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1.0 Interaction692 E3 ubiquitin-protein ligase CHIP (E3) activates Ubiquitin Complex (Homo sapiens) + Ubiquitin-conjugating enzyme E2 E1 (Homo sapiens) Interaction691 Ubiquitin-like modifier-activating enzyme 1 (E1) (Homo sapiens) + Ubiquitin Complex (Homo sapiens) activates Ubiquitin Complex (Homo sapiens) + Ubiquitin-conjugating enzyme E2 E1 (Homo sapiens) 6022 PubChem-compound P0CG47 UniProt Interaction693 Protein Substrates activates Ubiquitin Complex (Homo sapiens) + Ubiquitin-conjugating enzyme E2 E1 (Homo sapiens) Proteasome subunit beta type-3 Protein Substrates P0CG48 UniProt 1.0 Proteasome subunit alpha type-2 Ubiquitin-like modifier-activating enzyme 1 direct_interaction Ubiquitin-conjugating enzyme E2 E1 1.0 O15205 UniProt C10H14N5O7P Adenosine monophosphate 347.06308 1.0 26S proteasome CHEBI:16027 ChEBI HMDB0000538 HMDB ATP BioCyc Proteasome subunit alpha type-1 1.0 1.0 1.0 ADP BioCyc Proteasome subunit alpha type-4 1.0 1.0 1.0 E3 ubiquitin-protein ligase CHIP Polyubiquitin-B P49721 UniProt 5742 ChemSpider Ubiquitin D P49720 UniProt 1.0 PW064821 PathWhiz Adenosine monophosphate Ubiquitin–Proteasome Pathway 1.0 5858 ChemSpider 1.0 Proteasome subunit alpha type-5 1.0 Proteasome subunit alpha type-6 1.0 Proteasome subunit alpha type-5 Proteasome subunit alpha type-4 Proteasome subunit alpha type-3 Proteasome subunit beta type-2 Proteasome subunit beta type-1 1.0 Proteasome subunit alpha type-7 1.0 P25789 UniProt Proteasome subunit alpha type-2 P25788 UniProt Proteasome subunit beta type-5 Q9UNM6 UniProt Proteasome subunit alpha type-1 P25787 UniProt P25786 UniProt 1.0 1.0 1.0 1.0 26S protease regulatory subunit 6A 26S protease regulatory subunit 7 Peptide 26S protease regulatory subunit 4 Proteasome subunit alpha type-6 26S proteasome Proteasome subunit beta type-7 1.0 26S protease regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 13 26S protease regulatory subunit 6B Adenosine triphosphate Ubiquitin-like modifier-activating enzyme 1 1.0 Ubiquitin-conjugating enzyme E2 E1 Proteasome subunit beta type-6 Ubiquitin D Proteasome subunit beta type-6 Proteasome subunit beta type-5 Proteasome subunit beta type-4 Proteasome subunit beta type-3 P55036 UniProt C00008 KEGG Compound 26S protease regulatory subunit 10B Protein Substrates Proteasome subunit alpha type-7 Proteasome subunit beta type-7 C00002 KEGG Compound 26S protease regulatory subunit 10B 1.0 26S proteasome non-ATPase regulatory subunit 4 1.0 26S proteasome non-ATPase regulatory subunit 13 1.0 1.0 P62333 UniProt 26S protease regulatory subunit 8 1.0 1.0 5957 PubChem-compound 1.0 Polyubiquitin-C Protein Substrates_Ubiquitin Complex (Homo sapiens) 56-65-5 CAS C00020 KEGG Compound 1.0 Adenosine diphosphate C10H15N5O10P2 Adenosine diphosphate 427.02942 GO:0005737 GENE ONTOLOGY P20618 UniProt 1.0 Proteasome subunit beta type-2 1.0 Proteasome subunit beta type-1 Proteasome subunit alpha type-7 Proteasome subunit alpha type-6 Proteasome subunit alpha type-5 Proteasome subunit alpha type-4 Proteasome subunit alpha type-3 Proteasome subunit alpha type-2 Proteasome subunit alpha type-1 1.0 Q9UNE7 UniProt Ubiquitin-like modifier-activating enzyme 1 (E1) (Homo