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Rho-associated protein kinase 1 Interaction333 Guanosine triphosphate + Gαi/o inhibits Adenylyl cyclase Interaction332 Lysophosphatidic acid activates Lysophosphatidic acid receptor 1 (Homo sapiens) + Gα + Guanosine diphosphate + Gβγ (Homo sapiens) Interaction214 Ras activates RAF Interaction335 Guanosine triphosphate + Gαi/o activates PI3K Interaction334 Guanosine triphosphate + Gαi/o activates Ras 937 ChemSpider Interaction216 MEK activates MAPK Interaction337 RAC-alpha serine/threonine-protein kinase activates NF-κB Interaction215 RAF activates MEK Interaction336 PI3K activates RAC-alpha serine/threonine-protein kinase Inositol 1,4,5-trisphosphate Interaction339 Guanosine triphosphate + Gα12/13 activates Rho Interaction338 PI3K activates Rac Ras RAF MEK direct_interaction 1.0 MEK MAPK Serum response factor Lysophosphatidic acid receptor 1 (Homo sapiens)_Gα_Guanosine diphosphate_Gβγ (Homo sapiens) SMILES O Guanosine triphosphate_Gαq/11 1.0 Interaction340 Rho activates Serum response factor Interaction342 Guanosine triphosphate + Gαq/11 activates PLC Interaction341 Rho activates Rho-associated protein kinase 1 Interaction344 Calcium activates PKC Interaction343 1,2-diacyl-sn-glycerol activates PKC HMDB0000538 HMDB Interaction346 Rho-associated protein kinase 1 activates NF-κB MAPK Interaction345 PKC activates NF-κB C00681 KEGG Compound ATP BioCyc 1.0 1.0 PW064736 PathWhiz 559142 ChemSpider TransportCatalysis922 ACTIVATION C10H12N5O6P cAMP 329.05252 P59768 UniProt Gαq/11 1.0 PW000048 PathWhiz 5742 ChemSpider C00575 KEGG Compound CHEBI:16595 ChEBI 1.0 Q9NQ66 UniProt 85166-31-0 CAS Guanosine triphosphate P11831 UniProt Interaction242 Inositol 1,4,5-trisphosphate activates Inositol 1,4,5-trisphosphate receptor type 1 Inositol 1,4,5-trisphosphate receptor type 1 1.0 5851 ChemSpider Lysophosphatidic acid 6830 PubChem-compound C10H15N5O11P2 Guanosine diphosphate 443.02432 Serum response factor Rho 266 ChemSpider PPI BioCyc C10H16N5O14P3 Guanosine triphosphate 522.99066 Guanosine triphosphate RAC-alpha serine/threonine-protein kinase Rho-associated protein kinase 1 GO:0005886 GENE ONTOLOGY SMP0063746 SMPDB 1.0 1.0 inositol_1,4,5-trisphosphate BioCyc 1,2-diacyl-sn-glycerol Lysophosphatidic acid SubPathwayOutput C00001 KEGG Compound CHEBI:18361 ChEBI SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1 C00002 KEGG Compound RAC-alpha serine/threonine-protein kinase 388562 ChemSpider HMDB0000464 HMDB Guanosine triphosphate_Gα GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE BioCyc Rho 1,2-diacyl-sn-glycerol Gαi/o GO:0005634 GENE ONTOLOGY Reaction110768 false Lysophosphatidic acid receptor 1 (Homo sapiens) + Gα + Guanosine diphosphate + Gβγ (Homo sapiens) → Guanosine triphosphate + Gα + Gβγ + Lysophosphatidic acid + Lysophosphatidic acid receptor 1 (Homo sapiens) LEFT_TO_RIGHT 4.6.1.1 false 4.6.1.1 Adenosine triphosphate → Pyrophosphate + cAMP LEFT_TO_RIGHT CHEBI:17489 ChEBI 1.0 Q92633 UniProt CAMP BioCyc Adenosine triphosphate C00013 KEGG Compound HMDB0001201 HMDB O7P2 Pyrophosphate 173.91193 Q08828 UniProt Rac 5957 PubChem-compound 14127-61-8 CAS SMILES [Ca++] CHEBI:15996 ChEBI 56-65-5 CAS P31749 UniProt 1.0 C6H15O15P3 Inositol 1,4,5-trisphosphate 419.96237 