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C20H32O2 Arachidonic acid 304.24023 CHEBI:15843 ChEBI cAMP-dependent protein kinase catalytic subunit alpha Q13393 UniProt Interaction696 cAMP-dependent protein kinase catalytic subunit alpha activates Cyclic AMP-dependent transcription factor ATF-4 (Homo sapiens) + Phosphate Dual specificity mitogen-activated protein kinase kinase 7 Interaction577 Phospholipase D1 activates Phosphatidic Acid Interaction698 Cyclic AMP-dependent transcription factor ATF-4 (Homo sapiens) + Phosphate activates Lutropin subunit beta Epidermal growth factor receptor Interaction576 Cytosolic phospholipase A2 beta activates Arachidonic acid Interaction697 Cyclic AMP-dependent transcription factor ATF-4 (Homo sapiens) + Phosphate activates Follitropin subunit beta Interaction579 Cell division control protein 42 homolog activates Mitogen-activated protein kinase kinase kinase 1 Protein kinase C alpha type Interaction578 Proto-oncogene tyrosine-protein kinase Src activates Cell division control protein 42 homolog Interaction699 Cyclic AMP-dependent transcription factor ATF-4 (Homo sapiens) + Phosphate activates Glycoprotein hormones alpha chain P28482 UniProt 1.0 direct_interaction Matrix metalloproteinase-14 Dual specificity mitogen-activated protein kinase kinase 1 P0C869 UniProt 1.0 Cyclic AMP-dependent transcription factor ATF-4 (Homo sapiens)_Phosphate Mitogen-activated protein kinase 8 P04049 UniProt Protein kinase C alpha type Mitogen-activated protein kinase 14 Mitogen-activated protein kinase kinase kinase 1 P19419 UniProt Progonadoliberin-1 Gonadotropin-releasing hormone receptor Proheparin-binding EGF-like growth factor 1.0 Phosphate_Mitogen-activated protein kinase 8 (Homo sapiens) Voltage-depenent L-type calcium channel P01215 UniProt C10H12N5O6P cAMP 329.05252 Protein kinase C alpha type C00219 KEGG Compound Proheparin-binding EGF-like growth factor Cell division control protein 42 homolog Cyclic AMP-dependent transcription factor ATF-4 C00575 KEGG Compound Protein kinase C beta type Q9NQ66 UniProt Q13936 UniProt P01225 UniProt 1.0 GnRH Signaling Pathway P01229 UniProt P50281 UniProt P01112 UniProt O4P Phosphate 94.95342 1.0 Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens)_Phosphate 5851 ChemSpider BiologicalState217 Saccharomyces cerevisiae O43707 UniProt 266 ChemSpider Glycoprotein hormones alpha chain Q8TD86 UniProt Mitogen-activated protein kinase 1 P17252 UniProt Q16539 UniProt 1.0 1.0 Mitogen-activated protein kinase 1 Voltage-dependent calcium channel subunit alpha-2/delta-2 Growth factor receptor-bound protein 2 Epidermal growth factor receptor DG SMILES [O-]P([O-])([O-])=O Voltage-dependent L-type calcium channel subunit alpha-1F GO:0005886 GENE ONTOLOGY Phospholipase D1 C00009 KEGG Compound ETS domain-containing protein Elk-1 Phosphate_Mitogen-activated protein kinase 1 (Homo sapiens) 1.0 HMDB0001429 HMDB Interaction700 Mitogen-activated protein kinase kinase kinase 2 activates Dual specificity mitogen-activated protein kinase kinase 3 (Homo sapiens) + Phosphate Interaction702 Protein kinase C complex activates RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens) + Phosphate CHEBI:18367 ChEBI Interaction701 Dual specificity mitogen-activated protein kinase kinase 3 (Homo sapiens) + Phosphate activates Mitogen-activated protein kinase 14 (Homo sapiens) + Phosphate Q9NY47 UniProt 1032 ChemSpider Q07889 UniProt Interaction703 GTPase HRas activates RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens) + Phosphate HMDB0000464 HMDB 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 O60840 UniProt Interaction705 RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens) + Phosphate activates Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens) + Phosphate Interaction707 Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens) + Phosphate activates Phosphate + Mitogen-activated protein kinase 1 (Homo sapiens) Phosphate_Early growth response protein 1 (Homo sapiens)_ELK1 (Homo sapiens) Interaction709 Phosphate + Mitogen-activated protein kinase 1 (Homo sapiens) activates Phosphate + Early growth response protein 1 (Homo sapiens) + ELK1 (Homo sapiens) Growth factor receptor-bound protein 2 GO:0005634 GENE ONTOLOGY PW064816 PathWhiz Follitropin subunit beta Son of sevenless homolog 1 Epidermal growth factor receptor Q9Y2U5 UniProt Gonadotropin-releasing hormone receptor CHEBI:17489 ChEBI Son of sevenless homolog 1 P60953 UniProt CAMP BioCyc 72 kDa type IV collagenase Protein kinase C complex Q01668 UniProt 1.0 Phosphate_Transcription factor AP-1 (Homo sapiens) Transcription factor AP-1 Interaction713 Phosphate + Early growth response protein 1 (Homo sapiens) + ELK1 (Homo sapiens) activates Glycoprotein hormones alpha chain Interaction712 Phosphate + Early growth response protein 1 (Homo sapiens) + ELK1 (Homo sapiens) activates Lutropin subunit beta 444899 PubChem-compound Interaction715 Mitogen-activated protein kinase kinase kinase 1 activates Phosphate + Dual specificity mitogen-activated protein kinase kinase 7 (Homo sapiens) Extracellular Space Interaction714 Phosphate + Early growth response protein 1 (Homo sapiens) + ELK1 (Homo sapiens) activates Follitropin subunit beta Voltage-dependent L-type calcium channel subunit alpha-1D Q96NW7 UniProt Interaction716 Phosphate + Dual specificity mitogen-activated protein kinase kinase 7 (Homo sapiens) activates Phosphate + Mitogen-activated protein kinase 8 (Homo sapiens) Q08828 UniProt Interaction719 Phosphate + Transcription factor AP-1 (Homo sapiens) activates Lutropin subunit beta Q02750 UniProt Interaction718 Phosphate + Mitogen-activated protein kinase 8 (Homo sapiens) activates Phosphate + Transcription factor AP-1 (Homo sapiens) 14127-61-8 CAS SMILES [Ca++] 1.0 1.0 Calmodulin-like protein 6 RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens)_Phosphate DG GTPase HRas Interaction720 Phosphate + Transcription factor AP-1 (Homo sapiens) activates Glycoprotein hormones alpha chain Interaction721 Phosphate + Transcription factor AP-1 (Homo sapiens) activates Follitropin subunit beta Calcium/calmodulin-dependent protein kinase type II subunit alpha Leucine-rich repeat-containing protein 7 cAMP-dependent protein kinase catalytic subunit alpha RAF proto-oncogene serine/threonine-protein kinase GO:0005615 GENE ONTOLOGY CHEBI:29108 ChEBI GO:0005737 GENE ONTOLOGY 60-92-4 CAS 2.0 Arachidonic acid Dual specificity mitogen-activated protein kinase kinase 7 cAMP Calmodulin-like protein 6 Cytosolic phospholipase A2 beta Gonadotropin-releasing hormone receptor Q14643 UniProt Progonadoliberin-1 Protein kinase C beta type Inositol 1,4,5-trisphosphate receptor type 1 Endoplasmic Reticulum Dual specificity mitogen-activated protein kinase kinase 3 (Homo sapiens)_Phosphate CPD-8587 BioCyc Epidermal growth factor receptor Cyclic AMP-dependent transcription factor ATF-4 P30968 UniProt Leucine-rich repeat-containing protein 7 Voltage-dependent L-type calcium channel subunit