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HMDB0061362 HMDB Dual specificity mitogen-activated protein kinase kinase 4 STATs Epidermal growth factor receptor Protein kinase C alpha type direct_interaction Signal transducer and activator of transcription 3 1.0 Dual specificity mitogen-activated protein kinase kinase 1 Serum response factor Mitogen-activated protein kinase 8 P04049 UniProt P19419 UniProt Mitogen-activated protein kinase kinase kinase 1 C47H80O19P3 phosphatidylinositol 4,5-diphosphate 1041.4507 P29353 UniProt Protein kinase C alpha type P01100 UniProt Casein kinase II subunit alpha CHEBI:16595 ChEBI 85166-31-0 CAS Guanosine triphosphate EGF signaling pathway C10H17N5O17P4 Guanosine 3',5'-bis(diphosphate) 602.957 P11831 UniProt P01112 UniProt Tyrosine-protein kinase JAK1 Epidermal growth factor receptor phosphatidylinositol 4,5-diphosphate 6830 PubChem-compound Serum response factor 1,2-diacylglycerol 266 ChemSpider Proto-oncogene c-Fos P17252 UniProt 388557 ChemSpider C10H16N5O14P3 Guanosine triphosphate 522.99066 Growth factor receptor-bound protein 2 Epidermal growth factor receptor Proto-oncogene c-Fos Signal transducer and activator of transcription 2 Inositol 1,4,5-trisphosphate GO:0005886 GENE ONTOLOGY inositol_1,4,5-trisphosphate BioCyc Mitogen-activated protein kinase 8 388562 ChemSpider 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Q07889 UniProt HMDB0000464 HMDB Interaction706 Mitogen-activated protein kinase 8 without Magnesium activates FOS,JUN Complex Interaction708 Signal transducer and activator of transcription 3 activates STATs PW064815 PathWhiz Growth factor receptor-bound protein 2 24742074 PubChem-compound GO:0005634 GENE ONTOLOGY SMILES CC(=O)OCC(CO)OC(C)=O P19174 UniProt GTPase HRas Son of sevenless homolog 1 Signal transducer and activator of transcription 6 C01228 KEGG Compound Guanosine 3',5'-bis(diphosphate) Son of sevenless homolog 1 Transcription factor AP-1 Interaction711 Casein kinase II subunit alpha activates Serum response factor Interaction710 ETS domain-containing protein Elk_1 activates FOS,JUN Complex Interaction717 Ras GTPase-activating protein 1 activates GTPase HRas with GDP, Phosphate Signal transducer and activator of transcription 6 P23458 UniProt Q02750 UniProt 14127-61-8 CAS SMILES [Ca++] Pro-epidermal growth factor GTPase HRas CHEBI:15996 ChEBI Interaction722 Epidermal growth factor receptor activates SHC-transforming protein 1 Interaction724 Epidermal growth factor receptor activates Ras GTPase-activating protein 1 Interaction723 Epidermal growth factor receptor activates Son of sevenless homolog 1 HMDB0059638 HMDB P27361 UniProt Interaction725 Son of sevenless homolog 1 activates Guanosine triphosphate RAF proto-oncogene serine/threonine-protein kinase C6H15O15P3 Inositol 1,4,5-trisphosphate 419.96237 GO:0005737 GENE ONTOLOGY CHEBI:29108 ChEBI C7H12O5 1,2-diacylglycerol 176.06847 Signal transducer and activator of transcription 1-alpha/beta Protein kinase C beta type P52630 UniProt Epidermal growth factor receptor C01245 KEGG Compound Dual specificity mitogen-activated protein kinase kinase 4 Epidermal growth factor receptor Calcium 1.0 SMILES [H][C@]1(COP(O)(=O)OP(O)(O)=O)O[C@@]([H])(N2C=NC3=C2NC(=N)N=C3O)[C@]([H])(O)[C@]1([H])OP(O)(=O)OP(O)(O)=O CHEBI:17633 ChEBI P05771 UniProt P05412 UniProt C00044 KEGG Compound SMILES O[C@@H]1[C@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1OP(O)(O)=O 2.0 Signal transducer and activator of transcription 3 SMP0063810 SMPDB Cytoplasm Interaction198 pro-epidermal growth factor activates Epidermal growth factor receptor Homo sapiens ETS domain-containing protein Elk-1 Interaction637 Inositol 1,4,5-trisphosphate activates Calcium P68400 UniProt 439456 PubChem-compound Signal transducer and activator of transcription 1-alpha/beta 439450 PubChem-compound Tyrosine-protein kinase JAK1 P00533 UniProt Casein kinase II subunit alpha Interaction641 1,2-diacylglycerol activates Protein kinase C complex FOS,JUN Complex Interaction640 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma_1 activates phosphatidylinositol 4,5-diphosphate Interaction643 Mitogen-activated