sapiens)_Ubiquitin Complex (Homo sapiens) AMP BioCyc P17980 UniProt 1.0 1.0 HMDB0001341 HMDB 1.0 1.0 26S protease regulatory subunit 8 26S protease regulatory subunit 6B 26S protease regulatory subunit 6A 26S protease regulatory subunit 7 26S protease regulatory subunit 4 Proteasome subunit beta type-7 P28070 UniProt Proteasome subunit beta type-6 Proteasome subunit beta type-5 Proteasome subunit beta type-4 P28072 UniProt Proteasome subunit beta type-3 P28074 UniProt 1.0 SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 1.0 SMP0063816 SMPDB Cytoplasm 26S protease regulatory subunit 6A 26S proteasome (Homo sapiens)_Ubiquitin Complex (Homo sapiens)_Protein Substrates Reaction110968 false 26S proteasome (Homo sapiens) + Ubiquitin Complex (Homo sapiens) + Protein Substrates → Ubiquitin Complex LEFT_TO_RIGHT P35998 UniProt Reaction110969 false 26S proteasome (Homo sapiens) + Ubiquitin Complex (Homo sapiens) + Protein Substrates → Peptide LEFT_TO_RIGHT Reaction110966 false 26S proteasome + Protein Substrates + Ubiquitin Complex (Homo sapiens) → 26S proteasome (Homo sapiens) + Ubiquitin Complex (Homo sapiens) + Protein Substrates LEFT_TO_RIGHT Peptide CHEBI:15422 ChEBI Homo sapiens 1.0 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 13 26S protease regulatory subunit 10B 61-19-8 CAS SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 1.0 Q99436 UniProt 1.0 Proteasome subunit beta type-1 Reaction110960 false Ubiquitin-like modifier-activating enzyme 1 with ATP → Adenosine monophosphate LEFT_TO_RIGHT 1.0 Reaction110961 false Ubiquitin-like modifier-activating enzyme 1 (E1) (Homo sapiens) + Ubiquitin Complex (Homo sapiens) → Ubiquitin-like modifier-activating enzyme 1 (E1) LEFT_TO_RIGHT Reaction110964 false Ubiquitin Complex (Homo sapiens) + Ubiquitin-conjugating enzyme E2 E1 (Homo sapiens) → Protein Substrates + Ubiquitin Complex (Homo sapiens) LEFT_TO_RIGHT Reaction110965 false Protein Substrates + Ubiquitin Complex (Homo sapiens) → Protein Substrates + Ubiquitin Complex (Homo sapiens) LEFT_TO_RIGHT Reaction110962 false Ubiquitin Complex (Homo sapiens) + Ubiquitin-conjugating enzyme E2 E1 (Homo sapiens) → Ubiquitin-conjugating enzyme E2 E1 LEFT_TO_RIGHT Ubiquitin D Polyubiquitin-B C10H16N5O13P3 Adenosine triphosphate 506.99576 26S proteasome non-ATPase regulatory subunit 4 26S proteasome (Homo sapiens)_Ubiquitin Complex (Homo sapiens)_Protein Substrates Protein Substrates_Ubiquitin Complex (Homo sapiens) Ubiquitin Complex (Homo sapiens)_Ubiquitin-conjugating enzyme E2 E1 (Homo sapiens) 26S protease regulatory subunit 6B 1.0 CHEBI:16761 ChEBI P22314 UniProt HMDB0000045 HMDB 1.0 Polyubiquitin-C 1.0 26S protease regulatory subunit 4 Protein Substrates Reaction110970 false Adenosine triphosphate → Adenosine diphosphate LEFT_TO_RIGHT E3 ubiquitin-protein ligase CHIP 9606 TAXONOMY 1.0 1.0 5800 ChemSpider 1.0 P43686 UniProt P62195 UniProt P62191 UniProt Ubiquitin Complex 1.0 P60900 UniProt 1.0 58-64-0 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 1.0 1.0 Polyubiquitin-B 1.0 1.0 P28066 UniProt 1.0 1.0 1.0 6083 PubChem-compound 1.0 1.0 CHEBI:16670 ChEBI P51965 UniProt Polyubiquitin-C 26S protease regulatory subunit 7 Ubiquitin Complex O14818 UniProt Proteasome subunit beta type-4 