Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
Your source for quantitative metabolomics technologies and bioinformatics.

Loading Pathway...

Q14643 UniProt PKA-PKC Citrulline Inositol 1,4,5-trisphosphate receptor type 1 Nitrite Endoplasmic Reticulum C3H6N2O7 Glyceryl 1,2-dinitrate 182.0175 Glutamate [NMDA] receptor subunit epsilon-1 P62158 UniProt SMILES N[C@@H](CCCNC(N)=O)C(O)=O 4354 ChemSpider 1.0 127983 ChemSpider Protein kinase C alpha type 9367 ChemSpider C01245 KEGG Compound direct_interaction Calcium Nitric oxide Nitroglycerin C6H14N4O2 L-Arginine 174.11168 79076 PubChem-compound CHEBI:16301 ChEBI C00327 KEGG Compound 6992098 PubChem-compound Aldehyde dehydrogenase, mitochondrial P05091 UniProt Glutamate [NMDA] receptor subunit 3A Interaction746 Citrulline activates Nitric-oxide synthase, brain SMILES ON=O ReactionCatalysis169035 ACTIVATION ReactionCatalysis169034 ACTIVATION NITRIC-OXIDE BioCyc Interaction748 Nitric-oxide synthase, brain activates L-Arginine 4510 PubChem-compound 921 ChemSpider Interaction747 Nitric-oxide synthase, brain activates Nitric oxide SMILES O[C@@H]1[C@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1OP(O)(O)=O 1.0 HMDB0003378 HMDB SMP0063777 SMPDB Cytoplasm Q12879 UniProt Q8TCU5 UniProt Disks large homolog 4 P29475 UniProt Protein kinase C alpha type Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Disks large homolog 4 1.0 Homo sapiens 1.0 CHEBI:16595 ChEBI SMILES N[C@@H](CCCNC(N)=N)C(O)=O Glyceryl 1,2-dinitrate 439456 PubChem-compound Aldehyde dehydrogenase, mitochondrial C00062 KEGG Compound TransportCatalysis977 ACTIVATION 14797-65-0 CAS 28782 PubChem-compound 85166-31-0 CAS 946 PubChem-compound GO:0005783 GENE ONTOLOGY Nitric Oxide Signaling Pathway ARG BioCyc L-Arginine Interaction242 Inositol 1,4,5-trisphosphate activates Inositol 1,4,5-trisphosphate receptor type 1 L-CITRULLINE BioCyc CHEBI:16480 ChEBI Inositol 1,4,5-trisphosphate NO Nitric oxide 29.997988 cAMP-dependent protein kinase catalytic subunit beta Glutamate receptor ionotropic Nitric-oxide synthase, brain HMDB0001498 HMDB 266 ChemSpider Xanthine dehydrogenase/oxidase Inositol 1,4,5-trisphosphate receptor type 1 P17252 UniProt 9606 TAXONOMY Glutamate [NMDA] receptor subunit zeta-1 1.0 4.0 145068 PubChem-compound Nitric oxide C00076 KEGG Compound Calmodulin Q08209 UniProt CA%2b2 BioCyc Glutamate [NMDA] receptor subunit 3A PW064769 PathWhiz NITRITE BioCyc Ca Calcium 39.96259 1.0 inositol_1,4,5-trisphosphate BioCyc C3H5N3O9 Nitroglycerin 227.00258 HMDB0014865 HMDB CHEBI:16467 ChEBI CHEBI:16349 ChEBI Aldehyde dehydrogenase, mitochondrial SMILES [N]=O P22694 UniProt C00088 KEGG Compound Q05586 UniProt Glutamate [NMDA] receptor subunit epsilon-1 271 PubChem-compound Reaction179134 false Nitrite → Nitric oxide LEFT_TO_RIGHT 1.2.1.3 false 1.2.1.3 Nitroglycerin → Glyceryl 1,2-dinitrate + Nitrite LEFT_TO_RIGHT 388562 ChemSpider HMDB0000464 HMDB Nitric oxide synthase, brain SMILES OCC(CO[N+]([O-])=O)O[N+]([O-])=O 4.0 Interaction391 Nitric-oxide synthase, brain activates Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform 1.0 Interaction390 Disks large homolog 4 activates Nitric-oxide synthase, brain