GO:0005737 GENE ONTOLOGY CHEBI:29108 ChEBI 60-92-4 CAS PKC Phospholipid Biosynthesis SubPathway cAMP Guanosine diphosphate Q14643 UniProt Inositol 1,4,5-trisphosphate receptor type 1 Lysophosphatidic acid receptor 1 C04637 KEGG Compound Inositol 1,4,5-trisphosphate receptor type 1 Endoplasmic Reticulum Endoplasmic Reticulum Membrane 2.0 RAF C00035 KEGG Compound C01245 KEGG Compound 1,2-diacyl-sn-glycerol Inositol 1,4,5-trisphosphate receptor type 1 Calcium HMDB0000250 HMDB SMILES [O-]P([O-])(=O)OP([O-])([O-])=O 14000-31-8 CAS PI3K ReactionCatalysis101095 ACTIVATION C00044 KEGG Compound Water Ras SMILES O[C@@H]1[C@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1OP(O)(O)=O Rho-associated protein kinase 1 Adenylate cyclase type 1 RAC-alpha serine/threonine-protein kinase 4.0 Cytoplasm 1.0 1.0 Lysophosphatidic acid receptor 1 CHEBI:15422 ChEBI Homo sapiens Inositol 1,4,5-trisphosphate Reaction100922 false Water + phosphatidylinositol 4,5-bisphosphate → 1,2-diacyl-sn-glycerol + Inositol 1,4,5-trisphosphate LEFT_TO_RIGHT 7732-18-5 CAS Guanosine triphosphate_Gαi/o Lysophosphatidic acid_Lysophosphatidic acid receptor 1 (Homo sapiens) 439456 PubChem-compound GO:0005789 GENE ONTOLOGY 1.0 Inositol 1,4,5-trisphosphate receptor type 1 SMP0000025 SMPDB GO:0005783 GENE ONTOLOGY Gα12/13 C10H16N5O13P3 Adenosine triphosphate 506.99576 8977 PubChem-compound Adenylate cyclase type 1 ReactionCatalysis91035 ACTIVATION Pyrophosphate 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 HMDB0001498 HMDB SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@@H]2COP(O)(=O)O[C@H]2[C@H]1O 1.0 9606 TAXONOMY 962 PubChem-compound 1.0 P62873 UniProt PLC C00076 KEGG Compound 8630 ChemSpider CA%2b2 BioCyc Rho-associated protein kinase 1 HMDB0000058 HMDB Ca Calcium 39.96259 HMDB0002111 HMDB Cell Membrane CHEBI:15377 ChEBI 6569 ChemSpider SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 2.0 271 PubChem-compound CHEBI:17552 ChEBI GTP BioCyc 1.0 C00641 KEGG Compound HMDB0001273 HMDB 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 SubPathwayInteraction57757 SubPathway57757Reaction SubPathwayReaction Transport1035 false Calcium (→) Transport: Homo sapiens, Cell, Endoplasmic Reticulum to Homo sapiens, Cell, Cytoplasm LEFT_TO_RIGHT 4.0 644102 PubChem-compound Rho-associated protein kinase 1 PI3K SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1 NF-κB Rac Rho PLC Adenylyl cyclase PKC Gβγ H2O Water 18.010565 NF-κB 86-01-1 CAS phosphatidylinositol 4,5-bisphosphate Nucleus Q13464 UniProt 6076 PubChem-compound 1.0 Calcium Lysophosphatidic acid Guanosine triphosphate_Gα12/13 PKC 1.0 Gαi/o 1.0 Gαq/11 146-91-8 CAS Gα12/13 Adenylyl cyclase 1.0 1.0 phosphatidylinositol 4,5-bisphosphate Lysophosphatidic Acid LPA1 Signalling AKT1 Serum response factor ROCK1 Inositol 1,4,5- trisphosphate receptor type 1 LPAR1 LPAR1 Inositol 1,4,5- trisphosphate Ca + Ca + ATP cAMP PP i H 2 O Lysophosphatidic acid Adenylyl cyclase Ras RAF MEK MAPK PI3K Rac NF-κB Rho PLC 1,2-diacyl- sn-glycerol PKC phosphatidylinositol 4,5- bisphosphate Gαi/o Gα12/13 Gαq/11 Lysophosphatidic acid Magnesium Phospholipid Biosynthesis Magnesium Calcium GTP GTP GTP GTP ↑ Antigen presentation, pro-inflammatory cytokines, cell adhesion molecules, chemotactic factors GDP Endoplasmic Reticulum Calcium Ion Channel Nucleus MAPK/ERK Pathway PI3K-Akt Pathway Cytoplasm Types of Gα subunits Cell Membrane