alpha-1S 72 kDa type IV collagenase Epidermal growth factor receptor Early growth response protein 1 Dual specificity mitogen-activated protein kinase kinase 7 Calcium 1.0 IP3 Phosphatidic Acid 392692 ChemSpider Voltage-dependent L-type calcium channel subunit alpha-1D P05771 UniProt Voltage-dependent L-type calcium channel subunit alpha-1C Cell division control protein 42 homolog Voltage-dependent L-type calcium channel subunit alpha-1S P05412 UniProt Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Phosphate P18848 UniProt Q02641 UniProt Alpha-actinin-4 Q9UQM7 UniProt Adenylate cyclase type 1 P63092 UniProt Cytoplasm Voltage-dependent L-type calcium channel subunit alpha-1D SMP0063811 SMPDB 1.0 1.0 P29992 UniProt Phospholipase D1 Voltage-dependent L-type calcium channel subunit alpha-1C Lutropin subunit beta Homo sapiens Glycoprotein hormones alpha chain SMILES CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O Follitropin subunit beta P08253 UniProt Cytosolic phospholipase A2 beta Guanine nucleotide-binding protein subunit alpha-11 Phosphatidic Acid P46734 UniProt O14733 UniProt P00533 UniProt GO:0005783 GENE ONTOLOGY Voltage-dependent calcium channel subunit alpha-2/delta-2 Voltage-dependent L-type calcium channel subunit alpha-1F Guanine nucleotide-binding protein subunit alpha-11 Transport1187 false Calcium (?) Transport: Homo sapiens, Cell, Endoplasmic Reticulum to Homo sapiens, Cell, Cytoplasm LEFT_TO_RIGHT Mitogen-activated protein kinase kinase kinase 1 Dual specificity mitogen-activated protein kinase kinase 1 Adenylate cyclase type 1 Matrix metalloproteinase-14 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 Phosphate_Dual specificity mitogen-activated protein kinase kinase 7 (Homo sapiens) Voltage-dependent L-type calcium channel IP3 GO:0016020 GENE ONTOLOGY SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@@H]2COP(O)(=O)O[C@H]2[C@H]1O Alpha-actinin-4 Proto-oncogene tyrosine-protein kinase Src Inositol 1,4,5-trisphosphate receptor type 1 Mitogen-activated protein kinase 14 (Homo sapiens)_Phosphate Voltage-dependent L-type calcium channel subunit alpha-1S 9606 TAXONOMY Voltage-dependent L-type calcium channel subunit alpha-1F Q13233 UniProt P12931 UniProt Voltage-dependent L-type calcium channel subunit beta-1 Mitogen-activated protein kinase kinase kinase 2 Protein kinase C complex Interaction533 Growth factor receptor-bound protein 2 activates Son of sevenless homolog 1 Proto-oncogene tyrosine-protein kinase Src C00076 KEGG Compound P62993 UniProt CA%2b2 BioCyc P45983 UniProt HMDB0000058 HMDB ETS domain-containing protein Elk-1 cAMP-dependent protein kinase catalytic subunit alpha Ca Calcium 39.96259 1.0 Cell Membrane Mitogen-activated protein kinase 14 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short 14265-44-2 CAS 271 PubChem-compound Interaction548 Gonadotropin-releasing hormone receptor activates Guanine nucleotide-binding protein alpha RAF proto-oncogene serine/threonine-protein kinase Interaction547 Progonadoliberin-1 activates Gonadotropin-releasing hormone receptor Phosphate Interaction549 Guanine nucleotide-binding protein alpha activates Adenylate cyclase type 1 Proheparin-binding EGF-like growth factor Protein kinase C beta type Calcium 1.0 Membrane 1.0 Voltage-dependent L-type calcium channel subunit beta-1 Interaction551 cAMP activates cAMP-dependent protein kinase catalytic subunit alpha 4932 TAXONOMY Interaction550 Adenylate cyclase type 1 activates cAMP Interaction553 Gonadotropin-releasing