protein kinase 3 activates ETS domain-containing protein Elk_1 Interaction642 Protein kinase C complex activates ETS domain-containing protein Elk_1 Mitogen-activated protein kinase kinase kinase 1 Dual specificity mitogen-activated protein kinase kinase 1 Interaction645 Tyrosine-protein kinase JAK1 activates Signal transducer and activator of transcription 1-alpha/beta Interaction644 Epidermal growth factor receptor activates Tyrosine-protein kinase JAK1 Mitogen-activated protein kinase 3 Interaction646 Tyrosine-protein kinase JAK1 activates Signal transducer and activator of transcription 3 HMDB0001498 HMDB GTPase HRas Ras GTPase-activating protein 1 Signal transducer and activator of transcription 3 Pro-epidermal growth factor SMILES CCCCCCCCCCCCCCCCCC(=O)OCC(COP([O-])(=O)O[C@@H]1[C@H](O)[C@H](O)[C@@H](OP([O-])([O-])=O)[C@H](OP([O-])([O-])=O)[C@H]1O)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC P40763 UniProt Reaction110971 false Guanosine triphosphate → Guanosine 3',5'-bis(diphosphate) LEFT_TO_RIGHT P20936 UniProt 9606 TAXONOMY Q13233 UniProt 1.0 Protein kinase C complex ETS domain-containing protein Elk-1 C00076 KEGG Compound P62993 UniProt SHC-transforming protein 1 P45985 UniProt CA%2b2 BioCyc P45983 UniProt Ca Calcium 39.96259 Cell Membrane Reaction110957 false phosphatidylinositol 4,5-diphosphate → Inositol 1,4,5-trisphosphate LEFT_TO_RIGHT Reaction110956 false phosphatidylinositol 4,5-diphosphate → 1,2-diacylglycerol LEFT_TO_RIGHT ETS domain-containing protein Elk-1 P01133 UniProt Ras GTPase-activating protein 1 6569 ChemSpider 271 PubChem-compound Interaction669 GTPase HRas with GTP activates GTPase HRas with GDP, Phosphate RAF proto-oncogene serine/threonine-protein kinase GTP BioCyc Signal transducer and activator of transcription 1-alpha/beta Protein kinase C beta type Signal transducer and activator of transcription 2 HMDB0001273 HMDB Interaction672 GTPase HRas with GTP activates Mitogen-activated protein kinase kinase kinase 1 without Magnesium Interaction671 GTPase HRas with GTP activates RAF proto-oncogene serine/threonine-protein kinase without zinc Interaction674 Mitogen-activated protein kinase kinase kinase 1 without Magnesium activates Dual specificity mitogen-activated protein kinase kinase 1 Interaction673 RAF proto-oncogene serine/threonine-protein kinase without zinc activates Dual specificity mitogen-activated protein kinase kinase 1 Interaction676 Dual specificity mitogen-activated protein kinase kinase 1 activates Mitogen-activated protein kinase 3 SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1 Interaction678 Dual specificity mitogen-activated protein kinase kinase 4 activates Mitogen-activated protein kinase 8 without Magnesium Interaction677 Mitogen-activated protein kinase kinase kinase 1 without Magnesium activates Dual specificity mitogen-activated protein kinase kinase 4 Mitogen-activated protein kinase 3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 86-01-1 CAS Nucleus 1.0 Mitogen-activated protein kinase 8 Interaction566 Epidermal growth factor receptor activates Growth factor receptor-bound protein 2 Transcription factor AP-1 GTPase HRas SHC-transforming protein 1 Mitogen-activated protein kinase 3 P42226 UniProt P42224 UniProt 1.0 2.0 Pro-epidermal growth factor Epidermal growth factor receptor 1- phosphatidylinositol 4,5- bisphosphate phosphodiesterase gamma-1 Protein kinase C alpha type Protein kinase C beta type ETS domain- containing protein Elk-1 Mitogen- activated protein kinase 3 Tyrosine- protein kinase JAK1 Signal transducer and activator of transcription 1-alpha/beta Signal transducer and activator of transcription 3 GTPase HRas GTPase HRas RAF proto-oncogene serine/threonine- protein kinase Mitogen- activated protein kinase kinase kinase 1 Dual specificity mitogen- activated protein kinase kinase 1 Mitogen- activated protein kinase 3 Dual specificity mitogen- activated protein kinase kinase 4 Mitogen- activated protein kinase 8 Transcription factor AP-1 Proto-oncogene c-Fos Signal transducer and activator of transcription 3 Signal transducer and activator of transcription 1-alpha/beta Signal transducer and activator of transcription 2 Signal transducer and activator of transcription 6 Casein kinase II subunit alpha Serum response factor Ras GTPase- activating protein 1 Growth factor receptor-bound protein 2 SHC- transforming protein 1 Son of sevenless homolog 1 Ras GTPase- activating protein 1 Inositol 1,4,5- trisphosphate Ca + phosphatidylinositol 4,5-diphosphate 1,2- diacylglycerol GTP Guanosine 3',5'- bis(diphosphate) Guanosine triphosphate Guanosine diphosphate Phosphate ion Efflux Ca2+ from Hydrolyses EBS;SRE;SIE;TRE Cytoplasm Nucleus Extracellular Environment