Interaction393 PKA-PKC activates Nitric-oxide synthase, brain Interaction392 Calmodulin activates Nitric-oxide synthase, brain Interaction395 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform activates Nitric-oxide synthase, brain Transport1158 false Calcium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytoplasm LEFT_TO_RIGHT 2.0 C6H13N3O3 Citrulline 175.09569 372-75-8 CAS Nitrite C00533 KEGG Compound HMDB0000904 HMDB Extracellular Space C07455 KEGG Compound P47989 UniProt CHEBI:28787 ChEBI 10102-43-9 CAS 6082 ChemSpider 14127-61-8 CAS SMILES [Ca++] SMILES [O-][N+](=O)OCC(CO[N+]([O-])=O)O[N+]([O-])=O 1.0 HNO2 Nitrite 47.00073 P78352 UniProt Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Calcium 74-79-3 CAS Calmodulin cAMP-dependent protein kinase catalytic subunit beta 55-63-0 CAS Inositol 1,4,5-trisphosphate receptor type 1 HMDB0000517 HMDB Glutamate [NMDA] receptor subunit zeta-1 HMDB0002786 HMDB GO:0005615 GENE ONTOLOGY C6H15O15P3 Inositol 1,4,5-trisphosphate 419.96237 CHEBI:29108 ChEBI GO:0005737 GENE ONTOLOGY Xanthine dehydrogenase/oxidase 1.0 1.0 Nitric oxide synthase, brain Calmodulin Disks large homolog 4 Nitric oxide synthase, brain Calmodulin Serine/threonine- protein phosphatase 2B catalytic subunit alpha isoform Protein kinase C alpha type cAMP-dependent protein kinase catalytic subunit beta Nitric oxide synthase, brain Inositol 1,4,5- trisphosphate receptor type 1 Glutamate [NMDA] receptor subunit zeta-1 Glutamate [NMDA] receptor subunit epsilon-1 Glutamate [NMDA] receptor subunit 3A Aldehyde dehydrogenase, mitochondrial Xanthine dehydrogenase/oxidase Citrulline NO L-Arginine Inositol 1,4,5- trisphosphate Ca + Ca + Nitroglycerin Glyceryl 1,2-dinitrate Nitrite Ca + Ca + Ca + P i P i Ca + cCMP Regulation Long-Term Potentiation Neurotransmission Extracellular Cytoplasm IP3 binds to receptors on the endoplasmic reticulum and causes Ca2+ release from intracellular stores
Q14643 UniProt PKA-PKC Citrulline Inositol 1,4,5-trisphosphate receptor type 1 Nitrite Endoplasmic Reticulum C3H6N2O7 Glyceryl 1,2-dinitrate 182.0175 Glutamate [NMDA] receptor subunit epsilon-1 P62158 UniProt SMILES N[C@@H](CCCNC(N)=O)C(O)=O 4354 ChemSpider 1.0 127983 ChemSpider Protein kinase C alpha type 9367 ChemSpider C01245 KEGG Compound direct_interaction Calcium Nitric oxide Nitroglycerin C6H14N4O2 L-Arginine 174.11168 79076 PubChem-compound CHEBI:16301 ChEBI C00327 KEGG Compound 6992098 PubChem-compound Aldehyde dehydrogenase, mitochondrial P05091 UniProt Glutamate [NMDA] receptor subunit 3A Interaction746 Citrulline activates Nitric-oxide synthase, brain SMILES ON=O ReactionCatalysis169035 ACTIVATION ReactionCatalysis169034 ACTIVATION NITRIC-OXIDE BioCyc Interaction748 Nitric-oxide synthase, brain activates L-Arginine 4510 PubChem-compound 921 ChemSpider Interaction747 Nitric-oxide synthase, brain activates Nitric oxide SMILES O[C@@H]1[C@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1OP(O)(O)=O 1.0 HMDB0003378 HMDB SMP0063777 SMPDB Cytoplasm Q12879 UniProt Q8TCU5 UniProt Disks large homolog 4 P29475 UniProt Protein kinase C alpha type Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Disks large homolog 