hormone receptor activates Guanine nucleotide-binding protein subunit alpha-11 Interaction555 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta1 activates IP3 Interaction554 Guanine nucleotide-binding protein subunit alpha-11 activates 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta1 Interaction557 Calcium activates Calmodulin-like protein 6 Phosphate_Mitogen-activated protein kinase 1 (Homo sapiens) Interaction556 IP3 activates Inositol 1,4,5-trisphosphate receptor type 1 Calcium/calmodulin-dependent protein kinase type II subunit alpha Q99075 UniProt Interaction559 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta1 activates DG Interaction558 Calmodulin-like protein 6 activates Ternary complex (LRRC7, CAMK2a, ACTN4) 1.0 Voltage-dependent L-type calcium channel subunit alpha-1C Mitogen-activated protein kinase 1 P01148 UniProt HMDB0001043 HMDB Q13698 UniProt 1.0 Nucleus 506-32-1 CAS 1061 PubChem-compound 6076 PubChem-compound Interaction560 DG activates Protein kinase C complex 1.0 Voltage-dependent L-type calcium channel Interaction562 Voltage-dependent L-type calcium channel activates Protein kinase C complex Interaction561 Calcium activates Voltage-dependent L-type calcium channel Calcium Interaction564 MMP2-MMP14 activates Proheparin-binding EGF-like growth factor Mitogen-activated protein kinase kinase kinase 2 Mitogen-activated protein kinase 8 Interaction563 Protein kinase C complex activates Voltage-depenent L-type calcium channel Interaction566 Epidermal growth factor receptor activates Growth factor receptor-bound protein 2 Interaction565 Proheparin-binding EGF-like growth factor activates Epidermal growth factor receptor Dual specificity mitogen-activated protein kinase kinase 3 Transcription factor AP-1 Interaction567 Son of sevenless homolog 1 activates GTPase HRas GTPase HRas 1.0 P18146 UniProt Early growth response protein 1 Phosphate_Dual specificity mitogen-activated protein kinase kinase 7 (Homo sapiens) IP3 MMP2-MMP14 ARACHIDONIC_ACID BioCyc Dual specificity mitogen-activated protein kinase kinase 3 P17612 UniProt Ternary complex (LRRC7, CAMK2a, ACTN4) 1.0 Lutropin subunit beta 1.0 2.0 Mitogen- activated protein kinase 7 Protein- tyrosine kinase 2-beta Guanine nucleotide- binding protein G(s) subunit alpha isoforms short Adenylate cyclase type 1 cAMP-dependent protein kinase catalytic subunit alpha Guanine nucleotide- binding protein subunit alpha-11 1- phosphatidylinositol 4,5- bisphosphate phosphodiesterase beta-1 Inositol 1,4,5- trisphosphate receptor type 1 Calmodulin-like protein 6 Calcium/calmodulin- dependent protein kinase type II subunit alpha Protein kinase C beta type Voltage- dependent L-type calcium channel subunit alpha-1D Voltage- dependent L-type calcium channel subunit alpha-1S Voltage- dependent L-type calcium channel subunit alpha-1C Matrix metalloproteinase- 14 72 kDa type IV collagenase Proheparin- binding EGF-like growth factor Epidermal growth factor receptor Growth factor receptor-bound protein 2 Son of sevenless homolog 1 GTPase HRas Cytosolic phospholipase A2 beta Phospholipase D1 Proto-oncogene tyrosine- protein kinase Src Cell division control protein 42 homolog Mitogen- activated protein kinase kinase kinase 1 Progonadoliberin- 1 Gonadotropin- releasing hormone receptor Mitogen- activated protein kinase kinase kinase 2 Lutropin subunit beta Glycoprotein hormones alpha chain Follitropin subunit beta Cyclic AMP-dependent transcription factor ATF-4 Dual specificity