HMDB0061362 HMDB Dual specificity mitogen-activated protein kinase kinase 4 STATs Epidermal growth factor receptor Protein kinase C alpha type direct_interaction Signal transducer and activator of transcription 3 1.0 Dual specificity mitogen-activated protein kinase kinase 1 Serum response factor Mitogen-activated protein kinase 8 P04049 UniProt P19419 UniProt Mitogen-activated protein kinase kinase kinase 1 C47H80O19P3 phosphatidylinositol 4,5-diphosphate 1041.4507 P29353 UniProt Protein kinase C alpha type P01100 UniProt Casein kinase II subunit alpha CHEBI:16595 ChEBI 85166-31-0 CAS Guanosine triphosphate EGF signaling pathway C10H17N5O17P4 Guanosine 3',5'-bis(diphosphate) 602.957 P11831 UniProt P01112 UniProt Tyrosine-protein kinase JAK1 Epidermal growth factor receptor phosphatidylinositol 4,5-diphosphate 6830 PubChem-compound Serum response factor 1,2-diacylglycerol 266 ChemSpider Proto-oncogene c-Fos P17252 UniProt 388557 ChemSpider C10H16N5O14P3 Guanosine triphosphate 522.99066 Growth factor receptor-bound protein 2 Epidermal growth factor receptor Proto-oncogene c-Fos Signal transducer and activator of transcription 2 Inositol 1,4,5-trisphosphate GO:0005886 GENE ONTOLOGY inositol_1,4,5-trisphosphate BioCyc Mitogen-activated protein kinase 8 388562 ChemSpider 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Q07889 UniProt HMDB0000464 HMDB Interaction706 Mitogen-activated protein kinase 8 without Magnesium activates FOS,JUN Complex Interaction708 Signal transducer and activator of transcription 3 activates STATs PW064815 PathWhiz Growth factor receptor-bound protein 2 24742074 PubChem-compound GO:0005634 GENE ONTOLOGY SMILES CC(=O)OCC(CO)OC(C)=O P19174 UniProt GTPase HRas Son of sevenless homolog 1 Signal transducer and activator of transcription 6 C01228 KEGG Compound Guanosine 3',5'-bis(diphosphate) Son of sevenless homolog 1 Transcription factor AP-1 Interaction711 Casein kinase II subunit alpha activates Serum response factor Interaction710 ETS domain-containing protein Elk_1 activates FOS,JUN Complex Interaction717 Ras GTPase-activating protein 1 activates GTPase HRas with GDP, Phosphate Signal transducer and activator of transcription 6 P23458 UniProt Q02750 UniProt 14127-61-8 CAS SMILES [Ca++] Pro-epidermal growth factor GTPase HRas CHEBI:15996 ChEBI Interaction722 Epidermal growth factor receptor activates SHC-transforming protein 1 Interaction724 Epidermal growth factor receptor activates Ras GTPase-activating protein 1 Interaction723 Epidermal growth factor receptor activates Son of sevenless homolog 1 HMDB0059638 HMDB P27361 UniProt Interaction725 Son of sevenless homolog 1 activates Guanosine triphosphate RAF proto-oncogene serine/threonine-protein kinase C6H15O15P3 Inositol 1,4,5-trisphosphate 419.96237 GO:0005737 GENE ONTOLOGY CHEBI:29108 ChEBI C7H12O5 1,2-diacylglycerol 176.06847 Signal transducer and activator of transcription 1-alpha/beta Protein kinase C beta type P52630 UniProt Epidermal growth factor receptor C01245 KEGG Compound Dual specificity mitogen-activated protein kinase kinase 4 Epidermal growth factor receptor Calcium 1.0 SMILES [H][C@]1(COP(O)(=O)OP(O)(O)=O)O[C@@]([H])(N2C=NC3=C2NC(=N)N=C3O)[C@]([H])(O)[C@]1([H])OP(O)(=O)OP(O)(O)=O CHEBI:17633 ChEBI P05771 UniProt P05412 UniProt C00044 KEGG Compound SMILES O[C@@H]1[C@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H](O)[C@@H]1OP(O)(O)=O 2.0 Signal transducer and activator of transcription 3 SMP0063810 SMPDB Cytoplasm Interaction198 pro-epidermal growth factor activates Epidermal growth factor receptor Homo