4 1.0 Homo sapiens 1.0 CHEBI:16595 ChEBI SMILES N[C@@H](CCCNC(N)=N)C(O)=O Glyceryl 1,2-dinitrate 439456 PubChem-compound Aldehyde dehydrogenase, mitochondrial C00062 KEGG Compound TransportCatalysis977 ACTIVATION 14797-65-0 CAS 28782 PubChem-compound 85166-31-0 CAS 946 PubChem-compound GO:0005783 GENE ONTOLOGY Nitric Oxide Signaling Pathway ARG BioCyc L-Arginine Interaction242 Inositol 1,4,5-trisphosphate activates Inositol 1,4,5-trisphosphate receptor type 1 L-CITRULLINE BioCyc CHEBI:16480 ChEBI Inositol 1,4,5-trisphosphate NO Nitric oxide 29.997988 cAMP-dependent protein kinase catalytic subunit beta Glutamate receptor ionotropic Nitric-oxide synthase, brain HMDB0001498 HMDB 266 ChemSpider Xanthine dehydrogenase/oxidase Inositol 1,4,5-trisphosphate receptor type 1 P17252 UniProt 9606 TAXONOMY Glutamate [NMDA] receptor subunit zeta-1 1.0 4.0 145068 PubChem-compound Nitric oxide C00076 KEGG Compound Calmodulin Q08209 UniProt CA%2b2 BioCyc Glutamate [NMDA] receptor subunit 3A PW064769 PathWhiz NITRITE BioCyc Ca Calcium 39.96259 1.0 inositol_1,4,5-trisphosphate BioCyc C3H5N3O9 Nitroglycerin 227.00258 HMDB0014865 HMDB CHEBI:16467 ChEBI CHEBI:16349 ChEBI Aldehyde dehydrogenase, mitochondrial SMILES [N]=O P22694 UniProt C00088 KEGG Compound Q05586 UniProt Glutamate [NMDA] receptor subunit epsilon-1 271 PubChem-compound Reaction179134 false Nitrite → Nitric oxide LEFT_TO_RIGHT 1.2.1.3 false 1.2.1.3 Nitroglycerin → Glyceryl 1,2-dinitrate + Nitrite LEFT_TO_RIGHT 388562 ChemSpider HMDB0000464 HMDB Nitric oxide synthase, brain SMILES OCC(CO[N+]([O-])=O)O[N+]([O-])=O 4.0 Interaction391 Nitric-oxide synthase, brain activates Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform 1.0 Interaction390 Disks large homolog 4 activates Nitric-oxide synthase, brain Interaction393 PKA-PKC activates Nitric-oxide synthase, brain Interaction392 Calmodulin activates Nitric-oxide synthase, brain Interaction395 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform activates Nitric-oxide synthase, brain Transport1158 false Calcium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytoplasm LEFT_TO_RIGHT 2.0 C6H13N3O3 Citrulline 175.09569 372-75-8 CAS Nitrite C00533 KEGG Compound HMDB0000904 HMDB Extracellular Space C07455 KEGG Compound P47989 UniProt CHEBI:28787 ChEBI 10102-43-9 CAS 6082 ChemSpider 14127-61-8 CAS SMILES [Ca++] SMILES [O-][N+](=O)OCC(CO[N+]([O-])=O)O[N+]([O-])=O 1.0 HNO2 Nitrite 47.00073 P78352 UniProt Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Calcium 74-79-3 CAS Calmodulin cAMP-dependent protein kinase catalytic subunit beta 55-63-0 CAS Inositol 1,4,5-trisphosphate receptor type 1 HMDB0000517 HMDB Glutamate [NMDA] receptor subunit zeta-1 HMDB0002786 HMDB GO:0005615 GENE ONTOLOGY C6H15O15P3 Inositol 1,4,5-trisphosphate 419.96237 CHEBI:29108 ChEBI GO:0005737 GENE ONTOLOGY Xanthine dehydrogenase/oxidase 1.0 1.0 Nitric oxide synthase, brain Mitochondria CALM1 DLG4 NOS1 CALM1 PPP3CA PRKCA PRKACB NOS1 ITPR1 GRIN1 GRIN2A GRIN3A ALDH2 XDH Citrulline Nitric oxide L-Arginine Inositol 1,4,5- trisphosphate Calcium Calcium Nitroglycerin Glyceryl 1,2-dinitrate Nitrite Calcium Calcium Calcium Phosphate Phosphate Calcium