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Reaction110903 false Guanosine triphosphate → Cyclic GMP LEFT_TO_RIGHT Potassium voltage-gated channel subfamily KQT member 2 Potassium voltage-gated channel subfamily KQT member 3 Q9UBN4 UniProt 2.0 Adenylate cyclase type 10 Adenylate cyclase type 10 127983 ChemSpider 1.0 Short transient receptor potential channel 7 O75343 UniProt Short transient receptor potential channel 4 direct_interaction ReactionCatalysis101145 ACTIVATION 1.0 Calcium Nitric oxide cGMP-dependent protein kinase 2 1.0 1.0 HMDB0000250 HMDB SMILES [O-]P([O-])(=O)OP([O-])([O-])=O 14000-31-8 CAS HMDB0000538 HMDB C00044 KEGG Compound Q9HCX4 UniProt Potassium voltage-gated channel subfamily KQT member 5 ATP BioCyc Interaction468 3 Calcium activates Nitric-oxide synthase, endothelial NITRIC-OXIDE BioCyc Potassium voltage-gated channel subfamily KQT member 4 Nitric oxide synthase, endothelial cAMP HMDB0003378 HMDB Cyclic GMP O43526 UniProt 1.0 C10H12N5O7P Cyclic GMP 345.04742 O43525 UniProt ReactionCatalysis101096 ACTIVATION 559142 ChemSpider Transport1171 false Calcium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytoplasm LEFT_TO_RIGHT Cytoplasm SMP0063778 SMPDB C10H12N5O6P cAMP 329.05252 CHEBI:16356 ChEBI P29474 UniProt Nitric-oxide synthase, endothelial CHEBI:15422 ChEBI 1.0 Interaction476 Nitric oxide activates Soluble guanylyl cyclase Homo sapiens 2.0 Interaction478 cAMP activates Transient receptor potential cation channel CGMP BioCyc Interaction477 Cyclic GMP activates Transient receptor potential cation channel Short transient receptor potential channel 3 5742 ChemSpider Interaction479 Cyclic GMP activates cGMP-dependent protein kinase cGMP-dependent protein kinase 2 C00575 KEGG Compound Transient receptor potential cation channel subfamily V member 4 cGMP-dependent protein kinase 1 Q02153 UniProt Ion Channels and Their Functional Role in Vascular Endothelium Guanylate cyclase soluble subunit beta-2 Guanosine triphosphate Q9NR82 UniProt C10H16N5O13P3 Adenosine triphosphate 506.99576 3.0 Cyclic GMP Interaction484 cGMP-dependent protein kinase inhibits Potassium voltage-gated channel, KQT-like subfamily Q96PN6 UniProt CHEBI:16480 ChEBI 1.0 Guanylate cyclase soluble subunit alpha-2 5851 ChemSpider NO Nitric oxide 29.997988 6830 PubChem-compound Pyrophosphate SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@@H]2COP(O)(=O)O[C@H]2[C@H]1O Guanylate cyclase soluble subunit beta-1 Short transient receptor potential channel 4 266 ChemSpider Short transient receptor potential channel 7 TransportCatalysis989 ACTIVATION PPI BioCyc SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@@H]3COP(O)(=O)O[C@H]3[C@H]2O)C(=O)N1 1.0 9606 TAXONOMY 1.0 C10H16N5O14P3 Guanosine triphosphate 522.99066 145068 PubChem-compound PW064770 PathWhiz 1.0 Nitric oxide C00076 KEGG Compound 1.0 CA%2b2 BioCyc HMDB0000058 HMDB 1.0 Q9HBA0 UniProt Ca Calcium 39.96259 Q13237 UniProt Potassium voltage-gated channel subfamily KQT member 2 1.0 Guanylate cyclase soluble subunit alpha-2 Guanylate cyclase soluble subunit alpha-3 6569 ChemSpider SMILES [N]=O cGMP-dependent protein kinase 2 SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Guanylate cyclase soluble subunit beta-1 2.0 CHEBI:18361 ChEBI 271 PubChem-compound Guanylate cyclase soluble subunit alpha-3 GTP BioCyc 1.0 cGMP-dependent protein kinase 1 C00002 KEGG Compound HMDB0000464 HMDB Nitric oxide synthase, endothelial Transient receptor potential cation channel subfamily V member 4 cGMP-dependent protein kinase 1 HMDB0001314 HMDB Short transient receptor potential channel 3 