sapiens ETS domain-containing protein Elk-1 Interaction637 Inositol 1,4,5-trisphosphate activates Calcium P68400 UniProt 439456 PubChem-compound Signal transducer and activator of transcription 1-alpha/beta 439450 PubChem-compound Tyrosine-protein kinase JAK1 P00533 UniProt Casein kinase II subunit alpha Interaction641 1,2-diacylglycerol activates Protein kinase C complex FOS,JUN Complex Interaction640 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma_1 activates phosphatidylinositol 4,5-diphosphate Interaction643 Mitogen-activated protein kinase 3 activates ETS domain-containing protein Elk_1 Interaction642 Protein kinase C complex activates ETS domain-containing protein Elk_1 Mitogen-activated protein kinase kinase kinase 1 Dual specificity mitogen-activated protein kinase kinase 1 Interaction645 Tyrosine-protein kinase JAK1 activates Signal transducer and activator of transcription 1-alpha/beta Interaction644 Epidermal growth factor receptor activates Tyrosine-protein kinase JAK1 Mitogen-activated protein kinase 3 Interaction646 Tyrosine-protein kinase JAK1 activates Signal transducer and activator of transcription 3 HMDB0001498 HMDB GTPase HRas Ras GTPase-activating protein 1 Signal transducer and activator of transcription 3 Pro-epidermal growth factor SMILES CCCCCCCCCCCCCCCCCC(=O)OCC(COP([O-])(=O)O[C@@H]1[C@H](O)[C@H](O)[C@@H](OP([O-])([O-])=O)[C@H](OP([O-])([O-])=O)[C@H]1O)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC P40763 UniProt Reaction110971 false Guanosine triphosphate → Guanosine 3',5'-bis(diphosphate) LEFT_TO_RIGHT P20936 UniProt 9606 TAXONOMY Q13233 UniProt 1.0 Protein kinase C complex ETS domain-containing protein Elk-1 C00076 KEGG Compound P62993 UniProt SHC-transforming protein 1 P45985 UniProt CA%2b2 BioCyc P45983 UniProt Ca Calcium 39.96259 Cell Membrane Reaction110957 false phosphatidylinositol 4,5-diphosphate → Inositol 1,4,5-trisphosphate LEFT_TO_RIGHT Reaction110956 false phosphatidylinositol 4,5-diphosphate → 1,2-diacylglycerol LEFT_TO_RIGHT ETS domain-containing protein Elk-1 P01133 UniProt Ras GTPase-activating protein 1 6569 ChemSpider 271 PubChem-compound Interaction669 GTPase HRas with GTP activates GTPase HRas with GDP, Phosphate RAF proto-oncogene serine/threonine-protein kinase GTP BioCyc Signal transducer and activator of transcription 1-alpha/beta Protein kinase C beta type Signal transducer and activator of transcription 2 HMDB0001273 HMDB Interaction672 GTPase HRas with GTP activates Mitogen-activated protein kinase kinase kinase 1 without Magnesium Interaction671 GTPase HRas with GTP activates RAF proto-oncogene serine/threonine-protein kinase without zinc Interaction674 Mitogen-activated protein kinase kinase kinase 1 without Magnesium activates Dual specificity mitogen-activated protein kinase kinase 1 Interaction673 RAF proto-oncogene serine/threonine-protein kinase without zinc activates Dual specificity mitogen-activated protein kinase kinase 1 Interaction676 Dual specificity mitogen-activated protein kinase kinase 1 activates Mitogen-activated protein kinase 3 SMILES NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1 Interaction678 Dual specificity mitogen-activated protein kinase kinase 4 activates Mitogen-activated protein kinase 8 without Magnesium Interaction677 Mitogen-activated protein kinase kinase kinase 1 without Magnesium activates Dual specificity mitogen-activated protein kinase kinase 4 Mitogen-activated protein kinase 3 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 86-01-1 CAS Nucleus 1.0 Mitogen-activated protein kinase 8 Interaction566 Epidermal growth factor receptor activates Growth factor receptor-bound protein 2 Transcription factor AP-1 GTPase HRas SHC-transforming protein 1 Mitogen-activated protein kinase 3 P42226 UniProt P42224 UniProt 1.0 2.0 Nucleus EGF EGFR PLCG1 PRKCA PRKCB ELK1 MAPK3 JAK1 STAT1 STAT3 HRAS Unknown RAF1 MAP3K1 MAP2K1 MAPK3 MAP2K4 MAPK8 JUN FOS STAT3 STAT1 STAT2 STAT6 CSNK2A1 SRF RASA1 GRB2 Unknown SOS1 RASA1 Inositol 1,4,5- trisphosphate Calcium phosphatidylinositol 4,5-diphosphate 1,2- diacylglycerol Guanosine triphosphate Guanosine 3',5'- bis(diphosphate)