Proteasome subunit alpha type-3 Interaction687 Ubiquitin Complex activates Ubiquitin-like modifier-activating enzyme 1 (E1) (Homo sapiens) + Ubiquitin Complex (Homo sapiens) Interaction686 Ubiquitin-like modifier-activating enzyme 1 with ATP activates Ubiquitin Complex Interaction689 Ubiquitin-conjugating enzyme E2 E1 activates Ubiquitin-like modifier-activating enzyme 1 (E1) (Homo sapiens) + Ubiquitin Complex (Homo sapiens) Proteasome subunit beta type-2 1.0 Ubiquitin-like modifier- activating enzyme 1 Polyubiquitin-B Ubiquitin D Polyubiquitin-C Ubiquitin- conjugating enzyme E2 E1 E3 ubiquitin- protein ligase CHIP Ubiquitin-like modifier- activating enzyme 1 Ubiquitin- conjugating enzyme E2 E1 Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit beta type-1 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 26S protease regulatory subunit 4 26S protease regulatory subunit 7 26S protease regulatory subunit 6A 26S protease regulatory subunit 6B 26S protease regulatory subunit 8 26S protease regulatory subunit 10B 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 4 Polyubiquitin-B Ubiquitin D Polyubiquitin-C Ubiquitin-like modifier- activating enzyme 1 Polyubiquitin-B Ubiquitin D Polyubiquitin-C Polyubiquitin-B Ubiquitin D Polyubiquitin-C Ubiquitin- conjugating enzyme E2 E1 Polyubiquitin-B Ubiquitin D Polyubiquitin-C Polyubiquitin-B Ubiquitin D Polyubiquitin-C Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-3 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit beta type-1 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta type-4 Proteasome subunit beta type-5 Proteasome subunit beta type-6 Proteasome subunit beta type-7 26S protease regulatory subunit 4 26S protease regulatory subunit 7 26S protease regulatory subunit 6A 26S protease regulatory subunit 6B 26S protease regulatory subunit 8 26S protease regulatory subunit 10B 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 4 Polyubiquitin-B Ubiquitin D Polyubiquitin-C AMP ATP ADP Adenosine triphosphate Protein Substrates Peptide Protein Substrates Protein Substrates Protein Substrates (This is one example of E2) There are various types of E2, which interact with different types of protein (for more details see reference) (This is one example of E3) There are various types of E3, which interact with different types of proteins (for more details see reference) Multiple Cycles Cytoplasm
1.0 Interaction692 E3 ubiquitin-protein ligase CHIP (E3) activates Ubiquitin Complex (Homo sapiens) + Ubiquitin-conjugating enzyme E2 E1 (Homo sapiens) Interaction691 Ubiquitin-like modifier-activating enzyme 1 (E1) (Homo sapiens) + Ubiquitin Complex (Homo sapiens) activates Ubiquitin Complex (Homo sapiens) + Ubiquitin-conjugating enzyme E2 E1 (Homo sapiens) 6022 PubChem-compound P0CG47 UniProt Interaction693 Protein Substrates activates Ubiquitin Complex (Homo sapiens) + Ubiquitin-conjugating enzyme E2 E1 (Homo sapiens) Proteasome subunit beta type-3 Protein Substrates P0CG48 UniProt 1.0 Proteasome subunit alpha type-2 Ubiquitin-like modifier-activating enzyme 1 direct_interaction Ubiquitin-conjugating enzyme E2 E1 1.0 O15205 UniProt C10H14N5O7P Adenosine monophosphate 347.06308 1.0 26S proteasome CHEBI:16027 ChEBI HMDB0000538 