniProt CHEBI:18067 ChEBI 1.0 Reduced Vitamin K (phylloquinone) ReactionCatalysis2127 ACTIVATION C31H46O2 Reduced Vitamin K (phylloquinone) 450.3498 ReactionCatalysis2128 ACTIVATION HMDB59664 HMDB GO:0005615 GENE ONTOLOGY 439407 PubChem-compound CHEBI:28371 ChEBI 1.0 Unknown NQO1 VKORC1 Unknown Unknown GGCX Vitamin K1 NADPH Reduced Vitamin K (phylloquinone) NADP Oxidized dithiothreitol Vitamin K1 2,3-epoxide 1,4- Dithiothreitol Oxygen Carbon dioxide Water