mitogen- activated protein kinase kinase 3 Mitogen- activated protein kinase 14 RAF proto-oncogene serine/threonine- protein kinase Dual specificity mitogen- activated protein kinase kinase 1 Mitogen- activated protein kinase 1 Early growth response protein 1 ETS domain- containing protein Elk-1 Dual specificity mitogen- activated protein kinase kinase 7 Mitogen- activated protein kinase 8 Transcription factor AP-1 cAMP Ca + Ca + Arachidonic acid Ca + P i P i P i P i P i P i P i P i P i P i Protein kinase C alpha type IP3 DG Phosphatidic Acid Neuroactive ligand-receptor interaction Gonadotropins gene expression & secretion Indirect link or Unknown reaction cytokine-cytokine receptor interactions Indirect link or Unknown reaction Extracellular Space Cytoplasm of Pituitary gonadotrope cell Nucleus Indirect link or Unknown reaction cAMP Signaling Pathway Calcium Signaling Pathway Erk1/Erk2 Mapk Signaling Pathway
C20H32O2 Arachidonic acid 304.24023 CHEBI:15843 ChEBI cAMP-dependent protein kinase catalytic subunit alpha Q13393 UniProt Interaction696 cAMP-dependent protein kinase catalytic subunit alpha activates Cyclic AMP-dependent transcription factor ATF-4 (Homo sapiens) + Phosphate Dual specificity mitogen-activated protein kinase kinase 7 Interaction577 Phospholipase D1 activates Phosphatidic Acid Interaction698 Cyclic AMP-dependent transcription factor ATF-4 (Homo sapiens) + Phosphate activates Lutropin subunit beta Epidermal growth factor receptor Interaction576 Cytosolic phospholipase A2 beta activates Arachidonic acid Interaction697 Cyclic AMP-dependent transcription factor ATF-4 (Homo sapiens) + Phosphate activates Follitropin subunit beta Interaction579 Cell division control protein 42 homolog activates Mitogen-activated protein kinase kinase kinase 1 Protein kinase C alpha type Interaction578 Proto-oncogene tyrosine-protein kinase Src activates Cell division control protein 42 homolog Interaction699 Cyclic AMP-dependent transcription factor ATF-4 (Homo sapiens) + Phosphate activates Glycoprotein hormones alpha chain P28482 UniProt 1.0 direct_interaction Matrix metalloproteinase-14 Dual specificity mitogen-activated protein kinase kinase 1 P0C869 UniProt 1.0 Cyclic AMP-dependent transcription factor ATF-4 (Homo sapiens)_Phosphate Mitogen-activated protein kinase 8 P04049 UniProt Protein kinase C alpha type Mitogen-activated protein kinase 14 Mitogen-activated protein kinase kinase kinase 1 P19419 UniProt Progonadoliberin-1 Gonadotropin-releasing hormone receptor Proheparin-binding EGF-like growth factor 1.0 Phosphate_Mitogen-activated protein kinase 8 (Homo sapiens) Voltage-depenent L-type calcium channel P01215 UniProt C10H12N5O6P cAMP 329.05252 Protein kinase C alpha type C00219 KEGG Compound Proheparin-binding EGF-like growth factor Cell division control protein 42 homolog Cyclic AMP-dependent transcription factor ATF-4 C00575 KEGG Compound Protein kinase C beta type Q9NQ66 UniProt Q13936 UniProt P01225 UniProt 1.0 GnRH Signaling Pathway P01229 UniProt P50281 UniProt P01112 UniProt O4P Phosphate 94.95342 1.0 Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens)_Phosphate 5851 ChemSpider BiologicalState217 Saccharomyces cerevisiae O43707 UniProt 266 ChemSpider Glycoprotein hormones alpha chain Q8TD86 UniProt Mitogen-activated protein kinase 1 P17252 UniProt Q16539 UniProt 1.0 1.0 Mitogen-activated protein kinase 1 Voltage-dependent calcium channel subunit alpha-2/delta-2 Growth factor receptor-bound protein 2 Epidermal growth factor