1.0 cGMP-dependent protein kinase 1.0 HMDB0001273 HMDB 24316 PubChem-compound Potassium voltage-gated channel subfamily KQT member 3 Potassium voltage-gated channel subfamily KQT member 4 P56696 UniProt 644102 PubChem-compound CHEBI:17489 ChEBI Potassium voltage-gated channel subfamily KQT member 5 1.0 Transient receptor potential cation channel CAMP BioCyc cGMP-dependent protein kinase Adenosine triphosphate Guanylate cyclase soluble subunit beta-2 SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1 C00533 KEGG Compound 3.0 C00013 KEGG Compound 1.0 Extracellular Space 22734 ChemSpider O7P2 Pyrophosphate 173.91193 10102-43-9 CAS Calcium 5957 PubChem-compound 14127-61-8 CAS SMILES [Ca++] 1.0 Soluble guanylyl cyclase 86-01-1 CAS Q13976 UniProt P33402 UniProt 6076 PubChem-compound C00942 KEGG Compound 1.0 CHEBI:15996 ChEBI Calcium 56-65-5 CAS Q02108 UniProt GO:0005615 GENE ONTOLOGY GO:0005737 GENE ONTOLOGY CHEBI:29108 ChEBI 60-92-4 CAS 1.0 Reaction110894 false Nitric-oxide synthase, endothelial → Nitric oxide LEFT_TO_RIGHT Potassium voltage-gated channel, KQT-like subfamily Q13507 UniProt Reaction110775 false Adenosine triphosphate → Pyrophosphate + cAMP LEFT_TO_RIGHT cAMP 7665-99-8 CAS Adenylate Cyclase GNGT1 GNB1 GNAS Nitric oxide synthase, endothelial Soluble guanylyl cyclase Soluble guanylyl cyclase Soluble guanylyl cyclase Soluble guanylyl cyclase Transient receptor potential cation channel Transient receptor potential cation channel Transient receptor potential cation channel Transient receptor potential cation channel cGMP-dependent protein kinase cGMP-dependent protein kinase Potassium voltage-gated channel, KQT-like subfamily Potassium voltage-gated channel, KQT-like subfamily Potassium voltage-gated channel, KQT-like subfamily Potassium voltage-gated channel, KQT-like subfamily Ca + NO Cyclic GMP cAMP Ca + ATP PP i GTP Ca + Ca + Heme FAD Flavin Mononucleotide Tetrahydrobiopterin Magnesium G protein-coupled receptor Agonist Membrane potential Receptor-activated calcium channel Store-operated calcium channel Cyclic nucleotide–gated ion channel Hyperpolarization-activated cyclic nucleotide-gated ion channel
Reaction110903 false Guanosine triphosphate → Cyclic GMP LEFT_TO_RIGHT Potassium voltage-gated channel subfamily KQT member 2 Potassium voltage-gated channel subfamily KQT member 3 Q9UBN4 UniProt 2.0 Adenylate cyclase type 10 Adenylate cyclase type 10 127983 ChemSpider 1.0 Short transient receptor potential channel 7 O75343 UniProt Short transient receptor potential channel 4 direct_interaction ReactionCatalysis101145 ACTIVATION 1.0 Calcium Nitric oxide cGMP-dependent protein kinase 2 1.0 1.0 HMDB0000250 HMDB SMILES [O-]P([O-])(=O)OP([O-])([O-])=O 14000-31-8 CAS HMDB0000538 HMDB C00044 KEGG Compound Q9HCX4 UniProt Potassium voltage-gated channel subfamily KQT member 5 ATP BioCyc Interaction468 3 Calcium activates Nitric-oxide synthase, endothelial NITRIC-OXIDE BioCyc Potassium voltage-gated channel subfamily KQT member 4 Nitric oxide synthase, endothelial cAMP HMDB0003378 HMDB Cyclic GMP O43526 UniProt 1.0 C10H12N5O7P Cyclic GMP 345.04742 O43525 UniProt ReactionCatalysis101096 ACTIVATION 559142 ChemSpider Transport1171 false Calcium (→) Transport: Homo sapiens, Extracellular Space to Homo sapiens, Cell, Cytoplasm LEFT_TO_RIGHT Cytoplasm SMP0063778 SMPDB C10H12N5O6P cAMP 329.05252 CHEBI:16356 ChEBI P29474 UniProt Nitric-oxide synthase, endothelial CHEBI:15422 ChEBI 1.0 Interaction476 Nitric oxide activates Soluble guanylyl cyclase Homo sapiens 2.0 Interaction478 cAMP activates Transient receptor potential cation channel