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9606 TAXONOMY 962 PubChem-compound Epidermal growth factor receptor SubPathwayInhibition 6022 PubChem-compound Erlotinib 5800 ChemSpider 937 ChemSpider CL:0000000 CELL TYPE ONTOLOGY CPD-8587 BioCyc Cytosol HMDB02111 HMDB HMDB01341 HMDB Epidermal growth factor receptor 154044 ChemSpider SMILES [O-]P([O-])([O-])=O SMILES O GO:0005886 GENE ONTOLOGY SMILES COCCOC1=C(OCCOC)C=C2C(NC3=CC=CC(=C3)C#C)=NC=NC2=C1 Adenosine triphosphate Erlotinib Inhibition of Epidermal growth factor receptor InhibitorySubPathway BiologicalState2 Cell Membrane CHEBI:15377 ChEBI C00009 KEGG Compound C00008 KEGG Compound 14265-44-2 CAS Erlotinib SubPathwayInhibitor C00001 KEGG Compound 58-64-0 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 1.0 Water ATP BioCyc PW000251 PathWhiz CHEBI:18367 ChEBI 1032 ChemSpider 1.0 C00002 KEGG Compound SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Multidrug resistance protein 1 1.0 HMDB01429 HMDB HMDB00538 HMDB ReactionCoupledTransportCatalysis68 ACTIVATION ADP BioCyc SMP00472 SMPDB ReactionCoupledTransportCatalysis67 ACTIVATION Cell CHEBI:15422 ChEBI 1.0 183321-74-6 CAS CHEBI:114785 ChEBI 5742 ChemSpider 7732-18-5 CAS GO:0005829 GENE ONTOLOGY C22H23N3O4 Erlotinib 393.16885 H2O Water 18.010565 5957 PubChem-compound 2.0 P00533 UniProt 1061 PubChem-compound Erlotinib Action Pathway 176870 PubChem-compound Phosphate BiologicalState14 Q9UNQ0 UniProt C10H16N5O13P3 Adenosine triphosphate 506.99576 ATP-binding cassette sub-family G member 2 Multidrug resistance protein 1 SubPathwayControl553 InhibitorySubPathwayControl SubPathway553Control O4P Phosphate 94.95342 56-65-5 CAS 1.0 P08183 UniProt CHEBI:16761 ChEBI Adenosine diphosphate C10H15N5O10P2 Adenosine diphosphate 427.02942 3.6.3.44 false 3.6.3.44 Adenosine triphosphate + Erlotinib + Water ↔ Adenosine diphosphate + Erlotinib + Phosphate REVERSIBLE ATP-binding cassette sub-family G member 2 HMDB14671 HMDB Epidermal growth factor receptor Epidermal growth factor receptor Multidrug resistance protein 1 ATP-binding cassette sub-family G member 2 Erlotinib H 2 O ATP Erlotinib P i ADP H 2 O ATP Erlotinib P i ADP
9606 TAXONOMY 962 PubChem-compound Epidermal growth factor receptor SubPathwayInhibition 6022 PubChem-compound Erlotinib 5800 ChemSpider 937 ChemSpider CL:0000000 CELL TYPE ONTOLOGY CPD-8587 BioCyc Cytosol HMDB02111 HMDB HMDB01341 HMDB Epidermal growth factor receptor 154044 ChemSpider SMILES [O-]P([O-])([O-])=O SMILES O GO:0005886 GENE ONTOLOGY SMILES COCCOC1=C(OCCOC)C=C2C(NC3=CC=CC(=C3)C#C)=NC=NC2=C1 Adenosine triphosphate Erlotinib Inhibition of Epidermal growth factor receptor InhibitorySubPathway BiologicalState2 Homo sapiens, Cell, Cytosol Cell Membrane CHEBI:15377 ChEBI C00009 KEGG Compound C00008 KEGG Compound 14265-44-2 CAS Erlotinib SubPathwayInhibitor C00001 KEGG Compound 58-64-0 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 1.0 Water ATP BioCyc PW000251 PathWhiz CHEBI:18367 ChEBI 1032 ChemSpider 1.0 C00002 KEGG Compound SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Multidrug resistance protein 1 1.0 HMDB01429 HMDB HMDB00538 HMDB ReactionCoupledTransportCatalysis68 ACTIVATION ADP BioCyc http://identifiers.org/smpdb/SMP00472 SMPDB ReactionCoupledTransportCatalysis67 ACTIVATION Cell CHEBI:15422 ChEBI 1.0 183321-74-6 CAS CHEBI:114785 ChEBI 5742 ChemSpider 7732-18-5 CAS GO:0005829 GENE ONTOLOGY C22H23N3O4 Erlotinib 393.16885 H2O Water 18.010565 5957 PubChem-compound 2.0 P00533 UniProt 1061 PubChem-compound Erlotinib Action Pathway 176870 PubChem-compound Phosphate BiologicalState14 Homo sapiens, Cell Membrane Q9UNQ0 UniProt C10H16N5O13P3 Adenosine triphosphate 506.99576 ATP-binding cassette sub-family G member 2 Multidrug resistance protein 1 SubPathwayControl553 InhibitorySubPathwayControl SubPathway553Control O4P Phosphate 94.95342 56-65-5 CAS 1.0 P08183 UniProt CHEBI:16761 ChEBI Adenosine diphosphate C10H15N5O10P2 Adenosine diphosphate 427.02942 3.6.3.44 false 3.6.3.44 Adenosine triphosphate + Erlotinib + Water ↔ Adenosine diphosphate + Erlotinib + Phosphate REVERSIBLE ATP-binding cassette sub-family G member 2 HMDB14671 HMDB Epidermal growth factor receptor EGFR ABCB1 ABCG2 Erlotinib Water Adenosine triphosphate Erlotinib Phosphate Adenosine diphosphate Water Adenosine triphosphate Erlotinib Phosphate Adenosine diphosphate