receptor DG SMILES [O-]P([O-])([O-])=O Voltage-dependent L-type calcium channel subunit alpha-1F GO:0005886 GENE ONTOLOGY Phospholipase D1 C00009 KEGG Compound ETS domain-containing protein Elk-1 Phosphate_Mitogen-activated protein kinase 1 (Homo sapiens) 1.0 HMDB0001429 HMDB Interaction700 Mitogen-activated protein kinase kinase kinase 2 activates Dual specificity mitogen-activated protein kinase kinase 3 (Homo sapiens) + Phosphate Interaction702 Protein kinase C complex activates RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens) + Phosphate CHEBI:18367 ChEBI Interaction701 Dual specificity mitogen-activated protein kinase kinase 3 (Homo sapiens) + Phosphate activates Mitogen-activated protein kinase 14 (Homo sapiens) + Phosphate Q9NY47 UniProt 1032 ChemSpider Q07889 UniProt Interaction703 GTPase HRas activates RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens) + Phosphate HMDB0000464 HMDB 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 O60840 UniProt Interaction705 RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens) + Phosphate activates Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens) + Phosphate Interaction707 Dual specificity mitogen-activated protein kinase kinase 1 (Homo sapiens) + Phosphate activates Phosphate + Mitogen-activated protein kinase 1 (Homo sapiens) Phosphate_Early growth response protein 1 (Homo sapiens)_ELK1 (Homo sapiens) Interaction709 Phosphate + Mitogen-activated protein kinase 1 (Homo sapiens) activates Phosphate + Early growth response protein 1 (Homo sapiens) + ELK1 (Homo sapiens) Growth factor receptor-bound protein 2 GO:0005634 GENE ONTOLOGY PW064816 PathWhiz Follitropin subunit beta Son of sevenless homolog 1 Epidermal growth factor receptor Q9Y2U5 UniProt Gonadotropin-releasing hormone receptor CHEBI:17489 ChEBI Son of sevenless homolog 1 P60953 UniProt CAMP BioCyc 72 kDa type IV collagenase Protein kinase C complex Q01668 UniProt 1.0 Phosphate_Transcription factor AP-1 (Homo sapiens) Transcription factor AP-1 Interaction713 Phosphate + Early growth response protein 1 (Homo sapiens) + ELK1 (Homo sapiens) activates Glycoprotein hormones alpha chain Interaction712 Phosphate + Early growth response protein 1 (Homo sapiens) + ELK1 (Homo sapiens) activates Lutropin subunit beta 444899 PubChem-compound Interaction715 Mitogen-activated protein kinase kinase kinase 1 activates Phosphate + Dual specificity mitogen-activated protein kinase kinase 7 (Homo sapiens) Extracellular Space Interaction714 Phosphate + Early growth response protein 1 (Homo sapiens) + ELK1 (Homo sapiens) activates Follitropin subunit beta Voltage-dependent L-type calcium channel subunit alpha-1D Q96NW7 UniProt Interaction716 Phosphate + Dual specificity mitogen-activated protein kinase kinase 7 (Homo sapiens) activates Phosphate + Mitogen-activated protein kinase 8 (Homo sapiens) Q08828 UniProt Interaction719 Phosphate + Transcription factor AP-1 (Homo sapiens) activates Lutropin subunit beta Q02750 UniProt Interaction718 Phosphate + Mitogen-activated protein kinase 8 (Homo sapiens) activates Phosphate + Transcription factor AP-1 (Homo sapiens) 14127-61-8 CAS SMILES [Ca++] 1.0 1.0 Calmodulin-like protein 6 RAF proto-oncogene serine/threonine-protein kinase (Homo sapiens)_Phosphate DG GTPase HRas Interaction720 Phosphate + Transcription factor AP-1 (Homo sapiens) activates Glycoprotein hormones alpha chain Interaction721 Phosphate + Transcription factor AP-1 (Homo sapiens) activates Follitropin subunit beta