Rho-associated protein kinase 1 Interaction333 Guanosine triphosphate + Gαi/o inhibits Adenylyl cyclase Interaction332 Lysophosphatidic acid activates Lysophosphatidic acid receptor 1 (Homo sapiens) + Gα + Guanosine diphosphate + Gβγ (Homo sapiens) Interaction214 Ras activates RAF Interaction335 Guanosine triphosphate + Gαi/o activates PI3K Interaction334 Guanosine triphosphate + Gαi/o activates Ras 937 ChemSpider Interaction216 MEK activates MAPK Interaction337 RAC-alpha serine/threonine-protein kinase activates NF-κB Interaction215 RAF activates MEK Interaction336 PI3K activates RAC-alpha serine/threonine-protein kinase Inositol 1,4,5-trisphosphate Interaction339 Guanosine triphosphate + Gα12/13 activates Rho Interaction338 PI3K activates Rac Ras RAF MEK direct_interaction 1.0 MEK MAPK Serum response factor Lysophosphatidic acid receptor 1 (Homo sapiens)_Gα_Guanosine diphosphate_Gβγ (Homo sapiens) SMILES O Guanosine triphosphate_Gαq/11 1.0 Interaction340 Rho activates Serum response factor Interaction342 Guanosine triphosphate + Gαq/11 activates PLC Interaction341 Rho activates Rho-associated protein kinase 1 Interaction344 Calcium activates PKC Interaction343 1,2-diacyl-sn-glycerol activates PKC HMDB0000538 HMDB Interaction346 Rho-associated protein kinase 1 activates NF-κB MAPK Interaction345 PKC activates NF-κB C00681 KEGG Compound ATP BioCyc 1.0 1.0 PW064736 PathWhiz 559142 ChemSpider TransportCatalysis922 ACTIVATION C10H12N5O6P cAMP 329.05252 P59768 UniProt Gαq/11 1.0 PW000048 PathWhiz 5742 ChemSpider C00575 KEGG Compound CHEBI:16595 ChEBI 1.0 Q9NQ66 UniProt 85166-31-0 CAS Guanosine triphosphate P11831 UniProt Interaction242 Inositol 1,4,5-trisphosphate activates Inositol 1,4,5-trisphosphate receptor type 1 Inositol 1,4,5-trisphosphate receptor type 1 1.0 5851 ChemSpider Lysophosphatidic acid 6830 PubChem-compound C10H15N5O11P2 Guanosine diphosphate 443.02432 Serum response factor Rho 266 ChemSpider PPI BioCyc C10H16N5O14P3 Guanosine triphosphate 522.99066 Guanosine triphosphate RAC-alpha serine/threonine-protein kinase Rho-associated protein kinase 1 GO:0005886 GENE ONTOLOGY SMP0063746 SMPDB 1.0 1.0 inositol_1,4,5-trisphosphate BioCyc 1,2-diacyl-sn-glycerol Lysophosphatidic acid SubPathwayOutput C00001 KEGG Compound CHEBI:18361 ChEBI SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1 C00002 KEGG Compound RAC-alpha serine/threonine-protein kinase 388562 ChemSpider HMDB0000464 HMDB Guanosine triphosphate_Gα GDP-4-DEHYDRO-6-DEOXY-D-MANNOSE BioCyc Rho 1,2-diacyl-sn-glycerol Gαi/o GO:0005634 GENE ONTOLOGY Reaction110768 false Lysophosphatidic acid receptor 1 (Homo sapiens) + Gα + Guanosine diphosphate + Gβγ (Homo sapiens) → Guanosine triphosphate + Gα + Gβγ + Lysophosphatidic acid + Lysophosphatidic acid receptor 1 (Homo sapiens) LEFT_TO_RIGHT 4.6.1.1 false 4.6.1.1 Adenosine triphosphate → Pyrophosphate + cAMP LEFT_TO_RIGHT CHEBI:17489 ChEBI 1.0 Q92633 UniProt CAMP BioCyc Adenosine triphosphate C00013 KEGG Compound HMDB0001201 HMDB O7P2 Pyrophosphate 173.91193 Q08828 UniProt Rac 5957 PubChem-compound 14127-61-8 CAS SMILES [Ca++] CHEBI:15996 ChEBI 56-65-5 CAS P31749 UniProt 1.0 C6H15O15P3 Inositol 