HMDB ATP BioCyc Proteasome subunit alpha type-1 1.0 1.0 1.0 ADP BioCyc Proteasome subunit alpha type-4 1.0 1.0 1.0 E3 ubiquitin-protein ligase CHIP Polyubiquitin-B P49721 UniProt 5742 ChemSpider Ubiquitin D P49720 UniProt 1.0 PW064821 PathWhiz Adenosine monophosphate Ubiquitin–Proteasome Pathway 1.0 5858 ChemSpider 1.0 Proteasome subunit alpha type-5 1.0 Proteasome subunit alpha type-6 1.0 Proteasome subunit alpha type-5 Proteasome subunit alpha type-4 Proteasome subunit alpha type-3 Proteasome subunit beta type-2 Proteasome subunit beta type-1 1.0 Proteasome subunit alpha type-7 1.0 P25789 UniProt Proteasome subunit alpha type-2 P25788 UniProt Proteasome subunit beta type-5 Q9UNM6 UniProt Proteasome subunit alpha type-1 P25787 UniProt P25786 UniProt 1.0 1.0 1.0 1.0 26S protease regulatory subunit 6A 26S protease regulatory subunit 7 Peptide 26S protease regulatory subunit 4 Proteasome subunit alpha type-6 26S proteasome Proteasome subunit beta type-7 1.0 26S protease regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 13 26S protease regulatory subunit 6B Adenosine triphosphate Ubiquitin-like modifier-activating enzyme 1 1.0 Ubiquitin-conjugating enzyme E2 E1 Proteasome subunit beta type-6 Ubiquitin D Proteasome subunit beta type-6 Proteasome subunit beta type-5 Proteasome subunit beta type-4 Proteasome subunit beta type-3 P55036 UniProt C00008 KEGG Compound 26S protease regulatory subunit 10B Protein Substrates Proteasome subunit alpha type-7 Proteasome subunit beta type-7 C00002 KEGG Compound 26S protease regulatory subunit 10B 1.0 26S proteasome non-ATPase regulatory subunit 4 1.0 26S proteasome non-ATPase regulatory subunit 13 1.0 1.0 P62333 UniProt 26S protease regulatory subunit 8 1.0 1.0 5957 PubChem-compound 1.0 Polyubiquitin-C Protein Substrates_Ubiquitin Complex (Homo sapiens) 56-65-5 CAS C00020 KEGG Compound 1.0 Adenosine diphosphate C10H15N5O10P2 Adenosine diphosphate 427.02942 GO:0005737 GENE ONTOLOGY P20618 UniProt 1.0 Proteasome subunit beta type-2 1.0 Proteasome subunit beta type-1 Proteasome subunit alpha type-7 Proteasome subunit alpha type-6 Proteasome subunit alpha type-5 Proteasome subunit alpha type-4 Proteasome subunit alpha type-3 Proteasome subunit alpha type-2 Proteasome subunit alpha type-1 1.0 Q9UNE7 UniProt Ubiquitin-like modifier-activating enzyme 1 (E1) (Homo sapiens)_Ubiquitin Complex (Homo sapiens) AMP BioCyc P17980 UniProt 1.0 1.0 HMDB0001341 HMDB 1.0 1.0 26S protease regulatory subunit 8 26S protease regulatory subunit 6B 26S protease regulatory subunit 6A 26S protease regulatory subunit 7 26S protease regulatory subunit 4 Proteasome subunit beta type-7 P28070 UniProt Proteasome subunit beta type-6 Proteasome subunit beta type-5 Proteasome subunit beta type-4 P28072 UniProt Proteasome subunit beta type-3 P28074 UniProt 1.0 SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 1.0 SMP0063816 SMPDB Cytoplasm 26S protease regulatory subunit 6A 26S proteasome (Homo sapiens)_Ubiquitin Complex (Homo sapiens)_Protein Substrates Reaction110968 false 26S proteasome (Homo sapiens) + Ubiquitin Complex (Homo sapiens) + Protein Substrates → Ubiquitin Complex LEFT_TO_RIGHT P35998 UniProt Reaction110969 false 26S proteasome (Homo sapiens) + Ubiquitin