Calcium/calmodulin-dependent protein kinase type II subunit alpha Leucine-rich repeat-containing protein 7 cAMP-dependent protein kinase catalytic subunit alpha RAF proto-oncogene serine/threonine-protein kinase GO:0005615 GENE ONTOLOGY CHEBI:29108 ChEBI GO:0005737 GENE ONTOLOGY 60-92-4 CAS 2.0 Arachidonic acid Dual specificity mitogen-activated protein kinase kinase 7 cAMP Calmodulin-like protein 6 Cytosolic phospholipase A2 beta Gonadotropin-releasing hormone receptor Q14643 UniProt Progonadoliberin-1 Protein kinase C beta type Inositol 1,4,5-trisphosphate receptor type 1 Endoplasmic Reticulum Dual specificity mitogen-activated protein kinase kinase 3 (Homo sapiens)_Phosphate CPD-8587 BioCyc Epidermal growth factor receptor Cyclic AMP-dependent transcription factor ATF-4 P30968 UniProt Leucine-rich repeat-containing protein 7 Voltage-dependent L-type calcium channel subunit alpha-1S 72 kDa type IV collagenase Epidermal growth factor receptor Early growth response protein 1 Dual specificity mitogen-activated protein kinase kinase 7 Calcium 1.0 IP3 Phosphatidic Acid 392692 ChemSpider Voltage-dependent L-type calcium channel subunit alpha-1D P05771 UniProt Voltage-dependent L-type calcium channel subunit alpha-1C Cell division control protein 42 homolog Voltage-dependent L-type calcium channel subunit alpha-1S P05412 UniProt Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Phosphate P18848 UniProt Q02641 UniProt Alpha-actinin-4 Q9UQM7 UniProt Adenylate cyclase type 1 P63092 UniProt Cytoplasm Voltage-dependent L-type calcium channel subunit alpha-1D SMP0063811 SMPDB 1.0 1.0 P29992 UniProt Phospholipase D1 Voltage-dependent L-type calcium channel subunit alpha-1C Lutropin subunit beta Homo sapiens Glycoprotein hormones alpha chain SMILES CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O Follitropin subunit beta P08253 UniProt Cytosolic phospholipase A2 beta Guanine nucleotide-binding protein subunit alpha-11 Phosphatidic Acid P46734 UniProt O14733 UniProt P00533 UniProt GO:0005783 GENE ONTOLOGY Voltage-dependent calcium channel subunit alpha-2/delta-2 Voltage-dependent L-type calcium channel subunit alpha-1F Guanine nucleotide-binding protein subunit alpha-11 Transport1187 false Calcium (?) Transport: Homo sapiens, Cell, Endoplasmic Reticulum to Homo sapiens, Cell, Cytoplasm LEFT_TO_RIGHT Mitogen-activated protein kinase kinase kinase 1 Dual specificity mitogen-activated protein kinase kinase 1 Adenylate cyclase type 1 Matrix metalloproteinase-14 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 Phosphate_Dual specificity mitogen-activated protein kinase kinase 7 (Homo sapiens) Voltage-dependent L-type calcium channel IP3 GO:0016020 GENE ONTOLOGY SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@@H]2COP(O)(=O)O[C@H]2[C@H]1O Alpha-actinin-4 Proto-oncogene tyrosine-protein kinase Src Inositol 1,4,5-trisphosphate receptor type 1 Mitogen-activated protein kinase 14 (Homo sapiens)_Phosphate Voltage-dependent L-type calcium channel subunit alpha-1S 9606 TAXONOMY Voltage-dependent L-type calcium channel subunit alpha-1F Q13233 UniProt P12931 UniProt Voltage-dependent L-type calcium channel subunit beta-1 Mitogen-activated protein kinase kinase kinase 2 Protein kinase C complex Interaction533 Growth factor receptor-bound protein 2 activates Son of sevenless homolog 1 Proto-oncogene tyrosine-protein kinase Src C00076 KEGG Compound P62993 UniProt CA%2b2 BioCyc P45983 UniProt HMDB0000058 HMDB ETS domain-containing protein Elk-1 cAMP-dependent