CGMP BioCyc Interaction477 Cyclic GMP activates Transient receptor potential cation channel Short transient receptor potential channel 3 5742 ChemSpider Interaction479 Cyclic GMP activates cGMP-dependent protein kinase cGMP-dependent protein kinase 2 C00575 KEGG Compound Transient receptor potential cation channel subfamily V member 4 cGMP-dependent protein kinase 1 Q02153 UniProt Ion Channels and Their Functional Role in Vascular Endothelium Guanylate cyclase soluble subunit beta-2 Guanosine triphosphate Q9NR82 UniProt C10H16N5O13P3 Adenosine triphosphate 506.99576 3.0 Cyclic GMP Interaction484 cGMP-dependent protein kinase inhibits Potassium voltage-gated channel, KQT-like subfamily Q96PN6 UniProt CHEBI:16480 ChEBI 1.0 Guanylate cyclase soluble subunit alpha-2 5851 ChemSpider NO Nitric oxide 29.997988 6830 PubChem-compound Pyrophosphate SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@@H]2COP(O)(=O)O[C@H]2[C@H]1O Guanylate cyclase soluble subunit beta-1 Short transient receptor potential channel 4 266 ChemSpider Short transient receptor potential channel 7 TransportCatalysis989 ACTIVATION PPI BioCyc SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@@H]3COP(O)(=O)O[C@H]3[C@H]2O)C(=O)N1 1.0 9606 TAXONOMY 1.0 C10H16N5O14P3 Guanosine triphosphate 522.99066 145068 PubChem-compound PW064770 PathWhiz 1.0 Nitric oxide C00076 KEGG Compound 1.0 CA%2b2 BioCyc HMDB0000058 HMDB 1.0 Q9HBA0 UniProt Ca Calcium 39.96259 Q13237 UniProt Potassium voltage-gated channel subfamily KQT member 2 1.0 Guanylate cyclase soluble subunit alpha-2 Guanylate cyclase soluble subunit alpha-3 6569 ChemSpider SMILES [N]=O cGMP-dependent protein kinase 2 SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O Guanylate cyclase soluble subunit beta-1 2.0 CHEBI:18361 ChEBI 271 PubChem-compound Guanylate cyclase soluble subunit alpha-3 GTP BioCyc 1.0 cGMP-dependent protein kinase 1 C00002 KEGG Compound HMDB0000464 HMDB Nitric oxide synthase, endothelial Transient receptor potential cation channel subfamily V member 4 cGMP-dependent protein kinase 1 HMDB0001314 HMDB Short transient receptor potential channel 3 1.0 cGMP-dependent protein kinase 1.0 HMDB0001273 HMDB 24316 PubChem-compound Potassium voltage-gated channel subfamily KQT member 3 Potassium voltage-gated channel subfamily KQT member 4 P56696 UniProt 644102 PubChem-compound CHEBI:17489 ChEBI Potassium voltage-gated channel subfamily KQT member 5 1.0 Transient receptor potential cation channel CAMP BioCyc cGMP-dependent protein kinase Adenosine triphosphate Guanylate cyclase soluble subunit beta-2 SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1 C00533 KEGG Compound 3.0 C00013 KEGG Compound 1.0 Extracellular Space 22734 ChemSpider O7P2 Pyrophosphate 173.91193 10102-43-9 CAS Calcium 5957 PubChem-compound 14127-61-8 CAS SMILES [Ca++] 1.0 Soluble guanylyl cyclase 86-01-1 CAS Q13976 UniProt P33402 UniProt 6076 PubChem-compound C00942 KEGG Compound 1.0 CHEBI:15996 ChEBI Calcium 56-65-5 CAS Q02108 UniProt GO:0005615 GENE ONTOLOGY GO:0005737 GENE ONTOLOGY CHEBI:29108 ChEBI 60-92-4 CAS 1.0 Reaction110894 false Nitric-oxide synthase, endothelial → Nitric oxide LEFT_TO_RIGHT Potassium voltage-gated channel, KQT-like subfamily Q13507 UniProt Reaction110775 false Adenosine triphosphate → Pyrophosphate + cAMP LEFT_TO_RIGHT cAMP 7665-99-8 CAS ADCY10 GNGT1 GNB1 GNAS NOS3 GUCY1A2 GUCY1A3 GUCY1B2 GUCY1B3 TRPC3 TRPC4 TRPC7 TRPV4 PRKG1 PRKG2 KCNQ2 KCNQ3 KCNQ4 KCNQ5 Calcium Nitric oxide Cyclic GMP cAMP Calcium Adenosine triphosphate Pyrophosphate Guanosine triphosphate Calcium Calcium G protein-coupled receptor