1,4,5-trisphosphate 419.96237 GO:0005737 GENE ONTOLOGY CHEBI:29108 ChEBI 60-92-4 CAS PKC Phospholipid Biosynthesis SubPathway cAMP Guanosine diphosphate Q14643 UniProt Inositol 1,4,5-trisphosphate receptor type 1 Lysophosphatidic acid receptor 1 C04637 KEGG Compound Inositol 1,4,5-trisphosphate receptor type 1 Endoplasmic Reticulum Endoplasmic Reticulum Membrane 2.0 RAF C00035 KEGG Compound C01245 KEGG Compound 1,2-diacyl-sn-glycerol Inositol 1,4,5-trisphosphate receptor type 1 Calcium HMDB0000250 HMDB SMILES [O-]P([O-])(=O)OP([O-])([O-])=O 14000-31-8 CAS PI3K ReactionCatalysis101095 ACTIVATION C00044 KEGG Compound Water Ras SMILES O[C@@H]1[C@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1OP(O)(O)=O Rho-associated protein kinase 1 Adenylate cyclase type 1 RAC-alpha serine/threonine-protein kinase 4.0 Cytoplasm 1.0 1.0 Lysophosphatidic acid receptor 1 CHEBI:15422 ChEBI Homo sapiens Inositol 1,4,5-trisphosphate Reaction100922 false Water + phosphatidylinositol 4,5-bisphosphate → 1,2-diacyl-sn-glycerol + Inositol 1,4,5-trisphosphate LEFT_TO_RIGHT 7732-18-5 CAS Guanosine triphosphate_Gαi/o Lysophosphatidic acid_Lysophosphatidic acid receptor 1 (Homo sapiens) 439456 PubChem-compound GO:0005789 GENE ONTOLOGY 1.0 Inositol 1,4,5-trisphosphate receptor type 1 SMP0000025 SMPDB GO:0005783 GENE ONTOLOGY Gα12/13 C10H16N5O13P3 Adenosine triphosphate 506.99576 8977 PubChem-compound Adenylate cyclase type 1 ReactionCatalysis91035 ACTIVATION Pyrophosphate 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 HMDB0001498 HMDB SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@@H]2COP(O)(=O)O[C@H]2[C@H]1O 1.0 9606 TAXONOMY 962 PubChem-compound 1.0 P62873 UniProt PLC C00076 KEGG Compound 8630 ChemSpider CA%2b2 BioCyc Rho-associated protein kinase 1 HMDB0000058 HMDB Ca Calcium 39.96259 HMDB0002111 HMDB Cell Membrane CHEBI:15377 ChEBI 6569 ChemSpider SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 2.0 271 PubChem-compound CHEBI:17552 ChEBI GTP BioCyc 1.0 C00641 KEGG Compound HMDB0001273 HMDB 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 SubPathwayInteraction57757 SubPathway57757Reaction SubPathwayReaction Transport1035 false Calcium (→) Transport: Homo sapiens, Cell, Endoplasmic Reticulum to Homo sapiens, Cell, Cytoplasm LEFT_TO_RIGHT 4.0 644102 PubChem-compound Rho-associated protein kinase 1 PI3K SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1 NF-κB Rac Rho PLC Adenylyl cyclase PKC Gβγ H2O Water 18.010565 NF-κB 86-01-1 CAS phosphatidylinositol 4,5-bisphosphate Nucleus Q13464 UniProt 6076 PubChem-compound 1.0 Calcium Lysophosphatidic acid Guanosine triphosphate_Gα12/13 PKC 1.0 Gαi/o 1.0 Gαq/11 146-91-8 CAS Gα12/13 Adenylyl cyclase 1.0 1.0 phosphatidylinositol 4,5-bisphosphate Lysophosphatidic Acid LPA1 Signalling Endoplasmic Reticulum GNG2 GNG2 AKT1 SRF ROCK1 ITPR1 GNB1 LPAR1 GNB1 LPAR1 Inositol 1,4,5- trisphosphate Calcium Calcium Adenosine triphosphate cAMP Pyrophosphate Water Lysophosphatidic acid Adenylyl cyclase Ras RAF MEK MAPK PI3K Rac NF-κB Rho PLC 1,2-diacyl- sn-glycerol PKC phosphatidylinositol 4,5- bisphosphate Gαi/o Gα12/13 Gαq/11 Lysophosphatidic acid Phospholipid Biosynthesis Guanosine triphosphate Guanosine triphosphate Guanosine triphosphate Guanosine triphosphate Guanosine diphosphate