protein kinase catalytic subunit alpha Ca Calcium 39.96259 1.0 Cell Membrane Mitogen-activated protein kinase 14 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short 14265-44-2 CAS 271 PubChem-compound Interaction548 Gonadotropin-releasing hormone receptor activates Guanine nucleotide-binding protein alpha RAF proto-oncogene serine/threonine-protein kinase Interaction547 Progonadoliberin-1 activates Gonadotropin-releasing hormone receptor Phosphate Interaction549 Guanine nucleotide-binding protein alpha activates Adenylate cyclase type 1 Proheparin-binding EGF-like growth factor Protein kinase C beta type Calcium 1.0 Membrane 1.0 Voltage-dependent L-type calcium channel subunit beta-1 Interaction551 cAMP activates cAMP-dependent protein kinase catalytic subunit alpha 4932 TAXONOMY Interaction550 Adenylate cyclase type 1 activates cAMP Interaction553 Gonadotropin-releasing hormone receptor activates Guanine nucleotide-binding protein subunit alpha-11 Interaction555 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta1 activates IP3 Interaction554 Guanine nucleotide-binding protein subunit alpha-11 activates 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta1 Interaction557 Calcium activates Calmodulin-like protein 6 Phosphate_Mitogen-activated protein kinase 1 (Homo sapiens) Interaction556 IP3 activates Inositol 1,4,5-trisphosphate receptor type 1 Calcium/calmodulin-dependent protein kinase type II subunit alpha Q99075 UniProt Interaction559 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta1 activates DG Interaction558 Calmodulin-like protein 6 activates Ternary complex (LRRC7, CAMK2a, ACTN4) 1.0 Voltage-dependent L-type calcium channel subunit alpha-1C Mitogen-activated protein kinase 1 P01148 UniProt HMDB0001043 HMDB Q13698 UniProt 1.0 Nucleus 506-32-1 CAS 1061 PubChem-compound 6076 PubChem-compound Interaction560 DG activates Protein kinase C complex 1.0 Voltage-dependent L-type calcium channel Interaction562 Voltage-dependent L-type calcium channel activates Protein kinase C complex Interaction561 Calcium activates Voltage-dependent L-type calcium channel Calcium Interaction564 MMP2-MMP14 activates Proheparin-binding EGF-like growth factor Mitogen-activated protein kinase kinase kinase 2 Mitogen-activated protein kinase 8 Interaction563 Protein kinase C complex activates Voltage-depenent L-type calcium channel Interaction566 Epidermal growth factor receptor activates Growth factor receptor-bound protein 2 Interaction565 Proheparin-binding EGF-like growth factor activates Epidermal growth factor receptor Dual specificity mitogen-activated protein kinase kinase 3 Transcription factor AP-1 Interaction567 Son of sevenless homolog 1 activates GTPase HRas GTPase HRas 1.0 P18146 UniProt Early growth response protein 1 Phosphate_Dual specificity mitogen-activated protein kinase kinase 7 (Homo sapiens) IP3 MMP2-MMP14 ARACHIDONIC_ACID BioCyc Dual specificity mitogen-activated protein kinase kinase 3 P17612 UniProt Ternary complex (LRRC7, CAMK2a, ACTN4) 1.0 Lutropin subunit beta 1.0 2.0 Nucleus MAPK7 PTK2B GNAS ADCY1 PRKACA GNA11 PLCB1 ITPR1 CALML6 CAMK2A PRKCB CACNA1D CACNA1S CACNA1C MMP14 MMP2 HBEGF EGFR GRB2 SOS1 HRAS PLA2G4B PLD1 SRC CDC42 MAP3K1 GNRH1 GNRHR MAP3K2 LHB Unknown Unknown ATF4 MAP2K3 MAPK14 RAF1 MAP2K1 MAPK1 EGR1 ELK1 MAP2K7 MAPK8 JUN cAMP Calcium Calcium Arachidonic acid Calcium Phosphate Phosphate Phosphate Phosphate Phosphate Phosphate Phosphate Phosphate Phosphate Phosphate PRKCA IP3 DG Phosphatidic Acid