Complex (Homo sapiens) + Protein Substrates → Peptide LEFT_TO_RIGHT Reaction110966 false 26S proteasome + Protein Substrates + Ubiquitin Complex (Homo sapiens) → 26S proteasome (Homo sapiens) + Ubiquitin Complex (Homo sapiens) + Protein Substrates LEFT_TO_RIGHT Peptide CHEBI:15422 ChEBI Homo sapiens 1.0 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 13 26S protease regulatory subunit 10B 61-19-8 CAS SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 1.0 Q99436 UniProt 1.0 Proteasome subunit beta type-1 Reaction110960 false Ubiquitin-like modifier-activating enzyme 1 with ATP → Adenosine monophosphate LEFT_TO_RIGHT 1.0 Reaction110961 false Ubiquitin-like modifier-activating enzyme 1 (E1) (Homo sapiens) + Ubiquitin Complex (Homo sapiens) → Ubiquitin-like modifier-activating enzyme 1 (E1) LEFT_TO_RIGHT Reaction110964 false Ubiquitin Complex (Homo sapiens) + Ubiquitin-conjugating enzyme E2 E1 (Homo sapiens) → Protein Substrates + Ubiquitin Complex (Homo sapiens) LEFT_TO_RIGHT Reaction110965 false Protein Substrates + Ubiquitin Complex (Homo sapiens) → Protein Substrates + Ubiquitin Complex (Homo sapiens) LEFT_TO_RIGHT Reaction110962 false Ubiquitin Complex (Homo sapiens) + Ubiquitin-conjugating enzyme E2 E1 (Homo sapiens) → Ubiquitin-conjugating enzyme E2 E1 LEFT_TO_RIGHT Ubiquitin D Polyubiquitin-B C10H16N5O13P3 Adenosine triphosphate 506.99576 26S proteasome non-ATPase regulatory subunit 4 26S proteasome (Homo sapiens)_Ubiquitin Complex (Homo sapiens)_Protein Substrates Protein Substrates_Ubiquitin Complex (Homo sapiens) Ubiquitin Complex (Homo sapiens)_Ubiquitin-conjugating enzyme E2 E1 (Homo sapiens) 26S protease regulatory subunit 6B 1.0 CHEBI:16761 ChEBI P22314 UniProt HMDB0000045 HMDB 1.0 Polyubiquitin-C 1.0 26S protease regulatory subunit 4 Protein Substrates Reaction110970 false Adenosine triphosphate → Adenosine diphosphate LEFT_TO_RIGHT E3 ubiquitin-protein ligase CHIP 9606 TAXONOMY 1.0 1.0 5800 ChemSpider 1.0 P43686 UniProt P62195 UniProt P62191 UniProt Ubiquitin Complex 1.0 P60900 UniProt 1.0 58-64-0 CAS SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 1.0 1.0 Polyubiquitin-B 1.0 1.0 P28066 UniProt 1.0 1.0 1.0 6083 PubChem-compound 1.0 1.0 CHEBI:16670 ChEBI P51965 UniProt Polyubiquitin-C 26S protease regulatory subunit 7 Ubiquitin Complex O14818 UniProt Proteasome subunit beta type-4 Proteasome subunit alpha type-3 Interaction687 Ubiquitin Complex activates Ubiquitin-like modifier-activating enzyme 1 (E1) (Homo sapiens) + Ubiquitin Complex (Homo sapiens) Interaction686 Ubiquitin-like modifier-activating enzyme 1 with ATP activates Ubiquitin Complex Interaction689 Ubiquitin-conjugating enzyme E2 E1 activates Ubiquitin-like modifier-activating enzyme 1 (E1) (Homo sapiens) + Ubiquitin Complex (Homo sapiens) Proteasome subunit beta type-2 1.0 UBA1 UBB UBD UBC UBE2E1 STUB1 UBA1 UBE2E1 PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD13 PSMD4 UBB UBD UBC UBA1 UBB UBD UBC UBB UBD UBC UBE2E1 UBB UBD UBC UBB UBD UBC PSMA1 PSMA2 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMC6 PSMD13 PSMD4 UBB UBD UBC Adenosine monophosphate Adenosine triphosphate Adenosine diphosphate Protein Substrates Peptide Protein Substrates Protein Substrates Protein Substrates