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9606 TAXONOMY Caspase-7 Endonuclease G, mitochondrial High mobility group protein B2 High mobility group protein B1 DNA topoisomerase 2-alpha DNA fragmentation factor subunit alpha P26583 UniProt Interaction417 ICAD (Homo sapiens) + CAD protein (Homo sapiens) activates CAD-Topo II-HMG 1-HMG 2-H1 direct_interaction PW064764 PathWhiz DNA fragmentation factor subunit alpha High mobility group protein B2 Q14249 UniProt CAD-Topo II-HMG 1-HMG 2-H1 Reaction110821 false ICAD (Homo sapiens) + CAD protein (Homo sapiens) → ICAD LEFT_TO_RIGHT CAD protein CAD protein 1.0 1.0 Caspase-3 Caspase-7 CAD protein Apoptotic DNA Fragmentation and Tissue Homeostasis Interaction422 Caspase-3 activates ICAD (Homo sapiens) + CAD protein (Homo sapiens) Interaction425 Granzyme B activates ICAD (Homo sapiens) + CAD protein (Homo sapiens) Interaction424 Caspase-7 activates ICAD (Homo sapiens) + CAD protein (Homo sapiens) P27708 UniProt DNA topoisomerase 2-alpha Cytoplasm GO:0005634 GENE ONTOLOGY O00273 UniProt SMP0063772 SMPDB 6.0 Endonuclease G, mitochondrial Transport1157 false Endonuclease G, mitochondrial (→) Transport: Homo sapiens, Cell, Cytoplasm to Homo sapiens, Nucleus LEFT_TO_RIGHT Transport1156 false Endonuclease G, mitochondrial (→) Transport: Homo sapiens, Cell, Mitochondrion to Homo sapiens, Cell, Cytoplasm LEFT_TO_RIGHT 1.0 P11388 UniProt Homo sapiens Caspase-3 Granzyme B P42574 UniProt 1.0 Endonuclease G, mitochondrial P09429 UniProt Nucleus ICAD (Homo sapiens)_CAD protein (Homo sapiens) Granzyme B 1.0 P10144 UniProt 1.0 GO:0005739 GENE ONTOLOGY High mobility group protein B1 GO:0005737 GENE ONTOLOGY Endonuclease G, mitochondrial Mitochondrion P55210 UniProt CAD protein DNA topoisomerase 2-alpha High mobility group protein B1 High mobility group protein B2 Caspase-7 Granzyme B Caspase-3 Endonuclease G, mitochondrial Endonuclease G, mitochondrial Endonuclease G, mitochondrial DNA fragmentation factor subunit alpha DNA fragmentation factor subunit alpha CAD protein Hydrogen Cytoplasm Nucleus DNA Degradation Cut Mitochondria
9606 TAXONOMY Caspase-7 Endonuclease G, mitochondrial High mobility group protein B2 High mobility group protein B1 DNA topoisomerase 2-alpha DNA fragmentation factor subunit alpha P26583 UniProt Interaction417 ICAD (Homo sapiens) + CAD protein (Homo sapiens) activates CAD-Topo II-HMG 1-HMG 2-H1 direct_interaction PW064764 PathWhiz DNA fragmentation factor subunit alpha High mobility group protein B2 Q14249 UniProt CAD-Topo II-HMG 1-HMG 2-H1 Reaction110821 false ICAD (Homo sapiens) + CAD protein (Homo sapiens) → ICAD LEFT_TO_RIGHT CAD protein CAD protein 1.0 1.0 Caspase-3 Caspase-7 CAD protein Apoptotic DNA Fragmentation and Tissue Homeostasis Interaction422 Caspase-3 activates ICAD (Homo sapiens) + CAD protein (Homo sapiens) Interaction425 Granzyme B activates ICAD (Homo sapiens) + CAD protein (Homo sapiens) Interaction424 Caspase-7 activates ICAD (Homo sapiens) + CAD protein (Homo sapiens) P27708 UniProt DNA topoisomerase 2-alpha Cytoplasm GO:0005634 GENE ONTOLOGY O00273 UniProt SMP0063772 SMPDB 6.0 Endonuclease G, mitochondrial Transport1157 false Endonuclease G, mitochondrial (→) Transport: Homo sapiens, Cell, Cytoplasm to Homo sapiens, Nucleus LEFT_TO_RIGHT Transport1156 false Endonuclease G, mitochondrial (→) Transport: Homo sapiens, Cell, Mitochondrion to Homo sapiens, Cell, Cytoplasm LEFT_TO_RIGHT 1.0 P11388 UniProt Homo sapiens Caspase-3 Granzyme B P42574 UniProt 1.0 Endonuclease G, mitochondrial P09429 UniProt Nucleus ICAD (Homo sapiens)_CAD protein (Homo sapiens) Granzyme B 1.0 P10144 UniProt 1.0 GO:0005739 GENE ONTOLOGY High mobility group protein B1 GO:0005737 GENE ONTOLOGY Endonuclease G, mitochondrial Mitochondrion P55210 UniProt Nucleus CAD TOP2A HMGB1 HMGB2 CASP7 GZMB Unknown ENDOG ENDOG ENDOG DFFA DFFA CAD