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9606 TAXONOMY 962 PubChem-compound RAC-alpha serine/threonine-protein kinase Proto-oncogene vav 937 ChemSpider C00076 KEGG Compound Phosphoinositide 3-kinase regulatory subunit 6 Proto-oncogene vav MAPK pathway ActivatingSubPathway P48736 UniProt DG direct_interaction CA%2b2 BioCyc 1.0 1.0 SMILES O 1.0 Calcium IP3 ReactionCatalysis101109 ACTIVATION PIP2 Ca Calcium 39.96259 ReactionCatalysis101108 ACTIVATION SMP0063783 SMPDB HMDB0002111 HMDB CHEBI:15377 ChEBI akt murine thymoma viral oncogene homolog 1 (Homo sapiens)_Vav 1 guanine nucleotide exchange factor (Homo sapiens) PIP2 C00001 KEGG Compound 271 PubChem-compound Interaction429 DG activates Protein kinase C 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Interaction428 IP3 activates Calcium 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 HMDB0000464 HMDB PW064775 PathWhiz P15498 UniProt Water Reaction110790 false PIP2 + Water → DG + IP3 LEFT_TO_RIGHT 1.0 Cytoplasm Reaction110794 false PIP2 → IP3 LEFT_TO_RIGHT P19174 UniProt Interaction397 IP3 activates akt murine thymoma viral oncogene homolog 1 (Homo sapiens) + Vav 1 guanine nucleotide exchange factor (Homo sapiens) Phospholipase C Signaling Pathway 1.0 Homo sapiens Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 1.0 7732-18-5 CAS 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 RAC-alpha serine/threonine-protein kinase Phosphoinositide 3-kinase regulatory subunit 6 Q9NQ66 UniProt SubPathwayControl57770 SubPathway57770Control ActivatingSubPathwayControl H2O Water 18.010565 1.0 14127-61-8 CAS SMILES [Ca++] Protein kinase C alpha type Interaction6 Calcium activates Protein kinase C Protein kinase C alpha type DG Phosphatidylinositol 4,5-bisphosphate 3-kinase Q5UE93 UniProt 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 P31749 UniProt IP3 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform ReactionCatalysis101110 ACTIVATION 266 ChemSpider GO:0005737 GENE ONTOLOGY CHEBI:29108 ChEBI P17252 UniProt 1.0 Protein kinase C alpha type 1- phosphatidylinositol 4,5- bisphosphate phosphodiesterase beta-1 1- phosphatidylinositol 4,5- bisphosphate phosphodiesterase gamma-1 Phosphoinositide 3-kinase regulatory subunit 6 Phosphatidylinositol- 4,5- bisphosphate 3-kinase catalytic subunit gamma isoform RAC-alpha serine/threonine- protein kinase Proto-oncogene vav Ca + Ca + H 2 O Ca + Calcium Calcium IP3 IP3 DG PIP2 MAPK pathway Transcription Factors Cytoplasm Endoplasmic Reticulum Nucleus
9606 TAXONOMY 962 PubChem-compound RAC-alpha serine/threonine-protein kinase Proto-oncogene vav 937 ChemSpider C00076 KEGG Compound Phosphoinositide 3-kinase regulatory subunit 6 Proto-oncogene vav MAPK pathway ActivatingSubPathway P48736 UniProt DG direct_interaction CA%2b2 BioCyc 1.0 1.0 SMILES O 1.0 Calcium IP3 ReactionCatalysis101109 ACTIVATION PIP2 Ca Calcium 39.96259 ReactionCatalysis101108 ACTIVATION SMP0063783 SMPDB HMDB0002111 HMDB CHEBI:15377 ChEBI akt murine thymoma viral oncogene homolog 1 (Homo sapiens)_Vav 1 guanine nucleotide exchange factor (Homo sapiens) PIP2 C00001 KEGG Compound 271 PubChem-compound Interaction429 DG activates Protein kinase C 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Interaction428 IP3 activates Calcium 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 HMDB0000464 HMDB PW064775 PathWhiz P15498 UniProt Water Reaction110790 false PIP2 + Water → DG + IP3 LEFT_TO_RIGHT 1.0 Cytoplasm Reaction110794 false PIP2 → IP3 LEFT_TO_RIGHT P19174 UniProt Interaction397 IP3 activates akt murine thymoma viral oncogene homolog 1 (Homo sapiens) + Vav 1 guanine nucleotide exchange factor (Homo sapiens) Phospholipase C Signaling Pathway 1.0 Homo sapiens Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 1.0 7732-18-5 CAS 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 RAC-alpha serine/threonine-protein kinase Phosphoinositide 3-kinase regulatory subunit 6 Q9NQ66 UniProt SubPathwayControl57770 SubPathway57770Control ActivatingSubPathwayControl H2O Water 18.010565 1.0 14127-61-8 CAS SMILES [Ca++] Protein kinase C alpha type Interaction6 Calcium activates Protein kinase C Protein kinase C alpha type DG Phosphatidylinositol 4,5-bisphosphate 3-kinase Q5UE93 UniProt 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 P31749 UniProt IP3 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform ReactionCatalysis101110 ACTIVATION 266 ChemSpider GO:0005737 GENE ONTOLOGY CHEBI:29108 ChEBI P17252 UniProt 1.0 PRKCA PLCB1 PLCG1 Unknown PIK3CG AKT1 VAV1 Calcium Calcium Water Calcium IP3 IP3 DG PIP2 MAPK pathway