PRKCB
NFKB1
GNAQ
PLCB1
ITPR1
PRKCA
CACNA1A
CACNB1
CACNA2D2
HRH1
Inotp
Hsm
Doxamn
Ca+
Ca+
Doxamn
P45P
Ca2+
↑ Mediator Release
Diacylg
↑ Pro-inflammatory
Cytokines, Cell Adhesion
Molecules, Chemotactic
Factors
M C R H
Ca+
Ca2+
Nucleus
↑ Antigen Presentation
↓ Mast Cell Stabilization
Endoplamic Reticulum
There is an overall decrease
in calcium levels in the
cytosol caused by the
inhibition of the Gq
signaling cascade
Cytosol
T Cell
Clemastine antagonizes
Histamine H1 receptors in
endothelial cells,
preventing histamine from
activating the receptor
T Cell